BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s...BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively unexplored.AIM To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.METHODS This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024.Based on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human BCA.The intervention period lasted for 12 weeks.Bone mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.RESULTS No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P<0.05).After the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(P<0.05).After the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the intervention.However,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than that in the RD group(P<0.05).In both groups,the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels(P<0.05).Before the intervention,the levels of osteocalcin,serum calcium,PINP,β-CTX,and 25-hydroxyvitamin D were not significantly different between the two groups(P>0.05).After 12 weeks of intervention,the PN group exhibited higher levels of osteocalcin,serum calcium,and 25-hydroxyvitamin D,as well as lower levels of PINP andβ-CTX,compared to the RD group(P<0.05).In both groups,osteocalcin,serum calcium,and 25-hydroxyvitamin D levels were significantly higher,while PINP andβ-CTX levels were significantly lower after 12 weeks of intervention compared to baseline(P<0.05).CONCLUSION The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism,with effects that surpass those of conventional nutrition strategies.The findings of this study provide strong evidence for the nutritional management of AD patients.展开更多
Flower pollination algorithm (FPA) is one of the well-known evolutionary techniques used extensively to solve optimization problems. Despite its efficiency and wide use, the identical search behaviors may lead the alg...Flower pollination algorithm (FPA) is one of the well-known evolutionary techniques used extensively to solve optimization problems. Despite its efficiency and wide use, the identical search behaviors may lead the algorithm to converge to local optima. In this paper, an adaptive FPA based on chaotic map (CAFPA) is proposed. The proposed algorithm first used the ergodicity of the logistic chaos mechanism, and chaotic mapping of the initial population to make the initial iterative population more evenly distributed in the solution space. Then at the self-pollination stage, the over-random condition of the gamete renewal was improved, the traction force of contemporary optimal position was given, and adaptive logarithmic inertia weight was introduced to adjust the proportion between the contemporary pollen position and disturbance to improve the performance of the algorithm. By comparing the new algorithm with three famous optimization algorithms, the accuracy and performance of the proposed approach are evaluated by 14 well-known benchmark functions. Statistical comparisons of experimental results show that CAFPA is superior to FPA, PSO, and BOA in terms of convergence speed and robustness.展开更多
Quasi-spherical molecules are used to construct high-performance molecular ferroelectrics,but accurately producing polar crystals with low symmetry remains a challenge.Herein,we report a novel hightemperature multiaxi...Quasi-spherical molecules are used to construct high-performance molecular ferroelectrics,but accurately producing polar crystals with low symmetry remains a challenge.Herein,we report a novel hightemperature multiaxial molecular ferroelectric(C_(8)H_(14)NO)[FeCl_(4)](1)(C_(8)H_(14)NO=1-methyl-3-quininocyclone).Dielectric and differential scanning calorimetry(DSC)measurements showed that compound 1 had a high Curie temperature of 341.8 K.It crystallizes in the Cmc2_(1) space group at room temperature,showing switchable SHG response,moderate spontaneous polarization(P_(s)=0.24μC cm^(−2)),and clear ferroelectric domains.In addition,DSC and dielectric cycling tests indicate that compound 1 can be used as an excellent electric double-switch material.Notably,the distinct symmetry breaking,that is,4/mmmFmm2,leads to a biaxial ferroelectric with four equivalent directions of polarization.This discovery provides an effective approach for constructing multiaxial high-temperature molecular ferroelectrics.展开更多
基金Supported by Science and Technology Bureau of Quzhou,No.2022079.
文摘BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine disorders.However,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively unexplored.AIM To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD patients.METHODS This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December 2024.Based on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human BCA.The intervention period lasted for 12 weeks.Bone mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the intervention.RESULTS No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(P<0.05).After the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(P<0.05).After the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(P<0.05).The mini-mental state examination(MMSE)score was similar in both groups before the intervention.However,12 weeks after the intervention,the MMSE score in the PN group was significantly higher than that in the RD group(P<0.05).In both groups,the MMSE score significantly increased 12 weeks post-intervention compared to pre-intervention levels(P<0.05).Before the intervention,the levels of osteocalcin,serum calcium,PINP,β-CTX,and 25-hydroxyvitamin D were not significantly different between the two groups(P>0.05).After 12 weeks of intervention,the PN group exhibited higher levels of osteocalcin,serum calcium,and 25-hydroxyvitamin D,as well as lower levels of PINP andβ-CTX,compared to the RD group(P<0.05).In both groups,osteocalcin,serum calcium,and 25-hydroxyvitamin D levels were significantly higher,while PINP andβ-CTX levels were significantly lower after 12 weeks of intervention compared to baseline(P<0.05).CONCLUSION The human BCA-based dietary nutrition regimen plays a crucial role in improving BMD and bone metabolism,with effects that surpass those of conventional nutrition strategies.The findings of this study provide strong evidence for the nutritional management of AD patients.
基金National Natural Science Foundation of China (No. 71601071)the Science & Technology Program of Henan Province, China (No. 182102310886 and 162102110109)and an MOE Youth Foundation Project of Humanities and Social Sciences (No. 15YJC630079). We are particularly grateful to the suggestions of the editor and the anonymous reviewers which is greatly improved the quality of the paper.
文摘Flower pollination algorithm (FPA) is one of the well-known evolutionary techniques used extensively to solve optimization problems. Despite its efficiency and wide use, the identical search behaviors may lead the algorithm to converge to local optima. In this paper, an adaptive FPA based on chaotic map (CAFPA) is proposed. The proposed algorithm first used the ergodicity of the logistic chaos mechanism, and chaotic mapping of the initial population to make the initial iterative population more evenly distributed in the solution space. Then at the self-pollination stage, the over-random condition of the gamete renewal was improved, the traction force of contemporary optimal position was given, and adaptive logarithmic inertia weight was introduced to adjust the proportion between the contemporary pollen position and disturbance to improve the performance of the algorithm. By comparing the new algorithm with three famous optimization algorithms, the accuracy and performance of the proposed approach are evaluated by 14 well-known benchmark functions. Statistical comparisons of experimental results show that CAFPA is superior to FPA, PSO, and BOA in terms of convergence speed and robustness.
基金supported by the National Natural Science Foundation of China(Grant no.21761013,21671086,21461010,and 21471070)the Science and Technology Bureau project of Ganzhou.
文摘Quasi-spherical molecules are used to construct high-performance molecular ferroelectrics,but accurately producing polar crystals with low symmetry remains a challenge.Herein,we report a novel hightemperature multiaxial molecular ferroelectric(C_(8)H_(14)NO)[FeCl_(4)](1)(C_(8)H_(14)NO=1-methyl-3-quininocyclone).Dielectric and differential scanning calorimetry(DSC)measurements showed that compound 1 had a high Curie temperature of 341.8 K.It crystallizes in the Cmc2_(1) space group at room temperature,showing switchable SHG response,moderate spontaneous polarization(P_(s)=0.24μC cm^(−2)),and clear ferroelectric domains.In addition,DSC and dielectric cycling tests indicate that compound 1 can be used as an excellent electric double-switch material.Notably,the distinct symmetry breaking,that is,4/mmmFmm2,leads to a biaxial ferroelectric with four equivalent directions of polarization.This discovery provides an effective approach for constructing multiaxial high-temperature molecular ferroelectrics.
