The outstanding performance of O3-type NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)(NFM111)at both high and low temperatures coupled with its impressive specific capacity makes it an excellent cathode material for sodium-ion batte...The outstanding performance of O3-type NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)(NFM111)at both high and low temperatures coupled with its impressive specific capacity makes it an excellent cathode material for sodium-ion batteries.However,its poor cycling,owing to highpressure phase transitions,is one of its disadvantages.In this study,Cu/Ti was introduced into NFM111 cathode material using a solidphase method.Through both theoretically and experimentally,this study found that Cu doping provides a higher redox potential in NFM111,improving its reversible capacity and charge compensation process.The introduction of Ti would enhance the cycling stability of the material,smooth its charge and discharge curves,and suppress its high-voltage phase transitions.Accordingly,the NaNi_(0.27)Fe_(0.28)Mn_(0.33)Cu_(0.05)Ti_(0.06)O_(2)sample used in the study exhibited a remarkable rate performance of 142.97 mAh·g^(-1)at 0.1 C(2.0-4.2 V)and an excellent capacity retention of 72.81%after 300 cycles at 1C(1C=150 mA·g^(-1)).展开更多
Reductive soil disinfestation(RSD)is commonly employed for soil remediation in greenhouse cultivation.However,its influence on antibiotic resistance genes(ARGs)in soil remains uncertain.This study investigated the dyn...Reductive soil disinfestation(RSD)is commonly employed for soil remediation in greenhouse cultivation.However,its influence on antibiotic resistance genes(ARGs)in soil remains uncertain.This study investigated the dynamic changes in soil communities,potential bacterial pathogens,and ARG profiles under various organicmaterial treatments during RSD,including distillers’grains,potato peel,peanut vine,and peanut vine combined with charcoal.Results revealed that applying diverse organic materials in RSD significantly altered bacterial community composition and diminished the relative abundance of potential bacterial pathogens(P<0.05).The relative abundance of high-risk ARGs decreased by 10.7%-30.6%after RSD treatments,the main decreased ARG subtypeswere AAC(3)_Via,dfrA1,ErmB,lnuB,aadA.Actinobacteria was the primary host of ARGs and was suppressed by RSD.Soil physicochemical properties,such as total nitrogen,soil pH,total carbon,were crucial factors affecting ARG profiles.Our findings demonstrated that RSD treatment inhibited pathogenic bacteria and could be an option for reducing high-risk ARG proliferation in soil.展开更多
Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has b...Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last decades.However,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic strategies.Increasing evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s disease.These receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s disease.This review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.展开更多
The use of water resources for energy generation has become increasingly prevalent,encompassing the conversion of kinetic energy from streams,tides,and waves into renewable electrical power.Water energy sources offer ...The use of water resources for energy generation has become increasingly prevalent,encompassing the conversion of kinetic energy from streams,tides,and waves into renewable electrical power.Water energy sources offer numerous benefits,including widespread availability,stability,and the absence of carbon dioxide and other greenhouse gas emissions,making them a clean and environmentally friendly form of energy.In this work,we develop a droplet-based liquid-solid triboelectric nanogenerator(LS-TENG)using sophisticatedly designed inflatable columnar structures with inner and outer dual-electrodes.This device can be utilized to harvest both the internal droplet-rolling mechanical energy and the external droplet-falling mechanical energy,capable of being assembled into various structures for versatile applications.The design incorporates a combined structure of both internal and external TENG to optimize output performance via multiple energy harvesting strategies.The internal structure features a dual-electrode columnar-shaped LS-TENG,designed to harvest fluid kinetic energy from water droplets.By leveraging the back-and-forth motion of a small amount of water within the air column,mechanical energy can be readily collected,achieving a maximum mass power density of 9.02 W·Kg^(−1)and an energy conversion efficiency of 10.358%.The external component is a droplet-based LS-TENG,which utilizes a double-layer capacitor switch effect elucidated with an equivalent circuit model.Remarkably,without the need for pre-charging,a single droplet can generate over 140 V of high voltage,achieving a maximum power density of 7.35 W·m^(−2)and an energy conversion efficiency of 22.058%.The combined LS-TENG with a sophisticated inflatable columnar structure can simultaneously collect multiple types of energy with high efficacy,exhibiting great significance in potential applications such as TENG aeration rollers,inflatable lifejacket,wind energy harvesting,TENG tents,and green houses.展开更多
