Cerium(Ce) compounds have attracted considerable attention as key components in functional coatings due to their many outstanding properties.This work provides a comprehensive review of recent advances in the applicat...Cerium(Ce) compounds have attracted considerable attention as key components in functional coatings due to their many outstanding properties.This work provides a comprehensive review of recent advances in the application of Ce in functional coatings.The role of Ce in the improvement of functional properties such as corrosion-resistance,self-healing,superhydrophobicity,wear-resistance,and UV shielding is reviewed from the perspective of functional mechanism and applied research.Furthermore,the strategies,processes,practical problems,and current challenges in the research of functional coatings containing Ce are summarized and discussed.The objective is to highlight the great potential of Ce in functional coatings,and to explore new applications of Ce in the development of novel coatings.Thus,this work aims to enhance the application value of Ce,solving the problem of unbalanced application of rare-earth elements.展开更多
BACKGROUND Gastric cancer(GC)poses a significant threat to public health.However,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph nod...BACKGROUND Gastric cancer(GC)poses a significant threat to public health.However,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph node metastasis.Consequently,the stratification of lymph node dissection according to the specific type,particularly upper GC,has emerged as a prominent area of research.AIM To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and prognosis.METHODS Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum regression models were used to analyze risk factors affecting patient prognosis.The Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for GC.RESULTS Significant differences were observed between the two GC populations regarding tumor diameter,histological grade,pT stage,pN stage,tumor-node-metastasis(pTNM)stage,vascular invasion,and adjuvant chemotherapy usage(all P<0.05).Lymph node metastasis rates were highest for Siewert type II patients in groups Nos.1,3,2 and 7;for Siewert type III patients in groups Nos.3,1,2 and 7;and for other/unclassified patients in groups Nos.1,3,7,2.In the lower GC samples,the sequences were Nos.3,6,7,4.Pathological type,pT stage,pTNM stage,and positive vascular invasion were independent risk factors for development of lymph node metastasis.Age,pathological type,pT stage,pN stage,pTNM stage,vascular invasion,and absence of adjuvant chemotherapy were identified as independent prognostic factors.CONCLUSION Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.展开更多
Interface modulation is an important pathway for highly efficient electromagnetic wave absorption.Herein,tailored interfaces between Fe_(3)O_(4)particles and the hexagonal-YFeO_(3)(h-YFeO_(3))framework were constructe...Interface modulation is an important pathway for highly efficient electromagnetic wave absorption.Herein,tailored interfaces between Fe_(3)O_(4)particles and the hexagonal-YFeO_(3)(h-YFeO_(3))framework were constructed via facile self-assembly.The resulting interfa-cial electron rearrangement at the heterojunction led to enhanced dielectric and magnetic loss synergy.Experimental results and density function theory(DFT)simulations demonstrate a transition in electrical properties from a half-metallic monophase to metallic Fe_(3)O_(4)/h-YFeO_(3)composites,emphasizing the advantages of the formed heterointerface.The transformation of electron behavior is also accompan-ied by a redistribution of electrons at the Fe_(3)O_(4)/h-YFeO_(3)heterojunction,leading to the accumulation of localized electrons around the Y-O-Fe band bridge,consequently enhancing the polarization.A minimum reflection loss of-34.0 dB can be achieved at 12.0 GHz and 2.0 mm thickness with an effective bandwidth of 3.3 GHz due to the abundant interfaces,enhanced polarization,and rational impedance.Thus,the synergistic effects endow the Fe_(3)O_(4)/h-YFeO_(3)composites with high performance and tunable functional properties for efficient electromagnetic absorption.展开更多
Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while...Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.展开更多
Permanent-magnet synchronous machines(PMSMs)are widely used in robotics,rail transportation,and electric vehicles owing to their high power density,high efficiency,and high power factor.However,PMSMs often operate in ...Permanent-magnet synchronous machines(PMSMs)are widely used in robotics,rail transportation,and electric vehicles owing to their high power density,high efficiency,and high power factor.However,PMSMs often operate in harsh environments,where critical components such as windings and permanent magnets(PMs)are susceptible to failures.These faults can lead to a significant degradation in performance,posing substantial challenges to the reliable operation of PMSMs.This paper presents a comprehensive review of common fault types in PMSMs,along with their corresponding fault diagnosis and fault-tolerant control strategies.The underlying mechanisms of typical faults are systematically analyzed,followed by a detailed comparison of various diagnostic and fault-tolerant control methods to evaluate their respective advantages and limitations.Finally,the review concludes by identifying key research gaps in PMSM fault diagnosis and fault-tolerant control,while proposing potential future directions for advancing this field.展开更多
Alzheimer’s disease is the most common cause of dementia.It is an increasingly serious global health problem and has a significant impact on individuals and society.However,the precise cause of Alzheimer’s disease i...Alzheimer’s disease is the most common cause of dementia.It is an increasingly serious global health problem and has a significant impact on individuals and society.However,the precise cause of Alzheimer’s disease is still unknown.In this study,11,748 Web-of-Science-indexed manuscripts regarding Alzheimer’s disease,all published from 2015 to 2019,and their 693,938 references were analyzed.A document co-citation network map was drawn using CiteSpace software.Research frontiers and development trends were determined by retrieving subject headings with apparent changing word frequency trends,which can be used to forecast future research developments in Alzheimer’s disease.展开更多
The APPSwe/PSEN1 dE9（APP/PS1） transgenic mouse model is an Alzheimer＇s disease mouse model exhibiting symptoms of dementia, and is commonly used to explore pathological changes in the development of Alzheimer＇s di...The APPSwe/PSEN1 dE9（APP/PS1） transgenic mouse model is an Alzheimer＇s disease mouse model exhibiting symptoms of dementia, and is commonly used to explore pathological changes in the development of Alzheimer＇s disease. Previous clinical autopsy and imaging studies suggest that Alzheimer＇s disease patients have white matter and oligodendrocyte damage, but the underlying mechanisms of these have not been revealed. Therefore, the present study used APP/PS1 mice to assess cognitive change, myelin loss, and corresponding changes in oligodendrocytes, and to explore the underlying mechanisms. Morris water maze tests were performed to evaluate cognitive change in APP/PS1 mice and normal C57 BL/6 mice aged 3 and 6 months. Luxol fast blue staining of the corpus callosum and quantitative reverse transcription-polymerase chain reaction（q RT-PCR） for myelin basic protein（MBP） mRNA were carried out to quantify myelin damage. Immunohistochemistry staining for NG2 and qRT-PCR for monocarboxylic acid transporter 1（MCT1） mRNA were conducted to assess corresponding changes in oligodendrocytes. Our results demonstrate that compared with C57 BL/6 mice, there was a downregulation of MBP mRNA in APP/PS1 mice aged 3 months. This became more obvious in APP/PS1 mice aged 6 months accompanied by other abnormalities such as prolonged escape latency in the Morris water maze test, shrinkage of the corpus callosum, upregulation of NG2-immunoreactive cells, and downregulation of MCT1 mRNA. These findings indicate that the involvement of early demyelination at 3 months and the oligodendrocyte dysfunction at 6 months in APP/PS1 mice are in association with Alzheimer＇s disease pathogenesis.展开更多
