Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has b...Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.展开更多
AIM:To assess the diagnostic value of using magnifying chromoendoscopy combined with immunohisto-chemical staining of proliferating cell nuclear antigen (PCNA)and p53 in the detection of gastric precancerous lesions. ...AIM:To assess the diagnostic value of using magnifying chromoendoscopy combined with immunohisto-chemical staining of proliferating cell nuclear antigen (PCNA)and p53 in the detection of gastric precancerous lesions. METHODS:Ninety-five patients who were treated for abdominal discomfort,abdominal pain,bloating,and acid reflux at our hospital from January 2010 to December 2011 were included in the study.An ordinary gastroscopic procedure was initially performed to select the lesions.All subjects underwent magnifying chromo-endoscopy to observe morphological changes of gastric pits.Biopsies were then taken from each area of interest and sent for pathological examination and detection of PCNA and p53 expression by immunohistochemistry. An immunoreactivity score for each lesion was calcu-lated.Based on immunoreactivity scores,immunohisto-chemical staining was then considered. RESULTS:Compared to intestinal metaplasia,gastric pits were more diverse in size,more irregular in shape, and more disorderly in arrangement in moderate and severe dysplasia.PCNA and p53 expression was sig-nificantly higher in precancerous lesions(intestinal metaplasia and dysplasia)than in chronic gastritis. PCNA expression showed an upward trend in types A-F pits.The number of cases that showed strong PCNA positivity increased significantly with an increase in the severity of lesions.Rank sum test for independent samples showed that p53 expression was significantly higher in types E and F pits than in types A-D pits(H =33.068,P=0.000).Rank sum test for independent samples showed that PCNA expression was significantly higher in types E and F pits than in types A-D pits(H =31.791,P=0.001). CONCLUSION:The presence of types E and F pits,in which p53 and PCNA are highly expressed,is highly sug- gestive of the occurrence of early cancer,and patients developing these changes should be closely followed.展开更多
[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the co...[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the comprehensive development and utilization of the resources.[Methods]The volatile components of the roots were extracted by solid phase micro-extraction( SPME),and its volatile components were analyzed by gas chromatography-mass spectrometry( GC-MS); the contents of total flavonoids and total polysaccharides in the samples were measured by UV-spectrophotometry. [Results] 44 peaks were isolated from the roots and 30 components were identified,accounting for 80. 9% of the total volatile components; the content of total flavonoids in the roots was 9. 42%; the content of total polysaccharides in the roots was 11. 05%.[Conclusions] After a comprehensive investigation,the olefins in the roots generally have antibacterial activity,the contents of the total flavonoids and total polysaccharides contained in the roots were relatively high,the roots of Artemisia argyi do have broad prospects for the development.展开更多
Xiangzaoyou 2017 is an excellent early maturing variety bred from the combination of Neixiang 3A and the self-fertile restorer QN 2017 by Qiannan Institute of Agricultural Sciences of Guizhou Province,and it has been ...Xiangzaoyou 2017 is an excellent early maturing variety bred from the combination of Neixiang 3A and the self-fertile restorer QN 2017 by Qiannan Institute of Agricultural Sciences of Guizhou Province,and it has been approved by the Guizhou Crop Variety Approval Committee( Approval No.: Qianshendao 2006001).In order to promote its application in production,the research on the seed production techniques of Xiangzaoyou 2017 was carried out,and the key technical points of high-yield seed production of Xiangzaoyou 2017 were put forward.展开更多
The protection and utilization of great sites not only are related to the inheritance of historical and cultural heritage and academic research,but also directly affect local economic development and social and cultur...The protection and utilization of great sites not only are related to the inheritance of historical and cultural heritage and academic research,but also directly affect local economic development and social and cultural dissemination.In this paper,five major great sites in Zhengzhou City(Dahe Village Site,Zhengzhou Shangcheng Site,Xiaoshuangqiao Site,the Capital of Zheng and Han States,and Mausoleum of Song Dynasty Tombs of Song Emperors)are taken as research objects,and a set of index system for evaluating the protection and utilization of great sites is constructed.A comprehensive evaluation is conducted from seven aspects:protection management,research value,site utilization,cultural value dissemination,socio-economic benefits,utilization effects,and regional development coordination.This paper provides a comprehensive and scientific evaluation perspective for the protection and utilization of great sites,which helps to better grasp the direction of site protection and utilization,and develop more practical and effective strategies for site protection and utilization.展开更多
