Gestational diabetes mellitus(GDM)is a type of diabetes that arises during pregnancy,leading to long-term adverse consequences for maternal health and fetal development.However,the specific role of endocrine-disruptin...Gestational diabetes mellitus(GDM)is a type of diabetes that arises during pregnancy,leading to long-term adverse consequences for maternal health and fetal development.However,the specific role of endocrine-disrupting chemicals(EDCs)in the pathogenesis of GDM remains controversial.This prospective cohort study sought to investigate how coexposure to bisphenols,parabens,triclosan(TCS),benzophenone-type UV filters,and neonicotinoids(NEOs)affects the odds of GDM.Quantile-based g-computation and Bayesian kernel machine regression showed a significant inverse relationship between EDC mixtures and the reduced risk of GDM(OR=0.34,95%CI:0.13−0.87),which was mainly explained by bisphenol(OR=0.49,95%CI:0.29−0.80)and paraben(OR=0.60,95%CI:0.40−0.91)exposure.Bisphenol S(BPS),bisphenol Z(BPZ),ethylparaben(EtP),propylparaben(PrP),and butylparaben(BuP)were identified as key contributors to the joint effect.In addition,subgroup analyses suggested that the bisphenols-GDM association was more pronounced in younger/normal-weight participants.The sex-specific impact of exposure to bisphenols on the development of GDM was observed,whereas the second trimester represented a critical window for EDC exposure.Continued research efforts,focusing on causal pathways and nonmonotonic relationships,will be crucial to elucidate the complex influence of EDC exposure on the development of GDM.展开更多
Organophosphate esters(OPEs)are emerging flame retardants widely used in products such as furniture,electronic equipment,construction,and plastics.It has been demonstrated that OPEs are harmful to humans and aquatic o...Organophosphate esters(OPEs)are emerging flame retardants widely used in products such as furniture,electronic equipment,construction,and plastics.It has been demonstrated that OPEs are harmful to humans and aquatic organisms,thus posing a threat to ecosystems.Considering that reservoirs are critical sources of drinking water for residents in Southern China,this study quantified nine OPEs in water samples collected from 29 reservoirs and their tributaries.The temporal and spatial distributions of OPEs were analyzed and their ecological risks were assessed.The results showed an extensive presence of OPEs in reservoirs,and the median concentration of S9OPEs was much higher in the dry season(65.3 ng/L)than in the wet season(21.3 ng/L).Triisobutyl phosphate(TiBP)(median:5.24 ng/L)and tris(2-ethylhexyl)phosphate(TEHP)(median:10.8 ng/L)dominated in the wet and dry seasons,respectively.Other OPEs varied considerably in concentrations over time,related to their physical and chemical properties,environmental factors(e.g.,precipitation and temperature),and varied applications.Furthermore,the significant correlations of individual OPEs suggest their shared utilization,emission sources,and environmental behaviors.Spatially,there was no significant difference(P>0.05)among the S9OPEs concentrations in water samples from different sites(inlet,reservoir,outlet,and tributary)of the reservoirs.Additionally,the concentrations of OPEs in reservoir water samples could be linked to industrial development,economic conditions,and population density.OPEs in the reservoir pose low ecological risks(RQ<0.1),except for EDHPP and TEHP,which present median ecological risks(RQ?0.54 and 0.38,respectively).Future studies could investigate more OPEs and their joint effects with other organic pollutants,as well as survey the chemical reactions and degradation pathways of OPEs in different environmental matrices to assess their potential ecotoxicity more comprehensively.展开更多
Bisphenol A(BPA)and its bisphenol analogs(BPs)serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins.However,due to BPA’s detrimental health effects,there has been a growing global co...Bisphenol A(BPA)and its bisphenol analogs(BPs)serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins.However,due to BPA’s detrimental health effects,there has been a growing global consensus to restrict its use.The elderly,being particularly susceptible to neurodegenerative disorders,represent a population of concern;yet,research exploring the association between BPs exposure and neurodegenerative diseases in the elderly remains scarce.In this study,the urinary levels of six BPs among 267 participants from the Shenzhen aging-related disorder cohort in China during 2017–2018 were measured.Cognitive status was evaluated using the Mini-Mental State Examination(MMSE),and the impact of sociodemographic factors,lifestyle habits,and dietary practices was analyzed through the Extreme Gradient Boosting(XGBoost)classifier.In this study,BPA was the highest urinary level of bisphenol compound detected in the high-risk group(2.10 ng/mL,95.2%).Significant differences in BPs levels were observed to the degree of education,tea consumption frequency,meat intake frequency,and distance of main road groups(P<0.05).Notably,the absence of a significant positive correlation between BPF and BPA levels in high-risk groups for cognitive impairment implies more findings may be needed to fully evaluate BPF’s actual human exposure levels.The XGBoost models have further revealed that BPA analogs exposure and certain housing characteristics were substantial contributors to the potential impact on cognitive impairment during aging not only BPA.展开更多
基金supported by the National Natural Science Foundation of China(No.42277424,No.42077385 and No.42477296)the Shenzhen Science and Technology Program(JCYJ20230807110903008)+1 种基金the Guangdong Basic and Applied Basic Research Foundation(2022A1515011605 and 2024A1515012044)the Medical and Health Science and Technology Plan attached to Longgang District Science and Technology Development Special Funding(No.LGKCYLWS2022030).
