Leaf rust,caused by the fungus Puccinia triticina,is one of the most destructive diseases affecting global wheat production.Developing disease-resistant wheat varieties is the most cost-effective and environmentally f...Leaf rust,caused by the fungus Puccinia triticina,is one of the most destructive diseases affecting global wheat production.Developing disease-resistant wheat varieties is the most cost-effective and environmentally friendly approach to managing this disease.We phenotyped a collection of 559 wheat accessions from five continents for resistance to leaf rust in field trials at three locations in China(Zhoukou,Henan;Wuhan,Hubei;and Xinxiang,Henan)during the 2020–2021,2021–2022,and 2022–2023 cropping seasons,followed by best-linear-unbiased-estimation analysis across environments.These accessions were genotyped using the MGISEQ-2000 re-sequencing platform,and a genome-wide association analysis was subsequently performed.Twenty-four stable leaf rust resistance loci across 15 chromosomes were identified.Among these,11 loci may represent new sources of resistance.Notably,Lr.hzau-2BS.1 and Lr.hzau-7AL were consistently detected across all three environments and BLUE.Lr.hzau-2BS.1 has the highest frequency in European wheat accessions,whereas Lr.hzau-7AL is most prevalent in South American accessions.Gene-expression analysis identified 101 candidate genes associated with these loci.Closely linked Kompetitive Allele Specific PCR(KASP)markers,2B-209172 and 7A-348992,were developed for Lr.hzau-2BS.1 and Lr.hzau-7AL,respectively.Chinese wheat varieties Mianmai 45 and Liaomai 16,which carry resistance alleles at both loci and exhibit<5%leaf rust severity,represent valuable sources of leaf rust resistance for wheat breeding programs.These newly identified resistance loci and their KASP markers provide valuable resource for their exploitation in wheat breeding.展开更多
Recent research has indicated that sialic acid,such as free sialic acid(N-acetylneuraminic acid,Neu5Ac)and bound sialic acid(3ʹ-sialyllactose,3ʹ-SL),can ameliorate disorders associated with glycolipid metabolism,altho...Recent research has indicated that sialic acid,such as free sialic acid(N-acetylneuraminic acid,Neu5Ac)and bound sialic acid(3ʹ-sialyllactose,3ʹ-SL),can ameliorate disorders associated with glycolipid metabolism,although the underlying mechanisms have yet to be determined.We examined the effects of 3ʹ-SL on glycolipid metabolism in mice fed a high-fat diet.Male C57BL/6J mice were divided into 6 groups:2 model control groups(normal and high-fat diets)and 4 intervention groups(Neu5Ac,and low,moderate,and high-dose 3ʹ-SL).After 8 weeks of continuous gavage intervention,mice in the 3ʹ-SL intervention groups had lower body weight and total fat content;reduced fasting blood glucose,triglycerides,low-density lipoproteins and oxidized-low-density lipoproteins;and increased high-density lipoproteins,but no dosage-dependent of 3ʹ-SL intervention was found,moderate-dose 3ʹ-SL intervention as optimal for further exploration.3ʹ-SL intervention could increase respiratory exchange ratio,energy expenditure,and amount of exercise performed.3ʹ-SL increased the colonic abundances of Akkermansia,Lactobacillus,and Bacteroides,and reduced those of Erysipelatoclostridium,Faecalibaculum,and Aldercreutzia.Changes were also observed in colonic metabolites,and liver gene transcript and metabolites,which were mainly enriched in bile secretion,taurine and hypotaurine metabolism,and insulin resistance.Additionally,3ʹ-SL was observed to regulate genes associated with physiological rhythms,including Clock,Per2,Cry1,and Bhihe41.Collectively,our findings indicate that 3ʹ-SL can contribute to the prevention and control of disorders associated with glucose and lipid metabolism caused by high-fat diets.Compared with Neu5Ac,3ʹ-SL intervention can more effectively ameliorate intestinal flora disorders,enhance bile acid circulation,increase tissue energy expenditure,and reduce lipid synthesis,thereby promoting lipid-lowering effects mediated via the gut-liver axis,and can also enhance energy metabolism and alleviate disorders of glucolipid metabolism by altering physiological rhythms in high fat-diet mice.展开更多
H_2O_(2) is one of the most important chemicals in the world.Recently,the electrochemical synthesis of H_2O_(2)by two-electron oxygen reduction reaction(2e^(-)ORR)has attracted great interest.Carbon-based catalysts sh...H_2O_(2) is one of the most important chemicals in the world.Recently,the electrochemical synthesis of H_2O_(2)by two-electron oxygen reduction reaction(2e^(-)ORR)has attracted great interest.Carbon-based catalysts show great promise for electrocatalytic production of H_2O_(2),due to the ease of regulation of the carbon materials with regard to the pore structure,surface properties,and heteroatom doping.Biomass as the carbon precursor has the advantages of low cost,sustainable supply,and extensive availability.Conversion of biomass to functional carbon-based materials shows the attractive merits,such as low carbon emission in the life cycle and diversity of the obtained carbon materials due to the wide source of biomass feedstocks.In this article,a comprehensive review on the mechanisms and processes of electrochemical synthesis of H_2O_(2) by 2e^(-)ORR over carbon-based catalysts is provided.The potential biomass feedstock used for obtaining the carbon-based catalysts,and the strategies to prepare the catalysts by carbonization and heteroatom doping,as well as optimization of electrodes and design of electrolyzer,are discussed.It is recommended that future work focus on developing efficient methods to prepare the catalysts from low-cost biomass feedstock,understanding the mechanisms of 2e^(-)ORR over the catalysts,optimization of electrode materials loaded with biomass-derived catalysts,as well as development of electrolyzers for larger-scale applications.展开更多