Understanding the relationship between the supply and demand for ecosystem services(ESs)is critical for ecological management and decision-making.However,it is unknown whether demand and supply for ESs vary in terms o...Understanding the relationship between the supply and demand for ecosystem services(ESs)is critical for ecological management and decision-making.However,it is unknown whether demand and supply for ESs vary in terms of time and space.In this study,the InVEST model was used to spatially quantify the supply and demand for ESs in the Taihu Lake Basin(TLB)between 2010 and 2020.We compared the difference in supply and demand for ESs at four spatial scales.We found that:(1)The high deficit areas are mainly located in densely populated towns in the eastern and central regions,while the high surplus areas are mainly located in forested areas in the southwest.From 2010 to 2020,the surplus area shrank while the deficit area expanded.(2)The comprehensive supply-demand ratio of ESs in the TLB decreased from−0.03 to−0.05,especially the contradiction between carbon sequestration service and heat regulation service.(3)The mismatch between supply and demand on a small scale will have an impact on the overall supply and demand,and expanding the scope can also help to alleviate the contradiction between supply and demand on a small scale.Therefore,we recommend that decision-makers and managers incorporate scale analysis into ecosystem management decisions,realize the balance between supply and demand through reasonable ecological protection and ecological restoration and strengthen the analysis of ecosystem service flows and stakeholders.展开更多
The Fenton method is an effective technology for the removal of organic materials from wastewater.In this work,an induced catalyst Fe_(3)O_(4) was synthesized by a hydrothermal method,and the modulation of the chemica...The Fenton method is an effective technology for the removal of organic materials from wastewater.In this work,an induced catalyst Fe_(3)O_(4) was synthesized by a hydrothermal method,and the modulation of the chemical composition of Fe_(3)O_(4) crystals was achieved under the microwave shock method with the same effect as that of calcination treatment.Fe_(3)O_(4) catalyst for the removal of the dye Rhodamine B (Rh B) from polluted wastewater under microwave (MW),H_(2)O_(2) system.The results showed that Fe_(3)O_(4) nanomicrospheres prepared by microwave shock exhibited superior catalytic activity under the conditions of 500 W,0.4 mol/L H_(2)O_(2) and10 mg/L Rh B,and the removal rate of Rh B reached 98.5%after 10 min.The Fe_(3)O_(4) catalysts also exhibited good stability and degradation efficiency.Electron paramagnetic resonance experiments confirmed that·OH plays a major role in the rapid degradation of Rh B.Under microwave action,the catalyst produces electron-hole pairs,in which the holes react with OH-produced by water ionisation to form·OH,and the microwave-treated Fe_(3)O_(4) produces more active species.Fe^(3+)and Fe^(2+)serve as microwave catalytic activity centers and Fenton catalytic activity centers,respectively.This research demonstrates that optimizing the Fe^(2+)/Fe^(3+) ratio significantly enhances the degradation efficiency of Rh B.This study presents novel views regarding the mechanism of microwave synergistic catalyst-induced Fenton.展开更多
As the development of new power systems accelerates and the impacts of high renewable energy integration and extreme weather intensify,grid-alternative energy storage is garnering increasing attention for its grid-int...As the development of new power systems accelerates and the impacts of high renewable energy integration and extreme weather intensify,grid-alternative energy storage is garnering increasing attention for its grid-interaction benefits and clear business models.Consequently,assessing the value of grid-alternative energy storage in the systemtransition has become critically important.Considering the performance characteristics of storage,we propose a value assessment frame-work for grid-alternative energy storage,quantifying its non-wires-alternative effects from both cost and benefit perspectives.Building on this,we developed a collaborative planning model for energy storage and transmission grids,aimed at maximizing the economic benefits of storage systems while balancing investment and operational costs.The model considers regional grid interconnections and their interactions with system operation.By participating in system operations,grid-alternative energy storage not only maximizes its own economic benefits but also generates social welfare transfer effects.Furthermore,based on multi-regional interconnected planning,grid-alternative energy storage can reduce system costs by approximately 35%,with the most significant changes observed in generation costs.Multi-regional coordinated planning significantly enhances the sys-tem’s flexibility in regulation.However,when the load factor of interconnection lines between regions remains constant,system operational flexibility tends to decrease,leading to a roughly 28.9%increase in storage investment.Additionally,under regional coordinated planning,the greater the disparity in wind power integration across interconnected regions,the more noticeable the reduction in system costs.展开更多
