Understanding the influence of HCl on the NH_(3)-selective catalytic reduction reaction mechanism is crucial for designing highly efficient denitrification catalysts.The formation of chlorate species on the surface of...Understanding the influence of HCl on the NH_(3)-selective catalytic reduction reaction mechanism is crucial for designing highly efficient denitrification catalysts.The formation of chlorate species on the surface of the synthesized SbCeO_(x)catalyst,induced by HCl,significantly enhances low-temperature activity,as evidenced by a 30%increase in NO conversion at 155℃.Furthermore,it improves N_(2)selectivity at high temperatures,with a notable 17%increase observed at 405℃.Both experimental results and density functional theory calculations confirm that chlorate species form at Ce sites.This formation facilitates the creation of oxygen vacancies,boosting the oxygen exchange capacity.It also increases NH_(3)adsorption at the Ce sites,promotes the formation of Sb-OH,and reduces competitive OH adsorption on these sites.Notably,compared with the reaction mechanism without HCl,the presence of chlorate species enhances NH_(3)adsorption and activation,which is vital for subsequent catalytic reactions.展开更多
To enhance methane production efficiency in lignite anaerobic digestion and explore new ways for residual sludge utilization, this study employed the co-fermentation of lignite and residual sludge for biomethane conve...To enhance methane production efficiency in lignite anaerobic digestion and explore new ways for residual sludge utilization, this study employed the co-fermentation of lignite and residual sludge for biomethane conversion. The bacterial colony structure, metabolic pathways, and interactions between residual sludge and lignite in anaerobic methanogenic fermentation with different mass ratios were analyzed using macrogenomics sequencing. This study aimed to explore the mechanisms involved in the co-anaerobic fermentation of lignite and residual sludge. The results indicated that the addition of sludge enhanced the metabolic pathways in hydrolysis acidification, hydrogen-acetic acid production, and methanation phases. Notably, the enhancement of acetate- and carbon dioxide-nutrient metabolic pathways was more pronounced, with increased activity observed in related enzymes such as acetic acid kinase (k00925) and acetyl coenzyme synthetase (K01895). This increased enzymatic activity facilitated the microbial conversion of biomethane. The results of the study indicated that the sludge exhibited a promotional effect on the methane produced through the anaerobic fermentation of lignite, providing valuable insights for lignite and residual sludge resource utilization.展开更多
To study the weakly expansive clay obtained from a slope along Wuhan—Shiyan expressway in Hubei Province,soil-water property tests and some unsaturated triaxial tests with suction control were conducted,and the soil-...To study the weakly expansive clay obtained from a slope along Wuhan—Shiyan expressway in Hubei Province,soil-water property tests and some unsaturated triaxial tests with suction control were conducted,and the soil-water retention curve（SWRC） and unsaturated shear strength of this soil were obtained.Results show that the air-entry suction and the residual degree of saturation of the tested soil are 106 kPa and 8%,respectively.The boundary effect zone and the transition zone can be identified on the desorption curve,but the residual zone is not so obvious.The unsaturated shear strength increases as suction increases within the range of controlled suction in the test,and friction angle,b,in the triaxial shear test is 17.6°.Based on the results,constitutive models for predicting the unsaturated shear strength using the SWRC were evaluated,and comparisons between prediction and measurement were made.It is concluded that for engineering purpose,the constitutive model should be carefully selected based on soil properties when predicting the unsaturated shear strength using the SWRC.展开更多
The development of high-performance microwave absorption materials with strong absorption capacity and broad bandwidth is highly desirable in the field of electromagnetic pollution protection.Herein,ultralight polyimi...The development of high-performance microwave absorption materials with strong absorption capacity and broad bandwidth is highly desirable in the field of electromagnetic pollution protection.Herein,ultralight polyimide-based graphene foam with ordered lamellar structure is precisely designed and controllably constructed by bidirectional freezing process.More lamellar interfaces formed inside the foam per unit volume effectively facilitate the layer-by-layer dissipation for the vertical incident electromagnetic waves,thereby endowing the foam with efficient broadband electromagnetic absorption performance.More importantly,electromagnetic absorption performance can be controllably adjusted by optimizing impedance distribution and microstructure of skeletons.As a result,the optimized foam with an ultralow density of 9.10 mg/cm^(3)presents a minimum reflection loss value of-61.29 dB at 9.25 GHz and an effective absorption bandwidth of 5.51 GHz(7.06-12.57 GHz,covering the whole X band) when the thickness is 4.75 mm.展开更多
Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be...Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be inappropriate.Therefore,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 weeks.The effects of dietary iron supplementation with different sources and levels on semen quality in boars were investigated.Results 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(P<0.05),and higher serum superoxide dismutase levels and lower MDA levels in the 115 mg/kg MHA-Fe group(P<0.05).3)Boars in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups had lower serum hepcidin(P<0.01),ferritin(P<0.05),and transferrin receptor(P<0.01)concentrations,and boars in the 115 mg/kg MHA-Fe group had higher seminal plasma Fe concentrations compared with the control group.4)Boars in the 80 mg/kg and 115 mg/kg MHA-Fe groups had lower abnormal sperm rate and in situ oscillating sperm ratio compared to the control group at weeks 12 and/or 16 of the trial.However,the effect of Gly-Fe on improving semen quality in boars was not evident.5)Serum IL-6 level was positively correlated with hepcidin concentration(P<0.05),which in turn was significantly positively correlated with abnormal sperm rate(P<0.05).Furthermore,significant correlations were also found between indicators of iron status and oxidative stress and semen quality parameters.Conclusions Dietary supplementation with 80 mg/kg or 115 mg/kg MHA-Fe did not induce iron deficiency,but rather reduced serum inflammatory levels and hepcidin concentration,alleviated oxidative stress,increased body iron utilization,and improved semen quality in adult boars.展开更多
Zika virus(ZIKV)can infect a wide range of tissues including the developmental brain of human fetus.Whether specific viral genetic variants are linked to neuropathology is incompletely understood.To address this,we ha...Zika virus(ZIKV)can infect a wide range of tissues including the developmental brain of human fetus.Whether specific viral genetic variants are linked to neuropathology is incompletely understood.To address this,we have intracranially serially passaged a clinical ZIKV isolate(SW01)in neonatal mice and discovered variants that exhibit markedly increased virulence and neurotropism.Deep sequencing analysis combining with molecular virology studies revealed that a single 67D(Aspartic acid)to N(Asparagine)substitution on E protein is sufficient to confer the increased virulence and neurotropism in vivo.Notably,virus clones with D67N mutation had higher viral production and caused more severe cytopathic effect(CPE)in human neural astrocytes U251 cells in vitro,indicating its potential neurological toxicity to human brain.These findings revealed that a single mutation D67N on ZIKV envelope may lead to severe neuro lesion that may help to explain the neurovirulence of ZIKV and suggest monitoring the occurrence of this mutation during nature infection may be important.展开更多
Dear Editor,The family Totiviridae contains non-enveloped,doublestranded RNA viruses with genomes of approximately 4.6–7 kbp in length.These totiviruses are classified into five genera:Totivirus,Victorivirus,Trichomo...Dear Editor,The family Totiviridae contains non-enveloped,doublestranded RNA viruses with genomes of approximately 4.6–7 kbp in length.These totiviruses are classified into five genera:Totivirus,Victorivirus,Trichomonasvirus,Giardiavirus,and Leishmaniavirus(Nibert 2007).They are associated with latent infections of fungal or protozoan hosts(Li et al.2020).Recently,a few totiviruses have been identified and shown to have unexpected host distributions,including insects,plants.展开更多
Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of poly...Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of polycyclic aromatic hydrocarbons (PAHs) in Chinese pregnant women and their newborns, and to examine the association between levels of PAHs and infant birth weight. We conducted a cross-sectional study including 81 pairs of mothers and newborns from four hospitals in four different cities in China. High Performance Liquid Chromatography was used to measure the concentration of nine PAHs in maternal and cord blood and multiple linear regression analyses were used to evaluate the associations of these PAHs with infant birth weight. Anthracene (ANT) had the highest average concentration and detection rate (geometric mean = 69.54 ng/g and 76.5%, respectively) in maternal serum samples, while fluoranthene (FLT) had the highest concentration and detection rate (geometric mean = 68.4 ng/g and 50.6%, respectively) in the cord blood. Most of the measured PAHs in maternal serum and three PAHs in cord blood were inversely but non-significantly associated with birth weight. The strongest associations were observed for higher concentrations of benzo (a) pyrene (BaP) in maternal serum (230.7 g decrease for levels > median vs. < LOD;p = 0.151) and for ANT in cord blood (153.1 g decrease for levels < median vs. < LOD;p = 0.208). Ant and FLT were the predominant PAHs in the maternal and cord blood serum. Serum concentrations of several measured PAHs were associated with a decreased birth weight, although not significantly, suggesting that further studies with larger sample sizes are needed to validate our findings.展开更多
Objective:Early detection and treatment in patients with esophageal cancer is the most effective way to improve the prognosis.Patients with high-grade dysplasia(HGD)in esophageal mucosa might be involved with early es...Objective:Early detection and treatment in patients with esophageal cancer is the most effective way to improve the prognosis.Patients with high-grade dysplasia(HGD)in esophageal mucosa might be involved with early esophageal cancer,but the management of the disease is controversial.The purpose of our study was to explore the management of esophageal mucosa with HGD.Methods:We retrospectively analyzed 10 patients with HGD in esophageal mucosa,who underwent esophagectomy in Cancer Hospital of Fudan University from 1999 to 2006.The surgical approach,postoperative morbidity,in-hospital complications and pathological results of the patients were analyzed.Basing on our data together with other studies,we aimed at looking for an appropriate management for patients with HGD.Results:Of the 10 patients who received esophagectomy,the pathological results showed that 2(20%)cases were in situ carcinoma and 8(80%)cases were invasive cancer with no regional lymph nodes involved.30-day mortality was 0.One patient experienced cervical anastomotic leakage,but healed in 2 weeks.There was no pulmonary complication.Conclusion:Most patients with HGD actually have occult carcinoma.High percentage of patients with HGD would develop into cancer during their lifetime.Esophagectomy is now a selective approach for the treatment of the patients with HGD.展开更多