Purpose： A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor （EGFR） tyrosine kinase inhibitors （TKIs） in advanced no...Purpose： A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor （EGFR） tyrosine kinase inhibitors （TKIs） in advanced non-small-cell lung cancer （NSCLC）. This study aimed to identify predictive factors associated with prognostic benefits of gefitinib. Patients and methods： EGFR gene typing in 33 advanced NSCLC patients received gefitinib （250 mg/day） were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively. Results： The overall objective response rate （ORR） and median progression-flee survival （PFS） in the 33 patients treated by gefitinib were 45.5% and 3.0 （2.0-4.0） months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients （P〈0.01）. Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients （P〈0.05, P〈0.01, respectively）. However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR （P〈0.01）. Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS （P〈0.05）. Conclusions： EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients.展开更多
The power grid is undergoing a transformation from synchronous generators(SGs) toward inverter-based resources(IBRs). The stochasticity, asynchronicity, and limited-inertia characteristics of IBRs bring about challeng...The power grid is undergoing a transformation from synchronous generators(SGs) toward inverter-based resources(IBRs). The stochasticity, asynchronicity, and limited-inertia characteristics of IBRs bring about challenges to grid resilience. Virtual power plants(VPPs) are emerging technologies to improve the grid resilience and advance the transformation. By judiciously aggregating geographically distributed energy resources(DERs) as individual electrical entities, VPPs can provide capacity and ancillary services to grid operations and participate in electricity wholesale markets. This paper aims to provide a concise overview of the concept and development of VPPs and the latest progresses in VPP operation, with the focus on VPP scheduling and control. Based on this overview, we identify a few potential challenges in VPP operation and discuss the opportunities of integrating the multi-agent system(MAS)-based strategy into the VPP operation to enhance its scalability, performance and resilience.展开更多
In the real flow for high altitude,the initiation mechanism of the oblique detonation involves the coupling of complex wave structures and combustion waves,which may result in the phenomenon of extinction.The approach...In the real flow for high altitude,the initiation mechanism of the oblique detonation involves the coupling of complex wave structures and combustion waves,which may result in the phenomenon of extinction.The approach of stable initiation is one of the key factors that restricting the oblique detonation engine from theory to practice.The wave structure,initiation characteristics and characteristic parameters of the flow field are analyzed,the two-dimensional Euler equation considering the detailed chemical reactions of multi-component are solved.First,the approaches of blunt bump and transverse jet are combined used to shorten the detonation distance of the oblique detonation.Results show that these methods can promote the accelerated initiation of the oblique detonation effectively,and the detonation distance can be shortened more than 90%.There are two wave structures induced by the blunt bump:weak coupled and strong coupled,adding the transverse jet promotes the transition between these two wave structures.Then,the shape of the bump and the characteristic parameters of the transverse jet are optimized.The streamline-shape bump can eliminate the recirculation zone formed after the circle bump and the ellipse bump.The transverse jet will produce an oblique detonation wave at the front of the jet position,which changes the wave structure and initiation mode of the oblique detonation wave.It is expected to reveal the accelerated initiation mechanism of oblique detonation under the induction zone disturbance and complex flow environment,deepen the understanding of the detonation law of oblique detonation wave under real flow conditions,and provide a scientific basic for the development of the combustor of the oblique detonation engine.展开更多
A neuroprosthesis is a type of precision medical device that is intended to manipulate the neuronal signals of the brain in a closed-loop fashion,while simultaneously receiving stimuli from the environment and control...A neuroprosthesis is a type of precision medical device that is intended to manipulate the neuronal signals of the brain in a closed-loop fashion,while simultaneously receiving stimuli from the environment and controlling some part of a human brain or body.Incoming visual information can be processed by the brain in millisecond intervals.The retina computes visual scenes and sends its output to the cortex in the form of neuronal spikes for further computation.Thus,the neuronal signal of interest for a retinal neuroprosthesis is the neuronal spike.Closed-loop computation in a neuroprosthesis includes two stages:encoding a stimulus as a neuronal signal,and decoding it back into a stimulus.In this paper,we review some of the recent progress that has been achieved in visual computation models that use spikes to analyze natural scenes that include static images and dynamic videos.We hypothesize that in order to obtain a better understanding of the computational principles in the retina,a hypercircuit view of the retina is necessary,in which the different functional network motifs that have been revealed in the cortex neuronal network are taken into consideration when interacting with the retina.The different building blocks of the retina,which include a diversity of cell types and synaptic connections-both chemical synapses and electrical synapses(gap junctions)-make the retina an ideal neuronal network for adapting the computational techniques that have been developed in artificial intelligence to model the encoding and decoding of visual scenes.An overall systems approach to visual computation with neuronal spikes is necessary in order to advance the next generation of retinal neuroprosthesis as an artificial visual system.展开更多
