Background The deposition of intramuscular fat(IMF)in livestock can enhance the flavor and tenderness of meat products,significantly increasing consumer satisfaction.To achieve this industrial trait,this study investi...Background The deposition of intramuscular fat(IMF)in livestock can enhance the flavor and tenderness of meat products,significantly increasing consumer satisfaction.To achieve this industrial trait,this study investigated the regulatory effects of 20 dietary nutrients on sheep IMF deposition using a 3D organoid culture model.Results Key nutrients enhancing angiogenesis,adipocyte differentiation,and lipid accumulation were identified through assessments of capillary sprouts development,mRNA expression,and Oil Red O staining.Vitamins C(VC),E(VE),and K1(VK1),guanidinoacetic acid(GAA),leucine(Leu),lysine(Lys),methionine(Met),N-carbamylglutamate(NCG),tryptophan(Trp),α-linolenic acid(ALA),linoleic acid(LA),cis-9,trans-11 conjugated linoleic acid(c9,t11-CLA),acetic acid(HAc),and sodium acetate(NaAc)stimulated while vitamins B9(VB9),D(VD),K2(VK2),taurine(Tau),and sodium butyrate(NaBu)inhibited angiogenesis(P<0.05).Furthermore,VC,VE,VK1,VK2,GAA,Leu,NCG,Trp,ALA,LA,and HAc enhanced adipocyte differentiation,with VE,VK1,GAA,Leu,LA,and HAc additionally elevating lipid accumulation(P<0.05).Conclusions Various nutrients play distinct regulatory roles in angiogenesis,adipocyte differentiation,and lipid accumulation.These findings provide a roadmap for further optimizing the production of marbled meat through nutritional intervention in actual livestock breeding production.展开更多
Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of...Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of biomaterials,cells,and biomolecules in a layer-by-layer fashion,with precisely controlled spatial distribution.This technology is expected to address the organ-shortage issue in the future.In this review,we first introduce three categories of 3D bioprinting strategies:inkjet-based printing(IBP),extrusion-based printing(EBP),and light-based printing(LBP).Biomaterials and cells,which are normally referred to as“bioinks,”are then discussed.We also systematically describe the recent advancements of 3D bioprinting in fabricating cell-laden artificial tissues and organs with solid or hollow structures,including cartilage,bone,skin,muscle,vascular network,and so on.The development of organs-onchips utilizing 3D bioprinting technology for drug discovery and toxicity testing is reviewed as well.Finally,the main challenges in current studies and an outlook of the future research of 3D bioprinting are discussed.展开更多
Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early...Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent years.Understanding the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in vitro.Here,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment models.The study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study.展开更多
Deep learning has become an extremely popular method in recent years,and can be a powerful tool in complex,prior-knowledge-required areas,especially in the field of biomedicine,which is now facing the problem of inade...Deep learning has become an extremely popular method in recent years,and can be a powerful tool in complex,prior-knowledge-required areas,especially in the field of biomedicine,which is now facing the problem of inadequate medical resources.The application of deep learning in disease diagnosis has become a new research topic in derma-tology.This paper aims to provide a quick review of the classification of skin disease using deep learning to summa-rize the characteristics of skin lesions and the status of image technology.We study the characteristics of skin disease and review the research on skin disease classification using deep learning.We analyze these studies using datasets,data processing,classification models,and evaluation criteria.We summarize the development of this field,illustrate the key steps and influencing factors of dermatological diagnosis,and identify the challenges and opportunities at this stage.Our research confirms that a skin disease recognition method based on deep learning can be superior to professional dermatologists in specific scenarios and has broad research prospects.展开更多
[Objectives] To investigate the infrared identification of ZhuQin Formula and Atractylodes polysaccharides and its effect on immune function in immunocompromised mice. [Methods] In this experiment,the structure of pol...[Objectives] To investigate the infrared identification of ZhuQin Formula and Atractylodes polysaccharides and its effect on immune function in immunocompromised mice. [Methods] In this experiment,the structure of polysaccharides was analyzed by Fourier transform infrared spectroscopy. The experiment was divided into the polysaccharide groups of high,medium and low dose of ZhuQin,the extraction group of ZhuQin,the polysaccharide group of Atractylodes,the positive drug group,the blank group and the model group. The model of immunosuppressed mice was established by intraperitoneal injection of cyclophosphamide. The carbon clearance index,immune organ index,serum hemolysin,spleen T and B lymphocyte transformation rate were determined. [Results]The results show that the polysaccharides have obvious absorption peaks of polysaccharides; Formula extracts and polysaccharides can enhance the immune function of immunosuppressive mice at a certain dose level,and the effect of formula polysaccharide is better than that of extract and single traditional Chinese medicine polysaccharides. [Conclusions] The results suggest that the polysaccharides of ZhuQin Formula and Atractylodes may be acidic polysaccharides containing pyran ring and furan ring. ZhuQin Formula polysaccharide may play an immunomodulatory role mainly by improving the specific immunity of the organism.展开更多