Objective:To compare mini-probe endoscopic ultrasonography(MCUS)with computed tomography(CT)in pre-operative T and N staging of esophageal cancer,and to find out the MCUS parameters to judge lymph nodes metastasis for...Objective:To compare mini-probe endoscopic ultrasonography(MCUS)with computed tomography(CT)in pre-operative T and N staging of esophageal cancer,and to find out the MCUS parameters to judge lymph nodes metastasis for esophageal cancer.Methods:Thirty-five patients received both MCUS and CT preoperatively,on both of which the T and N stages were determined.The accuracy,sensitivity,specificity,positive predicting value and negative predicting value were compared with the postoperative pathological results.Results:The accuracy of MCUS was 85.7% in T staging and 85.7% and 80.0% in N staging by two different methods,which were 45.7% and 74.3%,respectively,by CT.Conclusion:MCUS is better than CT in preoperative staging for esophageal cancer.The ratio of short to long axis(S/L)combined with short axis is a useful way to determine lymph nodes metastasis.展开更多
Lottery has already been broadly used by countries to raise funds to construct the public organizations,but its function is decided by the rate of participation and expenditure levels.Using the lottery investigation d...Lottery has already been broadly used by countries to raise funds to construct the public organizations,but its function is decided by the rate of participation and expenditure levels.Using the lottery investigation data from Hainan Province,this paper analyzes the factors affecting the rate of participation and expenditure in Hainan Province by applying Probit and Tobit Model.It shows that factors such as gender,marriage,education level,attitude and the social environment have distinct influence on the individual lottery participation and expenditure decisions.Therefore,lottery is a restricted rational behavior affected by psychological and social environment variables.Publicity may play an important role in our country's lottery policy.Moreover,lottery policy in China should implement a development strategy which requires adjustment in product pattem and promotion approach.展开更多
Recent large-scale multi-omics studies have characterized the heterogeneity of esophageal squamous cell carcinoma(ESCC),but inconsistent clinical management has hindered the identification of prognostic markers and pa...Recent large-scale multi-omics studies have characterized the heterogeneity of esophageal squamous cell carcinoma(ESCC),but inconsistent clinical management has hindered the identification of prognostic markers and patient stratification.Here,we conducted genomic and transcriptomic profiling of 203 patients from the ECTOP-2002 study with full clinical information.Mutation in the mucin family,as well as APOBEC signature,were associated with poor prognosis.In contrast,activation of the epithelial-keratinization(EpK)pathway was strongly linked to favorable prognosis and lower post-chemotherapy recurrence rates.Independent validation supported S100A8+S100A9 complex as a key marker of EpK pathway.Furthermore,we established a prognostic stratification system,FU-ESCC subtyping,which defines three subtypes with distinct molecular and clinical features.The EpK-activated subtype retained characteristics of healthy squamous epithelial cells,showed high expression of the S100A8+S100A9 complex,and was associated with favorable prognosis.展开更多
N^(6)-methyladenosine(m^(6)A)in RNA within R-loops plays pivotal roles in transcription regulation and genome stability.However,the precise impacts and distinct mechanisms of m^(6)A on both regulatory and aberrant R-l...N^(6)-methyladenosine(m^(6)A)in RNA within R-loops plays pivotal roles in transcription regulation and genome stability.However,the precise impacts and distinct mechanisms of m^(6)A on both regulatory and aberrant R-loops remain poorly understood.Here,we reveal that METTL3,the nuclear m^(6)A writer,ensures genome integrity by differentially modulating R-loops in a position-and length-dependent manner.In mouse embryonic stem cells(m ESCs),Mettl3 depletion results in impaired cell proliferation and increased cell death due to excessive DNA damage.Notably,Mettl3 knockout reduces the overall abundance of R-loops,with a decrease in broad R-loops and an increase in sharp Rloops.R-loops are diminished near transcription end sites(TESs),leading to transcriptional readthrough of genes with m^(6)A-modified transcripts and potentially contributing to genome instability.Conversely,increased sharp R-loops located in the antisense orientation relative to gene transcription are associated with DNA damage hotspots.These findings unveil a dual regulatory mechanism in which METTL3-m^(6)A orchestrates transcription fidelity and genome stability through distinct R-loop-dependent manners.展开更多
The present study aimed to evaluate the effects of manganese methionine hydroxyl analog chelated(Mn-MHAC)as a manganese(Mn)source on growth performance and trace element deposition in broilers.A total of 432 Arbor Acr...The present study aimed to evaluate the effects of manganese methionine hydroxyl analog chelated(Mn-MHAC)as a manganese(Mn)source on growth performance and trace element deposition in broilers.A total of 432 Arbor Acres commercial female broilers were fed a basal corn-soybean diet containing Mn at 25.64 mg/kg diet for 10 d.They were then randomly assigned to 6 groups,including a control group(the basal diet),a Mn sulfate group(the basal diet supplemented with Mn at 100 mg/kg diet),and 4 Mn-MHAC groups(the basal diet supplemented with Mn-MHAC at 25,50,75 and 100 mg Mn/kg diet,respectively).The results showed that compared with the control group,groups supplemented with Mn-MHAC had a positive effect on BW(quadratic,P=0.017)and ADG(quadratic,P=0.017).Moreover,the Mn-MHAC(50 mg Mn/kg diet)group had significantly greater BW and ADG(P<0.05)compared with the other Mn-MHAC groups.Trace