This study proposed a force and shape collaborative control method that combined method of influence coefficients(MIC)and the elitist nondominated sorting genetic algorithm(NSGA-II)to reduce the shape deviation caused...This study proposed a force and shape collaborative control method that combined method of influence coefficients(MIC)and the elitist nondominated sorting genetic algorithm(NSGA-II)to reduce the shape deviation caused by manufacturing errors,gravity deformation,and fixturing errors and improve the shape accuracy of the assembled large composite fuselage panel.This study used a multi-point flexible assembly system driven by hexapod parallel robots.The proposed method simultaneously considers the shape deviation and assembly load of the panel.First,a multi-point flexible assembly system driven by hexapod parallel robots was introduced,with the relevant variables defined in the control process.In addition,the corresponding mathematical model was constructed.Subsequently,MIC was used to establish the prediction models between the displacements of actuators and displacements of panel shape control points,deformation loads applied by the actuators.Following the modeling,the shape deviation of the panel and the assembly load were used as the optimization objectives,and the displacements of actuators were optimized using NSGA-II.Finally,a typical composite fuselage panel case study was considered to demonstrate the effectiveness of the proposed method.展开更多
In recent years,carbon emissions have gradually evolved from an environment issue into a political and economic one.Carbon tariff has brought about new trade barriers of developed countries,and in order to enhance the...In recent years,carbon emissions have gradually evolved from an environment issue into a political and economic one.Carbon tariff has brought about new trade barriers of developed countries,and in order to enhance the industrial competitiveness of developed countries,it will produce unfavorable impact on developing countries.Concentrated on the manufacturing industry,which is the most intensive high-carbon industry in China's export structure,this article studies the relationship between carbon tariff policy and industry structure of export trade and builds up a relation between climate change and international trade.First,by means of establishing a partial equilibrium model,it applies geometric analysis and mathematical analysis to compute the impact on China's manufacturing export trade and the consequences of the introduction of the US carbon tariff to China's manufacturing industry that has already imposed a domestic shipping carbon tax.Furthermore,with the application of the GTAP model,it estimates the overall economic and welfare effects on China's manufacturing industry if the US and Europe introduce carbon tariff by means of four ways,and then analyzes the influence on China's manufacturing industry export structure and social welfare as well.The result shows that the introduction of the US carbon import tariff lowers China's export price and export volume,and the implementation of a domestic carbon tax justifies a higher export price and a lower export volume for China.However,the degree of export reduction is smaller than that under the effect of the US carbon tariff.In the case of developed countries imposing carbon tariff on China's energy-intensive industries,such as chemical rubber products,oil and coal-processing industry and paper industry,whose export would be reduced,the negative impact on the paper industry is the severest,which will decrease the paper industry's export ranging from 1.79%to 6.05%,whereas the other industries' export will increase.Anyhow,it will promote China's manufacturing industry to adjust the export structure to a certain extent.In addition,it will lead to a decrease in China's welfare,with a decrease between $2,134 billion and $8,347 billion.Finally,this paper provides information on international coordination,export structure adjustment and green manufacturing adjustment as a reference for the development of China's manufacturing industry.展开更多
Male sterility is a common biological phenomenon in plant kingdom and has been used to generate male-sterile lines, which are important genetic resources for commercial hybrid seed production. Although increasing numb...Male sterility is a common biological phenomenon in plant kingdom and has been used to generate male-sterile lines, which are important genetic resources for commercial hybrid seed production. Although increasing numbers of male-sterility genes have been identified in rice(Oryza sativa) and Arabidopsis(Arabidopsis thaliana), few male-sterility-related genes have been characterized in foxtail millet(Setaria italica). In this study, we isolated a male-sterile ethyl methanesulfonate-generated mutant in foxtail millet, no pollen 1(sinp1), which displayed abnormal Ubisch bodies, defective pollen exine and complete male sterility. Using bulk segregation analysis, we cloned SiNP1 and confirmed its function with CRISPR/Cas9 genome editing. SiNP1 encoded a putative glucose-methanol-choline oxidoreductase.Subcellular localization showed that the SiNP1 protein was preferentially localized to the endoplasmic reticulum and was predominantly expressed in panicle. Transcriptome analysis revealed that many genes were differentially expressed in the sinp1 mutant, some of which encoded proteins putatively involved in carbohydrate metabolism, fatty acid biosynthesis, and lipid transport and metabolism, which were closely associated with pollen wall development. Metabolome analysis revealed the disturbance of flavonoids metabolism and fatty acid biosynthesis in the mutant. In conclusion, identification of SiNP1 provides a candidate male-sterility gene for heterosis utilization in foxtail millet and gives further insight into the mechanism of pollen reproduction in plants.展开更多
A novel Fe-Y composite oxide(Fe:Y-6.5) nanocluster was synthesized by self-assembly approach.The α-Fe_(2)O_(3) and cubic-Y_(2)O_(3) nanocrystalline with diameter around 10 nm are homogeneously assembled to form a clu...A novel Fe-Y composite oxide(Fe:Y-6.5) nanocluster was synthesized by self-assembly approach.The α-Fe_(2)O_(3) and cubic-Y_(2)O_(3) nanocrystalline with diameter around 10 nm are homogeneously assembled to form a cluster architecture which are constituted of Fe6.5Y composite oxide particles.Additional oxygen vacancies are introduced with cubic-Y_(2)O_(3),and the oxygen vacancies as Fe^(3+)-V_(0)-Y^(3+) between α-Fe_(2)O_(3) and cubic-Y_(2)O_(3) nanocrystalline are generated by self-assembly process.Magnetic hysteresis loops recorded by vibrating sample magnetometry at 273 K display a ferromagnetic order,related to the fact that Fe^(3+)-V_(o)-Y^(3+) act as defect centers in the bound magnetic polaron model for Fe-Y composite oxide nanomaterial.The ferromagnetic prope rties are proportional to oxygen vacancy co ntents,and maximum magnetization(M_(m)) value of the nano-cluster reaches 5.14 A·m^(2)/g.展开更多