Three-dimensional （3D） printing is a novel promising technology based on 3D imaging and layer-by-layer additive fabrication. It has a profound influence on all aspects of our lives and is playing an increasing impor...Three-dimensional （3D） printing is a novel promising technology based on 3D imaging and layer-by-layer additive fabrication. It has a profound influence on all aspects of our lives and is playing an increasing important role in many areas including engineering, manufacturing, art, education and medicine. ＂3D bioprinting＂ has been put forward with the technical progress in 3D printing and might be a possible way to solve the serious problem of human organ shortage in tissue engineering and regenerative medicine. Many research groups flung them into this area and have already made some gratifying achievements. However, it is a long way to fabricate a live organ. Many elements lead to the limitation of 3D bioprinting. This review introduces the background and development history of 3D bioprinting, compares different approaches of 3D bioprinting and illustrates the key factors of the printing process. Meanwhile, this review also points out existing challenges of 3D bioprinting and has a great prospect. Some points proposed in this review might be served as reference for the research of this field.展开更多
OverviewThe Research Lab on 3D Bioprinting of Zhejiang University focuses on developing innovative 3D bioprinting equipment and technology for healthcare and biomedical applications, since founded in 2017. To further ...OverviewThe Research Lab on 3D Bioprinting of Zhejiang University focuses on developing innovative 3D bioprinting equipment and technology for healthcare and biomedical applications, since founded in 2017. To further enhance the international collaboration, a joint international research lab on 3D bioprinting of Zhejiang University and University of Oxford was set up. The lab is based on the State Key Laboratory of Fluid Power and Mechatronic Systems and the Oxford Centre for Tissue Engineering and Bioprocessing. The aim of the lab is to establish a world class research and development platform on 3D bioprinting. The lab has extensive and close collaborations with University of Oxford, University College London and multidisciplinary partners of Zhejiang University.展开更多
Three-dimensional(3D)printing technology is expected to solve the organ shortage problem.However,owing to the accuracy limitations,it is difficult for the current bioprinting technology to achieve an accurate control ...Three-dimensional(3D)printing technology is expected to solve the organ shortage problem.However,owing to the accuracy limitations,it is difficult for the current bioprinting technology to achieve an accurate control of the spatial position and distribution of a single cell or single component droplet.In this study,to accurately achieve the directional deposition of different cells and biological materials in the spatial position for the construction of large transplantable tissues and organs,a high-precision multichannel 3D bioprinter with submicron-level motion accuracy is designed,and concurrent and synergistic printing methods are proposed.Based on the high-precision motion characteristics of the gantry structure and the requirements of concurrent and synergistic printing,a 3D bioprint-ing system with a set of 6 channels is designed to achieve six-in-one printing.Based on the Visual C++environ-ment,a control system software that integrates the programmable multi-axis controller(PMAC)motion,pneumatic,and temperature control subsystems was developed and designed.Finally,based on measurements and experiments,the 3D bioprinter and its control system was verified to fulfil the requirements of multichannel,concurrent,and syn-ergistic printing with submicron-level motion accuracy,significantly shortening the printing time and improving the printing efficiency.This study not only provides an equipment basis for printing complex heterogeneous tissue structures,but also improves the flexibility and functionality of bioprinting,and ultimately makes the construction of complex multicellular tissues or organs possible.展开更多
The informativeness of environmental,social,and governance(ESG)scores and their actual impact on firms remains understudied.To address this gap in the literature,we make theoretical predictions and conduct empirical r...The informativeness of environmental,social,and governance(ESG)scores and their actual impact on firms remains understudied.To address this gap in the literature,we make theoretical predictions and conduct empirical research revealing that a high ESG score is associated with a lower probability of ESG scandals and lower stock returns during a scandal event.Our results suggest that ESG scores are heterogeneous but informative,and that a strong ESG reputation may have both positive and negative consequences for firms.Drawing on our findings,we develop a model and showcase that firms face an optimization problem when determining optimal ESG investment levels.Two equilibria may exist based on the trade-off between ESG scandal losses and ESG adjustment costs.Our model explains why certain firms make heterogeneous ESG decisions.展开更多