The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process th...The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process that leads to a significant deterioration of non-uniformity when scaling up to larger areas.Since the performance of gaseous detectors is highly dependent on the choice of working gas,optimizing the gas mixture offers a promising solution to improve the uniformity performance.This paper addresses these challenges through a combined approach of simulation based on Garfield++and experimental studies.The simulation investigates the properties of different mixing fractions of gas mixtures and their impact on detector performance,including gain uniformity and time resolution.To verify the simulation results,experimental tests were conducted using a multi-channel PICOSEC MM prototype with different gas mixtures.The experimental results are consistent with the findings of the simulation,indicating that a higher concentration of neon significantly improves the detector’s gain uniformity.Furthermore,the influence of gas mixtures on time resolution was explored as a critical performance indicator.The study presented in this paper offers valuable insights for improving uniformity in large-area PICOSEC MM detectors and optimizing overall performance.展开更多
The automatic diagnosis of depression plays a crucial role in preventing the deterioration of depression symptoms.The interview-based method is the most wildly adopted technique in depression diagnosis.However,the siz...The automatic diagnosis of depression plays a crucial role in preventing the deterioration of depression symptoms.The interview-based method is the most wildly adopted technique in depression diagnosis.However,the size of the collected conversation data is limited,and the sample distributions from different participants usually differ drastically.These factors present a great challenge in building a decent deep learning model for automatic depression diagnosis.Recently,large language models have demonstrated impressive capabilities and achieved human-level performance in various tasks under zero-shot and few-shot scenarios.This sheds new light on the development of AI solutions for domainspecific tasks with limited data.In this paper,we propose a two-stage approach that exploits the current most capable and cost-effective language model,ChatGPT,to make a depression diagnosis on interview-based data.Specifically,in the first stage,we use ChatGPT to summarize the raw dialogue sample,thereby facilitating the extraction of depression-related information.In the second stage,we use ChatGPT to classify the summarised data to predict the depressed state of the sample.Our method can achieve approximately 76%accuracy with a text-only modality on the DAIC-WOZ dataset.In addition,our method outperforms the performance of the state-of-the-art model by 6.2%in the D4 dataset.Our work highlights the potential of using large language models for diagnosis-based depression diagnosis.展开更多
When the protective and protected systems are detached,the former can be allowed to absorb the kinetic energy of the impacting projectile through large deformation without considering the back face signature of the la...When the protective and protected systems are detached,the former can be allowed to absorb the kinetic energy of the impacting projectile through large deformation without considering the back face signature of the latter.This paper presents a novel double-face knitted fabric(DFKF)designed for this very impacting scenario.Shooting tests equipped with high-speed camera were used to characterize the ballistic performance with the impact velocities ranging from 100 m/s to 450 m/s.The results showed that the ballistic limits(V_(bl))of DFKF are approximately triple and double that of its counterpart UD and plain fabrics,respectively.For mass-normalized metrics,the specific energy absorption(SEA)is 250%and 350%greater than the UD and plain fabrics at their corresponding V_(bl)s.The quasi-static tests showed that the DFKF displayed greater resilience,crease recovery properties,and flexibility,which also made it an especially better candidate than UD and plain weaves for the design of umbrella surface cloth.It was also found that DFKF is dependent on yarn count and the incorporation of spandex.A prototype anti-ballistic umbrella is manufactured using DFKF made of 200D multi-filament yarn.The ballistic performance is also sensitive to the impact site when the umbrella is subjected to impact.展开更多
