Obstructive sleep apnea(OSA)is a global public health concern characterized by repeated upper airway collapse during sleep.Research indicates that OSA is a risk factor for the development of various diseases,including...Obstructive sleep apnea(OSA)is a global public health concern characterized by repeated upper airway collapse during sleep.Research indicates that OSA is a risk factor for the development of various diseases,including cardiovascular disease,metabolic disorders,respiratory diseases,neurodegenerative diseases,and cancer.Exosomes,extracellular vesicles released by most cell types,play a key role in intercellular communication by transporting their contents—such as microRNA,messenger RNA,DNA,proteins,and lipids—to target cells.Intermittent hypoxia associated with OSA alters circulating exosomes and promotes a range of cellular structural and functional disturbances involved in the pathogenesis of OSA-related diseases.This review discusses the potential roles of exosomes and exosome-derived molecules in the onset and progression of OSA-associated diseases,explores the possible underlying mechanisms,and highlights novel strategies for developing exosome-based therapies for these conditions.展开更多
In the era of big data and the Internet of Things,the digital information of athletes is particularly significant in sports competitions.Here,an intelligent self-powered take-off board sensor(TBS)based on triboelectri...In the era of big data and the Internet of Things,the digital information of athletes is particularly significant in sports competitions.Here,an intelligent self-powered take-off board sensor(TBS)based on triboelectric nanogenerator(TENG)with a solid-wooden substrate is provided for precise detection of athletes’take-off status in the sport of triple-jumping,which is sufficient for triplejumping training judgment with a high accuracy of 1 mm.Meanwhile,a foul alarm system and a distance between the athlete’s foot and take-off line(GAP)measurement system are further developed to provide take-off data for athletes and referees.The induced charges are formed by the TBS during taking-off,and then the real-time exercise data is acquired and processed via the test program.This work presents a self-powered sports sensor for intelligent sports monitoring and promotes the application of TENG-based sensors in intelligent sports.展开更多
基金supported by the National Natural Science Foundation of China(Nos.82001490,82100039,82170039,and 82360006)the National Key Clinical Specialty Construction Projects of China,and the China Scholarship Council(No.202406370116).
文摘Obstructive sleep apnea(OSA)is a global public health concern characterized by repeated upper airway collapse during sleep.Research indicates that OSA is a risk factor for the development of various diseases,including cardiovascular disease,metabolic disorders,respiratory diseases,neurodegenerative diseases,and cancer.Exosomes,extracellular vesicles released by most cell types,play a key role in intercellular communication by transporting their contents—such as microRNA,messenger RNA,DNA,proteins,and lipids—to target cells.Intermittent hypoxia associated with OSA alters circulating exosomes and promotes a range of cellular structural and functional disturbances involved in the pathogenesis of OSA-related diseases.This review discusses the potential roles of exosomes and exosome-derived molecules in the onset and progression of OSA-associated diseases,explores the possible underlying mechanisms,and highlights novel strategies for developing exosome-based therapies for these conditions.
基金supported by the National Natural Science Foundation of China(No.61503051).
文摘In the era of big data and the Internet of Things,the digital information of athletes is particularly significant in sports competitions.Here,an intelligent self-powered take-off board sensor(TBS)based on triboelectric nanogenerator(TENG)with a solid-wooden substrate is provided for precise detection of athletes’take-off status in the sport of triple-jumping,which is sufficient for triplejumping training judgment with a high accuracy of 1 mm.Meanwhile,a foul alarm system and a distance between the athlete’s foot and take-off line(GAP)measurement system are further developed to provide take-off data for athletes and referees.The induced charges are formed by the TBS during taking-off,and then the real-time exercise data is acquired and processed via the test program.This work presents a self-powered sports sensor for intelligent sports monitoring and promotes the application of TENG-based sensors in intelligent sports.