To alleviate problems with access and affordability,six targeted anticancer medications(TAMs)were listed in the Provincial Reimbursement Drug List(PRDL)for the first time in Zhejiang,China in February 2015.In the pres...To alleviate problems with access and affordability,six targeted anticancer medications(TAMs)were listed in the Provincial Reimbursement Drug List(PRDL)for the first time in Zhejiang,China in February 2015.In the present study,we aimed to evaluate the implementation of the PRDL policy on TAMs use.Using the pharmaceutical procurement data of these six listed TAMs(study group)and four unlisted TAMs(control group)from 22 tertiary hospitals in Zhejiang,China dated between January 2014 and February 2017,interrupted time-series analysis was adopted to examine differences in the average hospital purchasing volume(HPV)and the average hospital purchasing spending(HPS)between the two groups.The average daily cost of listed TAMs in the study group was decreased after April 2015.After enlistment,the average HPV per month was significantly increased by 34.6 defined daily doses(DDDs)(P<0.001),and the average HPS per month was significantly increased by USD 6614.9(P<0.001)for the listed TAMs in the study group(n=6).Neither the average HPV nor the average HPS changed significantly for the unlisted TAMs in the control group(n=4).The PRDL policy showed positive effects on improving patients’affordability and promoting access to TAMs in Zhejiang.The government should conduct further price negotiations and include more TAMs with clinical benefits into reimbursement schemes to relieve patients’financial burden and promote access.展开更多
The Moving Picture Experts Group （MPEG） has been developing a 3D video （3DV） coding standard for depth-based 3DV data representations, especially for multiview video plus depth （MVD） format. With MVD, depth-imag...The Moving Picture Experts Group （MPEG） has been developing a 3D video （3DV） coding standard for depth-based 3DV data representations, especially for multiview video plus depth （MVD） format. With MVD, depth-image-based rendering （DIBR）is used to synthesize virtual views that are based on a few transmitted pairs of texture and depth data. In this paper, we discuss ongoing 3DV standardization and summarize coding tools proposed in the responses to MPEG＇ s call for proposals on 3DV coding.展开更多
The development of a tailless Flapping Wing Micro Aerial Vehicle(FWMAV)inspired by the hummingbird is presented in this work.By implementing mechanical simplifications,it is possible to use planar machining technology...The development of a tailless Flapping Wing Micro Aerial Vehicle(FWMAV)inspired by the hummingbird is presented in this work.By implementing mechanical simplifications,it is possible to use planar machining technology for manufacturing of the FWMAV’s body,greatly reducing assembly errors.Traditionally,studies on flapping wing aircraft are limited to open-loop wing kinematics control.In this work,an instantaneous closed-loop wing trajectory tracking control system is introduced to minimize wings’trajectory tracking errors.The control system is based on Field-Oriented Control(FOC)with a loop shaping compensation technique near the flapping frequency.Through frequency analysis,the loop shaping compensator ensures the satisfactory bandwidth and performance for the closed-loop flapping system.To implement the proposed controller,a compact autopilot board integrated with FOC hardware is designed,weighing only 2.5 g.By utilizing precise wing trajectory tracking control,the hummingbird-inspired FWMAV demonstrates superior ability to resist external disturbances and exhibits reduced attitude tracking errors during hovering flight compared to the open-loop wing motion.展开更多
Passively stabilized double-wing Flapping Micro Air Vehicles(FMAVs)do not require active control and exhibit good electromagnetic interference resistance,with significant research value.In this paper,the dynamic model...Passively stabilized double-wing Flapping Micro Air Vehicles(FMAVs)do not require active control and exhibit good electromagnetic interference resistance,with significant research value.In this paper,the dynamic model of FMAV was established as the foundation for identifying flapping damping coefficients.Through a pendulum experiment,we ascertain the flapping damping of the damper using the energy conservation method.Besides,fitting relationships between the damper area,damper mass,and the moment of inertia are developed.The factors influencing the bottom damper damping are deter-mined using correlation coefficients and hypothesis testing methods.Additionally,stable dampers are installed on both the top and bottom of the FMAV to achieve passive stability in simulations.The minimum damper areas for the FMAV were optimized using genetic algorithms,resulting in a minimum top damper area of 128 cm^(2) and a minimum bottom damper area of 80 cm^(2).A prototype with a mass of 25.5 g and a wingspan of 22 cm has been constructed.Prototype testing demonstrated that FMAV can take off stably with a 3 g payload and a tilt angle of 5°.During testing,the area-to-mass ratio of the FMAV reached 7.29 cm^(2)/g,achieving passive stability with the world's smallest area-to-mass ratio.展开更多
Age-related macular degeneration(AMD)causes irreversible blindness in people aged over 50 worldwide.The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD.In the current study,we used t...Age-related macular degeneration(AMD)causes irreversible blindness in people aged over 50 worldwide.The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD.In the current study,we used the ComBat and Training Distribution Matching method to integrate data obtained from the Gene Expression Omnibus database.We analyzed the integrated sequencing data by the Gene Set Enrichment Analysis.Peroxisome and tumor necrosis factor-α(TNF-α)signaling and nuclear factor kappa B(NF-κB)were among the top 10 pathways,and thus we selected them to construct AMD cell models to identify differentially expressed circular RNAs(circRNAs).We then constructed a competing endogenous RNA network,which is related to differentially expressed circRNAs.This network included seven circRNAs,15 microRNAs,and 82 mRNAs.The Kyoto Encyclopedia of Genes and Genomes analysis of mRNAs in this network showed that the hypoxia-inducible factor-1(HIF-1)signaling pathway was a common downstream event.The results of the current study may provide insights into the pathological processes of atrophic AMD.展开更多
In this paper,we study a distributed model to cooperatively compute variational inequalities over time-varying directed graphs.Here,each agent has access to a part of the full mapping and holds a local view of the glo...In this paper,we study a distributed model to cooperatively compute variational inequalities over time-varying directed graphs.Here,each agent has access to a part of the full mapping and holds a local view of the global set constraint.By virtue of an auxiliary vector to compensate the graph imbalance,we propose a consensus-based distributed projection algorithm relying on local computation and communication at each agent.We show the convergence of this algorithm over uniformly jointly strongly connected unbalanced digraphs with nonidentical local constraints.We also provide a numerical example to illustrate the effectiveness of our algorithm.展开更多