Malicious social robots are the disseminators of malicious information on social networks,which seriously affect information security and network environments.Efficient and reliable classification of social robots is ...Malicious social robots are the disseminators of malicious information on social networks,which seriously affect information security and network environments.Efficient and reliable classification of social robots is crucial for detecting information manipulation in social networks.Supervised classification based on manual feature extraction has been widely used in social robot detection.However,these methods not only involve the privacy of users but also ignore hidden feature information,especially the graph feature,and the label utilization rate of semi-supervised algorithms is low.Aiming at the problems of shallow feature extraction and low label utilization rate in existing social network robot detection methods,in this paper a robot detection scheme based on weighted network topology is proposed,which introduces an improved network representation learning algorithm to extract the local structure features of the network,and combined with the graph convolution network(GCN)algorithm based on the graph filter,to obtain the global structure features of the network.An end-to-end semi-supervised combination model(Semi-GSGCN)is established to detect malicious social robots.Experiments on a social network dataset(cresci-rtbust-2019)show that the proposed method has high versatility and effectiveness in detecting social robots.In addition,this method has a stronger insight into robots in social networks than other methods.展开更多
The aim of this prospective blinded study was to evaluate an automated algorithm for spike-andwave discharge（SWD） detection applied to EEGs from genetic absence epilepsy rats from Strasbourg（GAERS）.Five GAERS unde...The aim of this prospective blinded study was to evaluate an automated algorithm for spike-andwave discharge（SWD） detection applied to EEGs from genetic absence epilepsy rats from Strasbourg（GAERS）.Five GAERS underwent four sessions of 20-min EEG recording.Each EEG was manually analyzed for SWDs longer than one second by two investigators and automatically using an algorithm developed in MATLAB（？）.The sensitivity,specificity,positive predictive value（PPV）,and negative predictive value（NPV） were calculated for the manual（reference） versus the automatic（test） methods.The results showed that the algorithm had specificity,sensitivity,PPV and NPV 〉94%,comparable to published methods that are based on analyzing EEG changes in the frequency domain.This provides a good alternative as a method designed to mimic human manual marking in the time domain.展开更多
Sluggish kinetics of lithium/sulfur(Li/S)conversion chemistry and the ion channels formation in the cathode is still a bottleneck for developing future Li/S batteries with high-rate,long-cycling and high-energy.Here,a...Sluggish kinetics of lithium/sulfur(Li/S)conversion chemistry and the ion channels formation in the cathode is still a bottleneck for developing future Li/S batteries with high-rate,long-cycling and high-energy.Here,a rational cathode structure design of an oxygen(O)and nitrogen(N)tailoring carbon fiber aerogel(OCNF)as a host material integrated with platinum(Pt)electrocatalysis interface is employed to regulate Li/S conversion chemistry and ion channel.The Pt nanoparticles were uniformly sprayed onto the S surface to construct the electrocatalysis interface(Pt/S/OCNF)for generating ion channels to promote the effective penetration of electrolyte into the cathode.This Pt/S/OCNF gives the cathode a high sulfur utilization of 77.5%,an excellent rate capacity of 813.2 m Ah/g(2 C),and an outstanding long-cycling performance with a capacitance retention of 82.6%and a decay of 0.086%per cycle after 200 cycles at 0.5 C.Density functional theory(DFT)calculations reveal that the Pt electrocatalysis interface makes the cathode a high density of state(DOS)at Fermi level to facilitate the electrical conductivity,charge transfer kinetics and electrocatalysis to accelerate the lithium polysulfides(LiPSs)electrochemical conversion.Furthermore,the unique chemisorption structure and adsorption ability of Li2Sn(n=1,2,4,6,8)and S8on OCNF are attributed to the bridging effects of interfacial Pt and the bonding of N-Li.The Pt electrocatalysis interface combined with the unique 3D hierarchical porous structure and abundant functional active sites at OCNF guarantee strong adsorption confinement,fast Li/S electrocatalytic conversion and unblocked ion channels for electrolyte permeation in cathode.展开更多
Dr.Lian Shen earned his Bachelor of Sciencedegree in Mechanics and Mechanical Engineering from the Department of Modern Mechanics at University of Science and Technology of China in 1993and his Doctorof Science degree...Dr.Lian Shen earned his Bachelor of Sciencedegree in Mechanics and Mechanical Engineering from the Department of Modern Mechanics at University of Science and Technology of China in 1993and his Doctorof Science degree in Fluid Mechanics from the Department of Ocean Engineeringat Massachusetts Institute of Technology in 2001.展开更多
SPECIAL motor systems are high-efficiency and high-quality electromechanical energy conversion devices suitable for complex operating conditions.As key components,special motor systems are widely used in the fields of...SPECIAL motor systems are high-efficiency and high-quality electromechanical energy conversion devices suitable for complex operating conditions.As key components,special motor systems are widely used in the fields of aerospace,energy,power,transportation,high-end manufacturing,etc.Innovations of fundamental theories and application technologies in special motor systems can promote the progress of related disciplines and fields,which has drawn great attentions from countries all over the world.展开更多
One of the yield components in rice is the number of effective tillers per unit area that produce harvestable seeds.Increasing tillers per unit area can be achieved by high planting density(HPD);however,a real gain in...One of the yield components in rice is the number of effective tillers per unit area that produce harvestable seeds.Increasing tillers per unit area can be achieved by high planting density(HPD);however,a real gain in grain yield by this practice can be realized only with an associated increase in effective tillers.The tiller angle,defined as the angle between the main culm and lateral tillers,is one of the critical determinants of rice plant architecture(Wang and Li,2008).Narrow tiller angle leads to compact plant architecture,allowing better light penetration and airflow between plants,which is a prerequisite for increasing grain yield by HPD(Wang et al.,2022b).The importance of reduced tiller angle has been evidenced during rice domestication,which transitioned wild rice with a more prostrate growth habit to cultivated rice with a more upright stance,thus enabling increased planting density and yield under agricultural conditions(Wu et al.,2018;Wang et al.,2022b).In modern rice cultivation,the dry direct seeding and the seedling throwing method(random transplanting)are being introduced to reduce labor costs(Hafeez ur et al.,2019).These practices usually result in HPD compared with controlled line transplanting and,as such,varieties with compact plant architecture are much preferred(Hafeez ur et al.,2019).展开更多