element deposition results also showed that tibial Mn increased(linear or quadratic,P-0.002 and 0.009,respectively)in groups fed diets with increased levels of Mn-MHAC.In contrast,Fe deposition decreased both in the heart(linear,P-0.020)and tibia(P<0.05).In addition,the Mn-MHAC supplement noticeably lowered serum Mn-SOD activity(linear or quadratic,P-0.048 and 0.019,respectively).The relative mRNA levels of divalent metal transporter 1(DMT1)(P=0.024),ferro-portin 1(FPN1)(P=0.049),and Cu transporter-1(CTR1)(P<0.001)in the duodenum,as well as CTR1 in the jejunum and ileum(P=0.040 and 0.011,respectively)were higher in the Mn-supplemented group than in the control group.Furthermore,the relative mRNA level of DMT1 in the jejunum and ileum of broilers in the Mn-MHAC group(50 mg Mn/kg diet)did not differ from those in the control group,but was lower than those in the Mn sulfate group(P<0.05).In conclusion,Mn-MHAC dietary supplementation improved the growth performance and trace element deposition in broilers.From this study,we recommend the opti-mum Mn-MHAC level to meet the Mn requirement of broilers is 50 to 75 mg Mn/kg diet.展开更多
In this research,the highly efficient external cavity feedback technology based on volume Bragg grating(VBG)is studied.By using the structure of a fast axis collimating lens,the beam transformation system,a slow axis ...In this research,the highly efficient external cavity feedback technology based on volume Bragg grating(VBG)is studied.By using the structure of a fast axis collimating lens,the beam transformation system,a slow axis collimating lens,and VBG,the divergence angle of the fast and slow axes of the diode laser incident on the VBG is reduced effectively,and the feedback efficiency of the external cavity is improved.Combined with beam combining technology,fiber coupling technology,and precision temperature control technology,a high-power and narrow-linewidth diode laser pump source of kilowatt class is realized for alkali metal vapor laser pumping.The core diameter of the optical fiber is 1000μm,the numerical aperture is 0.22,the output power from the fiber is 1013 W,the fiber coupling efficiency exceeds 89%,and the external cavity efficiency exceeds 91%.The central wavelength is 852.052 nm(in air),which is tunable from 851.956 nm to 852.152 nm,and the spectral linewidth is 0.167 nm.Research results can be used for cesium alkali metal vapor laser pumping.展开更多
Timely identifying and quantifying significant spatial and temporal variability in agricultural field has been a crucial factor for improving agricultural production and management.This paper focuses on the mainstream...Timely identifying and quantifying significant spatial and temporal variability in agricultural field has been a crucial factor for improving agricultural production and management.This paper focuses on the mainstream techniques and applications can be adopted to improve the field information collection method.In this paper,the development of wireless sensor networks(WSNs)and remote sensing(RS)technology were reviewed,especially the micro unmanned aerial vehicle(mUAV)-based WSNs and mUAV-based RS by analyzing its applications in field information collection,and pointed out its existing benefits and limitations.A system encompassed multiple technique approaches was proposed in this paper which is called air-ground multi-sensor monitoring system.With the diversification methods of in-field information collection and the improvement of detection precision,an infield information collection system will play an important role in controlling the farming operations of mechanized agriculture and optimizing the management of agricultural machinery group.In the future,the combination of mUAV,WSNs and RS for crop and soil monitoring will become a powerful tool to obtain field information,increase production,optimize the overall farming practices and input of resources and provide comprehensive reference for the study of soil-crops-machine relationships.展开更多
Lung cancer is one of the leading causes of cancer incidence and mortality worldwide.While smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nicke...Lung cancer is one of the leading causes of cancer incidence and mortality worldwide.While smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nickel,and silica are well-established risk factors,many lung cancer cases cannot be explained by these known risk factors.Over the last two decades the incidence of adenocarcinoma has risen,and it now surpasses squamous cell carcinoma as the most common histologic subtype.This increase warrants new efforts to identify additional risk factors for specific lung cancer subtypes as well as a comprehensive review of current evidence from epidemiologic studies to inform future studies.Given the myriad exposures individuals experience in real-world settings,it is essential to investigate mixture effects from complex exposures and gene-environment interactions in relation to lung cancer and its subtypes.展开更多
文摘Understanding the influence of HCl on the NH_(3)-selective catalytic reduction reaction mechanism is crucial for designing highly efficient denitrification catalysts.The formation of chlorate species on the surface of the synthesized SbCeO_(x)catalyst,induced by HCl,significantly enhances low-temperature activity,as evidenced by a 30%increase in NO conversion at 155℃.Furthermore,it improves N_(2)selectivity at high temperatures,with a notable 17%increase observed at 405℃.Both experimental results and density functional theory calculations confirm that chlorate species form at Ce sites.This formation facilitates the creation of oxygen vacancies,boosting the oxygen exchange capacity.It also increases NH_(3)adsorption at the Ce sites,promotes the formation of Sb-OH,and reduces competitive OH adsorption on these sites.Notably,compared with the reaction mechanism without HCl,the presence of chlorate species enhances NH_(3)adsorption and activation,which is vital for subsequent catalytic reactions.