Imperfections in practical detectors,including limited detection efficiency,and inherent electronic noise,can seriously decrease the transmission distance of continuous-variable measurement-device-independent quantum ...Imperfections in practical detectors,including limited detection efficiency,and inherent electronic noise,can seriously decrease the transmission distance of continuous-variable measurement-device-independent quantum key distribution systems.Owing to the difficulties inherent in realizing a high-efficiency fiber homodyne detector,challenges still exist in continuous-variable measurement-device-independent quantum key distribution system implementation.We offer an alternative approach in an attempt to solve these difficulties and improve the potential for system implementation.Here,a novel practical detector modeling method is utilized,which is combined with a one-time shot-noise-unit calibration method for the purpose of system realization.The new modeling method benefits greatly from taking advantage of one-time shot-noise-unit calibration methods,such as measuring electronic noise and shot noise directly to a novel shot-noise unit,so as to eliminate the statistical fluctuations found in previous methods;this makes the implementation of such systems simpler,and the calibration progress more accurate.We provide a simulation of the secret key rate versus distance with different parameters.In addition,the minimal detection efficiency required at each distance,as well as the contrast between the two methods,are also shown,so as to provide a reference in terms of system realization.展开更多
As an effective therapy for treating unilateral neglect,Mirror Therapy(MT)is employed in the upper limb motor function rehabilitation of hemiplegic patients.However,traditional MT has a serious limitation—the Impaire...As an effective therapy for treating unilateral neglect,Mirror Therapy(MT)is employed in the upper limb motor function rehabilitation of hemiplegic patients.However,traditional MT has a serious limitation—the Impaired Limb(IL)doesn't actually move.In this study,a novel performance-based assistance strategy suitable for Robotic Mirror Therapy(RMT)based on MT is proposed.A guiding assistance based on the progress difference HL and IL is constructed in trajectory guidance,and a multi-stiffness region correction force field based on trajectory tracking error is designed to constrain IL's deviation from the intended path in trajectory correction assistance.To validate the presented strategy,a series of experiments on a RMT system based on the end-effector upper limb rehabilitation robot are conducted.The results verify the performance and feasibility of this strategy.展开更多
With the rapid development of AI technology,the field of rehabilitation therapy has ushered in unprecedented opportunities for innovation.This paper provides a comprehensive review of the current applications of AI in...With the rapid development of AI technology,the field of rehabilitation therapy has ushered in unprecedented opportunities for innovation.This paper provides a comprehensive review of the current applications of AI in rehabilitation therapy and the chall enges it faces,while also exploring its future development trends.The research finds that the application of AI technology in rehabilitation therapy has significantly improved rehabilitation efficiency and patients’quality of life.AI can develop person alized rehabilitation plans based on individual patient conditions,achieve precise assessments and training through smart assistive devices,and break through the limitations of time and space with remote rehabilitation services.However,th e application of AI in rehabilitation therapy still faces several challenges,including high technological costs,data privacy concerns,and public acceptance.Looking forward,as technologies such as 5G,the Internet of Things,and brain-machine interfaces deeply integ rate with AI,rehabilitation medicine is expected to move toward a new stage of greater precision and intelligence.展开更多
Organic mulching is widely applied in agricultural and forest ecosystems to improve crop yields and maintain soil quality.However,its long-term impact on soil organic carbon(SOC)stability and the underlying mechanisms...Organic mulching is widely applied in agricultural and forest ecosystems to improve crop yields and maintain soil quality.However,its long-term impact on soil organic carbon(SOC)stability and the underlying mechanisms remain unclear.An in situ experiment was initiated in 2018 in the subtropical region of China,with the non-mulched treatment serving as the control group(0 year of mulching),to investigate the effects of mulching on the organic carbon components(particulate organic carbon,POC,and mineral-associated organic carbon,MAOC)in Phyllostachys praecox bamboo forests across different mulching durations of 1,3,and 5 years.Our results indicated that five-year mulching decreased soil POC concentration by 13.36%,while increasing MAOC and SOC by 130.3%and 64.53%,respectively,compared to no mulching.The POC/MAOC ratio dropped,indicating improved SOC stability.Additionally,soil pH decreased with mulching duration,while bacterial and fungal diversity,available phosphorus content,andβ-xylosidase activity significantly increased.Structural equation modeling indicated that POC was mainly regulated by available phosphorus and fungal communities.While MAOC was affected by soil pH,which also mediated its response by influencing enzyme activity and bacterial diversity.In bamboo forest ecosystems,long-term organic mulching enhances SOC sequestration and stability,providing insights into SOC management for sustainable forestry.Such information indicates continuous mulching can be used to improve SOC sequestration in subtropical bamboo ecosystems.展开更多
基金supported by the National Key Research and Development Program of China(2022YFD1201300,2022YFD1201500)Biological Breeding-National Science and Technology Major Project(2023ZD04025)+1 种基金National Natural Science Foundation of China(W2412009,32372173,32101779,32260485)the Hubei Hongshan Laboratory(2022hspy001,2021hskf008,and 2022hspy010).