Rural electrification is a crucial component of the power system that requires urgent innovation and transformation to enhance electrification levels.However,various challenges hinder the progress in rural electrifica...Rural electrification is a crucial component of the power system that requires urgent innovation and transformation to enhance electrification levels.However,various challenges hinder the progress in rural electrification,primarily due to remote locations and unique consumption patterns.To effectively coordinate the local energy distribution,an energy management framework utilizing peer-to-peer(P2P)based interactive operations is proposed,which minimizes the reliance on long-distance transmission while enhancing the rural electrification level.The proposed P2P-based energy management framework incorporates various distributed generation resources across rural areas,facilitating direct energy transactions between neighboring community-based villages.Additionally,the P2P energy trading is modeled as a Nash bargaining(NB)problem,which accounts for the allocation of network loss costs and operational state of the rural distribution network.To protect the privacy of individual villages,an improved adaptive alternating direction method of multipliers(AADMM)is proposed to solve the NB problem.The AADMM utilizes a local curvature approximation scheme during parameter updates,allowing for automatic adjustments of the fixed penalty parameter within the standard alternating direction method of multipliers(ADMM).This enhancement improves the convergence rates without requiring central oversight.Simulation results demonstrate significant reductions in operational costs for both the overall network and individual village participants.The proposed P2P-based energy management framework also enhances the bus voltage stability and reduces the line transmission power,thereby further enhancing rural electrification levels.The adaptability and extensibility of this framework are further validated using the IEEE 33-bus and 118-bus distribution systems.Additionally,the AADMM shows higher convergence rates compared with the standard ADMM.展开更多
The field of cancer research is increasingly recognizing the complex interplay between biomechanics and tumor epigenetics.Biomechanics plays a significant role in the occurrence,development,and metastasis of cancer an...The field of cancer research is increasingly recognizing the complex interplay between biomechanics and tumor epigenetics.Biomechanics plays a significant role in the occurrence,development,and metastasis of cancer and may exert influence by impacting the epigenetic modifications of tumors.In this review,we investigate a spectrum of biomechanical tools,including computational models,measurement instruments,and in vitro simulations.These tools not only assist in deciphering the mechanisms behind these epigenetic changes but also provide novel methods for characterizing tumors,which are significant for diagnosis and treatment.Finally,we discuss the potential of new therapies that target the biomechanical properties of the tumor microenvironment.There is hope that by altering factors such as the stiffness of the extracellular matrix or interfering with mechano-sensing pathways,we can halt tumor progression through epigenetic mechanisms.We emphasize the necessity for multidisciplinary efforts to integrate biomechanics with tumor epigenetics more comprehensively.Such collaboration is anticipated to advance therapeutic strategies and enhance our understanding of cancer biology,signaling the dawn of a new era in cancer treatment and research.展开更多
基金supported by the Key Research and Development Program-Key Projects(2021YFD1200900,2023YFD1301302)the grants from the National Natural Science Foundation of China(32272892,32472886)+2 种基金the Bayannaoer Research Institute Young Scientist Project(2024BYNECAU003)the Chinese Universities Scientific Fund(2025TC101)the 2115 Talent Development Program of China Agricultural University。
文摘Background The deposition of intramuscular fat(IMF)in livestock can enhance the flavor and tenderness of meat products,significantly increasing consumer satisfaction.To achieve this industrial trait,this study investigated the regulatory effects of 20 dietary nutrients on sheep IMF deposition using a 3D organoid culture model.Results Key nutrients enhancing angiogenesis,adipocyte differentiation,and lipid accumulation were identified through assessments of capillary sprouts development,mRNA expression,and Oil Red O staining.Vitamins C(VC),E(VE),and K1(VK1),guanidinoacetic acid(GAA),leucine(Leu),lysine(Lys),methionine(Met),N-carbamylglutamate(NCG),tryptophan(Trp),α-linolenic acid(ALA),linoleic acid(LA),cis-9,trans-11 conjugated linoleic acid(c9,t11-CLA),acetic acid(HAc),and sodium acetate(NaAc)stimulated while vitamins B9(VB9),D(VD),K2(VK2),taurine(Tau),and sodium butyrate(NaBu)inhibited angiogenesis(P<0.05).Furthermore,VC,VE,VK1,VK2,GAA,Leu,NCG,Trp,ALA,LA,and HAc enhanced adipocyte differentiation,with VE,VK1,GAA,Leu,LA,and HAc additionally elevating lipid accumulation(P<0.05).Conclusions Various nutrients play distinct regulatory roles in angiogenesis,adipocyte differentiation,and lipid accumulation.These findings provide a roadmap for further optimizing the production of marbled meat through nutritional intervention in actual livestock breeding production.