Natural rubber is an indispensable material of strategic importance that has critical applications in industry and the military.However,the development of the natural rubber industry is impeded by the red root rot dis...Natural rubber is an indispensable material of strategic importance that has critical applications in industry and the military.However,the development of the natural rubber industry is impeded by the red root rot disease of rubber trees caused by Ganoderma pseudoferreum,which is one of the most devastating diseases in the rubber tree growing regions in China.To combat this disease,we screened the antifungal activity of 223 candidate bacterial strains against G.pseudoferreum,and found that Bacillus velezensis strain SF305 exhibited significant antifungal activity against G.pseudoferreum.Bacillus velezensis SF305 had a nearly 70%efficacy against the red root rot disease of rubber trees with the therapeutic treatment(Tre),while it exhibited over 90%protection effectiveness with the preventive treatment(Pre).The underlying biocontrol mechanism revealed that B.velezensis SF305 could reduce the disease severity of red root rot by degrading the mycelia of G.pseudoferreum.An antiSMASH analysis revealed that B.velezensis SF305 contains 15 gene clusters related to secondary metabolite synthesis,13 of which are conserved in species of B.velezensis,but surprisingly,B.velezensis SF305 possesses 2 unique secondary metabolite gene clusters.One is predicted to synthesize locillomycin,and the other is a novel nonribosomal peptides synthetase(NRPS)gene cluster.Genomic analysis showed that B.velezensis SF305 harbors genes involved in motility,chemotaxis,biofilm formation,stress resistance,volatile organic compounds(VOCs)and synthesis of the auxin indole-3-acetic acid(IAA),suggesting its plant growth-promoting rhizobacteria(PGPR)properties.Bacillus velezensis SF305 can promote plant growth and efficiently antagonize some important phytopathogenic fungi and bacteria.This study indicates that B.velezensis SF305 is a versatile plant probiotic bacterium.To the best of our knowledge,this is the first time a B.velezensis strain has been reported as a promising biocontrol agent against the red root rot disease of rubber trees.展开更多
基金supported by grants from the National Natural Science Foundation of China(G.F.Wang,grant number 82204071)(P.Y.Su,grant numbers 81874268 and 82473655)the Research Funds of the Center for Big Data and Population Health of IHM(P.Y.Su,No.JKS2023016)Anhui Provincial Health Commission Scientific Research Project(Y.Zhou,No.AHWJ2023A30027)。
文摘Vitamin D deficiency(VDD)represents a significant nutritional concern among children and adolescents.The estimated prevalence of VDD in China is 46.8%in this population^([1]).VDD during childhood and adolescence has been associated with the onset of various conditions,including acute respiratory infections,asthma,atopic dermatitis,and food allergies^([2]).Multiple factors,including age,sun exposure,adiposity,and genetics,influence vitamin D levels^([2,3]).Increasing attention has been directed toward understanding the environmental determinants that may influence vitamin D status.Given the potential of metallic pollutants to disrupt endocrine function and their ubiquity in the environment,investigating the effects of metal exposure on human vitamin D status,particularly in vulnerable populations,is imperative.
基金Supported by Grant from the Medical and Health Research Program of Inner Mongolia Autonomous Region,No.2010069
文摘AIM:To assess the diagnostic value of using magnifying chromoendoscopy combined with immunohisto-chemical staining of proliferating cell nuclear antigen (PCNA)and p53 in the detection of gastric precancerous lesions. METHODS:Ninety-five patients who were treated for abdominal discomfort,abdominal pain,bloating,and acid reflux at our hospital from January 2010 to December 2011 were included in the study.An ordinary gastroscopic procedure was initially performed to select the lesions.All subjects underwent magnifying chromo-endoscopy to observe morphological changes of gastric pits.Biopsies were then taken from each area of interest and sent for pathological examination and detection of PCNA and p53 expression by immunohistochemistry. An immunoreactivity score for each lesion was calcu-lated.Based on immunoreactivity scores,immunohisto-chemical staining was then considered. RESULTS:Compared to intestinal metaplasia,gastric pits were more diverse in size,more irregular in shape, and more disorderly in arrangement in moderate and severe dysplasia.PCNA and p53 expression was sig-nificantly higher in precancerous lesions(intestinal metaplasia and dysplasia)than in chronic gastritis. PCNA expression showed an upward trend in types A-F pits.The number of cases that showed strong PCNA positivity increased significantly with an increase in the severity of lesions.Rank sum test for independent samples showed that p53 expression was significantly higher in types E and F pits than in types A-D pits(H =33.068,P=0.000).Rank sum test for independent samples showed that PCNA expression was significantly higher in types E and F pits than in types A-D pits(H =31.791,P=0.001). CONCLUSION:The presence of types E and F pits,in which p53 and PCNA are highly expressed,is highly sug- gestive of the occurrence of early cancer,and patients developing these changes should be closely followed.