文摘To enhance methane production efficiency in lignite anaerobic digestion and explore new ways for residual sludge utilization, this study employed the co-fermentation of lignite and residual sludge for biomethane conversion. The bacterial colony structure, metabolic pathways, and interactions between residual sludge and lignite in anaerobic methanogenic fermentation with different mass ratios were analyzed using macrogenomics sequencing. This study aimed to explore the mechanisms involved in the co-anaerobic fermentation of lignite and residual sludge. The results indicated that the addition of sludge enhanced the metabolic pathways in hydrolysis acidification, hydrogen-acetic acid production, and methanation phases. Notably, the enhancement of acetate- and carbon dioxide-nutrient metabolic pathways was more pronounced, with increased activity observed in related enzymes such as acetic acid kinase (k00925) and acetyl coenzyme synthetase (K01895). This increased enzymatic activity facilitated the microbial conversion of biomethane. The results of the study indicated that the sludge exhibited a promotional effect on the methane produced through the anaerobic fermentation of lignite, providing valuable insights for lignite and residual sludge resource utilization.
基金Supported by the China National Key Technology R&D Program(2006BAJ27B02-02)the National Natural Science Foundation of China(40772180,40728003)Shanghai Leading Academic Discipline Project(B308)
文摘To study the weakly expansive clay obtained from a slope along Wuhan—Shiyan expressway in Hubei Province,soil-water property tests and some unsaturated triaxial tests with suction control were conducted,and the soil-water retention curve（SWRC） and unsaturated shear strength of this soil were obtained.Results show that the air-entry suction and the residual degree of saturation of the tested soil are 106 kPa and 8%,respectively.The boundary effect zone and the transition zone can be identified on the desorption curve,but the residual zone is not so obvious.The unsaturated shear strength increases as suction increases within the range of controlled suction in the test,and friction angle,b,in the triaxial shear test is 17.6°.Based on the results,constitutive models for predicting the unsaturated shear strength using the SWRC were evaluated,and comparisons between prediction and measurement were made.It is concluded that for engineering purpose,the constitutive model should be carefully selected based on soil properties when predicting the unsaturated shear strength using the SWRC.
基金financially supported by the National Natural Science Foundation of China (Nos. 21674019, 21704014, 52003106, 22008086, and 52003107)China Postdoctoral Science Foundation (Nos. 2020M671332, 2021M691265, and 2021M691266)+2 种基金Fundamental Research Funds for the Central Universities (Nos. 2232019A3-03 and JUSRP12032)Ministry of Education of the People’s Republic of China (No. 6141A0202202)Shanghai Scientific and Technological Innovation Project (No. 18JC1410600)。
文摘The development of high-performance microwave absorption materials with strong absorption capacity and broad bandwidth is highly desirable in the field of electromagnetic pollution protection.Herein,ultralight polyimide-based graphene foam with ordered lamellar structure is precisely designed and controllably constructed by bidirectional freezing process.More lamellar interfaces formed inside the foam per unit volume effectively facilitate the layer-by-layer dissipation for the vertical incident electromagnetic waves,thereby endowing the foam with efficient broadband electromagnetic absorption performance.More importantly,electromagnetic absorption performance can be controllably adjusted by optimizing impedance distribution and microstructure of skeletons.As a result,the optimized foam with an ultralow density of 9.10 mg/cm^(3)presents a minimum reflection loss value of-61.29 dB at 9.25 GHz and an effective absorption bandwidth of 5.51 GHz(7.06-12.57 GHz,covering the whole X band) when the thickness is 4.75 mm.
基金China Agriculture Research System(CARS-36)Major Project of Technical Innovation in Hubei Province(No.2022BBA0056)+1 种基金Dekon-Huazhong Agricultural University Project Co-operation AgreementSchool-Enterprise Cooperation Project-Micronutrient Nutrition and Mechanism of Breeding Pigs。
文摘Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be inappropriate.Therefore,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 weeks.The effects of dietary iron supplementation with different sources and levels on semen quality in boars were investigated.Results 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(P<0.05),and higher serum superoxide dismutase levels and lower MDA levels in the 115 mg/kg MHA-Fe group(P<0.05).3)Boars in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups had lower serum hepcidin(P<0.01),ferritin(P<0.05),and transferrin receptor(P<0.01)concentrations,and boars in the 115 mg/kg MHA-Fe group had higher seminal plasma Fe concentrations compared with the control group.4)Boars in the 80 mg/kg and 115 mg/kg MHA-Fe groups had lower abnormal sperm rate and in situ oscillating sperm ratio compared to the control group at weeks 12 and/or 16 of the trial.However,the effect of Gly-Fe on improving semen quality in boars was not evident.5)Serum IL-6 level was positively correlated with hepcidin concentration(P<0.05),which in turn was significantly positively correlated with abnormal sperm rate(P<0.05).Furthermore,significant correlations were also found between indicators of iron status and oxidative stress and semen quality parameters.Conclusions Dietary supplementation with 80 mg/kg or 115 mg/kg MHA-Fe did not induce iron deficiency,but rather reduced serum inflammatory levels and hepcidin concentration,alleviated oxidative stress,increased body iron utilization,and improved semen quality in adult boars.