基金The authors would like to acknowledge support from the National Natural Science Foundation of China(51875518,51475419,and 81501607)the Natural Science Foundation of Zhejiang Province of China(LY15H160019)the Key Research and Development Projects of Zhejiang Province(2017C01054).
文摘Three-dimensional(3D)bioprinting is a rapidly growing technology that has been widely used in tissue engineering,disease studies,and drug screening.It provides the unprecedented capacity of depositing various types of biomaterials,cells,and biomolecules in a layer-by-layer fashion,with precisely controlled spatial distribution.This technology is expected to address the organ-shortage issue in the future.In this review,we first introduce three categories of 3D bioprinting strategies:inkjet-based printing(IBP),extrusion-based printing(EBP),and light-based printing(LBP).Biomaterials and cells,which are normally referred to as“bioinks,”are then discussed.We also systematically describe the recent advancements of 3D bioprinting in fabricating cell-laden artificial tissues and organs with solid or hollow structures,including cartilage,bone,skin,muscle,vascular network,and so on.The development of organs-onchips utilizing 3D bioprinting technology for drug discovery and toxicity testing is reviewed as well.Finally,the main challenges in current studies and an outlook of the future research of 3D bioprinting are discussed.
基金We would like to thank the support by the National Key Research and Development Program of China(2018YFA0703000)National Natural Science Foundation of China(Grant No.51875518)+1 种基金Key Research and Development Projects of Zhejiang Province(Grant No.2017C01054 and No.2018C03062)the Fundamental Research Funds for the Central Universities(Grant No.2019XZZX003-02,2019FZA4002).
文摘Treatments for lesions in central nervous system(CNS)are always faced with challenges due to the anatomical and physiological particularity of the CNS despite the fact that several achievements have been made in early diagnosis and precision medicine to improve the survival and quality of life of patients with brain tumors in recent years.Understanding the complexity as well as role of the microenvironment of brain tumors may suggest a better revealing of the molecular mechanism of brain tumors and new therapeutic directions,which requires an accurate recapitulation of the complex microenvironment of human brain in vitro.Here,a 3D bioprinted in vitro brain matrix-mimetic microenvironment model with hyaluronic acid(HA)and normal glial cells(HEBs)is developed which simulates both mechanical and biological properties of human brain microenvironment in vivo through the investigation of the formulation of bioinks and optimization of printing process and parameters to study the effects of different concentration of gelatin(GA)within the bioink and different printing structures of the scaffold on the performance of the brain matrix-mimetic microenvironment models.The study provides experimental models for the exploration of the multiple factors in the brain microenvironment and scaffolds for GBM invasion study.
基金Supported by Key Research and Development Projects of Zhejiang Province of China(Grant No.2017C01054)National Key Research and Development Program of China(Grant No.2018YFA0703000)+1 种基金National Natural Science Foundation of China(Grant No.51875518)Fundamental Research Funds for the Central Universities of China(Grant Nos.2019XZZX003-02,2019FZA4002).