文摘[Objectives] To analyze the volatile components,the contents of total flavonoids and total polysaccharides of the roots of Artemisia argyi Levl. et Van. var. argyi cv. Qiai,and to provide a scientific basis for the comprehensive development and utilization of the resources.[Methods]The volatile components of the roots were extracted by solid phase micro-extraction( SPME),and its volatile components were analyzed by gas chromatography-mass spectrometry( GC-MS); the contents of total flavonoids and total polysaccharides in the samples were measured by UV-spectrophotometry. [Results] 44 peaks were isolated from the roots and 30 components were identified,accounting for 80. 9% of the total volatile components; the content of total flavonoids in the roots was 9. 42%; the content of total polysaccharides in the roots was 11. 05%.[Conclusions] After a comprehensive investigation,the olefins in the roots generally have antibacterial activity,the contents of the total flavonoids and total polysaccharides contained in the roots were relatively high,the roots of Artemisia argyi do have broad prospects for the development.
基金Supported by the Science and Technology Support Project of Science and Technology Department of Guizhou Province(Yankehe NY[2011]No.3084)
文摘Xiangzaoyou 2017 is an excellent early maturing variety bred from the combination of Neixiang 3A and the self-fertile restorer QN 2017 by Qiannan Institute of Agricultural Sciences of Guizhou Province,and it has been approved by the Guizhou Crop Variety Approval Committee( Approval No.: Qianshendao 2006001).In order to promote its application in production,the research on the seed production techniques of Xiangzaoyou 2017 was carried out,and the key technical points of high-yield seed production of Xiangzaoyou 2017 were put forward.
文摘The protection and utilization of great sites not only are related to the inheritance of historical and cultural heritage and academic research,but also directly affect local economic development and social and cultural dissemination.In this paper,five major great sites in Zhengzhou City(Dahe Village Site,Zhengzhou Shangcheng Site,Xiaoshuangqiao Site,the Capital of Zheng and Han States,and Mausoleum of Song Dynasty Tombs of Song Emperors)are taken as research objects,and a set of index system for evaluating the protection and utilization of great sites is constructed.A comprehensive evaluation is conducted from seven aspects:protection management,research value,site utilization,cultural value dissemination,socio-economic benefits,utilization effects,and regional development coordination.This paper provides a comprehensive and scientific evaluation perspective for the protection and utilization of great sites,which helps to better grasp the direction of site protection and utilization,and develop more practical and effective strategies for site protection and utilization.
基金supported by the Key Research Program of Frontier Sciences of Chinese Academy of Sciences(ZDBS-LY-7011).
文摘Understanding the relationship between the supply and demand for ecosystem services(ESs)is critical for ecological management and decision-making.However,it is unknown whether demand and supply for ESs vary in terms of time and space.In this study,the InVEST model was used to spatially quantify the supply and demand for ESs in the Taihu Lake Basin(TLB)between 2010 and 2020.We compared the difference in supply and demand for ESs at four spatial scales.We found that:(1)The high deficit areas are mainly located in densely populated towns in the eastern and central regions,while the high surplus areas are mainly located in forested areas in the southwest.From 2010 to 2020,the surplus area shrank while the deficit area expanded.(2)The comprehensive supply-demand ratio of ESs in the TLB decreased from−0.03 to−0.05,especially the contradiction between carbon sequestration service and heat regulation service.(3)The mismatch between supply and demand on a small scale will have an impact on the overall supply and demand,and expanding the scope can also help to alleviate the contradiction between supply and demand on a small scale.Therefore,we recommend that decision-makers and managers incorporate scale analysis into ecosystem management decisions,realize the balance between supply and demand through reasonable ecological protection and ecological restoration and strengthen the analysis of ecosystem service flows and stakeholders.