文摘Leaf rust,caused by the fungus Puccinia triticina,is one of the most destructive diseases affecting global wheat production.Developing disease-resistant wheat varieties is the most cost-effective and environmentally friendly approach to managing this disease.We phenotyped a collection of 559 wheat accessions from five continents for resistance to leaf rust in field trials at three locations in China(Zhoukou,Henan;Wuhan,Hubei;and Xinxiang,Henan)during the 2020–2021,2021–2022,and 2022–2023 cropping seasons,followed by best-linear-unbiased-estimation analysis across environments.These accessions were genotyped using the MGISEQ-2000 re-sequencing platform,and a genome-wide association analysis was subsequently performed.Twenty-four stable leaf rust resistance loci across 15 chromosomes were identified.Among these,11 loci may represent new sources of resistance.Notably,Lr.hzau-2BS.1 and Lr.hzau-7AL were consistently detected across all three environments and BLUE.Lr.hzau-2BS.1 has the highest frequency in European wheat accessions,whereas Lr.hzau-7AL is most prevalent in South American accessions.Gene-expression analysis identified 101 candidate genes associated with these loci.Closely linked Kompetitive Allele Specific PCR(KASP)markers,2B-209172 and 7A-348992,were developed for Lr.hzau-2BS.1 and Lr.hzau-7AL,respectively.Chinese wheat varieties Mianmai 45 and Liaomai 16,which carry resistance alleles at both loci and exhibit<5%leaf rust severity,represent valuable sources of leaf rust resistance for wheat breeding programs.These newly identified resistance loci and their KASP markers provide valuable resource for their exploitation in wheat breeding.
基金supported by the Incubation Fund of Zhongshan Hospital,Fudan University(Xiamen Branch)(2020ZSXMYS24).
文摘Recent research has indicated that sialic acid,such as free sialic acid(N-acetylneuraminic acid,Neu5Ac)and bound sialic acid(3ʹ-sialyllactose,3ʹ-SL),can ameliorate disorders associated with glycolipid metabolism,although the underlying mechanisms have yet to be determined.We examined the effects of 3ʹ-SL on glycolipid metabolism in mice fed a high-fat diet.Male C57BL/6J mice were divided into 6 groups:2 model control groups(normal and high-fat diets)and 4 intervention groups(Neu5Ac,and low,moderate,and high-dose 3ʹ-SL).After 8 weeks of continuous gavage intervention,mice in the 3ʹ-SL intervention groups had lower body weight and total fat content;reduced fasting blood glucose,triglycerides,low-density lipoproteins and oxidized-low-density lipoproteins;and increased high-density lipoproteins,but no dosage-dependent of 3ʹ-SL intervention was found,moderate-dose 3ʹ-SL intervention as optimal for further exploration.3ʹ-SL intervention could increase respiratory exchange ratio,energy expenditure,and amount of exercise performed.3ʹ-SL increased the colonic abundances of Akkermansia,Lactobacillus,and Bacteroides,and reduced those of Erysipelatoclostridium,Faecalibaculum,and Aldercreutzia.Changes were also observed in colonic metabolites,and liver gene transcript and metabolites,which were mainly enriched in bile secretion,taurine and hypotaurine metabolism,and insulin resistance.Additionally,3ʹ-SL was observed to regulate genes associated with physiological rhythms,including Clock,Per2,Cry1,and Bhihe41.Collectively,our findings indicate that 3ʹ-SL can contribute to the prevention and control of disorders associated with glucose and lipid metabolism caused by high-fat diets.Compared with Neu5Ac,3ʹ-SL intervention can more effectively ameliorate intestinal flora disorders,enhance bile acid circulation,increase tissue energy expenditure,and reduce lipid synthesis,thereby promoting lipid-lowering effects mediated via the gut-liver axis,and can also enhance energy metabolism and alleviate disorders of glucolipid metabolism by altering physiological rhythms in high fat-diet mice.
基金supported by the National Natural Science Foundation of China(Nos.22478222,22178197,and U23A6005)the Dr.Jentai Yang Sustainable Environmental Protection and Eco-humanistic Education Fund(No.20253000027)which isadministered by the Overseas Chinese Environmental Engineers and Scientists Association。
文摘H_2O_(2) is one of the most important chemicals in the world.Recently,the electrochemical synthesis of H_2O_(2)by two-electron oxygen reduction reaction(2e^(-)ORR)has attracted great interest.Carbon-based catalysts show great promise for electrocatalytic production of H_2O_(2),due to the ease of regulation of the carbon materials with regard to the pore structure,surface properties,and heteroatom doping.Biomass as the carbon precursor has the advantages of low cost,sustainable supply,and extensive availability.Conversion of biomass to functional carbon-based materials shows the attractive merits,such as low carbon emission in the life cycle and diversity of the obtained carbon materials due to the wide source of biomass feedstocks.In this article,a comprehensive review on the mechanisms and processes of electrochemical synthesis of H_2O_(2) by 2e^(-)ORR over carbon-based catalysts is provided.The potential biomass feedstock used for obtaining the carbon-based catalysts,and the strategies to prepare the catalysts by carbonization and heteroatom doping,as well as optimization of electrodes and design of electrolyzer,are discussed.It is recommended that future work focus on developing efficient methods to prepare the catalysts from low-cost biomass feedstock,understanding the mechanisms of 2e^(-)ORR over the catalysts,optimization of electrode materials loaded with biomass-derived catalysts,as well as development of electrolyzers for larger-scale applications.