Neuromorphic computing extends beyond sequential processing modalities and outperforms traditional von Neumann architectures in implementing more complicated tasks,e.g.,pattern processing,image recognition,and decisio...Neuromorphic computing extends beyond sequential processing modalities and outperforms traditional von Neumann architectures in implementing more complicated tasks,e.g.,pattern processing,image recognition,and decision making.It features parallel interconnected neural networks,high fault tolerance,robustness,autonomous learning capability,and ultralow energy dissipation.The algorithms of artificial neural network(ANN)have also been widely used because of their facile self-organization and self-learning capabilities,which mimic those of the human brain.To some extent,ANN reflects several basic functions of the human brain and can be efficiently integrated into neuromorphic devices to perform neuromorphic computations.This review highlights recent advances in neuromorphic devices assisted by machine learning algorithms.First,the basic structure of simple neuron models inspired by biological neurons and the information processing in simple neural networks are particularly discussed.Second,the fabrication and research progress of neuromorphic devices are presented regarding to materials and structures.Furthermore,the fabrication of neuromorphic devices,including stand-alone neuromorphic devices,neuromorphic device arrays,and integrated neuromorphic systems,is discussed and demonstrated with reference to some respective studies.The applications of neuromorphic devices assisted by machine learning algorithms in different fields are categorized and investigated.Finally,perspectives,suggestions,and potential solutions to the current challenges of neuromorphic devices are provided.展开更多
Understanding the synergistic effect between ligands at the atomic level to control the catalytic selectivity of catalysts remains a significant challenge due to the complexity of ligand interactions and limitations i...Understanding the synergistic effect between ligands at the atomic level to control the catalytic selectivity of catalysts remains a significant challenge due to the complexity of ligand interactions and limitations in current analytical techniques.Herein,using precisely structured metal nanoclusters as models,we discovered that altering the electronegativity of substituents on donor thiolate ligands can modulate the bond dissociation energy of coordinated phosphine ligands on the clusters.This change leads to the selective dissociation of ligands during the catalytic process,thereby enabling control over catalytic selectivity with an abrupt increase in formate production from~0%to 23%.This work provides crucial insights into understanding ligand interactions on metal nanoparticle surfaces at the atomic level and lays the foundation for designing highly selective catalysts in the future.展开更多
The Natural Forest Protection Project(NFPP),initiated by the Chinese government in 2000,is a crucial ecological construction project that has played a significant role in forest restoration in China.Forests in the Qin...The Natural Forest Protection Project(NFPP),initiated by the Chinese government in 2000,is a crucial ecological construction project that has played a significant role in forest restoration in China.Forests in the Qinghai-Tibet Plateau(QTP)serve as important habitats for many rare and endemic birds.Understanding the conservation efficiency of NFPP implementation on these birds holds significant practical significance.In this study,we utilized land use change matrices to analyze the forest changes in the QTP before and after NFPP implementation,predicted the potential spatial distribution of 16 nationally protected birds using Species Distribution Models(SDMs),and compared the impacts of this project on bird habitats under different carbon emission scenarios.Mann-Whitney U tests were employed to analyze the adaptation of different birds to forest changes during NFPP implementation.Our results showed that NFPP protected 172,398 km^(2) of primary forests and added 6379 km^(2) of secondary forests in our study area.The potential spatial distribution and sympatric species richness of the 16 protected birds slightly increased after NFPP implementation under different climate change scenarios,and NFPP implementation contributed to improving the potential spatial distribution of birds.Compared to newly established secondary forests,protected primary forests exhibited enhanced conservation for forest birds(Z-value>0 for six bird species,P<0.1),while being less suitable for non-forest birds(significantly unsuitable for three non-forest bird species,Z-value<0,P<0.05;non-significantly unsuitable for four non-forest bird species,Zvalue<0,P>0.1).This indicates that the protection of primary forests during NFPP implementation benefits forest bird conservation while the addition of secondary forests is beneficial to non-forest birds.To enhance the role of NFPP in avian conservation in the QTP,it is suggested to increase the landscape heterogeneity of forest,particularly in newly established secondary forests.展开更多
Throughout versatile metal compositions and unique structural characteristics,polynary metal atom catalysts(PACs)readily harness synergistic intermetallic effects,significantly boosting the catalytic performances.Thes...Throughout versatile metal compositions and unique structural characteristics,polynary metal atom catalysts(PACs)readily harness synergistic intermetallic effects,significantly boosting the catalytic performances.These catalysts are featured by favorable catalytic activity,stability and selectivity,offering avenues to tackle challenges in energy conversion,environmental protection and chemical synthesis.Nevertheless,an in-depth understanding and comprehensive summary of the structure-performance relationship for the emerging PACs remains elusive.This review embarks from the classification of PACs,delving further into the origins of catalytic activity and mechanisms underpinning performance enhancement.At the beginning,it outlines the fundamental concepts,preparation methods and accurate recognition of PACs.Subsequently,it centers on discussing the origins of activity,strategies for performance optimization,mechanisms of action,and application scenarios across diverse catalytic reactions.Moreover,the unexplored issues and future perspectives of PACs are proposed at the end,stating their pivotal roles in advancing green chemistry and the sustainable energy realm.This review overall aims to provide valuable insight and guidance for the preparation and application of PACs.展开更多