基金supported by Beijing Natural Science Foundation(No.2232062)the Fundamental Research Funds for the Central Universities (No.2652022006)。
文摘The Fenton method is an effective technology for the removal of organic materials from wastewater.In this work,an induced catalyst Fe_(3)O_(4) was synthesized by a hydrothermal method,and the modulation of the chemical composition of Fe_(3)O_(4) crystals was achieved under the microwave shock method with the same effect as that of calcination treatment.Fe_(3)O_(4) catalyst for the removal of the dye Rhodamine B (Rh B) from polluted wastewater under microwave (MW),H_(2)O_(2) system.The results showed that Fe_(3)O_(4) nanomicrospheres prepared by microwave shock exhibited superior catalytic activity under the conditions of 500 W,0.4 mol/L H_(2)O_(2) and10 mg/L Rh B,and the removal rate of Rh B reached 98.5%after 10 min.The Fe_(3)O_(4) catalysts also exhibited good stability and degradation efficiency.Electron paramagnetic resonance experiments confirmed that·OH plays a major role in the rapid degradation of Rh B.Under microwave action,the catalyst produces electron-hole pairs,in which the holes react with OH-produced by water ionisation to form·OH,and the microwave-treated Fe_(3)O_(4) produces more active species.Fe^(3+)and Fe^(2+)serve as microwave catalytic activity centers and Fenton catalytic activity centers,respectively.This research demonstrates that optimizing the Fe^(2+)/Fe^(3+) ratio significantly enhances the degradation efficiency of Rh B.This study presents novel views regarding the mechanism of microwave synergistic catalyst-induced Fenton.
基金funded by the Technology Project of State Grid Jibei Electric Power Supply Co.,Ltd.(Grant Number:52018F240001).
文摘As the development of new power systems accelerates and the impacts of high renewable energy integration and extreme weather intensify,grid-alternative energy storage is garnering increasing attention for its grid-interaction benefits and clear business models.Consequently,assessing the value of grid-alternative energy storage in the systemtransition has become critically important.Considering the performance characteristics of storage,we propose a value assessment frame-work for grid-alternative energy storage,quantifying its non-wires-alternative effects from both cost and benefit perspectives.Building on this,we developed a collaborative planning model for energy storage and transmission grids,aimed at maximizing the economic benefits of storage systems while balancing investment and operational costs.The model considers regional grid interconnections and their interactions with system operation.By participating in system operations,grid-alternative energy storage not only maximizes its own economic benefits but also generates social welfare transfer effects.Furthermore,based on multi-regional interconnected planning,grid-alternative energy storage can reduce system costs by approximately 35%,with the most significant changes observed in generation costs.Multi-regional coordinated planning significantly enhances the sys-tem’s flexibility in regulation.However,when the load factor of interconnection lines between regions remains constant,system operational flexibility tends to decrease,leading to a roughly 28.9%increase in storage investment.Additionally,under regional coordinated planning,the greater the disparity in wind power integration across interconnected regions,the more noticeable the reduction in system costs.
基金supported by the National Natural Science Foundation of China(12125505).
文摘The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process that leads to a significant deterioration of non-uniformity when scaling up to larger areas.Since the performance of gaseous detectors is highly dependent on the choice of working gas,optimizing the gas mixture offers a promising solution to improve the uniformity performance.This paper addresses these challenges through a combined approach of simulation based on Garfield++and experimental studies.The simulation investigates the properties of different mixing fractions of gas mixtures and their impact on detector performance,including gain uniformity and time resolution.To verify the simulation results,experimental tests were conducted using a multi-channel PICOSEC MM prototype with different gas mixtures.The experimental results are consistent with the findings of the simulation,indicating that a higher concentration of neon significantly improves the detector’s gain uniformity.Furthermore,the influence of gas mixtures on time resolution was explored as a critical performance indicator.The study presented in this paper offers valuable insights for improving uniformity in large-area PICOSEC MM detectors and optimizing overall performance.
基金supported by the Science and Technology Innovation 2030 Project of China(2021ZD0202600).