Sorghum,the fifth most important food crop globally,is a source of silage forage,fiber,syrup,and biofuel.Moreover,it is widely recognized as an ideal model crop for studying stress biology becaused of its ability to t...Sorghum,the fifth most important food crop globally,is a source of silage forage,fiber,syrup,and biofuel.Moreover,it is widely recognized as an ideal model crop for studying stress biology becaused of its ability to tolerate multiple abiotic stresses,including high salt-alkali conditions,drought,and heat.However,functional genomics studies on sorghum have been challenging,primarily due to the limited availability of genetic resources and effective genetic transformation techniques.In this study,we developed the Sorghum Genomics and Mutation Database(SGMD),aiming to advance the genetic understanding of sorghum.Our effort encompassed a telomere-to-telomere genome assembly of an inbred sorghum line,E048,yielding 729.46 Mb of sequence data representing the complete genome.Alongside the high-quality sequence data,a gene expression atlas covering 13 distinct tissues was developed.We constructed a saturated ethyl methane sulfonate mutant library comprising 13,226 independent mutants.Causal genes in chlorosis and leafy mutants from the library were easily identified by leveraging the MutMap and MutMap+methodologies,demonstrating the powerful application of this library for identifying functional genes.To facilitate sorghum research,we performed whole-genome sequencing of 179 M2 mutant lines,resulting in 2,291,074 mutations that covered 97.54% of all genes.In addition,an Agrobacterium-mediated sorghum transformation platform was established for gene function studies.In summary,this work establishes a comprehensive platform and provides valuable resources for functional genomics investigations and genetic improvement of sorghum.展开更多
Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown. We investigated th...Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown. We investigated the promise of efficacy and safety of different doses of tenecteplase manufactured in China, in patients who had an acute ischaemic stroke with large/ medium vessel occlusion beyond 4.5- hour time window. Methods The CHinese Acute tissue- Based imaging selection for Lysis In Stroke- Tenecteplase was an investigator- initiated, umbrella phase IIa, open- label, blinded- endpoint, Simon’s two- stage randomised clinical trial in 13 centres across China's Mainland. Participants who had salvageable brain tissue on automated perfusion imaging and presented within 4.5-24 hours from time of last seen well were randomised to receive 0.25 mg/ kg tenecteplase or 0.32 mg/kg tenecteplase, both with a bolus infusion over 5-10 s. The primary outcome was proportion of patients with promise of efficacy and safety defined as reaching major reperfusion without symptomatic intracranial haemorrhage at 24-48 hours after thrombolysis. Assessors were blinded to treatment allocation. All participants who received tenecteplase were included in the analysis. Results A total of 86 patients who had an acute ischaemic stroke identified with anterior large/medium vessel occlusion or severe stenosis were included in this study from November 2019 to December 2021. All of the 86 patients enrolled either received 0.25 mg/kg (n=43) or 0.32 mg/kg (n=43) tenecteplase, and were available for primary outcome analysis. Fourteen out of 43 patients in the 0.25 mg/kg tenecteplase group and 10 out of 43 patients in the 0.32 mg/kg tenecteplase group reached the primary outcome, providing promise of efficacy and safety for both doses based on Simon’s two- stage design. Discussion Among patients with anterior large/medium vessel occlusion and significant penumbral mismatch presented within 4.5-24 hours from time of last seen well, tenecteplase 0.25 mg/kg and 0.32 mg/kg both provided sufficient promise of efficacy and safety.展开更多
To solve the engineering problem of the first tunnel lining cracking caused by the second tunnel construction of double-arch highway tunnels,a research method combining distributed optical-fibre monitoring,inversion a...To solve the engineering problem of the first tunnel lining cracking caused by the second tunnel construction of double-arch highway tunnels,a research method combining distributed optical-fibre monitoring,inversion analysis and numerical simulation that can reflect lining cracking was presented.Optical fibres were laid on opposite sides of the steel arches inside the first tunnel lining.Embedded optical-fibre monitoring was conducted continuously during the second tunnel driving.Based on the fibre-optic strain profile,the lining cracking was deduced and warned in time.The mechanical behaviour of the steel arch was investigated by the inversion analysis,which took into consideration the integrated impact of axial force and flexural moment.A two-dimensional(2D)load-structure method–based numerical model was established,considering the influence of different load distributions in each construction condition.The total strain rotating crack constitutive model was applied to reflect the cracking behaviour of concrete lining in the simulation,and the model was calibrated and verified in the laboratory.Comparative analysis between the simulated strain distribution and the distributed optical-fibre monitoring results was carried out.The deformation mode and crack distribution of the lining were analysed.The cracking mechanism was explained.Specifically,the second tunnel construction led to the loading at the top of the middle partition wall and the release of rock pressure in the first tunnel.Under these load changes,the secondary lining of the first tunnel cracked on the inner side of the top of the middle partition wall owing to tension,and compression-bending failure occurred near the right arch foot.Finally,the influence of the parameters on the lining force was analysed,and a construction optimisation scheme was proposed.展开更多
文摘Cerium(Ce) compounds have attracted considerable attention as key components in functional coatings due to their many outstanding properties.This work provides a comprehensive review of recent advances in the application of Ce in functional coatings.The role of Ce in the improvement of functional properties such as corrosion-resistance,self-healing,superhydrophobicity,wear-resistance,and UV shielding is reviewed from the perspective of functional mechanism and applied research.Furthermore,the strategies,processes,practical problems,and current challenges in the research of functional coatings containing Ce are summarized and discussed.The objective is to highlight the great potential of Ce in functional coatings,and to explore new applications of Ce in the development of novel coatings.Thus,this work aims to enhance the application value of Ce,solving the problem of unbalanced application of rare-earth elements.