基金supported in part by the following grants:Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29040301 to X.J.)National Key R&D Program of China(2016YFC1201000 to X.J.)+2 种基金Ministry of Science and Technology of China(2016YFE0133500 to X.J.)the National Natural Science Foundation of China(31770190 and 81925025 to CF.Q.)European Union Horizon 2020 Research and Innovation Programme under ZIKAlliance Grant Agreement(734548 to X.J.)
文摘Zika virus(ZIKV)can infect a wide range of tissues including the developmental brain of human fetus.Whether specific viral genetic variants are linked to neuropathology is incompletely understood.To address this,we have intracranially serially passaged a clinical ZIKV isolate(SW01)in neonatal mice and discovered variants that exhibit markedly increased virulence and neurotropism.Deep sequencing analysis combining with molecular virology studies revealed that a single 67D(Aspartic acid)to N(Asparagine)substitution on E protein is sufficient to confer the increased virulence and neurotropism in vivo.Notably,virus clones with D67N mutation had higher viral production and caused more severe cytopathic effect(CPE)in human neural astrocytes U251 cells in vitro,indicating its potential neurological toxicity to human brain.These findings revealed that a single mutation D67N on ZIKV envelope may lead to severe neuro lesion that may help to explain the neurovirulence of ZIKV and suggest monitoring the occurrence of this mutation during nature infection may be important.
基金supported by grants from the National Key R&D Program of China(2017YFC1200802)National Science and Technology Major Project of China(2018ZX10711001003-001)+1 种基金the State Key Laboratories Program of China(SKLPBS1817)the Yunnan Health Training Project of High Level Talents(D-201604)
文摘Dear Editor,The family Totiviridae contains non-enveloped,doublestranded RNA viruses with genomes of approximately 4.6–7 kbp in length.These totiviruses are classified into five genera:Totivirus,Victorivirus,Trichomonasvirus,Giardiavirus,and Leishmaniavirus(Nibert 2007).They are associated with latent infections of fungal or protozoan hosts(Li et al.2020).Recently,a few totiviruses have been identified and shown to have unexpected host distributions,including insects,plants.
文摘Adverse birth outcomes are a leading cause of mortality in children in China, but the environmental influences of these conditions remain largely unexplained in this population. We aimed to evaluate the levels of polycyclic aromatic hydrocarbons (PAHs) in Chinese pregnant women and their newborns, and to examine the association between levels of PAHs and infant birth weight. We conducted a cross-sectional study including 81 pairs of mothers and newborns from four hospitals in four different cities in China. High Performance Liquid Chromatography was used to measure the concentration of nine PAHs in maternal and cord blood and multiple linear regression analyses were used to evaluate the associations of these PAHs with infant birth weight. Anthracene (ANT) had the highest average concentration and detection rate (geometric mean = 69.54 ng/g and 76.5%, respectively) in maternal serum samples, while fluoranthene (FLT) had the highest concentration and detection rate (geometric mean = 68.4 ng/g and 50.6%, respectively) in the cord blood. Most of the measured PAHs in maternal serum and three PAHs in cord blood were inversely but non-significantly associated with birth weight. The strongest associations were observed for higher concentrations of benzo (a) pyrene (BaP) in maternal serum (230.7 g decrease for levels > median vs. < LOD;p = 0.151) and for ANT in cord blood (153.1 g decrease for levels < median vs. < LOD;p = 0.208). Ant and FLT were the predominant PAHs in the maternal and cord blood serum. Serum concentrations of several measured PAHs were associated with a decreased birth weight, although not significantly, suggesting that further studies with larger sample sizes are needed to validate our findings.
文摘Objective:Early detection and treatment in patients with esophageal cancer is the most effective way to improve the prognosis.Patients with high-grade dysplasia(HGD)in esophageal mucosa might be involved with early esophageal cancer,but the management of the disease is controversial.The purpose of our study was to explore the management of esophageal mucosa with HGD.Methods:We retrospectively analyzed 10 patients with HGD in esophageal mucosa,who underwent esophagectomy in Cancer Hospital of Fudan University from 1999 to 2006.The surgical approach,postoperative morbidity,in-hospital complications and pathological results of the patients were analyzed.Basing on our data together with other studies,we aimed at looking for an appropriate management for patients with HGD.Results:Of the 10 patients who received esophagectomy,the pathological results showed that 2(20%)cases were in situ carcinoma and 8(80%)cases were invasive cancer with no regional lymph nodes involved.30-day mortality was 0.One patient experienced cervical anastomotic leakage,but healed in 2 weeks.There was no pulmonary complication.Conclusion:Most patients with HGD actually have occult carcinoma.High percentage of patients with HGD would develop into cancer during their lifetime.Esophagectomy is now a selective approach for the treatment of the patients with HGD.
