The initial step in the resource utilization of Chinese medicine residues(CMRs)involves dehydration pretreatment,which results in high concentrations of organic wastewater and leads to environmental pollution.Meanwhil...The initial step in the resource utilization of Chinese medicine residues(CMRs)involves dehydration pretreatment,which results in high concentrations of organic wastewater and leads to environmental pollution.Meanwhile,to address the issue of anaerobic systems failing due to acidification under shock loading,a microaerobic expanded granular sludge bed(EGSB)and moving bed sequencing batch reactor(MBSBR)combined process was proposed in this study.Microaeration facilitated hydrolysis,improved the removal of nitrogen and phosphorus pollutants,maintained a low concentration of volatile fatty acids(VFAs),and enhanced system stability.In addition,microaeration promoted microbial richness and diversity,enriching three phyla:Bacteroidota,Synergistota and Firmicutes associated with hydrolytic acidification.Furthermore,aeration intensity in MBSBR was optimized.Elevated levels of dissolved oxygen(DO)impacted biofilm structure,suppressed denitrifying bacteria activity,led to nitrate accumulation,and hindered simultaneous nitrification and denitrification(SND).Maintaining a DO concentration of 2 mg/L enhanced the removal of nitrogen and phosphorus while conserving energy.The combined process achieved removal efficiencies of 98.25%,90.49%,and 98.55%for chemical oxygen demand(COD),total nitrogen(TN),and total phosphorus(TP),respectively.Typical pollutants liquiritin(LQ)and glycyrrhizic acid(GA)were completely degraded.This study presents an innovative approach for the treatment of high-concentration organic wastewater and provides a reliable solution for the pollution control in utilization of CMRs resources.展开更多
Solar-driven(or light-driven)production of hydrogen peroxide(H_(2)O_(2))from water(H_(2)O)and molecular oxygen(O_(2))has recently received increasing attention as a green and sustainable alternative to conventional me...Solar-driven(or light-driven)production of hydrogen peroxide(H_(2)O_(2))from water(H_(2)O)and molecular oxygen(O_(2))has recently received increasing attention as a green and sustainable alternative to conventional methods.However,the field of photocatalytic H_(2)O_(2)production is still in its infancy,primarily because of limited H_(2)O_(2)production efficiency.Over the past few years,a wide range of inorganic,organic,and organic-inorganic hybrid photocatalysts have been developed via diverse synthetic and modification strategies to increase the H_(2)O_(2)yield.Among them,organic-inorganic hybrid photocatalysts have shown higher H_(2)O_(2)production performance than single-component systems;at the same time,the advancements and challenges of these hybrid systems have not been comprehensively reviewed.Therefore,this review summarizes the advantages/limitations,recent progress,and potential challenges of organic-inorganic hybrid photocatalysts for H_(2)O_(2)production.First,we elucidate the superiority of the photocatalytic H_(2)O_(2)production over the conventional anthraquinone oxidation process.Then,we summarize the advantages and limitations of inorganic,organic,and organic-inorganic hybrid photocatalysts and discuss in detail the design,synthetic strategies,and photochemical properties of organic-inorganic hybrid photocatalysts.Finally,this review outlines the challenges and outlook for future research in this emerging area.展开更多
A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as wel...A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.展开更多
V-pits have been intensively studied for their role in light-emitting diodes(LEDs).The coverage of V-pits in InGaN/GaN multiquantum wells(MQWs)is critical for suppressing leakage path through electron blocking layer(E...V-pits have been intensively studied for their role in light-emitting diodes(LEDs).The coverage of V-pits in InGaN/GaN multiquantum wells(MQWs)is critical for suppressing leakage path through electron blocking layer(EBL).In this study,we have investigated the coverage of V-pits in green mini-LEDs modulated via growth parameters optimization and systematically analyzed the characteristics of the photoelectric properties associated with V-pits coverage on device.Elevated temperatures and pressures result in enhanced adatoms migration,which can achieve a coverage up to 98.8% of V-pits,improving the crystal quality due to stable surface.Electrical characterization reveals that although high-coverage devices exhibit suppressed leakage current,their peak external quantum efficiency(EQE)decreases,more seriously spectral blue shift and operating voltage increase due to compromised hole transport uniformity.Intriguingly,intermediate-coverage samples demonstrate superior breakdown voltage characteristics.Current-voltage curve analysis shows the ideality factor increases from 1.8 to 2.5 with improved coverage,indicating aggravated Shockley-Read-Hall(SRH)recombination with covered V-pits.展开更多
Ice-assisted synthesis is a facile,effective,and eco-friendly approach for preparing environmental functional materials.The quasi-liquid layer(QLL)or ice grain boundary(IGB)of the ice provides ideal interface-confined...Ice-assisted synthesis is a facile,effective,and eco-friendly approach for preparing environmental functional materials.The quasi-liquid layer(QLL)or ice grain boundary(IGB)of the ice provides ideal interface-confined environments for preparing two-dimensional(2D)sheet-like,three-dimensional(3D)hierarchical porous,polymeric hybrid,and atomically dispersed materials via the in-situ interfacial chemical reactions.Ice-templating physical pretreatment allows directional assembly of preformed materials,sheet exfoliation from bulk materials,transfer or cleaning of 2D materials,uniform dispersion of precursors,and self-assembly of nanoparticles.Additionally,the ice-melting process offers a novel way to prepare nanomaterials of uniform size due to the ultraslow release of reactants from the ice crystals.Furthermore,environmental applications of ice-assisted synthetic materials have been concluded.Advanced membrane materials synthesized based on ice chemistry exhibit superior water permeance,ion selectivity,and disinfection.Also,ice-assisted synthesis has innate advantages for designing environmental functional catalysts or adsorbents dedicated to environmental remediation.Finally,the challenges of the current progress in this field are discussed.展开更多
Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality,necessitating novel therapeutic targets.This study explores the oncogenic role of integrin-linked kinase-associated phosphatase(ILKAP)in HCC ...Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality,necessitating novel therapeutic targets.This study explores the oncogenic role of integrin-linked kinase-associated phosphatase(ILKAP)in HCC and its underlying mechanisms.Database analyses(TCGA,UALCAN)revealed ILKAP overexpression in HCC,correlating with poor prognosis.Functional assays demonstrated that ILKAP knockdown significantly suppressed HCC cell proliferation and migration in vitro,while xenograft models confirmed its role in tumor growth in vivo.RNA sequencing identified 357 differentially expressed genes(DEGs),including 48 protein-coding DEGs,with glycolytic enzyme PGAM1 notably downregulated upon ILKAP silencing.ILKAP and PGAM1 expression were positively correlated in HCC tissues,and elevated PGAM1 levels were linked to worse survival.Notably,restoring PGAM1 in ILKAP-knockdown cells rescued proliferation and invasion,underscoring PGAM1’s critical role in ILKAP-mediated tumor progression.ILKAP depletion also reduced extracellular acidification rates and altered glycolysis-related gene expression,highlighting its role in metabolic reprogramming.These findings suggest that ILKAP drives HCC malignancy by modulating PGAM1 and glycolysis,providing a potential therapeutic target for HCC treatment.Further elucidation of the ILKAP-PGAM1 axis may offer new strategies for liver cancer management.展开更多
Photocatalytic nonoxidative coupling of CH_(4)to multicarbon(C^(2+))hydrocarbons(e.g.,C,H4)and H,under ambient conditions provides a promising energy-conserving approach for utilization of carbon resource.However,as t...Photocatalytic nonoxidative coupling of CH_(4)to multicarbon(C^(2+))hydrocarbons(e.g.,C,H4)and H,under ambient conditions provides a promising energy-conserving approach for utilization of carbon resource.However,as the methyl intermediates prefer to undergo self-coupling to produce ethane,it is a challenging task to control the selective conversion of CH to higher valueadded CH4.Herein,we adopt a synergistic catalysis strategy by integrating Pd-Zn active sites on visible light-responsive defective WO_(3)nanosheets for synergizing the adsorption,activation,and dehydrogenation processes in CH_(4)to C_(2)H_(4)conversion.Benefiting from the synergy,our model catalyst achieves a remarkable C^(2+)compounds yield of 31.85μmolgh with an exceptionally high C,H4 selectivity of 75.3%and a stoichiometric H_(2)evolution.In situ spectroscopic studies reveal that the Zn sites promote the adsorption and activation of CH_(4)molecules to generate methyl and methoxy intermediates with the assistance of lattice oxygen,while the Pd sites facilitate the dehydrogenation of methoxy to methylene radicals for producing C_(2)H_(4)and suppress overoxidation.This work demonstrates a strategy for designing efficient photocatalysts toward selective coupling of CH_(4)to higher value-added chemicals and highlights the importance of synergistic active sites to the synergy of key steps in catalytic reactions.展开更多
基金funding from the National Key R&D Program of China(No.2019YFC1906600)the National Natural Science Foundation of China(No.52200049)+3 种基金the China Postdoctoral Science Foundation(No.2022TQ0089)the Heilongjiang Province Postdoctoral Science Foundation(No.LBH-Z22181)the State Key Laboratory of Urban Water Resource and Environment(Harbin Institute of Technology)(No.2023DX06)the Fundamental Research Funds for the Central Universities。
文摘The initial step in the resource utilization of Chinese medicine residues(CMRs)involves dehydration pretreatment,which results in high concentrations of organic wastewater and leads to environmental pollution.Meanwhile,to address the issue of anaerobic systems failing due to acidification under shock loading,a microaerobic expanded granular sludge bed(EGSB)and moving bed sequencing batch reactor(MBSBR)combined process was proposed in this study.Microaeration facilitated hydrolysis,improved the removal of nitrogen and phosphorus pollutants,maintained a low concentration of volatile fatty acids(VFAs),and enhanced system stability.In addition,microaeration promoted microbial richness and diversity,enriching three phyla:Bacteroidota,Synergistota and Firmicutes associated with hydrolytic acidification.Furthermore,aeration intensity in MBSBR was optimized.Elevated levels of dissolved oxygen(DO)impacted biofilm structure,suppressed denitrifying bacteria activity,led to nitrate accumulation,and hindered simultaneous nitrification and denitrification(SND).Maintaining a DO concentration of 2 mg/L enhanced the removal of nitrogen and phosphorus while conserving energy.The combined process achieved removal efficiencies of 98.25%,90.49%,and 98.55%for chemical oxygen demand(COD),total nitrogen(TN),and total phosphorus(TP),respectively.Typical pollutants liquiritin(LQ)and glycyrrhizic acid(GA)were completely degraded.This study presents an innovative approach for the treatment of high-concentration organic wastewater and provides a reliable solution for the pollution control in utilization of CMRs resources.
