The aim of this study was to compare the accuracies of cognitive fusion-guided targeted biopsy(TB),systematic biopsy(SB),and combined TB+SB for the detection of prostate cancer(PCa)and clinically significant PCa(csPCa...The aim of this study was to compare the accuracies of cognitive fusion-guided targeted biopsy(TB),systematic biopsy(SB),and combined TB+SB for the detection of prostate cancer(PCa)and clinically significant PCa(csPCa)in males with lesions detected by magnetic resonance imaging(MRI).We conducted a retrospective analysis of individuals who underwent prostate biopsy at Peking University People's Hospital(Beijing,China),with an emphasis on patients with both transrectal TB and SB.The main objective was to determine the precisions of SB,TB,and TB+SB for diagnosing PCa and csPCa.We also evaluated the detection rates of TB,SB,TB+ipsilateral-SB(ipsi-SB),TB+contralateral-SB(contra-SB),and TB+SB for PCa and csPCa in patients with unilateral MRI lesions.We compared the diagnostic yields of the various biopsy schemes using the McNemar’s test.A total of 180 patients were enrolled.The rates of PCa detection using TB,SB,and TB+SB were 52.8%,62.2%,and 66.7%,respectively,and the corresponding rates for csPCa were 46.1%,56.7%,and 58.3%,respectively.Among patients with unilateral MRI lesions,the PCa detection rates for TB,SB,TB+ipsi-SB,TB+contra-SB,and TB+SB were 53.3%,64.8%,65.6%,61.5%,and 68.0%,respectively.TB+ipsi-SB detected 96.4%of PCa and 95.9%of csPCa cases.These findings suggest that the combination of TB+SB has better diagnostic accuracy compared with SB or TB alone.For patients with unilateral MRI lesions,the combination of TB+ipsi-SB may be suitable in clinical settings.展开更多
Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suf...Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suffer from motor deficits including tremors,muscle rigidity,bradykinesia and psychological abnormality[2].The main pathological change of PD is the degeneration and death of dopaminergic neurons in the substantia nigra pars compacta,which leads to a significant decrease in dopamine content in the striatum.The pathogenesis of PD is fairly complex.Genetic factors,environmental factors,aging,oxidative stress,and inflammation may be related to the degeneration and death of PD dopaminergic neurons[3].展开更多
基金supported by the National Natural Science Foundation of China(No.82071777)Peking University People's Hospital Scientific Research Development Funds(No.RDJP2022-10).
文摘The aim of this study was to compare the accuracies of cognitive fusion-guided targeted biopsy(TB),systematic biopsy(SB),and combined TB+SB for the detection of prostate cancer(PCa)and clinically significant PCa(csPCa)in males with lesions detected by magnetic resonance imaging(MRI).We conducted a retrospective analysis of individuals who underwent prostate biopsy at Peking University People's Hospital(Beijing,China),with an emphasis on patients with both transrectal TB and SB.The main objective was to determine the precisions of SB,TB,and TB+SB for diagnosing PCa and csPCa.We also evaluated the detection rates of TB,SB,TB+ipsilateral-SB(ipsi-SB),TB+contralateral-SB(contra-SB),and TB+SB for PCa and csPCa in patients with unilateral MRI lesions.We compared the diagnostic yields of the various biopsy schemes using the McNemar’s test.A total of 180 patients were enrolled.The rates of PCa detection using TB,SB,and TB+SB were 52.8%,62.2%,and 66.7%,respectively,and the corresponding rates for csPCa were 46.1%,56.7%,and 58.3%,respectively.Among patients with unilateral MRI lesions,the PCa detection rates for TB,SB,TB+ipsi-SB,TB+contra-SB,and TB+SB were 53.3%,64.8%,65.6%,61.5%,and 68.0%,respectively.TB+ipsi-SB detected 96.4%of PCa and 95.9%of csPCa cases.These findings suggest that the combination of TB+SB has better diagnostic accuracy compared with SB or TB alone.For patients with unilateral MRI lesions,the combination of TB+ipsi-SB may be suitable in clinical settings.
基金This study was financially supported by Henan Youth Science Foundation of Henan Province(No.232300421310)Postdoctoral Foundation of China(No.2022M711080)+4 种基金The National Natural Science Foundation of China(No.82274612)Program for Science&Technology Innovation Talents in Universities of Henan Province(No.23HASTIT044)Innovative Research Team(in Science and Technology)in University of Henan Province(21IRTSTHN026)Henan Province Traditional Chinese Medicine Scientific Research Special Project(No.2022ZYZD21)Joint Research Fund of Science and Technology R&D Plan of Henan Province(NO.222301420068).
文摘Parkinson’s disease(PD)is characterized by motor symptoms and non-motor symptoms chiefly attributed to the loss of dopaminergic neurons in the substantia nigra pars compacta[1].Approximately 3 million PD patients suffer from motor deficits including tremors,muscle rigidity,bradykinesia and psychological abnormality[2].The main pathological change of PD is the degeneration and death of dopaminergic neurons in the substantia nigra pars compacta,which leads to a significant decrease in dopamine content in the striatum.The pathogenesis of PD is fairly complex.Genetic factors,environmental factors,aging,oxidative stress,and inflammation may be related to the degeneration and death of PD dopaminergic neurons[3].