文摘Objective:To compare mini-probe endoscopic ultrasonography(MCUS)with computed tomography(CT)in pre-operative T and N staging of esophageal cancer,and to find out the MCUS parameters to judge lymph nodes metastasis for esophageal cancer.Methods:Thirty-five patients received both MCUS and CT preoperatively,on both of which the T and N stages were determined.The accuracy,sensitivity,specificity,positive predicting value and negative predicting value were compared with the postoperative pathological results.Results:The accuracy of MCUS was 85.7% in T staging and 85.7% and 80.0% in N staging by two different methods,which were 45.7% and 74.3%,respectively,by CT.Conclusion:MCUS is better than CT in preoperative staging for esophageal cancer.The ratio of short to long axis(S/L)combined with short axis is a useful way to determine lymph nodes metastasis.
文摘Lottery has already been broadly used by countries to raise funds to construct the public organizations,but its function is decided by the rate of participation and expenditure levels.Using the lottery investigation data from Hainan Province,this paper analyzes the factors affecting the rate of participation and expenditure in Hainan Province by applying Probit and Tobit Model.It shows that factors such as gender,marriage,education level,attitude and the social environment have distinct influence on the individual lottery participation and expenditure decisions.Therefore,lottery is a restricted rational behavior affected by psychological and social environment variables.Publicity may play an important role in our country's lottery policy.Moreover,lottery policy in China should implement a development strategy which requires adjustment in product pattem and promotion approach.
基金supported by National Key R&D Program of China(2022YFA1103900)National Natural Science Foundation of China(82430099)+1 种基金the Clinical Research Special Project of Shanghai Municipal Health Commission(202440070)the Medical Research Special Project for Shanghai Science and Technology Innovation Action Plan(24Y12800400).
文摘Recent large-scale multi-omics studies have characterized the heterogeneity of esophageal squamous cell carcinoma(ESCC),but inconsistent clinical management has hindered the identification of prognostic markers and patient stratification.Here,we conducted genomic and transcriptomic profiling of 203 patients from the ECTOP-2002 study with full clinical information.Mutation in the mucin family,as well as APOBEC signature,were associated with poor prognosis.In contrast,activation of the epithelial-keratinization(EpK)pathway was strongly linked to favorable prognosis and lower post-chemotherapy recurrence rates.Independent validation supported S100A8+S100A9 complex as a key marker of EpK pathway.Furthermore,we established a prognostic stratification system,FU-ESCC subtyping,which defines three subtypes with distinct molecular and clinical features.The EpK-activated subtype retained characteristics of healthy squamous epithelial cells,showed high expression of the S100A8+S100A9 complex,and was associated with favorable prognosis.
基金supported by the National Key Research and Development Program of China(2024YFA1802100)the Strategic Priority Research Program of Chinese Academy of Sciences(XDB0570101)+5 种基金the National Natural Science Foundation of China(32370644,32121001)the National Key Research and Development Program of China(2024YFC3405901,2020YFA0803401)the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(ZDBS-LYSM013)Beijing Natural Science Foundation(L244023)Next-Generation Bioinformatics Algorithms(XDA0460302)CAS Youth Interdisciplinary Team。
文摘N^(6)-methyladenosine(m^(6)A)in RNA within R-loops plays pivotal roles in transcription regulation and genome stability.However,the precise impacts and distinct mechanisms of m^(6)A on both regulatory and aberrant R-loops remain poorly understood.Here,we reveal that METTL3,the nuclear m^(6)A writer,ensures genome integrity by differentially modulating R-loops in a position-and length-dependent manner.In mouse embryonic stem cells(m ESCs),Mettl3 depletion results in impaired cell proliferation and increased cell death due to excessive DNA damage.Notably,Mettl3 knockout reduces the overall abundance of R-loops,with a decrease in broad R-loops and an increase in sharp Rloops.R-loops are diminished near transcription end sites(TESs),leading to transcriptional readthrough of genes with m^(6)A-modified transcripts and potentially contributing to genome instability.Conversely,increased sharp R-loops located in the antisense orientation relative to gene transcription are associated with DNA damage hotspots.These findings unveil a dual regulatory mechanism in which METTL3-m^(6)A orchestrates transcription fidelity and genome stability through distinct R-loop-dependent manners.
基金National key research and development program of China(2016YFD0200900,2016YFD0501200)the Chinese Academy of Science STS Project(KFJ-STS-QYZD-095)Agricultural innovation project of Hunan Province(2019TD01).