文摘BACKGROUND Gastric cancer(GC)poses a significant threat to public health.However,the clinicopathological features and tumor biological behaviors vary among the GC patients,leading to individual variations in lymph node metastasis.Consequently,the stratification of lymph node dissection according to the specific type,particularly upper GC,has emerged as a prominent area of research.AIM To investigate the distribution of metastatic lymph nodes in patients with upper and lower GC and to analyze the differences in related pathological elements and prognosis.METHODS Differential analysis between upper and lower GC patients with various clinicopathological factors was performed using the chi-square test and rank-sum regression models were used to analyze risk factors affecting patient prognosis.The Kaplan-Meier method was used to construct survival curves associated with prognostic risk factors for GC.RESULTS Significant differences were observed between the two GC populations regarding tumor diameter,histological grade,pT stage,pN stage,tumor-node-metastasis(pTNM)stage,vascular invasion,and adjuvant chemotherapy usage(all P<0.05).Lymph node metastasis rates were highest for Siewert type II patients in groups Nos.1,3,2 and 7;for Siewert type III patients in groups Nos.3,1,2 and 7;and for other/unclassified patients in groups Nos.1,3,7,2.In the lower GC samples,the sequences were Nos.3,6,7,4.Pathological type,pT stage,pTNM stage,and positive vascular invasion were independent risk factors for development of lymph node metastasis.Age,pathological type,pT stage,pN stage,pTNM stage,vascular invasion,and absence of adjuvant chemotherapy were identified as independent prognostic factors.CONCLUSION Upper GC showed a significantly higher malignancy grade and different lymph node metastasis pattern than lower GC.
基金supported by the National Natural Science Foundation of China(Nos.52122106 and 52027802)the“Pioneer”Research and Development Program of Zhejiang Province,China(No.2022C01230)+2 种基金the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering,China(No.2021SZ-FR005)the Space Application System of China Manned Space Program(No.KJZ-YY-NCL03)the opening fund of Key Laboratory of Rare Earths,Chinese Academy of Sciences。
文摘Interface modulation is an important pathway for highly efficient electromagnetic wave absorption.Herein,tailored interfaces between Fe_(3)O_(4)particles and the hexagonal-YFeO_(3)(h-YFeO_(3))framework were constructed via facile self-assembly.The resulting interfa-cial electron rearrangement at the heterojunction led to enhanced dielectric and magnetic loss synergy.Experimental results and density function theory(DFT)simulations demonstrate a transition in electrical properties from a half-metallic monophase to metallic Fe_(3)O_(4)/h-YFeO_(3)composites,emphasizing the advantages of the formed heterointerface.The transformation of electron behavior is also accompan-ied by a redistribution of electrons at the Fe_(3)O_(4)/h-YFeO_(3)heterojunction,leading to the accumulation of localized electrons around the Y-O-Fe band bridge,consequently enhancing the polarization.A minimum reflection loss of-34.0 dB can be achieved at 12.0 GHz and 2.0 mm thickness with an effective bandwidth of 3.3 GHz due to the abundant interfaces,enhanced polarization,and rational impedance.Thus,the synergistic effects endow the Fe_(3)O_(4)/h-YFeO_(3)composites with high performance and tunable functional properties for efficient electromagnetic absorption.
基金supported by grants from the Biological Breeding-National Science and Technology Major Project(2024ZD04077)the National Natural Science Foundation of China(31801323)+1 种基金the Innovation Program of the Chinese Academy of Agricultural Sciencesthe Science and Technology Innovation Project of the Shandong Academy of Agricultural Sciences(CXGC2023F14)。
文摘Endodermal cells and starch-accumulating amyloplasts are well-known gravity sensors initiating shoot gravitropism in Arabidopsis thaliana.The transcription factors SHR and SGR1 regulate endodermal cell formation,while PGM has been demonstrated to regulate starch biosynthesis within chloroplasts,which eventually leads to starch accumulation in amyloplasts.However,the molecular mechanisms of gravity sensing in monocot shoots remain largely unexplored.In this study,we investigated the roles of these genes in rice(Oryza sativa),a model monocot,using CRISPR-Cas9 to generate single,double,and higher-order mutants.The rice genome harbors two orthologs each of SHR and SGR and a single ortholog of PGM.Our results revealed that single mutants of OsPGM,but not OsSHR or OsSGR,showed compromised shoot gravitropism.However,double mutants shr1shr2 and sgr1sgr2 displayed wider tiller angles and reduced gravity sensing,suggesting functional redundancy within each gene pair.Higher-order mutants exhibited progressively severe phenotypes,with quintuple mutants almost unresponsive to gravity stimulation.These findings suggest that these genes act additively through distinct but converging pathways in shoot gravitropism regulation.This study provides novel insights into the molecular mechanisms underlying gravity sensing in monocots and offers valuable knowledge for precision breeding to optimize rice architecture.
基金supported by National Natural Science Foundation of China under Project 52437003 and 52421004in part by the National Key R&D Program of China under Project 2023YFB3406000in part by Heilongjiang Provincial Natural Science Foundation under Project YQ2022E029.
文摘Permanent-magnet synchronous machines(PMSMs)are widely used in robotics,rail transportation,and electric vehicles owing to their high power density,high efficiency,and high power factor.However,PMSMs often operate in harsh environments,where critical components such as windings and permanent magnets(PMs)are susceptible to failures.These faults can lead to a significant degradation in performance,posing substantial challenges to the reliable operation of PMSMs.This paper presents a comprehensive review of common fault types in PMSMs,along with their corresponding fault diagnosis and fault-tolerant control strategies.The underlying mechanisms of typical faults are systematically analyzed,followed by a detailed comparison of various diagnostic and fault-tolerant control methods to evaluate their respective advantages and limitations.Finally,the review concludes by identifying key research gaps in PMSM fault diagnosis and fault-tolerant control,while proposing potential future directions for advancing this field.
文摘Alzheimer’s disease is the most common cause of dementia.It is an increasingly serious global health problem and has a significant impact on individuals and society.However,the precise cause of Alzheimer’s disease is still unknown.In this study,11,748 Web-of-Science-indexed manuscripts regarding Alzheimer’s disease,all published from 2015 to 2019,and their 693,938 references were analyzed.A document co-citation network map was drawn using CiteSpace software.Research frontiers and development trends were determined by retrieving subject headings with apparent changing word frequency trends,which can be used to forecast future research developments in Alzheimer’s disease.
