Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continu...Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.展开更多
Estuarine wetland is the transitional interface linking terrestrial with marine ecosystems,and wetland microbes are crucial to the biogeochemical cycles of nutrients.The soil samples were collected in four seasons(spr...Estuarine wetland is the transitional interface linking terrestrial with marine ecosystems,and wetland microbes are crucial to the biogeochemical cycles of nutrients.The soil samples were collected in four seasons(spring,S1;summer,S2;autumn,S3;and winter,S4)from Suaeda wetland of Shuangtaizi River estuary,Northeast China,and the variations of bacterial community were evaluated by high-throughput sequencing.Soil properties presented a significant seasonal change,including p H,carbon(C)and total nitrogen(TN),and the microbial diversity,richness and structure also differed with seasons.Canonical correspondence analysis(CCA)and Mantel tests implied that soil p H,C and TN were the key factors structuring the microbial community.Gillisia(belonging to Bacteroidetes)and Woeseia(affiliating with Gammaproteobacteria)were the two primary components in the rhizosphere soils,displaying opposite variations with seasons.Based on PICRUSt(Phylogenetic Investigation of Communities by Reconstruction of Unobserved States)prediction,the xenobiotics biodegradation related genes exhibited a seasonal decline,while the majority of biomarker genes involved in nitrogen cycle showed an ascending trend.These findings could advance the understanding of rhizosphere microbiota of Suaeda in estuarine wetland.展开更多
In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of ...In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of stroke patients.Traditional Chinese medicine has signifi‐cant therapeutic effects in treating this disease.This article provides a classification and review of traditional Chinese medicine treatment methods for post-stroke depression,and looks forward to the current problems.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82003977,82274134 and 82274139)the National Key Research and Development Plan(No.2017YFC1702200)+1 种基金the Key Research and Development Program of Zhejiang Province(No.2020C04020)the Science and Technology Program of Zhejiang Province(No.2025C02183).
文摘Inflammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic inflammatory condition affecting the gastrointestinal tract.The global incidence and prevalence of IBD continue to increase.While multiple clinical treatments exist,conventional therapies frequently present limitations and adverse effects.Natural polysaccharides(PSs)have emerged as a significant focus of research interest due to their therapeutic potential and applications in functional foods and health products.This review synthesizes current understanding of IBD pathophysiology and the mechanisms by which natural PSs counter IBD,including their capacity to restore immune homeostasis and intestinal barrier function,modulate gut microbiota and metabolites,reduce oxidative stress,and address irregularities in autophagy and endoplasmic reticulum stress(ERS).The review examines the structure-activity relationships of PSs demonstrating anti-IBD effects and identifies promising therapeutic products.The discussion encompasses pharmacokinetics,safety evaluations,and clinical applications of these compounds.This comprehensive review establishes a theoretical foundation for developing natural PS-based therapeutic approaches for IBD management.
基金supported by the National Natural Science Foundation of China(Nos.31970107,51508068)the Fundamental Research Funds for the Central Universities(No.DUT19JC17)support from the Undergraduate Innovation and En-trepreneurship Training Program in Dalian University of Technology。
文摘Estuarine wetland is the transitional interface linking terrestrial with marine ecosystems,and wetland microbes are crucial to the biogeochemical cycles of nutrients.The soil samples were collected in four seasons(spring,S1;summer,S2;autumn,S3;and winter,S4)from Suaeda wetland of Shuangtaizi River estuary,Northeast China,and the variations of bacterial community were evaluated by high-throughput sequencing.Soil properties presented a significant seasonal change,including p H,carbon(C)and total nitrogen(TN),and the microbial diversity,richness and structure also differed with seasons.Canonical correspondence analysis(CCA)and Mantel tests implied that soil p H,C and TN were the key factors structuring the microbial community.Gillisia(belonging to Bacteroidetes)and Woeseia(affiliating with Gammaproteobacteria)were the two primary components in the rhizosphere soils,displaying opposite variations with seasons.Based on PICRUSt(Phylogenetic Investigation of Communities by Reconstruction of Unobserved States)prediction,the xenobiotics biodegradation related genes exhibited a seasonal decline,while the majority of biomarker genes involved in nitrogen cycle showed an ascending trend.These findings could advance the understanding of rhizosphere microbiota of Suaeda in estuarine wetland.
文摘In recent years,the incidence rate of stroke has increased year by year.Post stroke depres‐sion is one of its main complications,which seriously affects the recovery of physiological functions and quality of life of stroke patients.Traditional Chinese medicine has signifi‐cant therapeutic effects in treating this disease.This article provides a classification and review of traditional Chinese medicine treatment methods for post-stroke depression,and looks forward to the current problems.