文摘Purpose： A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor （EGFR） tyrosine kinase inhibitors （TKIs） in advanced non-small-cell lung cancer （NSCLC）. This study aimed to identify predictive factors associated with prognostic benefits of gefitinib. Patients and methods： EGFR gene typing in 33 advanced NSCLC patients received gefitinib （250 mg/day） were analyzed with mutant-enriched PCR assay. Gefitinib response was evaluated with potential predictive factors retrospectively. Results： The overall objective response rate （ORR） and median progression-flee survival （PFS） in the 33 patients treated by gefitinib were 45.5% and 3.0 （2.0-4.0） months. The ORR and median PFS in EGFR gene mutation patients were significantly higher/longer than those in EGFR gene wild-type patients （P〈0.01）. Similarly, the ORR and median PFS in non-smoker patients were significantly higher/longer than those in smoker patients （P〈0.05, P〈0.01, respectively）. However, no difference for ORR and median PFS occurred between male and female patients. Logistic multivariate analysis showed that only EGFR mutated gene was significantly associated with the ORR （P〈0.01）. Both EGFR mutated gene and non-smoker were the major factors that contributed to PFS （P〈0.05）. Conclusions： EGFR mutated gene and non-smoker status are potential predictors for gefitinib response in NSCLC patients.
基金Department of Navy Awards N00014-22-1-2001 and N00014-23-1-2124 issued by the Office of Naval Research。
文摘The power grid is undergoing a transformation from synchronous generators(SGs) toward inverter-based resources(IBRs). The stochasticity, asynchronicity, and limited-inertia characteristics of IBRs bring about challenges to grid resilience. Virtual power plants(VPPs) are emerging technologies to improve the grid resilience and advance the transformation. By judiciously aggregating geographically distributed energy resources(DERs) as individual electrical entities, VPPs can provide capacity and ancillary services to grid operations and participate in electricity wholesale markets. This paper aims to provide a concise overview of the concept and development of VPPs and the latest progresses in VPP operation, with the focus on VPP scheduling and control. Based on this overview, we identify a few potential challenges in VPP operation and discuss the opportunities of integrating the multi-agent system(MAS)-based strategy into the VPP operation to enhance its scalability, performance and resilience.
基金supported by the National Natural Science Foundation of China(No.12202365)the Guangdong Basic and Applied Basic Research Foundation,China(Nos.2022A1515011565,2023A1515010031)+2 种基金the Natural Science Foundation of Chongqing,China(No.2022NSCQMSX5709)the Foundation of State Key Laboratory of High Temperature Gas Dynamics,China(No.2021KF10)the China Postdoctoral Science Foundation(Nos.2021M692633,2022T150534).
文摘In the real flow for high altitude,the initiation mechanism of the oblique detonation involves the coupling of complex wave structures and combustion waves,which may result in the phenomenon of extinction.The approach of stable initiation is one of the key factors that restricting the oblique detonation engine from theory to practice.The wave structure,initiation characteristics and characteristic parameters of the flow field are analyzed,the two-dimensional Euler equation considering the detailed chemical reactions of multi-component are solved.First,the approaches of blunt bump and transverse jet are combined used to shorten the detonation distance of the oblique detonation.Results show that these methods can promote the accelerated initiation of the oblique detonation effectively,and the detonation distance can be shortened more than 90%.There are two wave structures induced by the blunt bump:weak coupled and strong coupled,adding the transverse jet promotes the transition between these two wave structures.Then,the shape of the bump and the characteristic parameters of the transverse jet are optimized.The streamline-shape bump can eliminate the recirculation zone formed after the circle bump and the ellipse bump.The transverse jet will produce an oblique detonation wave at the front of the jet position,which changes the wave structure and initiation mode of the oblique detonation wave.It is expected to reveal the accelerated initiation mechanism of oblique detonation under the induction zone disturbance and complex flow environment,deepen the understanding of the detonation law of oblique detonation wave under real flow conditions,and provide a scientific basic for the development of the combustor of the oblique detonation engine.
基金supported by the National Basic Research Program of China(2015CB351806)the National Natural Science Foundation of China(61806011,61825101,61425025,and U1611461)+4 种基金the National Postdoctoral Program for Innovative Talents(BX20180005)the China Postdoctoral Science Foundation(2018M630036)the International Talent Exchange Program of Beijing Municipal Commission of Science and Technology(Z181100001018026)the Zhejiang Lab(2019KC0AB03 and 2019KC0AD02)the Royal Society Newton Advanced Fellowship(NAF-R1-191082).
文摘A neuroprosthesis is a type of precision medical device that is intended to manipulate the neuronal signals of the brain in a closed-loop fashion,while simultaneously receiving stimuli from the environment and controlling some part of a human brain or body.Incoming visual information can be processed by the brain in millisecond intervals.The retina computes visual scenes and sends its output to the cortex in the form of neuronal spikes for further computation.Thus,the neuronal signal of interest for a retinal neuroprosthesis is the neuronal spike.Closed-loop computation in a neuroprosthesis includes two stages:encoding a stimulus as a neuronal signal,and decoding it back into a stimulus.In this paper,we review some of the recent progress that has been achieved in visual computation models that use spikes to analyze natural scenes that include static images and dynamic videos.We hypothesize that in order to obtain a better understanding of the computational principles in the retina,a hypercircuit view of the retina is necessary,in which the different functional network motifs that have been revealed in the cortex neuronal network are taken into consideration when interacting with the retina.The different building blocks of the retina,which include a diversity of cell types and synaptic connections-both chemical synapses and electrical synapses(gap junctions)-make the retina an ideal neuronal network for adapting the computational techniques that have been developed in artificial intelligence to model the encoding and decoding of visual scenes.An overall systems approach to visual computation with neuronal spikes is necessary in order to advance the next generation of retinal neuroprosthesis as an artificial visual system.
