Mild cognitive impairment(MCI),which is a high-risk transitional phase leading to Alzheimer’s disease,is characterized by mild memory deficits and specific cognitive dysfunctions.Without effective intervention,a sign...Mild cognitive impairment(MCI),which is a high-risk transitional phase leading to Alzheimer’s disease,is characterized by mild memory deficits and specific cognitive dysfunctions.Without effective intervention,a significant proportion of patients with MCI progress to dementia.However,current pharmacological treatments are characterized by side effects and poor patient compliance.Therefore,it is necessary to develop effective,noninvasive alternative treatments.Repetitive transcranial magnetic stimulation(rTMS)is becoming a widely studied noninvasive treatment for central nervous system disease.The therapeutic effects of rTMS on patients with MCI and its underlying mechanism are noteworthy issues.Recently,a growing number of studies have shown that meningeal lymphatic vessel damage may be related to cognitive dysfunction.Whether the improvement of the meningeal lymphatic system is an important mechanism through which rTMS improves the clinical manifestations of MCI is worthy of further study.展开更多
In recent years,increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system(CNS)diseases.Studies have indicated that CNS diseases and conditions associated wi...In recent years,increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system(CNS)diseases.Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage dysfunction include neurodegenerative diseases,stroke,infections,traumatic brain injury,tumors,functional cranial disorders,and hydrocephalus.However,the understanding of the regulatory and damage mechanisms of meningeal lymphatics under physiological and pathological conditions is currently limited.Given the importance of a profound understanding of the interplay between meningeal lymphatic drainage and CNS diseases,this review covers seven key aspects:the development and structure of meningeal lymphatic vessels,methods for observing meningeal lymphatics,the function of meningeal lymphatics,the molecular mechanisms of meningeal lymphatic injury,the relationships between meningeal lymphatic vessels and CNS diseases,potential regulatory mechanisms of meningeal lymphatics,and conclusions and outstanding questions.We will explore the relationship between the development,structure,and function of meningeal lymphatics,review current methods for observing meningeal lymphatic vessels in both animal models and humans,and identify unresolved key points in meningeal lymphatic research.The aim of this review is to provide new directions for future research and therapeutic strategies targeting meningeal lymphatics by critically analyzing recent advancements in the field,identifying gaps in current knowledge,and proposing innovative approaches to address thesegaps.展开更多
基金Supported by the Heilongjiang Provincial Health Commission Scientific Research Project,No.20230404040027the Scientific Technology Project of Qiqihar City,No.CSFGG-2025030.
文摘Mild cognitive impairment(MCI),which is a high-risk transitional phase leading to Alzheimer’s disease,is characterized by mild memory deficits and specific cognitive dysfunctions.Without effective intervention,a significant proportion of patients with MCI progress to dementia.However,current pharmacological treatments are characterized by side effects and poor patient compliance.Therefore,it is necessary to develop effective,noninvasive alternative treatments.Repetitive transcranial magnetic stimulation(rTMS)is becoming a widely studied noninvasive treatment for central nervous system disease.The therapeutic effects of rTMS on patients with MCI and its underlying mechanism are noteworthy issues.Recently,a growing number of studies have shown that meningeal lymphatic vessel damage may be related to cognitive dysfunction.Whether the improvement of the meningeal lymphatic system is an important mechanism through which rTMS improves the clinical manifestations of MCI is worthy of further study.
基金supported by the National Natural Science Foundation of China(Grant No.82371361 to Zhi Chen and Grant No.82371333 to Yujie Chen)the Chongqing Municipal Health Commission(YXGD202451 to Yujie Chen)+2 种基金the Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science&Technology Bureau,Grant No.2023GGXM003 to Hua Feng)the State Key Laboratory of Trauma,Burn and Combined Injury(Grant No.SKLYQ202002 to Yujie Chen)the Health Commission of Heilongjiang Province(Grant No.20230404040027 to Qiang Zhang).
文摘In recent years,increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system(CNS)diseases.Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage dysfunction include neurodegenerative diseases,stroke,infections,traumatic brain injury,tumors,functional cranial disorders,and hydrocephalus.However,the understanding of the regulatory and damage mechanisms of meningeal lymphatics under physiological and pathological conditions is currently limited.Given the importance of a profound understanding of the interplay between meningeal lymphatic drainage and CNS diseases,this review covers seven key aspects:the development and structure of meningeal lymphatic vessels,methods for observing meningeal lymphatics,the function of meningeal lymphatics,the molecular mechanisms of meningeal lymphatic injury,the relationships between meningeal lymphatic vessels and CNS diseases,potential regulatory mechanisms of meningeal lymphatics,and conclusions and outstanding questions.We will explore the relationship between the development,structure,and function of meningeal lymphatics,review current methods for observing meningeal lymphatic vessels in both animal models and humans,and identify unresolved key points in meningeal lymphatic research.The aim of this review is to provide new directions for future research and therapeutic strategies targeting meningeal lymphatics by critically analyzing recent advancements in the field,identifying gaps in current knowledge,and proposing innovative approaches to address thesegaps.