Influenza B viruses(IBVs)primarily infect humans and are a common cause of respiratory infections in humans.Here,to systematically analyze the antigenicity of the IBVs Hemagglutinin(HA)protein,31 B/Victoria and 19 B/Y...Influenza B viruses(IBVs)primarily infect humans and are a common cause of respiratory infections in humans.Here,to systematically analyze the antigenicity of the IBVs Hemagglutinin(HA)protein,31 B/Victoria and 19 B/Yamagata representative circulating strains were selected from Global Initiative of Sharing All Influenza Data(GISAID),and pseudotyped viruses were constructed with the vesicular stomatitis virus system.Guinea pigs were immunized with three doses of vaccines(one dose of DNA vaccines following two doses of pseudotyped virus vaccines)of the seven IBV vaccine strains,and neutralizing antibodies against the pseudotyped viruses were tested.By comparing differences between various vaccine strains,we constructed several pseudotyped viruses that contained various mutations based on vaccine strainBV-21.The vaccine strains showed good neutralization levels against the epidemic virus strains of the same year,with neutralization titers ranging from 370 to 840,while the level of neutralization against viruses prevalent in previous years decreased 1–10-fold.Each of the high-frequency epidemic strains of B/Victoria andB/Yamagata not only induced high neutralizing titers,but also had broadly neutralizing effects against virus strains of different years,with neutralizing titers ranging from1000 to 7200.R141G,D197 N,and R203K were identified as affecting the antigenicity of IBV.These mutation sites provide valuable references for the selection and design of a universal IBV vaccine strain in the future.展开更多
Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of env...Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of environmental friendliness, mechanical properties, and stability. Here, we report a super-strong, biodegradable, and washable cellulose-based conductive macrofibers, which is prepared by wet-stretching and wet-twisting bacterial cellulose hydrogel incorporated with carbon nanotubes and polypyrrole. The cellulose-based conductive macrofibers possess high tensile strength of 449 MPa(able to lift 2 kg weights), good electrical conductivity(~ 5.32 S cm^(-1)), and excellent stability(Tensile strength and conductivity only decrease by 6.7% and 8.1% after immersing in water for 1 day). The degradation experiment demonstrates macrofibers can be degraded within 108 h in the cellulase solution. The designed fabric-based TENG from the cellulose-base conductive macrofibers shows a maximum open-circuit voltage of 170 V, short-circuit current of 0.8 μA, and output power at 352 μW, which is capable of powering the commercial electronics by charging the capacitors. More importantly, the fabric-based TENGs can be attached to the human body and work as self-powered sensors to effectively monitor human motions. This study suggests the potential of biodegradable, super-strong, and washable conductive cellulose-based fiber for designing eco-friendly fabric-based TENG for energy harvesting and biomechanical monitoring.展开更多
Peatlands are one of the major natural sources of methane （CH4）, but the level of CH4 efflux is uncertain, especially in alpine peatlands. In this study, CH4 emission fluxes from natural and drained peatlands on the...Peatlands are one of the major natural sources of methane （CH4）, but the level of CH4 efflux is uncertain, especially in alpine peatlands. In this study, CH4 emission fluxes from natural and drained peatlands on the Qinghai- Tibet Plateau, southwest China, were measured from June to October in 2013 using the opaque static chamber technique and the Fast Greenhouse Gas Analyzer （DLT-100, Los Gatos Research Corp.）. CH4 emission fluxes ranged from 2.07 to 56.33 mg m^-2 h^-1 in natural peatlands and from 0.02 to 0.42 mg m^-2 h^-1 in drained peatlands. Mean CH4 emission flux was 19.13 mg m^-2 h^-1 in natural peatlands and 0.14 mg m^-2 h^-1 in drained peatlands. These results showed that drainage led to a significant decrease in CH4 emissions. CH4 emission fluxes for all sampling plots were significantly correlated with variation in water table depth for linear （R^2 = 0.453, P 〈 0.01） and exponential functions （R^2 = 0.429, P 〈 0.01）.展开更多
Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the pre...Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. Results showed that LYT infusions(1/100 and 1/50, m/V)as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis(lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism(higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis(lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. Taken together, LYT exhibits the activities in alleviating diabetic symptoms, ameliorating glucose and lipid dysmetabolism and fatty liver, and preventing diabetic nephropathy in diabetic mice. These activities may be explored for the prevention and treatment of diabetes in humans.展开更多