基金supported by the National Natural Science Foundation of China,No.81371395the Liaoning Scientific and Technological Preferential Finance for Returned Overseas 2015 of China,No.[2015]125+2 种基金the Natural Science Foundation of Liaoning Province of China,No.20170541021,2015020547a grant from the Shenyang Science Technology Project,No.F16-206-9-12the China Post-doctoral Science Foundation,No.2015M581375
文摘The APPSwe/PSEN1 dE9（APP/PS1） transgenic mouse model is an Alzheimer＇s disease mouse model exhibiting symptoms of dementia, and is commonly used to explore pathological changes in the development of Alzheimer＇s disease. Previous clinical autopsy and imaging studies suggest that Alzheimer＇s disease patients have white matter and oligodendrocyte damage, but the underlying mechanisms of these have not been revealed. Therefore, the present study used APP/PS1 mice to assess cognitive change, myelin loss, and corresponding changes in oligodendrocytes, and to explore the underlying mechanisms. Morris water maze tests were performed to evaluate cognitive change in APP/PS1 mice and normal C57 BL/6 mice aged 3 and 6 months. Luxol fast blue staining of the corpus callosum and quantitative reverse transcription-polymerase chain reaction（q RT-PCR） for myelin basic protein（MBP） mRNA were carried out to quantify myelin damage. Immunohistochemistry staining for NG2 and qRT-PCR for monocarboxylic acid transporter 1（MCT1） mRNA were conducted to assess corresponding changes in oligodendrocytes. Our results demonstrate that compared with C57 BL/6 mice, there was a downregulation of MBP mRNA in APP/PS1 mice aged 3 months. This became more obvious in APP/PS1 mice aged 6 months accompanied by other abnormalities such as prolonged escape latency in the Morris water maze test, shrinkage of the corpus callosum, upregulation of NG2-immunoreactive cells, and downregulation of MCT1 mRNA. These findings indicate that the involvement of early demyelination at 3 months and the oligodendrocyte dysfunction at 6 months in APP/PS1 mice are in association with Alzheimer＇s disease pathogenesis.
基金supported by National Natural Science Foundation of China(No.52105502)Fund of National Engineering and Research Center for Commercial Aircraft Manufacturing(Nos.COMAC-SFGS-2019-263 and COMAC-SFGS-2019-3731)the Fundamental Research Funds for the Central Universities(No.3042021601).
文摘This study proposed a force and shape collaborative control method that combined method of influence coefficients(MIC)and the elitist nondominated sorting genetic algorithm(NSGA-II)to reduce the shape deviation caused by manufacturing errors,gravity deformation,and fixturing errors and improve the shape accuracy of the assembled large composite fuselage panel.This study used a multi-point flexible assembly system driven by hexapod parallel robots.The proposed method simultaneously considers the shape deviation and assembly load of the panel.First,a multi-point flexible assembly system driven by hexapod parallel robots was introduced,with the relevant variables defined in the control process.In addition,the corresponding mathematical model was constructed.Subsequently,MIC was used to establish the prediction models between the displacements of actuators and displacements of panel shape control points,deformation loads applied by the actuators.Following the modeling,the shape deviation of the panel and the assembly load were used as the optimization objectives,and the displacements of actuators were optimized using NSGA-II.Finally,a typical composite fuselage panel case study was considered to demonstrate the effectiveness of the proposed method.
基金Humanities and Social Science Project of the Ministry of Education[grant number 12YJA790052]Scientific Research Projects in Liaoning Provincial Department of Education[grant number W2013081]Innovation Team Project of Dalian Maritime University[grant number 3132013329]
文摘In recent years,carbon emissions have gradually evolved from an environment issue into a political and economic one.Carbon tariff has brought about new trade barriers of developed countries,and in order to enhance the industrial competitiveness of developed countries,it will produce unfavorable impact on developing countries.Concentrated on the manufacturing industry,which is the most intensive high-carbon industry in China's export structure,this article studies the relationship between carbon tariff policy and industry structure of export trade and builds up a relation between climate change and international trade.First,by means of establishing a partial equilibrium model,it applies geometric analysis and mathematical analysis to compute the impact on China's manufacturing export trade and the consequences of the introduction of the US carbon tariff to China's manufacturing industry that has already imposed a domestic shipping carbon tax.Furthermore,with the application of the GTAP model,it estimates the overall economic and welfare effects on China's manufacturing industry if the US and Europe introduce carbon tariff by means of four ways,and then analyzes the influence on China's manufacturing industry export structure and social welfare as well.The result shows that the introduction of the US carbon import tariff lowers China's export price and export volume,and the implementation of a domestic carbon tax justifies a higher export price and a lower export volume for China.However,the degree of export reduction is smaller than that under the effect of the US carbon tariff.In the case of developed countries imposing carbon tariff on China's energy-intensive industries,such as chemical rubber products,oil and coal-processing industry and paper industry,whose export would be reduced,the negative impact on the paper industry is the severest,which will decrease the paper industry's export ranging from 1.79%to 6.05%,whereas the other industries' export will increase.Anyhow,it will promote China's manufacturing industry to adjust the export structure to a certain extent.In addition,it will lead to a decrease in China's welfare,with a decrease between $2,134 billion and $8,347 billion.Finally,this paper provides information on international coordination,export structure adjustment and green manufacturing adjustment as a reference for the development of China's manufacturing industry.
基金supported by the National Natural Science Foundation of China(31771807)the China Agriculture Research System(CARS06-13.5-A04)+1 种基金the National Key Research and Development Program of China(2018YFD1000700 and 2018YFD1000701)the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences。
文摘Male sterility is a common biological phenomenon in plant kingdom and has been used to generate male-sterile lines, which are important genetic resources for commercial hybrid seed production. Although increasing numbers of male-sterility genes have been identified in rice(Oryza sativa) and Arabidopsis(Arabidopsis thaliana), few male-sterility-related genes have been characterized in foxtail millet(Setaria italica). In this study, we isolated a male-sterile ethyl methanesulfonate-generated mutant in foxtail millet, no pollen 1(sinp1), which displayed abnormal Ubisch bodies, defective pollen exine and complete male sterility. Using bulk segregation analysis, we cloned SiNP1 and confirmed its function with CRISPR/Cas9 genome editing. SiNP1 encoded a putative glucose-methanol-choline oxidoreductase.Subcellular localization showed that the SiNP1 protein was preferentially localized to the endoplasmic reticulum and was predominantly expressed in panicle. Transcriptome analysis revealed that many genes were differentially expressed in the sinp1 mutant, some of which encoded proteins putatively involved in carbohydrate metabolism, fatty acid biosynthesis, and lipid transport and metabolism, which were closely associated with pollen wall development. Metabolome analysis revealed the disturbance of flavonoids metabolism and fatty acid biosynthesis in the mutant. In conclusion, identification of SiNP1 provides a candidate male-sterility gene for heterosis utilization in foxtail millet and gives further insight into the mechanism of pollen reproduction in plants.