文摘The present study aimed to evaluate the effects of manganese methionine hydroxyl analog chelated(Mn-MHAC)as a manganese(Mn)source on growth performance and trace element deposition in broilers.A total of 432 Arbor Acres commercial female broilers were fed a basal corn-soybean diet containing Mn at 25.64 mg/kg diet for 10 d.They were then randomly assigned to 6 groups,including a control group(the basal diet),a Mn sulfate group(the basal diet supplemented with Mn at 100 mg/kg diet),and 4 Mn-MHAC groups(the basal diet supplemented with Mn-MHAC at 25,50,75 and 100 mg Mn/kg diet,respectively).The results showed that compared with the control group,groups supplemented with Mn-MHAC had a positive effect on BW(quadratic,P=0.017)and ADG(quadratic,P=0.017).Moreover,the Mn-MHAC(50 mg Mn/kg diet)group had significantly greater BW and ADG(P<0.05)compared with the other Mn-MHAC groups.Trace element deposition results also showed that tibial Mn increased(linear or quadratic,P-0.002 and 0.009,respectively)in groups fed diets with increased levels of Mn-MHAC.In contrast,Fe deposition decreased both in the heart(linear,P-0.020)and tibia(P<0.05).In addition,the Mn-MHAC supplement noticeably lowered serum Mn-SOD activity(linear or quadratic,P-0.048 and 0.019,respectively).The relative mRNA levels of divalent metal transporter 1(DMT1)(P=0.024),ferro-portin 1(FPN1)(P=0.049),and Cu transporter-1(CTR1)(P<0.001)in the duodenum,as well as CTR1 in the jejunum and ileum(P=0.040 and 0.011,respectively)were higher in the Mn-supplemented group than in the control group.Furthermore,the relative mRNA level of DMT1 in the jejunum and ileum of broilers in the Mn-MHAC group(50 mg Mn/kg diet)did not differ from those in the control group,but was lower than those in the Mn sulfate group(P<0.05).In conclusion,Mn-MHAC dietary supplementation improved the growth performance and trace element deposition in broilers.From this study,we recommend the opti-mum Mn-MHAC level to meet the Mn requirement of broilers is 50 to 75 mg Mn/kg diet.
基金This work was supported by the National Natural Science Foundation of China(NSFC)(No.61991433)Pilot Project of CAS(No.XDB43030302)+2 种基金Equipment Pre-research(No.2006ZYGG0304)Key Research and Development Project of Guangdong Province(No.2020B090922003)R&D Program of Jilin Province(No.20190302042GX).
文摘In this research,the highly efficient external cavity feedback technology based on volume Bragg grating(VBG)is studied.By using the structure of a fast axis collimating lens,the beam transformation system,a slow axis collimating lens,and VBG,the divergence angle of the fast and slow axes of the diode laser incident on the VBG is reduced effectively,and the feedback efficiency of the external cavity is improved.Combined with beam combining technology,fiber coupling technology,and precision temperature control technology,a high-power and narrow-linewidth diode laser pump source of kilowatt class is realized for alkali metal vapor laser pumping.The core diameter of the optical fiber is 1000μm,the numerical aperture is 0.22,the output power from the fiber is 1013 W,the fiber coupling efficiency exceeds 89%,and the external cavity efficiency exceeds 91%.The central wavelength is 852.052 nm(in air),which is tunable from 851.956 nm to 852.152 nm,and the spectral linewidth is 0.167 nm.Research results can be used for cesium alkali metal vapor laser pumping.
基金financially supported by the Thirteen Fifth National Key Research and Development Program of China(Grant No.2016YFD0700102)Chang Jiang Scholars and Innovative Research Team in University of China(Grant No.IRT13039).
文摘Timely identifying and quantifying significant spatial and temporal variability in agricultural field has been a crucial factor for improving agricultural production and management.This paper focuses on the mainstream techniques and applications can be adopted to improve the field information collection method.In this paper,the development of wireless sensor networks(WSNs)and remote sensing(RS)technology were reviewed,especially the micro unmanned aerial vehicle(mUAV)-based WSNs and mUAV-based RS by analyzing its applications in field information collection,and pointed out its existing benefits and limitations.A system encompassed multiple technique approaches was proposed in this paper which is called air-ground multi-sensor monitoring system.With the diversification methods of in-field information collection and the improvement of detection precision,an infield information collection system will play an important role in controlling the farming operations of mechanized agriculture and optimizing the management of agricultural machinery group.In the future,the combination of mUAV,WSNs and RS for crop and soil monitoring will become a powerful tool to obtain field information,increase production,optimize the overall farming practices and input of resources and provide comprehensive reference for the study of soil-crops-machine relationships.
基金supported by the Non-profit Central Research Insti-tute Fund of Chinese Academy of Medical Sciences(grant number:2021-RC310-009).
文摘Lung cancer is one of the leading causes of cancer incidence and mortality worldwide.While smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nickel,and silica are well-established risk factors,many lung cancer cases cannot be explained by these known risk factors.Over the last two decades the incidence of adenocarcinoma has risen,and it now surpasses squamous cell carcinoma as the most common histologic subtype.This increase warrants new efforts to identify additional risk factors for specific lung cancer subtypes as well as a comprehensive review of current evidence from epidemiologic studies to inform future studies.Given the myriad exposures individuals experience in real-world settings,it is essential to investigate mixture effects from complex exposures and gene-environment interactions in relation to lung cancer and its subtypes.