Colloidal solution combustion synthesis(CSCS)is a simple and easy method for mass-production of crystalline nanomaterials with tunable pore structure.In this work,mesoporous Mn/CeO_(2) catalysts were fabricated via CS...Colloidal solution combustion synthesis(CSCS)is a simple and easy method for mass-production of crystalline nanomaterials with tunable pore structure.In this work,mesoporous Mn/CeO_(2) catalysts were fabricated via CSCS method coupled with a dip-coating process and used for photocatalytic oxidation(PCO)of toluene.Under vacuum ultraviolet(VUV)irradiation,a high toluene removal efficiency of about 92%was achieved with a toluene reaction rate of about 118μmol/g/h in a continuous flow reactor.A possible degradation pathway was proposed based on the analysis of intermediates by Fourier transform infrared photoluminescence spectra(FTIR)and GC-Mass.Hydrogen temperature-programmed reduction(H_(2)-TPR),Brunauer-Emmett-Teller(BET)surface areas,photoluminescence spectra(PL)spectra and X-ray photoelectron spectroscopy(XPS)were carried out to analyze physical and chemical properties of the catalysts.Compared with Mn_(x)Ce_(1-x)O_(2) catalysts synthesized by one step CSCS method,Mn/CeO_(2) has a higher photocatalytic activity,which is attributed to the presence of higher contents of Ce^(3+),Mn^(2+)and Mn^(3+)species.The presence of higher contents of these species plays a key role in the activity enhancement of toluene oxidation and ozone decomposition.This method is facile,efficient and scalable,and it may become a promising industrial application technology for catalyst synthesis in the near future.展开更多
Background:Myocardial infarction(MI)is an acute condition in which the heart mus-cle dies due to the lack of blood supply.Previous research has suggested that au-tophagy and angiogenesis play vital roles in the preven...Background:Myocardial infarction(MI)is an acute condition in which the heart mus-cle dies due to the lack of blood supply.Previous research has suggested that au-tophagy and angiogenesis play vital roles in the prevention of heart failure after MI,and miR-106a is considered to be an important regulatory factor in MI.But the specific mechanism remains unknown.In this study,using cultured venous endothelial cells and a rat model of MI,we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and angiogenesis.Methods:We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial cells.Then we identified ATG7,which was the down-stream target gene of miR-106a.The expression of miR-106a and ATG7 was investi-gated in the rat model of MI.Results:We found that miR-106a inhibits the proliferation,cell cycle,autophagy and angiogenesis,but promoted the apoptosis of vein endothelial cells.Moreover,ATG7 was identified as the target of miR-106a,and ATG7 rescued the inhibition of autophagy and angiogenesis by miR-106a.The expression of miR-106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction areas.Conclusion:Our results indicate that miR-106a may inhibit autophagy and angiogenesis by targeting ATG7.This mechanism may be a potential therapeutic treatment for MI.展开更多
Development Geography is a branch of geography which studies the socioeconomic development of different countries and regions worldwide.Its related research provides informative ideas for promoting regionally co-ordin...Development Geography is a branch of geography which studies the socioeconomic development of different countries and regions worldwide.Its related research provides informative ideas for promoting regionally co-ordinated development.This study introduces the basic connotation and theory of Development Geography re-search,and clarifies its primary indicators and core approaches to provide solutions for regional development.Finally,the application in regional development research under globalization is proposed.It is considered that the systematically integrated geography paradigm highlights the advantages of Development Geography in re-gional development research.As a result of its“differentiation characteristics-diffusion state-convergence mode”,an important theoretical basis and methodological paradigm are provided to explore the features of regional de-velopment.Since the development gaps among regions exist long throughout the world,Development Geography research ought to focus on new characteristics and challenges of regional development,to provide a theoretical basis for synergy management of sustainable development goals and international cooperation.This contributes to high-quality regional development.展开更多
基金supported by the Low-Cost Long-Life Batteries program,China(No.WL-24-08-01)the National Natural Science Foundation of China(No.22279007)。
文摘The outstanding performance of O3-type NaNi_(1/3)Fe_(1/3)Mn_(1/3)O_(2)(NFM111)at both high and low temperatures coupled with its impressive specific capacity makes it an excellent cathode material for sodium-ion batteries.However,its poor cycling,owing to highpressure phase transitions,is one of its disadvantages.In this study,Cu/Ti was introduced into NFM111 cathode material using a solidphase method.Through both theoretically and experimentally,this study found that Cu doping provides a higher redox potential in NFM111,improving its reversible capacity and charge compensation process.The introduction of Ti would enhance the cycling stability of the material,smooth its charge and discharge curves,and suppress its high-voltage phase transitions.Accordingly,the NaNi_(0.27)Fe_(0.28)Mn_(0.33)Cu_(0.05)Ti_(0.06)O_(2)sample used in the study exhibited a remarkable rate performance of 142.97 mAh·g^(-1)at 0.1 C(2.0-4.2 V)and an excellent capacity retention of 72.81%after 300 cycles at 1C(1C=150 mA·g^(-1)).
基金supported by the Key Research and Development Program of Shandong Province,China(No 2021CXGC010803)Pan’an County Chinese Medicine Industry Project(No.PZYF202103).