基金Project supported by National Key R&D Program of China(2017YFB0305801)the Joint Funds of NSFC-Liaoning(U1508213)。
文摘A novel Fe-Y composite oxide(Fe:Y-6.5) nanocluster was synthesized by self-assembly approach.The α-Fe_(2)O_(3) and cubic-Y_(2)O_(3) nanocrystalline with diameter around 10 nm are homogeneously assembled to form a cluster architecture which are constituted of Fe6.5Y composite oxide particles.Additional oxygen vacancies are introduced with cubic-Y_(2)O_(3),and the oxygen vacancies as Fe^(3+)-V_(0)-Y^(3+) between α-Fe_(2)O_(3) and cubic-Y_(2)O_(3) nanocrystalline are generated by self-assembly process.Magnetic hysteresis loops recorded by vibrating sample magnetometry at 273 K display a ferromagnetic order,related to the fact that Fe^(3+)-V_(o)-Y^(3+) act as defect centers in the bound magnetic polaron model for Fe-Y composite oxide nanomaterial.The ferromagnetic prope rties are proportional to oxygen vacancy co ntents,and maximum magnetization(M_(m)) value of the nano-cluster reaches 5.14 A·m^(2)/g.
基金This research was funded by the National Key R&D Program of China[Grant Number 2017YFB0802703]Beijing Natural Science Foundation[Grant Number 4202002]+1 种基金the research project of the Department of Computer Science in BJUT[Grant Number 2019JSJKY004]Beijing Municipal Postdoc Science Foundation[No Grant Number]and Beijing Chaoyang District Postdoc Science Foundation[No Grant Number].
文摘Malicious social robots are the disseminators of malicious information on social networks,which seriously affect information security and network environments.Efficient and reliable classification of social robots is crucial for detecting information manipulation in social networks.Supervised classification based on manual feature extraction has been widely used in social robot detection.However,these methods not only involve the privacy of users but also ignore hidden feature information,especially the graph feature,and the label utilization rate of semi-supervised algorithms is low.Aiming at the problems of shallow feature extraction and low label utilization rate in existing social network robot detection methods,in this paper a robot detection scheme based on weighted network topology is proposed,which introduces an improved network representation learning algorithm to extract the local structure features of the network,and combined with the graph convolution network(GCN)algorithm based on the graph filter,to obtain the global structure features of the network.An end-to-end semi-supervised combination model(Semi-GSGCN)is established to detect malicious social robots.Experiments on a social network dataset(cresci-rtbust-2019)show that the proposed method has high versatility and effectiveness in detecting social robots.In addition,this method has a stronger insight into robots in social networks than other methods.
基金the sponsorship of the Victoria Government through its Science Technology and Innovation Initiative administered by the Department of Industry, Innovation and Regional Developmentthe Australian Research Council for continuing financial support
文摘The aim of this prospective blinded study was to evaluate an automated algorithm for spike-andwave discharge（SWD） detection applied to EEGs from genetic absence epilepsy rats from Strasbourg（GAERS）.Five GAERS underwent four sessions of 20-min EEG recording.Each EEG was manually analyzed for SWDs longer than one second by two investigators and automatically using an algorithm developed in MATLAB（？）.The sensitivity,specificity,positive predictive value（PPV）,and negative predictive value（NPV） were calculated for the manual（reference） versus the automatic（test） methods.The results showed that the algorithm had specificity,sensitivity,PPV and NPV 〉94%,comparable to published methods that are based on analyzing EEG changes in the frequency domain.This provides a good alternative as a method designed to mimic human manual marking in the time domain.
基金funding support from National Key R&D Program of China(No.2016YFB0100100)The National Natural Science Foundation of China(Nos.21961024,21961025,21433013,U1832218)+5 种基金Inner Mongolia Natural Science Foundation(No.2018JQ05)Supported by Incentive Funding from Nano Innovation Institute(NII)of Inner Mongolia University for Nationalities(IMUN)Inner Mongolia Autonomous Region Funding Project for Science&Technology Achievement Transformation(No.CGZH2018156)Inner Mongolia Autonomous Region Incentive Funding Guided Project for Science&Technology Innovation(2016)Inner Mongolia Autonomous Region Science&Technology Planning Project for Applied Technology Research and Development(No.2019GG261)Tongliao Funding Project for Application Technology Research&Development(2017)。
文摘Sluggish kinetics of lithium/sulfur(Li/S)conversion chemistry and the ion channels formation in the cathode is still a bottleneck for developing future Li/S batteries with high-rate,long-cycling and high-energy.Here,a rational cathode structure design of an oxygen(O)and nitrogen(N)tailoring carbon fiber aerogel(OCNF)as a host material integrated with platinum(Pt)electrocatalysis interface is employed to regulate Li/S conversion chemistry and ion channel.The Pt nanoparticles were uniformly sprayed onto the S surface to construct the electrocatalysis interface(Pt/S/OCNF)for generating ion channels to promote the effective penetration of electrolyte into the cathode.This Pt/S/OCNF gives the cathode a high sulfur utilization of 77.5%,an excellent rate capacity of 813.2 m Ah/g(2 C),and an outstanding long-cycling performance with a capacitance retention of 82.6%and a decay of 0.086%per cycle after 200 cycles at 0.5 C.Density functional theory(DFT)calculations reveal that the Pt electrocatalysis interface makes the cathode a high density of state(DOS)at Fermi level to facilitate the electrical conductivity,charge transfer kinetics and electrocatalysis to accelerate the lithium polysulfides(LiPSs)electrochemical conversion.Furthermore,the unique chemisorption structure and adsorption ability of Li2Sn(n=1,2,4,6,8)and S8on OCNF are attributed to the bridging effects of interfacial Pt and the bonding of N-Li.The Pt electrocatalysis interface combined with the unique 3D hierarchical porous structure and abundant functional active sites at OCNF guarantee strong adsorption confinement,fast Li/S electrocatalytic conversion and unblocked ion channels for electrolyte permeation in cathode.
文摘Dr.Lian Shen earned his Bachelor of Sciencedegree in Mechanics and Mechanical Engineering from the Department of Modern Mechanics at University of Science and Technology of China in 1993and his Doctorof Science degree in Fluid Mechanics from the Department of Ocean Engineeringat Massachusetts Institute of Technology in 2001.
文摘SPECIAL motor systems are high-efficiency and high-quality electromechanical energy conversion devices suitable for complex operating conditions.As key components,special motor systems are widely used in the fields of aerospace,energy,power,transportation,high-end manufacturing,etc.Innovations of fundamental theories and application technologies in special motor systems can promote the progress of related disciplines and fields,which has drawn great attentions from countries all over the world.