基金supported by the Guangdong Basic and Applied Basic research Foundation (Grant No.2022A1515011565)Foundation of State Key Laboratory of High Temperature Gas Dynamics (Grant No.2021KF10)the China Postdoctoral Science Foundation (Grant Nos.2021M692633 and 2022T150534).
文摘To alleviate problems with access and affordability,six targeted anticancer medications(TAMs)were listed in the Provincial Reimbursement Drug List(PRDL)for the first time in Zhejiang,China in February 2015.In the present study,we aimed to evaluate the implementation of the PRDL policy on TAMs use.Using the pharmaceutical procurement data of these six listed TAMs(study group)and four unlisted TAMs(control group)from 22 tertiary hospitals in Zhejiang,China dated between January 2014 and February 2017,interrupted time-series analysis was adopted to examine differences in the average hospital purchasing volume(HPV)and the average hospital purchasing spending(HPS)between the two groups.The average daily cost of listed TAMs in the study group was decreased after April 2015.After enlistment,the average HPV per month was significantly increased by 34.6 defined daily doses(DDDs)(P<0.001),and the average HPS per month was significantly increased by USD 6614.9(P<0.001)for the listed TAMs in the study group(n=6).Neither the average HPV nor the average HPS changed significantly for the unlisted TAMs in the control group(n=4).The PRDL policy showed positive effects on improving patients’affordability and promoting access to TAMs in Zhejiang.The government should conduct further price negotiations and include more TAMs with clinical benefits into reimbursement schemes to relieve patients’financial burden and promote access.
文摘The Moving Picture Experts Group （MPEG） has been developing a 3D video （3DV） coding standard for depth-based 3DV data representations, especially for multiview video plus depth （MVD） format. With MVD, depth-image-based rendering （DIBR）is used to synthesize virtual views that are based on a few transmitted pairs of texture and depth data. In this paper, we discuss ongoing 3DV standardization and summarize coding tools proposed in the responses to MPEG＇ s call for proposals on 3DV coding.
基金support by the National Natural Science Foundation of China(No.62073217,No.61871266)the Fund of the Ministry of Education of the People’s Republic of China(6141A02022607,6141A020227)the Fund of the Professional Technical Service Platform of Shanghai(19DZ2291103).
文摘The development of a tailless Flapping Wing Micro Aerial Vehicle(FWMAV)inspired by the hummingbird is presented in this work.By implementing mechanical simplifications,it is possible to use planar machining technology for manufacturing of the FWMAV’s body,greatly reducing assembly errors.Traditionally,studies on flapping wing aircraft are limited to open-loop wing kinematics control.In this work,an instantaneous closed-loop wing trajectory tracking control system is introduced to minimize wings’trajectory tracking errors.The control system is based on Field-Oriented Control(FOC)with a loop shaping compensation technique near the flapping frequency.Through frequency analysis,the loop shaping compensator ensures the satisfactory bandwidth and performance for the closed-loop flapping system.To implement the proposed controller,a compact autopilot board integrated with FOC hardware is designed,weighing only 2.5 g.By utilizing precise wing trajectory tracking control,the hummingbird-inspired FWMAV demonstrates superior ability to resist external disturbances and exhibits reduced attitude tracking errors during hovering flight compared to the open-loop wing motion.
基金support by the Natural Science Foundation of China under Grant 61871266the Professional technical service platform of Shanghai under Grant 19DZ2291103.
文摘Passively stabilized double-wing Flapping Micro Air Vehicles(FMAVs)do not require active control and exhibit good electromagnetic interference resistance,with significant research value.In this paper,the dynamic model of FMAV was established as the foundation for identifying flapping damping coefficients.Through a pendulum experiment,we ascertain the flapping damping of the damper using the energy conservation method.Besides,fitting relationships between the damper area,damper mass,and the moment of inertia are developed.The factors influencing the bottom damper damping are deter-mined using correlation coefficients and hypothesis testing methods.Additionally,stable dampers are installed on both the top and bottom of the FMAV to achieve passive stability in simulations.The minimum damper areas for the FMAV were optimized using genetic algorithms,resulting in a minimum top damper area of 128 cm^(2) and a minimum bottom damper area of 80 cm^(2).A prototype with a mass of 25.5 g and a wingspan of 22 cm has been constructed.Prototype testing demonstrated that FMAV can take off stably with a 3 g payload and a tilt angle of 5°.During testing,the area-to-mass ratio of the FMAV reached 7.29 cm^(2)/g,achieving passive stability with the world's smallest area-to-mass ratio.
基金funded by the National Natural Science Foundation of China(Grant No.81970821)the Postgraduate Research Innovation Program of Jiangsu Provinc(Grant No.SJCX21_0624).