文摘Reductive soil disinfestation(RSD)is commonly employed for soil remediation in greenhouse cultivation.However,its influence on antibiotic resistance genes(ARGs)in soil remains uncertain.This study investigated the dynamic changes in soil communities,potential bacterial pathogens,and ARG profiles under various organicmaterial treatments during RSD,including distillers’grains,potato peel,peanut vine,and peanut vine combined with charcoal.Results revealed that applying diverse organic materials in RSD significantly altered bacterial community composition and diminished the relative abundance of potential bacterial pathogens(P<0.05).The relative abundance of high-risk ARGs decreased by 10.7%-30.6%after RSD treatments,the main decreased ARG subtypeswere AAC(3)_Via,dfrA1,ErmB,lnuB,aadA.Actinobacteria was the primary host of ARGs and was suppressed by RSD.Soil physicochemical properties,such as total nitrogen,soil pH,total carbon,were crucial factors affecting ARG profiles.Our findings demonstrated that RSD treatment inhibited pathogenic bacteria and could be an option for reducing high-risk ARG proliferation in soil.
文摘Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated tau.Targeting amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last decades.However,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic strategies.Increasing evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s disease.These receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s disease.This review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.
基金Natural Science Foundation of Tibet Autonomous Region to Gong Ga,China(No.2016ZR-NY-11)Funding for Preventive Veterinary Research in Tibet Agriculture&Animal Husbandry University(No.2017)Central Government Supports Special Funds for the Development of Local Colleges and Universities in China(No.2016-397)~~
基金supported by the National Key Research and Development Program of China(2023YFB3208102,2021YFB3200304)the National Natural Science Foundation of China(52073031)+2 种基金Beijing Nova Program(Z211100002121148)Fundamental Research Funds for the Central Universities(E0EG6801X2)the‘Hundred Talents Program’of the Chinese Academy of Sciences.
文摘The use of water resources for energy generation has become increasingly prevalent,encompassing the conversion of kinetic energy from streams,tides,and waves into renewable electrical power.Water energy sources offer numerous benefits,including widespread availability,stability,and the absence of carbon dioxide and other greenhouse gas emissions,making them a clean and environmentally friendly form of energy.In this work,we develop a droplet-based liquid-solid triboelectric nanogenerator(LS-TENG)using sophisticatedly designed inflatable columnar structures with inner and outer dual-electrodes.This device can be utilized to harvest both the internal droplet-rolling mechanical energy and the external droplet-falling mechanical energy,capable of being assembled into various structures for versatile applications.The design incorporates a combined structure of both internal and external TENG to optimize output performance via multiple energy harvesting strategies.The internal structure features a dual-electrode columnar-shaped LS-TENG,designed to harvest fluid kinetic energy from water droplets.By leveraging the back-and-forth motion of a small amount of water within the air column,mechanical energy can be readily collected,achieving a maximum mass power density of 9.02 W·Kg^(−1)and an energy conversion efficiency of 10.358%.The external component is a droplet-based LS-TENG,which utilizes a double-layer capacitor switch effect elucidated with an equivalent circuit model.Remarkably,without the need for pre-charging,a single droplet can generate over 140 V of high voltage,achieving a maximum power density of 7.35 W·m^(−2)and an energy conversion efficiency of 22.058%.The combined LS-TENG with a sophisticated inflatable columnar structure can simultaneously collect multiple types of energy with high efficacy,exhibiting great significance in potential applications such as TENG aeration rollers,inflatable lifejacket,wind energy harvesting,TENG tents,and green houses.
基金financially supported by the National Natural Science Foundation of China(No.52073031)the National Key Research and Development Program of China(Nos.2023YFB3208102,2021YFB3200304)+4 种基金the China National Postdoctoral Program for Innovative Talents(No.BX2021302)the Beijing Nova Program(Nos.Z191100001119047,Z211100002121148)the Fundamental Research Funds for the Central Universities(No.E0EG6801X2)the‘Hundred Talents Program’of the Chinese Academy of Sciencesthe BrainLink program funded by the MSIT through the NRF of Korea(No.RS-2023-00237308).
文摘Neuromorphic computing extends beyond sequential processing modalities and outperforms traditional von Neumann architectures in implementing more complicated tasks,e.g.,pattern processing,image recognition,and decision making.It features parallel interconnected neural networks,high fault tolerance,robustness,autonomous learning capability,and ultralow energy dissipation.The algorithms of artificial neural network(ANN)have also been widely used because of their facile self-organization and self-learning capabilities,which mimic those of the human brain.To some extent,ANN reflects several basic functions of the human brain and can be efficiently integrated into neuromorphic devices to perform neuromorphic computations.This review highlights recent advances in neuromorphic devices assisted by machine learning algorithms.First,the basic structure of simple neuron models inspired by biological neurons and the information processing in simple neural networks are particularly discussed.Second,the fabrication and research progress of neuromorphic devices are presented regarding to materials and structures.Furthermore,the fabrication of neuromorphic devices,including stand-alone neuromorphic devices,neuromorphic device arrays,and integrated neuromorphic systems,is discussed and demonstrated with reference to some respective studies.The applications of neuromorphic devices assisted by machine learning algorithms in different fields are categorized and investigated.Finally,perspectives,suggestions,and potential solutions to the current challenges of neuromorphic devices are provided.