基金supported by grants from the Biological Breeding-National Science and Technology Major Project(2024ZD04077)the National Natural Science Foundation of China(31801323)the Innovation Program of the Chinese Academy of Agricultural Sciences.
文摘One of the yield components in rice is the number of effective tillers per unit area that produce harvestable seeds.Increasing tillers per unit area can be achieved by high planting density(HPD);however,a real gain in grain yield by this practice can be realized only with an associated increase in effective tillers.The tiller angle,defined as the angle between the main culm and lateral tillers,is one of the critical determinants of rice plant architecture(Wang and Li,2008).Narrow tiller angle leads to compact plant architecture,allowing better light penetration and airflow between plants,which is a prerequisite for increasing grain yield by HPD(Wang et al.,2022b).The importance of reduced tiller angle has been evidenced during rice domestication,which transitioned wild rice with a more prostrate growth habit to cultivated rice with a more upright stance,thus enabling increased planting density and yield under agricultural conditions(Wu et al.,2018;Wang et al.,2022b).In modern rice cultivation,the dry direct seeding and the seedling throwing method(random transplanting)are being introduced to reduce labor costs(Hafeez ur et al.,2019).These practices usually result in HPD compared with controlled line transplanting and,as such,varieties with compact plant architecture are much preferred(Hafeez ur et al.,2019).
基金supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China(32241042,32430077,32222010,and 32241038)and Chinese Universities Scientific Fund Chinese Universities Scientific Fund grant(1201-—15054001).
文摘Sorghum,the fifth most important food crop globally,is a source of silage forage,fiber,syrup,and biofuel.Moreover,it is widely recognized as an ideal model crop for studying stress biology becaused of its ability to tolerate multiple abiotic stresses,including high salt-alkali conditions,drought,and heat.However,functional genomics studies on sorghum have been challenging,primarily due to the limited availability of genetic resources and effective genetic transformation techniques.In this study,we developed the Sorghum Genomics and Mutation Database(SGMD),aiming to advance the genetic understanding of sorghum.Our effort encompassed a telomere-to-telomere genome assembly of an inbred sorghum line,E048,yielding 729.46 Mb of sequence data representing the complete genome.Alongside the high-quality sequence data,a gene expression atlas covering 13 distinct tissues was developed.We constructed a saturated ethyl methane sulfonate mutant library comprising 13,226 independent mutants.Causal genes in chlorosis and leafy mutants from the library were easily identified by leveraging the MutMap and MutMap+methodologies,demonstrating the powerful application of this library for identifying functional genes.To facilitate sorghum research,we performed whole-genome sequencing of 179 M2 mutant lines,resulting in 2,291,074 mutations that covered 97.54% of all genes.In addition,an Agrobacterium-mediated sorghum transformation platform was established for gene function studies.In summary,this work establishes a comprehensive platform and provides valuable resources for functional genomics investigations and genetic improvement of sorghum.
基金National Key R&D Program of China(2017YFC1308201)Clinical Research Plan of SHDC(SHDC2020CR1041B)Shanghai Municipal Key Clinical Specialty(shslczdzk06102).
文摘Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown. We investigated the promise of efficacy and safety of different doses of tenecteplase manufactured in China, in patients who had an acute ischaemic stroke with large/ medium vessel occlusion beyond 4.5- hour time window. Methods The CHinese Acute tissue- Based imaging selection for Lysis In Stroke- Tenecteplase was an investigator- initiated, umbrella phase IIa, open- label, blinded- endpoint, Simon’s two- stage randomised clinical trial in 13 centres across China's Mainland. Participants who had salvageable brain tissue on automated perfusion imaging and presented within 4.5-24 hours from time of last seen well were randomised to receive 0.25 mg/ kg tenecteplase or 0.32 mg/kg tenecteplase, both with a bolus infusion over 5-10 s. The primary outcome was proportion of patients with promise of efficacy and safety defined as reaching major reperfusion without symptomatic intracranial haemorrhage at 24-48 hours after thrombolysis. Assessors were blinded to treatment allocation. All participants who received tenecteplase were included in the analysis. Results A total of 86 patients who had an acute ischaemic stroke identified with anterior large/medium vessel occlusion or severe stenosis were included in this study from November 2019 to December 2021. All of the 86 patients enrolled either received 0.25 mg/kg (n=43) or 0.32 mg/kg (n=43) tenecteplase, and were available for primary outcome analysis. Fourteen out of 43 patients in the 0.25 mg/kg tenecteplase group and 10 out of 43 patients in the 0.32 mg/kg tenecteplase group reached the primary outcome, providing promise of efficacy and safety for both doses based on Simon’s two- stage design. Discussion Among patients with anterior large/medium vessel occlusion and significant penumbral mismatch presented within 4.5-24 hours from time of last seen well, tenecteplase 0.25 mg/kg and 0.32 mg/kg both provided sufficient promise of efficacy and safety.
基金funded by the National Natural Science Foundation of China(Grant No.041307087)the Construction Technology Risk and Optimization Analysis on the Xiangli Expressway Special Structure Tunnels Project,China(Yunjiaoke[2018]No.36).
文摘To solve the engineering problem of the first tunnel lining cracking caused by the second tunnel construction of double-arch highway tunnels,a research method combining distributed optical-fibre monitoring,inversion analysis and numerical simulation that can reflect lining cracking was presented.Optical fibres were laid on opposite sides of the steel arches inside the first tunnel lining.Embedded optical-fibre monitoring was conducted continuously during the second tunnel driving.Based on the fibre-optic strain profile,the lining cracking was deduced and warned in time.The mechanical behaviour of the steel arch was investigated by the inversion analysis,which took into consideration the integrated impact of axial force and flexural moment.A two-dimensional(2D)load-structure method–based numerical model was established,considering the influence of different load distributions in each construction condition.The total strain rotating crack constitutive model was applied to reflect the cracking behaviour of concrete lining in the simulation,and the model was calibrated and verified in the laboratory.Comparative analysis between the simulated strain distribution and the distributed optical-fibre monitoring results was carried out.The deformation mode and crack distribution of the lining were analysed.The cracking mechanism was explained.Specifically,the second tunnel construction led to the loading at the top of the middle partition wall and the release of rock pressure in the first tunnel.Under these load changes,the secondary lining of the first tunnel cracked on the inner side of the top of the middle partition wall owing to tension,and compression-bending failure occurred near the right arch foot.Finally,the influence of the parameters on the lining force was analysed,and a construction optimisation scheme was proposed.