基金supported by National Natural Science Foundation of China (Nos. 52170030 and 52200049)State Key Laboratory of Urban Water Resource and Environment(Harbin Institute of Technology) (No. 2024TS28)+1 种基金Fundamental Research Funds for the Central UniversitiesYoung Scientist Studio of Harbin Institute of Technology
文摘Solar-driven(or light-driven)production of hydrogen peroxide(H_(2)O_(2))from water(H_(2)O)and molecular oxygen(O_(2))has recently received increasing attention as a green and sustainable alternative to conventional methods.However,the field of photocatalytic H_(2)O_(2)production is still in its infancy,primarily because of limited H_(2)O_(2)production efficiency.Over the past few years,a wide range of inorganic,organic,and organic-inorganic hybrid photocatalysts have been developed via diverse synthetic and modification strategies to increase the H_(2)O_(2)yield.Among them,organic-inorganic hybrid photocatalysts have shown higher H_(2)O_(2)production performance than single-component systems;at the same time,the advancements and challenges of these hybrid systems have not been comprehensively reviewed.Therefore,this review summarizes the advantages/limitations,recent progress,and potential challenges of organic-inorganic hybrid photocatalysts for H_(2)O_(2)production.First,we elucidate the superiority of the photocatalytic H_(2)O_(2)production over the conventional anthraquinone oxidation process.Then,we summarize the advantages and limitations of inorganic,organic,and organic-inorganic hybrid photocatalysts and discuss in detail the design,synthetic strategies,and photochemical properties of organic-inorganic hybrid photocatalysts.Finally,this review outlines the challenges and outlook for future research in this emerging area.
文摘A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.
基金supported by the Special Key Project of Technological Innovation and Application Development in Chongqing(CSTB2023TIADKPX0017)the National Natural Science Foundation of China(Grant 22275154).
文摘V-pits have been intensively studied for their role in light-emitting diodes(LEDs).The coverage of V-pits in InGaN/GaN multiquantum wells(MQWs)is critical for suppressing leakage path through electron blocking layer(EBL).In this study,we have investigated the coverage of V-pits in green mini-LEDs modulated via growth parameters optimization and systematically analyzed the characteristics of the photoelectric properties associated with V-pits coverage on device.Elevated temperatures and pressures result in enhanced adatoms migration,which can achieve a coverage up to 98.8% of V-pits,improving the crystal quality due to stable surface.Electrical characterization reveals that although high-coverage devices exhibit suppressed leakage current,their peak external quantum efficiency(EQE)decreases,more seriously spectral blue shift and operating voltage increase due to compromised hole transport uniformity.Intriguingly,intermediate-coverage samples demonstrate superior breakdown voltage characteristics.Current-voltage curve analysis shows the ideality factor increases from 1.8 to 2.5 with improved coverage,indicating aggravated Shockley-Read-Hall(SRH)recombination with covered V-pits.