文摘Deep learning has become an extremely popular method in recent years,and can be a powerful tool in complex,prior-knowledge-required areas,especially in the field of biomedicine,which is now facing the problem of inadequate medical resources.The application of deep learning in disease diagnosis has become a new research topic in derma-tology.This paper aims to provide a quick review of the classification of skin disease using deep learning to summa-rize the characteristics of skin lesions and the status of image technology.We study the characteristics of skin disease and review the research on skin disease classification using deep learning.We analyze these studies using datasets,data processing,classification models,and evaluation criteria.We summarize the development of this field,illustrate the key steps and influencing factors of dermatological diagnosis,and identify the challenges and opportunities at this stage.Our research confirms that a skin disease recognition method based on deep learning can be superior to professional dermatologists in specific scenarios and has broad research prospects.
基金Supported by Public Welfare and Industry Special Fund Project of the Ministry of Agriculture(201303040-05)Natural Science Foundation Project of CQCSTC(2013FYF110600)
文摘[Objectives] To investigate the infrared identification of ZhuQin Formula and Atractylodes polysaccharides and its effect on immune function in immunocompromised mice. [Methods] In this experiment,the structure of polysaccharides was analyzed by Fourier transform infrared spectroscopy. The experiment was divided into the polysaccharide groups of high,medium and low dose of ZhuQin,the extraction group of ZhuQin,the polysaccharide group of Atractylodes,the positive drug group,the blank group and the model group. The model of immunosuppressed mice was established by intraperitoneal injection of cyclophosphamide. The carbon clearance index,immune organ index,serum hemolysin,spleen T and B lymphocyte transformation rate were determined. [Results]The results show that the polysaccharides have obvious absorption peaks of polysaccharides; Formula extracts and polysaccharides can enhance the immune function of immunosuppressive mice at a certain dose level,and the effect of formula polysaccharide is better than that of extract and single traditional Chinese medicine polysaccharides. [Conclusions] The results suggest that the polysaccharides of ZhuQin Formula and Atractylodes may be acidic polysaccharides containing pyran ring and furan ring. ZhuQin Formula polysaccharide may play an immunomodulatory role mainly by improving the specific immunity of the organism.
基金Acknowledgements The authors would like to acknowledge the support from National Natural Science Foundation of China under Grant 81501607 and 51475419, Natural Science Foundation of Zhejiang Province of China under Grant LY15H160019, Key Research and Development Projects of Zhejiang Province under Grant 2017C 1054.
文摘Three-dimensional （3D） printing is a novel promising technology based on 3D imaging and layer-by-layer additive fabrication. It has a profound influence on all aspects of our lives and is playing an increasing important role in many areas including engineering, manufacturing, art, education and medicine. ＂3D bioprinting＂ has been put forward with the technical progress in 3D printing and might be a possible way to solve the serious problem of human organ shortage in tissue engineering and regenerative medicine. Many research groups flung them into this area and have already made some gratifying achievements. However, it is a long way to fabricate a live organ. Many elements lead to the limitation of 3D bioprinting. This review introduces the background and development history of 3D bioprinting, compares different approaches of 3D bioprinting and illustrates the key factors of the printing process. Meanwhile, this review also points out existing challenges of 3D bioprinting and has a great prospect. Some points proposed in this review might be served as reference for the research of this field.
文摘OverviewThe Research Lab on 3D Bioprinting of Zhejiang University focuses on developing innovative 3D bioprinting equipment and technology for healthcare and biomedical applications, since founded in 2017. To further enhance the international collaboration, a joint international research lab on 3D bioprinting of Zhejiang University and University of Oxford was set up. The lab is based on the State Key Laboratory of Fluid Power and Mechatronic Systems and the Oxford Centre for Tissue Engineering and Bioprocessing. The aim of the lab is to establish a world class research and development platform on 3D bioprinting. The lab has extensive and close collaborations with University of Oxford, University College London and multidisciplinary partners of Zhejiang University.
基金Supported by National Key Research and Development Program of China(Grant No.2018YFA0703000)National Natural Science Foundation of China(Grant No.51875518)Fundamental Research Funds for the Central Universities of China(Grant Nos.2019XZZX003-02,2019FZA4002).