基金financially supported by the National Natural Science Foundation of China(Nos.22301155,22171156,21803001)Taishan Scholar Foundation of Shandong Province(China)+2 种基金the Natural Science Foundation of Shandong Province(No.ZR2023QB122)Shandong Province Excellent Youth Innovation TeamStartup Funds from Qingdao University of Science and Technology
文摘Understanding the synergistic effect between ligands at the atomic level to control the catalytic selectivity of catalysts remains a significant challenge due to the complexity of ligand interactions and limitations in current analytical techniques.Herein,using precisely structured metal nanoclusters as models,we discovered that altering the electronegativity of substituents on donor thiolate ligands can modulate the bond dissociation energy of coordinated phosphine ligands on the clusters.This change leads to the selective dissociation of ligands during the catalytic process,thereby enabling control over catalytic selectivity with an abrupt increase in formate production from~0%to 23%.This work provides crucial insights into understanding ligand interactions on metal nanoparticle surfaces at the atomic level and lays the foundation for designing highly selective catalysts in the future.
基金funded by Central Fiscal Forestry and Grassland Ecological Protection and Restoration Fund in 2022(grant number:HYGJ22069P(2022zfcg03469)-HT01)National Natural Science Foundation of China(grant number:3152010390332070452)。
文摘The Natural Forest Protection Project(NFPP),initiated by the Chinese government in 2000,is a crucial ecological construction project that has played a significant role in forest restoration in China.Forests in the Qinghai-Tibet Plateau(QTP)serve as important habitats for many rare and endemic birds.Understanding the conservation efficiency of NFPP implementation on these birds holds significant practical significance.In this study,we utilized land use change matrices to analyze the forest changes in the QTP before and after NFPP implementation,predicted the potential spatial distribution of 16 nationally protected birds using Species Distribution Models(SDMs),and compared the impacts of this project on bird habitats under different carbon emission scenarios.Mann-Whitney U tests were employed to analyze the adaptation of different birds to forest changes during NFPP implementation.Our results showed that NFPP protected 172,398 km^(2) of primary forests and added 6379 km^(2) of secondary forests in our study area.The potential spatial distribution and sympatric species richness of the 16 protected birds slightly increased after NFPP implementation under different climate change scenarios,and NFPP implementation contributed to improving the potential spatial distribution of birds.Compared to newly established secondary forests,protected primary forests exhibited enhanced conservation for forest birds(Z-value>0 for six bird species,P<0.1),while being less suitable for non-forest birds(significantly unsuitable for three non-forest bird species,Z-value<0,P<0.05;non-significantly unsuitable for four non-forest bird species,Zvalue<0,P>0.1).This indicates that the protection of primary forests during NFPP implementation benefits forest bird conservation while the addition of secondary forests is beneficial to non-forest birds.To enhance the role of NFPP in avian conservation in the QTP,it is suggested to increase the landscape heterogeneity of forest,particularly in newly established secondary forests.
基金supported by the National Natural Science Foundation of China(22179089)。
文摘Throughout versatile metal compositions and unique structural characteristics,polynary metal atom catalysts(PACs)readily harness synergistic intermetallic effects,significantly boosting the catalytic performances.These catalysts are featured by favorable catalytic activity,stability and selectivity,offering avenues to tackle challenges in energy conversion,environmental protection and chemical synthesis.Nevertheless,an in-depth understanding and comprehensive summary of the structure-performance relationship for the emerging PACs remains elusive.This review embarks from the classification of PACs,delving further into the origins of catalytic activity and mechanisms underpinning performance enhancement.At the beginning,it outlines the fundamental concepts,preparation methods and accurate recognition of PACs.Subsequently,it centers on discussing the origins of activity,strategies for performance optimization,mechanisms of action,and application scenarios across diverse catalytic reactions.Moreover,the unexplored issues and future perspectives of PACs are proposed at the end,stating their pivotal roles in advancing green chemistry and the sustainable energy realm.This review overall aims to provide valuable insight and guidance for the preparation and application of PACs.
基金supported by a grant from the National Key R&D Program of China(No.2021YFC2301700)the Ministry of Science and Technology(China)of China(No.2021YFC2302500)the Establishment of a method for detecting neutralizing antibodies with pseudotyped viruses of China Pharmacopeia[grant number 2021S03].