基金supported by National Natural Science Foundation of China(Nos.52170030,52200049)China Postdoctoral Science Foundation(No.2022TQ0089)+2 种基金State Key Laboratory of Urban-rural Water Resource and Environment(Harbin Institute of Technology)(No.2024TS28)Young Scientist Studio of Harbin Institute of TechnologyFundamental Research Funds for the Central Universities。
文摘Ice-assisted synthesis is a facile,effective,and eco-friendly approach for preparing environmental functional materials.The quasi-liquid layer(QLL)or ice grain boundary(IGB)of the ice provides ideal interface-confined environments for preparing two-dimensional(2D)sheet-like,three-dimensional(3D)hierarchical porous,polymeric hybrid,and atomically dispersed materials via the in-situ interfacial chemical reactions.Ice-templating physical pretreatment allows directional assembly of preformed materials,sheet exfoliation from bulk materials,transfer or cleaning of 2D materials,uniform dispersion of precursors,and self-assembly of nanoparticles.Additionally,the ice-melting process offers a novel way to prepare nanomaterials of uniform size due to the ultraslow release of reactants from the ice crystals.Furthermore,environmental applications of ice-assisted synthetic materials have been concluded.Advanced membrane materials synthesized based on ice chemistry exhibit superior water permeance,ion selectivity,and disinfection.Also,ice-assisted synthesis has innate advantages for designing environmental functional catalysts or adsorbents dedicated to environmental remediation.Finally,the challenges of the current progress in this field are discussed.
基金supported by grants from the Natural Science Foundation of Zhejiang Province(No.LGF22H080016)the Key Research and Development Select Projects of Zhejiang Provincial Department of Science and Technology(No.2020C03008)+1 种基金the Zhejiang Medical Health Science and Technology Project(No.2022RC124)the Hangzhou Medical College Basal Research Fund(No.KYZD2024004).
文摘Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality,necessitating novel therapeutic targets.This study explores the oncogenic role of integrin-linked kinase-associated phosphatase(ILKAP)in HCC and its underlying mechanisms.Database analyses(TCGA,UALCAN)revealed ILKAP overexpression in HCC,correlating with poor prognosis.Functional assays demonstrated that ILKAP knockdown significantly suppressed HCC cell proliferation and migration in vitro,while xenograft models confirmed its role in tumor growth in vivo.RNA sequencing identified 357 differentially expressed genes(DEGs),including 48 protein-coding DEGs,with glycolytic enzyme PGAM1 notably downregulated upon ILKAP silencing.ILKAP and PGAM1 expression were positively correlated in HCC tissues,and elevated PGAM1 levels were linked to worse survival.Notably,restoring PGAM1 in ILKAP-knockdown cells rescued proliferation and invasion,underscoring PGAM1’s critical role in ILKAP-mediated tumor progression.ILKAP depletion also reduced extracellular acidification rates and altered glycolysis-related gene expression,highlighting its role in metabolic reprogramming.These findings suggest that ILKAP drives HCC malignancy by modulating PGAM1 and glycolysis,providing a potential therapeutic target for HCC treatment.Further elucidation of the ILKAP-PGAM1 axis may offer new strategies for liver cancer management.
基金supported by the National Key R&D Program of China(2020YFA0406103)the National Natural Science Foundation of China(22232003,21725102,91961106,91963108,22175165,and 51902253)+5 种基金the DNL Cooperation Fund,the CAS(DNL201922)the Strategic Priority Research Program of the CAS(XDPB14)the Open Funding Project of National Key Laboratory of Human Factors Engineering(No.SYFD062010K)the Youth Innovation Promotion Association CAS(2021451),the Natural Science Foundation of Shaanxi Province(2020JQ-778)the USTC Research Funds of the Double First-Class Initiative(YD2060002020)the Fundamental Research Funds for Central Universities of the Central South University(WK2400000004)。
文摘Photocatalytic nonoxidative coupling of CH_(4)to multicarbon(C^(2+))hydrocarbons(e.g.,C,H4)and H,under ambient conditions provides a promising energy-conserving approach for utilization of carbon resource.However,as the methyl intermediates prefer to undergo self-coupling to produce ethane,it is a challenging task to control the selective conversion of CH to higher valueadded CH4.Herein,we adopt a synergistic catalysis strategy by integrating Pd-Zn active sites on visible light-responsive defective WO_(3)nanosheets for synergizing the adsorption,activation,and dehydrogenation processes in CH_(4)to C_(2)H_(4)conversion.Benefiting from the synergy,our model catalyst achieves a remarkable C^(2+)compounds yield of 31.85μmolgh with an exceptionally high C,H4 selectivity of 75.3%and a stoichiometric H_(2)evolution.In situ spectroscopic studies reveal that the Zn sites promote the adsorption and activation of CH_(4)molecules to generate methyl and methoxy intermediates with the assistance of lattice oxygen,while the Pd sites facilitate the dehydrogenation of methoxy to methylene radicals for producing C_(2)H_(4)and suppress overoxidation.This work demonstrates a strategy for designing efficient photocatalysts toward selective coupling of CH_(4)to higher value-added chemicals and highlights the importance of synergistic active sites to the synergy of key steps in catalytic reactions.
