Influenza,an acute respiratory infectious disease caused by the influenza virus,exhibits distinct seasonal patterns in China,with peak activity occurring in winter and spring in northern regions,and in winter and summ...Influenza,an acute respiratory infectious disease caused by the influenza virus,exhibits distinct seasonal patterns in China,with peak activity occurring in winter and spring in northern regions,and in winter and summer in southern areas[1].The World Health Organization(WHO)emphasizes that early warning and epidemic intensity assessments are critical public health strategies for influenza prevention and control.Internet-based flu surveillance,with real-time data and low costs,effectively complements traditional methods.The Baidu Search Index,which reflects flu-related queries,strongly correlates with influenza trends,aiding in regional activity assessment and outbreak tracking[2].展开更多
Severe fever with thrombocytopenia syndrome(SFTS)is a life-threatening tick-borne disease characterized by cytokine dysregulation and immune-mediated hyperinflammation.This multicenter retrospective study analyzed the...Severe fever with thrombocytopenia syndrome(SFTS)is a life-threatening tick-borne disease characterized by cytokine dysregulation and immune-mediated hyperinflammation.This multicenter retrospective study analyzed the dynamics of 17 cytokines across acute and recovery phases using 287 serum samples collected between 2010 and 2023 from high-incidence regions of China,evaluating their associations with disease severity,sex,age,and antibody responses.The results demonstrated that elevations of interleukin(IL)-6,interferon(IFN)-α,IL-8,and IFN-γ-induced protein 10(IP-10)during the acute phase were associated with hyperinflammation,while IL-10 balanced inflammatory control and may have contributed to viral persistence.During recovery,most cytokines declined;however,IL-8 and IP-10 remained elevated longer in some patients,reflecting heterogeneity in recovery trajectories.Severe cases exhibited significantly higher levels of IL-10,IFN-γ,IL-6,IFN-α,tumor necrosis factor(TNF)-α,IL-8,and IP-10,underscoring their potential as biomarkers for disease severity prediction.Sex-based differences revealed higher IFN-γand IL-8 levels in females,potentially due to hormonal and genetic factors,while older patients exhibited elevated IL-10,IFN-γ,and IFN-α,reflecting immune dysregulation and age-related shifts in adaptive immunity.Correlation analysis revealed distinct immune response patterns,with IL-10 strongly correlating with IFN-γand minimal antibody-cytokine associations observed during the acute phase.In contrast,in the recovery phase,immunoglobulin G(IgG)negatively correlated with IL-10,IFN-γ,and IP-10,and immunoglobulin M(IgM)positively correlated with IL-10,IFN-γ,IL-6,IFN-α,TNF-α,IL-8,and IP-10,reflecting dynamic immune regulation and the interplay between humoral and cellular immunity.These findings provide critical insights into the immunopathogenesis of SFTS,supporting the development of cytokine-targeted therapies and advanced diagnostic tools to improve clinical outcomes.展开更多
What is already known on this topic?Human brucellosis,a neglected zoonotic disease,causes more than 500,000 new cases each year globally.The disease is of major public health concern in China,and northern provinces ar...What is already known on this topic?Human brucellosis,a neglected zoonotic disease,causes more than 500,000 new cases each year globally.The disease is of major public health concern in China,and northern provinces are traditionally endemic areas.What is added by this report?This is the first published outbreak of occupational brucellosis involving multiple clusters in Hubei Province.This investigation characterizes the transmission chain of the outbreak and reveals that provinces south of the Yangtze River are faced with a series of challenges and hurdles to overcome including,but not limited to,health education,law enforcement,and occupational protection.What are the implications for public health practice?In addition to measures aimed at this outbreak,the local agricultural department has issued special notices based on this investigation to adjust and strengthen local eradication program of brucellosis.展开更多
基金supported by the National Key Research and Development Program of China(Project No.2023YFC2307500).
文摘Influenza,an acute respiratory infectious disease caused by the influenza virus,exhibits distinct seasonal patterns in China,with peak activity occurring in winter and spring in northern regions,and in winter and summer in southern areas[1].The World Health Organization(WHO)emphasizes that early warning and epidemic intensity assessments are critical public health strategies for influenza prevention and control.Internet-based flu surveillance,with real-time data and low costs,effectively complements traditional methods.The Baidu Search Index,which reflects flu-related queries,strongly correlates with influenza trends,aiding in regional activity assessment and outbreak tracking[2].
基金supported by the National Key R&D Program of China(ZDYF-2022YFC2303402)the Young Scientists Fund of China CDC(CCDC-2022A104)+1 种基金the National Major Science and Technology Project of China(2018ZX10711001)the Peak Discipline Project of Anhui Medical University(Collaborative Education Innovation Project,2024GWXTYRZ002).
文摘Severe fever with thrombocytopenia syndrome(SFTS)is a life-threatening tick-borne disease characterized by cytokine dysregulation and immune-mediated hyperinflammation.This multicenter retrospective study analyzed the dynamics of 17 cytokines across acute and recovery phases using 287 serum samples collected between 2010 and 2023 from high-incidence regions of China,evaluating their associations with disease severity,sex,age,and antibody responses.The results demonstrated that elevations of interleukin(IL)-6,interferon(IFN)-α,IL-8,and IFN-γ-induced protein 10(IP-10)during the acute phase were associated with hyperinflammation,while IL-10 balanced inflammatory control and may have contributed to viral persistence.During recovery,most cytokines declined;however,IL-8 and IP-10 remained elevated longer in some patients,reflecting heterogeneity in recovery trajectories.Severe cases exhibited significantly higher levels of IL-10,IFN-γ,IL-6,IFN-α,tumor necrosis factor(TNF)-α,IL-8,and IP-10,underscoring their potential as biomarkers for disease severity prediction.Sex-based differences revealed higher IFN-γand IL-8 levels in females,potentially due to hormonal and genetic factors,while older patients exhibited elevated IL-10,IFN-γ,and IFN-α,reflecting immune dysregulation and age-related shifts in adaptive immunity.Correlation analysis revealed distinct immune response patterns,with IL-10 strongly correlating with IFN-γand minimal antibody-cytokine associations observed during the acute phase.In contrast,in the recovery phase,immunoglobulin G(IgG)negatively correlated with IL-10,IFN-γ,and IP-10,and immunoglobulin M(IgM)positively correlated with IL-10,IFN-γ,IL-6,IFN-α,TNF-α,IL-8,and IP-10,reflecting dynamic immune regulation and the interplay between humoral and cellular immunity.These findings provide critical insights into the immunopathogenesis of SFTS,supporting the development of cytokine-targeted therapies and advanced diagnostic tools to improve clinical outcomes.
文摘What is already known on this topic?Human brucellosis,a neglected zoonotic disease,causes more than 500,000 new cases each year globally.The disease is of major public health concern in China,and northern provinces are traditionally endemic areas.What is added by this report?This is the first published outbreak of occupational brucellosis involving multiple clusters in Hubei Province.This investigation characterizes the transmission chain of the outbreak and reveals that provinces south of the Yangtze River are faced with a series of challenges and hurdles to overcome including,but not limited to,health education,law enforcement,and occupational protection.What are the implications for public health practice?In addition to measures aimed at this outbreak,the local agricultural department has issued special notices based on this investigation to adjust and strengthen local eradication program of brucellosis.