文摘Influenza B viruses(IBVs)primarily infect humans and are a common cause of respiratory infections in humans.Here,to systematically analyze the antigenicity of the IBVs Hemagglutinin(HA)protein,31 B/Victoria and 19 B/Yamagata representative circulating strains were selected from Global Initiative of Sharing All Influenza Data(GISAID),and pseudotyped viruses were constructed with the vesicular stomatitis virus system.Guinea pigs were immunized with three doses of vaccines(one dose of DNA vaccines following two doses of pseudotyped virus vaccines)of the seven IBV vaccine strains,and neutralizing antibodies against the pseudotyped viruses were tested.By comparing differences between various vaccine strains,we constructed several pseudotyped viruses that contained various mutations based on vaccine strainBV-21.The vaccine strains showed good neutralization levels against the epidemic virus strains of the same year,with neutralization titers ranging from 370 to 840,while the level of neutralization against viruses prevalent in previous years decreased 1–10-fold.Each of the high-frequency epidemic strains of B/Victoria andB/Yamagata not only induced high neutralizing titers,but also had broadly neutralizing effects against virus strains of different years,with neutralizing titers ranging from1000 to 7200.R141G,D197 N,and R203K were identified as affecting the antigenicity of IBV.These mutation sites provide valuable references for the selection and design of a universal IBV vaccine strain in the future.
基金financially supported by BRICS STI Framework Programme 3rd call 2019the National Key Research and Development Program of China(Grant No.2018YFE0123700)+3 种基金the National Natural Science Foundation of China(Grant Nos.51973076 and 52073031)State Key Laboratory of New Textile Materials and Advanced Processing Technologies(Grant No.FZ2021005)the Fundamental Research Funds for the Central Universities(Grant Nos.2020kfyXJJS035,WUT2018IVB006,and Z191100001119047)。
文摘Electronic fibers used to fabricate wearable triboelectric nanogenerator(TENG) for harvesting human mechanical energy have been extensively explored. However, little attention is paid to their mutual advantages of environmental friendliness, mechanical properties, and stability. Here, we report a super-strong, biodegradable, and washable cellulose-based conductive macrofibers, which is prepared by wet-stretching and wet-twisting bacterial cellulose hydrogel incorporated with carbon nanotubes and polypyrrole. The cellulose-based conductive macrofibers possess high tensile strength of 449 MPa(able to lift 2 kg weights), good electrical conductivity(~ 5.32 S cm^(-1)), and excellent stability(Tensile strength and conductivity only decrease by 6.7% and 8.1% after immersing in water for 1 day). The degradation experiment demonstrates macrofibers can be degraded within 108 h in the cellulase solution. The designed fabric-based TENG from the cellulose-base conductive macrofibers shows a maximum open-circuit voltage of 170 V, short-circuit current of 0.8 μA, and output power at 352 μW, which is capable of powering the commercial electronics by charging the capacitors. More importantly, the fabric-based TENGs can be attached to the human body and work as self-powered sensors to effectively monitor human motions. This study suggests the potential of biodegradable, super-strong, and washable conductive cellulose-based fiber for designing eco-friendly fabric-based TENG for energy harvesting and biomechanical monitoring.
基金financially supported by Grant Projects on Clean Development Mechanism in China(No.2012076)the special basic scientific research expenses from Research Institute of Forestry New Technology,Chinese Academy of Forestry(No.CAFINT2014K06)
文摘Peatlands are one of the major natural sources of methane （CH4）, but the level of CH4 efflux is uncertain, especially in alpine peatlands. In this study, CH4 emission fluxes from natural and drained peatlands on the Qinghai- Tibet Plateau, southwest China, were measured from June to October in 2013 using the opaque static chamber technique and the Fast Greenhouse Gas Analyzer （DLT-100, Los Gatos Research Corp.）. CH4 emission fluxes ranged from 2.07 to 56.33 mg m^-2 h^-1 in natural peatlands and from 0.02 to 0.42 mg m^-2 h^-1 in drained peatlands. Mean CH4 emission flux was 19.13 mg m^-2 h^-1 in natural peatlands and 0.14 mg m^-2 h^-1 in drained peatlands. These results showed that drainage led to a significant decrease in CH4 emissions. CH4 emission fluxes for all sampling plots were significantly correlated with variation in water table depth for linear （R^2 = 0.453, P 〈 0.01） and exponential functions （R^2 = 0.429, P 〈 0.01）.
基金supported by the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization (SKLTOF20200127 and SKLT0F20200108)the Open Fund of Key Laboratory of Tea Plant Resources Comprehensive Development in South Henan Province (HNKLTOF2020005)the Zhejiang Provincial Basic Public Welfare Research Program Project (LGF20H280007)。
文摘Our previous study found that large-leaf yellow tea(LYT)had interesting hypoglycemic activity in high-fat diet-induced obese mice and highly safety in healthy mice. To study the anti-diabetic potential of LYT, the present study further investigated the preventive effects and mechanisms of action of LYT administration on diabetes and diabetic nephropathy in high-fat diet plus streptozotocin-induced diabetic mice. Results showed that LYT infusions(1/100 and 1/50, m/V)as drinking fluid for 4 weeks reduced diabetic polydipsia and polyuria, enhanced glucose tolerance and insulin sensitivity, and lowered fasting blood glucose level. The underlying mechanisms involve downregulation of gluconeogenesis(lower protein levels of TXNIP and FBP and enzyme activity of FBP), upregulation of lipid catabolism(higher protein levels of CPT-1α and PPARα), downregulation of lipogenesis(lower protein level of SREBP-1), and modification of the structure and abundance of gut microbiota to modulate metabolic homeostasis. Moreover, LYT administration prevented diabetic nephropathy, possibly due to reduced glucose-caused osmotic diuresis and lowered levels of renal PKC-β2, NLRP3 as well as membrane PKC-α, AQP2 and glycosylated AQP2 proteins. Taken together, LYT exhibits the activities in alleviating diabetic symptoms, ameliorating glucose and lipid dysmetabolism and fatty liver, and preventing diabetic nephropathy in diabetic mice. These activities may be explored for the prevention and treatment of diabetes in humans.