文摘Gestational diabetes mellitus(GDM)is a type of diabetes that arises during pregnancy,leading to long-term adverse consequences for maternal health and fetal development.However,the specific role of endocrine-disrupting chemicals(EDCs)in the pathogenesis of GDM remains controversial.This prospective cohort study sought to investigate how coexposure to bisphenols,parabens,triclosan(TCS),benzophenone-type UV filters,and neonicotinoids(NEOs)affects the odds of GDM.Quantile-based g-computation and Bayesian kernel machine regression showed a significant inverse relationship between EDC mixtures and the reduced risk of GDM(OR=0.34,95%CI:0.13−0.87),which was mainly explained by bisphenol(OR=0.49,95%CI:0.29−0.80)and paraben(OR=0.60,95%CI:0.40−0.91)exposure.Bisphenol S(BPS),bisphenol Z(BPZ),ethylparaben(EtP),propylparaben(PrP),and butylparaben(BuP)were identified as key contributors to the joint effect.In addition,subgroup analyses suggested that the bisphenols-GDM association was more pronounced in younger/normal-weight participants.The sex-specific impact of exposure to bisphenols on the development of GDM was observed,whereas the second trimester represented a critical window for EDC exposure.Continued research efforts,focusing on causal pathways and nonmonotonic relationships,will be crucial to elucidate the complex influence of EDC exposure on the development of GDM.
基金supported by the National Natural Science Foundation of China(No.42277424 and No.42077385)the Shenzhen Science and Technology Program(JCYJ20230807110903008 and JCYJ20210324122400002).
文摘Organophosphate esters(OPEs)are emerging flame retardants widely used in products such as furniture,electronic equipment,construction,and plastics.It has been demonstrated that OPEs are harmful to humans and aquatic organisms,thus posing a threat to ecosystems.Considering that reservoirs are critical sources of drinking water for residents in Southern China,this study quantified nine OPEs in water samples collected from 29 reservoirs and their tributaries.The temporal and spatial distributions of OPEs were analyzed and their ecological risks were assessed.The results showed an extensive presence of OPEs in reservoirs,and the median concentration of S9OPEs was much higher in the dry season(65.3 ng/L)than in the wet season(21.3 ng/L).Triisobutyl phosphate(TiBP)(median:5.24 ng/L)and tris(2-ethylhexyl)phosphate(TEHP)(median:10.8 ng/L)dominated in the wet and dry seasons,respectively.Other OPEs varied considerably in concentrations over time,related to their physical and chemical properties,environmental factors(e.g.,precipitation and temperature),and varied applications.Furthermore,the significant correlations of individual OPEs suggest their shared utilization,emission sources,and environmental behaviors.Spatially,there was no significant difference(P>0.05)among the S9OPEs concentrations in water samples from different sites(inlet,reservoir,outlet,and tributary)of the reservoirs.Additionally,the concentrations of OPEs in reservoir water samples could be linked to industrial development,economic conditions,and population density.OPEs in the reservoir pose low ecological risks(RQ<0.1),except for EDHPP and TEHP,which present median ecological risks(RQ?0.54 and 0.38,respectively).Future studies could investigate more OPEs and their joint effects with other organic pollutants,as well as survey the chemical reactions and degradation pathways of OPEs in different environmental matrices to assess their potential ecotoxicity more comprehensively.
基金supported by the National Natural Science Foundation of China(No.42277424,No.42077385,and No.42477296)the Shenzhen Science and Technology Program(JCYJ20230807110903008 and JCYJ20240813150902004)+1 种基金Sanming Project of Medicine in Shenzhen(SZSM202211010)Shenzhen Key Medical Discipline Construction Fund(SZXK069).
文摘Bisphenol A(BPA)and its bisphenol analogs(BPs)serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins.However,due to BPA’s detrimental health effects,there has been a growing global consensus to restrict its use.The elderly,being particularly susceptible to neurodegenerative disorders,represent a population of concern;yet,research exploring the association between BPs exposure and neurodegenerative diseases in the elderly remains scarce.In this study,the urinary levels of six BPs among 267 participants from the Shenzhen aging-related disorder cohort in China during 2017–2018 were measured.Cognitive status was evaluated using the Mini-Mental State Examination(MMSE),and the impact of sociodemographic factors,lifestyle habits,and dietary practices was analyzed through the Extreme Gradient Boosting(XGBoost)classifier.In this study,BPA was the highest urinary level of bisphenol compound detected in the high-risk group(2.10 ng/mL,95.2%).Significant differences in BPs levels were observed to the degree of education,tea consumption frequency,meat intake frequency,and distance of main road groups(P<0.05).Notably,the absence of a significant positive correlation between BPF and BPA levels in high-risk groups for cognitive impairment implies more findings may be needed to fully evaluate BPF’s actual human exposure levels.The XGBoost models have further revealed that BPA analogs exposure and certain housing characteristics were substantial contributors to the potential impact on cognitive impairment during aging not only BPA.