文摘The automatic diagnosis of depression plays a crucial role in preventing the deterioration of depression symptoms.The interview-based method is the most wildly adopted technique in depression diagnosis.However,the size of the collected conversation data is limited,and the sample distributions from different participants usually differ drastically.These factors present a great challenge in building a decent deep learning model for automatic depression diagnosis.Recently,large language models have demonstrated impressive capabilities and achieved human-level performance in various tasks under zero-shot and few-shot scenarios.This sheds new light on the development of AI solutions for domainspecific tasks with limited data.In this paper,we propose a two-stage approach that exploits the current most capable and cost-effective language model,ChatGPT,to make a depression diagnosis on interview-based data.Specifically,in the first stage,we use ChatGPT to summarize the raw dialogue sample,thereby facilitating the extraction of depression-related information.In the second stage,we use ChatGPT to classify the summarised data to predict the depressed state of the sample.Our method can achieve approximately 76%accuracy with a text-only modality on the DAIC-WOZ dataset.In addition,our method outperforms the performance of the state-of-the-art model by 6.2%in the D4 dataset.Our work highlights the potential of using large language models for diagnosis-based depression diagnosis.
基金support from the following for aspects of the research,authorship,and/or publication of this article:National Natural Science Foundation of China(Grant No.12302187)Innovation Program of Wuhan-Shuguang Project(Grant No.202201080102).
文摘When the protective and protected systems are detached,the former can be allowed to absorb the kinetic energy of the impacting projectile through large deformation without considering the back face signature of the latter.This paper presents a novel double-face knitted fabric(DFKF)designed for this very impacting scenario.Shooting tests equipped with high-speed camera were used to characterize the ballistic performance with the impact velocities ranging from 100 m/s to 450 m/s.The results showed that the ballistic limits(V_(bl))of DFKF are approximately triple and double that of its counterpart UD and plain fabrics,respectively.For mass-normalized metrics,the specific energy absorption(SEA)is 250%and 350%greater than the UD and plain fabrics at their corresponding V_(bl)s.The quasi-static tests showed that the DFKF displayed greater resilience,crease recovery properties,and flexibility,which also made it an especially better candidate than UD and plain weaves for the design of umbrella surface cloth.It was also found that DFKF is dependent on yarn count and the incorporation of spandex.A prototype anti-ballistic umbrella is manufactured using DFKF made of 200D multi-filament yarn.The ballistic performance is also sensitive to the impact site when the umbrella is subjected to impact.
基金financially supported by the National Key Research and Development Program of China(2023YFD1200204)the Special Fund for Hainan Excellent Team“Rubber Genetics and Breeding”,China(20210203)。
文摘Natural rubber is an indispensable material of strategic importance that has critical applications in industry and the military.However,the development of the natural rubber industry is impeded by the red root rot disease of rubber trees caused by Ganoderma pseudoferreum,which is one of the most devastating diseases in the rubber tree growing regions in China.To combat this disease,we screened the antifungal activity of 223 candidate bacterial strains against G.pseudoferreum,and found that Bacillus velezensis strain SF305 exhibited significant antifungal activity against G.pseudoferreum.Bacillus velezensis SF305 had a nearly 70%efficacy against the red root rot disease of rubber trees with the therapeutic treatment(Tre),while it exhibited over 90%protection effectiveness with the preventive treatment(Pre).The underlying biocontrol mechanism revealed that B.velezensis SF305 could reduce the disease severity of red root rot by degrading the mycelia of G.pseudoferreum.An antiSMASH analysis revealed that B.velezensis SF305 contains 15 gene clusters related to secondary metabolite synthesis,13 of which are conserved in species of B.velezensis,but surprisingly,B.velezensis SF305 possesses 2 unique secondary metabolite gene clusters.One is predicted to synthesize locillomycin,and the other is a novel nonribosomal peptides synthetase(NRPS)gene cluster.Genomic analysis showed that B.velezensis SF305 harbors genes involved in motility,chemotaxis,biofilm formation,stress resistance,volatile organic compounds(VOCs)and synthesis of the auxin indole-3-acetic acid(IAA),suggesting its plant growth-promoting rhizobacteria(PGPR)properties.Bacillus velezensis SF305 can promote plant growth and efficiently antagonize some important phytopathogenic fungi and bacteria.This study indicates that B.velezensis SF305 is a versatile plant probiotic bacterium.To the best of our knowledge,this is the first time a B.velezensis strain has been reported as a promising biocontrol agent against the red root rot disease of rubber trees.