基金supported by an international collaboration funding of China Petrochemical Technology Company Limited。
文摘Colloidal solution combustion synthesis(CSCS)is a simple and easy method for mass-production of crystalline nanomaterials with tunable pore structure.In this work,mesoporous Mn/CeO_(2) catalysts were fabricated via CSCS method coupled with a dip-coating process and used for photocatalytic oxidation(PCO)of toluene.Under vacuum ultraviolet(VUV)irradiation,a high toluene removal efficiency of about 92%was achieved with a toluene reaction rate of about 118μmol/g/h in a continuous flow reactor.A possible degradation pathway was proposed based on the analysis of intermediates by Fourier transform infrared photoluminescence spectra(FTIR)and GC-Mass.Hydrogen temperature-programmed reduction(H_(2)-TPR),Brunauer-Emmett-Teller(BET)surface areas,photoluminescence spectra(PL)spectra and X-ray photoelectron spectroscopy(XPS)were carried out to analyze physical and chemical properties of the catalysts.Compared with Mn_(x)Ce_(1-x)O_(2) catalysts synthesized by one step CSCS method,Mn/CeO_(2) has a higher photocatalytic activity,which is attributed to the presence of higher contents of Ce^(3+),Mn^(2+)and Mn^(3+)species.The presence of higher contents of these species plays a key role in the activity enhancement of toluene oxidation and ozone decomposition.This method is facile,efficient and scalable,and it may become a promising industrial application technology for catalyst synthesis in the near future.
基金National Natural Science Foundation of China,Grant/Award Number:32070542Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021A1515010873 and 2022A1515011455+1 种基金Breed Industry Innovation Park of Guangdong Xiaoerhua Pig,Grant/Award Number:2022-4408X1-43010402-0019Hainan Provincial Natural Science Foundation,Grant/Award Number:818MS132。
文摘Background:Myocardial infarction(MI)is an acute condition in which the heart mus-cle dies due to the lack of blood supply.Previous research has suggested that au-tophagy and angiogenesis play vital roles in the prevention of heart failure after MI,and miR-106a is considered to be an important regulatory factor in MI.But the specific mechanism remains unknown.In this study,using cultured venous endothelial cells and a rat model of MI,we aimed to identify the potential target genes of miR-106a and discover the mechanisms of inhibiting autophagy and angiogenesis.Methods:We first explored the biological functions of miR-106a on autophagy and angiogenesis on endothelial cells.Then we identified ATG7,which was the down-stream target gene of miR-106a.The expression of miR-106a and ATG7 was investi-gated in the rat model of MI.Results:We found that miR-106a inhibits the proliferation,cell cycle,autophagy and angiogenesis,but promoted the apoptosis of vein endothelial cells.Moreover,ATG7 was identified as the target of miR-106a,and ATG7 rescued the inhibition of autophagy and angiogenesis by miR-106a.The expression of miR-106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction areas.Conclusion:Our results indicate that miR-106a may inhibit autophagy and angiogenesis by targeting ATG7.This mechanism may be a potential therapeutic treatment for MI.
基金This research was supported by the Foundation for Innovative Re-search Groups of the National Natural Science Foundation of China(Grant No.72221002)The case analysis was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA23070400).
文摘Development Geography is a branch of geography which studies the socioeconomic development of different countries and regions worldwide.Its related research provides informative ideas for promoting regionally co-ordinated development.This study introduces the basic connotation and theory of Development Geography re-search,and clarifies its primary indicators and core approaches to provide solutions for regional development.Finally,the application in regional development research under globalization is proposed.It is considered that the systematically integrated geography paradigm highlights the advantages of Development Geography in re-gional development research.As a result of its“differentiation characteristics-diffusion state-convergence mode”,an important theoretical basis and methodological paradigm are provided to explore the features of regional de-velopment.Since the development gaps among regions exist long throughout the world,Development Geography research ought to focus on new characteristics and challenges of regional development,to provide a theoretical basis for synergy management of sustainable development goals and international cooperation.This contributes to high-quality regional development.