文摘Three-dimensional(3D)printing technology is expected to solve the organ shortage problem.However,owing to the accuracy limitations,it is difficult for the current bioprinting technology to achieve an accurate control of the spatial position and distribution of a single cell or single component droplet.In this study,to accurately achieve the directional deposition of different cells and biological materials in the spatial position for the construction of large transplantable tissues and organs,a high-precision multichannel 3D bioprinter with submicron-level motion accuracy is designed,and concurrent and synergistic printing methods are proposed.Based on the high-precision motion characteristics of the gantry structure and the requirements of concurrent and synergistic printing,a 3D bioprint-ing system with a set of 6 channels is designed to achieve six-in-one printing.Based on the Visual C++environ-ment,a control system software that integrates the programmable multi-axis controller(PMAC)motion,pneumatic,and temperature control subsystems was developed and designed.Finally,based on measurements and experiments,the 3D bioprinter and its control system was verified to fulfil the requirements of multichannel,concurrent,and syn-ergistic printing with submicron-level motion accuracy,significantly shortening the printing time and improving the printing efficiency.This study not only provides an equipment basis for printing complex heterogeneous tissue structures,but also improves the flexibility and functionality of bioprinting,and ultimately makes the construction of complex multicellular tissues or organs possible.
基金funded by Hong Kong Polytechnic University under grand number P0047740.
文摘The informativeness of environmental,social,and governance(ESG)scores and their actual impact on firms remains understudied.To address this gap in the literature,we make theoretical predictions and conduct empirical research revealing that a high ESG score is associated with a lower probability of ESG scandals and lower stock returns during a scandal event.Our results suggest that ESG scores are heterogeneous but informative,and that a strong ESG reputation may have both positive and negative consequences for firms.Drawing on our findings,we develop a model and showcase that firms face an optimization problem when determining optimal ESG investment levels.Two equilibria may exist based on the trade-off between ESG scandal losses and ESG adjustment costs.Our model explains why certain firms make heterogeneous ESG decisions.
基金supported by National Natural Science Foundation of China(No.52207128).
文摘Rural electrification is a crucial component of the power system that requires urgent innovation and transformation to enhance electrification levels.However,various challenges hinder the progress in rural electrification,primarily due to remote locations and unique consumption patterns.To effectively coordinate the local energy distribution,an energy management framework utilizing peer-to-peer(P2P)based interactive operations is proposed,which minimizes the reliance on long-distance transmission while enhancing the rural electrification level.The proposed P2P-based energy management framework incorporates various distributed generation resources across rural areas,facilitating direct energy transactions between neighboring community-based villages.Additionally,the P2P energy trading is modeled as a Nash bargaining(NB)problem,which accounts for the allocation of network loss costs and operational state of the rural distribution network.To protect the privacy of individual villages,an improved adaptive alternating direction method of multipliers(AADMM)is proposed to solve the NB problem.The AADMM utilizes a local curvature approximation scheme during parameter updates,allowing for automatic adjustments of the fixed penalty parameter within the standard alternating direction method of multipliers(ADMM).This enhancement improves the convergence rates without requiring central oversight.Simulation results demonstrate significant reductions in operational costs for both the overall network and individual village participants.The proposed P2P-based energy management framework also enhances the bus voltage stability and reduces the line transmission power,thereby further enhancing rural electrification levels.The adaptability and extensibility of this framework are further validated using the IEEE 33-bus and 118-bus distribution systems.Additionally,the AADMM shows higher convergence rates compared with the standard ADMM.
基金supported by Science and Technology Program of Zhejiang Province(Grant No.2023C03071).
文摘The field of cancer research is increasingly recognizing the complex interplay between biomechanics and tumor epigenetics.Biomechanics plays a significant role in the occurrence,development,and metastasis of cancer and may exert influence by impacting the epigenetic modifications of tumors.In this review,we investigate a spectrum of biomechanical tools,including computational models,measurement instruments,and in vitro simulations.These tools not only assist in deciphering the mechanisms behind these epigenetic changes but also provide novel methods for characterizing tumors,which are significant for diagnosis and treatment.Finally,we discuss the potential of new therapies that target the biomechanical properties of the tumor microenvironment.There is hope that by altering factors such as the stiffness of the extracellular matrix or interfering with mechano-sensing pathways,we can halt tumor progression through epigenetic mechanisms.We emphasize the necessity for multidisciplinary efforts to integrate biomechanics with tumor epigenetics more comprehensively.Such collaboration is anticipated to advance therapeutic strategies and enhance our understanding of cancer biology,signaling the dawn of a new era in cancer treatment and research.