文摘Age-related macular degeneration(AMD)causes irreversible blindness in people aged over 50 worldwide.The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD.In the current study,we used the ComBat and Training Distribution Matching method to integrate data obtained from the Gene Expression Omnibus database.We analyzed the integrated sequencing data by the Gene Set Enrichment Analysis.Peroxisome and tumor necrosis factor-α(TNF-α)signaling and nuclear factor kappa B(NF-κB)were among the top 10 pathways,and thus we selected them to construct AMD cell models to identify differentially expressed circular RNAs(circRNAs).We then constructed a competing endogenous RNA network,which is related to differentially expressed circRNAs.This network included seven circRNAs,15 microRNAs,and 82 mRNAs.The Kyoto Encyclopedia of Genes and Genomes analysis of mRNAs in this network showed that the hypoxia-inducible factor-1(HIF-1)signaling pathway was a common downstream event.The results of the current study may provide insights into the pathological processes of atrophic AMD.
基金supported by the National Natural Science Foundation of China(No.61973043)Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX0100).
文摘In this paper,we study a distributed model to cooperatively compute variational inequalities over time-varying directed graphs.Here,each agent has access to a part of the full mapping and holds a local view of the global set constraint.By virtue of an auxiliary vector to compensate the graph imbalance,we propose a consensus-based distributed projection algorithm relying on local computation and communication at each agent.We show the convergence of this algorithm over uniformly jointly strongly connected unbalanced digraphs with nonidentical local constraints.We also provide a numerical example to illustrate the effectiveness of our algorithm.
基金the National Natural Science Foundation of China (Grant Nos.61531003 and 62001044)the Fundamental Research Funds for the Central Universities of China。
文摘Imperfections in practical detectors,including limited detection efficiency,and inherent electronic noise,can seriously decrease the transmission distance of continuous-variable measurement-device-independent quantum key distribution systems.Owing to the difficulties inherent in realizing a high-efficiency fiber homodyne detector,challenges still exist in continuous-variable measurement-device-independent quantum key distribution system implementation.We offer an alternative approach in an attempt to solve these difficulties and improve the potential for system implementation.Here,a novel practical detector modeling method is utilized,which is combined with a one-time shot-noise-unit calibration method for the purpose of system realization.The new modeling method benefits greatly from taking advantage of one-time shot-noise-unit calibration methods,such as measuring electronic noise and shot noise directly to a novel shot-noise unit,so as to eliminate the statistical fluctuations found in previous methods;this makes the implementation of such systems simpler,and the calibration progress more accurate.We provide a simulation of the secret key rate versus distance with different parameters.In addition,the minimal detection efficiency required at each distance,as well as the contrast between the two methods,are also shown,so as to provide a reference in terms of system realization.
基金supported by the National Natural Science Foundation of China Grant no.61973205.
文摘As an effective therapy for treating unilateral neglect,Mirror Therapy(MT)is employed in the upper limb motor function rehabilitation of hemiplegic patients.However,traditional MT has a serious limitation—the Impaired Limb(IL)doesn't actually move.In this study,a novel performance-based assistance strategy suitable for Robotic Mirror Therapy(RMT)based on MT is proposed.A guiding assistance based on the progress difference HL and IL is constructed in trajectory guidance,and a multi-stiffness region correction force field based on trajectory tracking error is designed to constrain IL's deviation from the intended path in trajectory correction assistance.To validate the presented strategy,a series of experiments on a RMT system based on the end-effector upper limb rehabilitation robot are conducted.The results verify the performance and feasibility of this strategy.
文摘With the rapid development of AI technology,the field of rehabilitation therapy has ushered in unprecedented opportunities for innovation.This paper provides a comprehensive review of the current applications of AI in rehabilitation therapy and the chall enges it faces,while also exploring its future development trends.The research finds that the application of AI technology in rehabilitation therapy has significantly improved rehabilitation efficiency and patients’quality of life.AI can develop person alized rehabilitation plans based on individual patient conditions,achieve precise assessments and training through smart assistive devices,and break through the limitations of time and space with remote rehabilitation services.However,th e application of AI in rehabilitation therapy still faces several challenges,including high technological costs,data privacy concerns,and public acceptance.Looking forward,as technologies such as 5G,the Internet of Things,and brain-machine interfaces deeply integ rate with AI,rehabilitation medicine is expected to move toward a new stage of greater precision and intelligence.
基金supported by the National Natural Science Foundation of China(Grant No.32301672)the Natural Science Research Project of Colleges and Universities of Anhui Province(Grant No.2023AH050990)。
文摘Organic mulching is widely applied in agricultural and forest ecosystems to improve crop yields and maintain soil quality.However,its long-term impact on soil organic carbon(SOC)stability and the underlying mechanisms remain unclear.An in situ experiment was initiated in 2018 in the subtropical region of China,with the non-mulched treatment serving as the control group(0 year of mulching),to investigate the effects of mulching on the organic carbon components(particulate organic carbon,POC,and mineral-associated organic carbon,MAOC)in Phyllostachys praecox bamboo forests across different mulching durations of 1,3,and 5 years.Our results indicated that five-year mulching decreased soil POC concentration by 13.36%,while increasing MAOC and SOC by 130.3%and 64.53%,respectively,compared to no mulching.The POC/MAOC ratio dropped,indicating improved SOC stability.Additionally,soil pH decreased with mulching duration,while bacterial and fungal diversity,available phosphorus content,andβ-xylosidase activity significantly increased.Structural equation modeling indicated that POC was mainly regulated by available phosphorus and fungal communities.While MAOC was affected by soil pH,which also mediated its response by influencing enzyme activity and bacterial diversity.In bamboo forest ecosystems,long-term organic mulching enhances SOC sequestration and stability,providing insights into SOC management for sustainable forestry.Such information indicates continuous mulching can be used to improve SOC sequestration in subtropical bamboo ecosystems.
