Transition metal compounds(TMCs)with high theoretical capacity have been considered as promising battery-type electrode materials for hybrid supercapacitors(HSCs),yet they often encounter low rate capability and poor ...Transition metal compounds(TMCs)with high theoretical capacity have been considered as promising battery-type electrode materials for hybrid supercapacitors(HSCs),yet they often encounter low rate capability and poor cycling performance.Herein,the NiCoSe2 nanoparticles strongly bonded on the N-doped SiC nanowires(N-S@b-NCS)with Ni/Co-N bonds in their interfaces are firstly constructed via an electrodeposition method.Theoretical calculations indicate that the unique interfacial chemical bonding with built-in electric field can not only significantly facilitate charge transfer and reduce the ion diffusion barrier,but also effectively guarantee structure integration induced by the timely release of stress concentration.Benefiting from the advantages,the achieved N-S@b-NCS exhibits high specific capacity of 254.4 mAh·g^(-1)at 1 A·g^(-1)and still retains 183.2 mAh·g^(-1)even at 100 A·g^(-1),as well as outstanding cycling stability with~90%capacity retention after 30,000 cycles.Additionally,a hybrid supercapacitor assembled by the obtained N-S@b-NCS displays a high energy density of 71.4 Wh·kg^(-1)at 16 kW·kg^(-1)and excellent durability.This work provides a creative strategy for how to construct the bonded interface with ions diffusion highway and long-term cycling stability,which can greatly push the large-scale applications of the TMCs.展开更多
Three-dimensional reconstruction of tissue architecture is crucial for biomedical research.Tissue optical clearing technology overcomes light scattering limitations in biological tissues,providing an essential tool fo...Three-dimensional reconstruction of tissue architecture is crucial for biomedical research.Tissue optical clearing technology overcomes light scattering limitations in biological tissues,providing an essential tool for high-resolution three-dimensional imaging.Given the high degree of similarity between large model animals(e.g.,pigs,non-human primates)and humans in terms of anatomical structure,physiologic function,and disease mechanisms,the application of this technology in these models holds significant value for biomedical research.While well-established tissue clearing protocols exist for tissue sections,whole organs,and even entire bodies in rodents,scaling up to large animal specimens presents substantial challenges due to dimensional effects and compositional variations.This review systematically examines the methodological translation from rodent to large animals,particularly on species-specific differences in brain architecture and parenchymal organ composition that critically impact clearing efficiency.We comprehensively summarize recent applications in large animals,focusing on representative areas including neural circuit mapping,sensory organ imaging,and other related research domains,while proposing optimization strategies to overcome cross-species compatibility barriers.We hope this review will serve as a valuable reference for advancing tissue optical clearing applications in large-animal biomedical research.展开更多
The hypoxic microenvironment is an essential characteristic of most malignant tu-mors.Notably,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical path...The hypoxic microenvironment is an essential characteristic of most malignant tu-mors.Notably,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via HIF-1a.In the intra-tumoral hypoxic environment,HIF-1αis highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in patients.Recently,it has been indicated that HiF-1αinvolves in various critical pro-cesses of life events and tumor development via regulating the expression of HiF-1a target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,etc.Apart from solid tumors,accumulating evidence has re-vealed that HiF-1αis also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple myeloma.Targeted inhibition of HiF-1a can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic agents.In the review,we elaborated on the basic structure and biological functions of HIF-1a and summarized their current role in various malignancies.It is expected that they will have future potential fortargeted therapy.展开更多
As a representative chemotherapeutic drug,docetaxel(DTX)has been used for breast cancer treatment for decades.However,the poor solubility of DTX limits its efficacy,and the DTX based therapy increases the metastasis r...As a representative chemotherapeutic drug,docetaxel(DTX)has been used for breast cancer treatment for decades.However,the poor solubility of DTX limits its efficacy,and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4(CXCR4)expression during the treatment.Herein,we conjugated CXCR4 antagonist peptide(CTCE)with DTX(termed CTCE-DTX)as an anti-metastasis agent to treat breast cancer.CTCE-DTX could selfassemble to nanoparticles,targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX efficacy.Thus,the CTCE-DTX NPs achieved promising efficacy on inhibiting both bonespecific metastasis and lung metastasis of triple-negative breast cancer.Our work provided a rational strategy on designing peptide-drug conjugates with synergistic anti-tumor efficacy.展开更多
基金supported by the National Natural Science Foundation of China(Nos.52072196,52202262,22379081,and 22379080)the Natural Science Foundation of Shandong Province(Nos.ZR202108180009 and ZR2023QE059).
文摘Transition metal compounds(TMCs)with high theoretical capacity have been considered as promising battery-type electrode materials for hybrid supercapacitors(HSCs),yet they often encounter low rate capability and poor cycling performance.Herein,the NiCoSe2 nanoparticles strongly bonded on the N-doped SiC nanowires(N-S@b-NCS)with Ni/Co-N bonds in their interfaces are firstly constructed via an electrodeposition method.Theoretical calculations indicate that the unique interfacial chemical bonding with built-in electric field can not only significantly facilitate charge transfer and reduce the ion diffusion barrier,but also effectively guarantee structure integration induced by the timely release of stress concentration.Benefiting from the advantages,the achieved N-S@b-NCS exhibits high specific capacity of 254.4 mAh·g^(-1)at 1 A·g^(-1)and still retains 183.2 mAh·g^(-1)even at 100 A·g^(-1),as well as outstanding cycling stability with~90%capacity retention after 30,000 cycles.Additionally,a hybrid supercapacitor assembled by the obtained N-S@b-NCS displays a high energy density of 71.4 Wh·kg^(-1)at 16 kW·kg^(-1)and excellent durability.This work provides a creative strategy for how to construct the bonded interface with ions diffusion highway and long-term cycling stability,which can greatly push the large-scale applications of the TMCs.
基金supported by the National Natural Science Foundation of China(Grant Nos.62375096,82361138569,82372012,82402341)the Open Competition Project of Wuhan East Lake High-tech Development Zone(Grant No.2023KJB224)the Innovation Project of Optics Valley Laboratory(Grant No.OVL2025BB008).
文摘Three-dimensional reconstruction of tissue architecture is crucial for biomedical research.Tissue optical clearing technology overcomes light scattering limitations in biological tissues,providing an essential tool for high-resolution three-dimensional imaging.Given the high degree of similarity between large model animals(e.g.,pigs,non-human primates)and humans in terms of anatomical structure,physiologic function,and disease mechanisms,the application of this technology in these models holds significant value for biomedical research.While well-established tissue clearing protocols exist for tissue sections,whole organs,and even entire bodies in rodents,scaling up to large animal specimens presents substantial challenges due to dimensional effects and compositional variations.This review systematically examines the methodological translation from rodent to large animals,particularly on species-specific differences in brain architecture and parenchymal organ composition that critically impact clearing efficiency.We comprehensively summarize recent applications in large animals,focusing on representative areas including neural circuit mapping,sensory organ imaging,and other related research domains,while proposing optimization strategies to overcome cross-species compatibility barriers.We hope this review will serve as a valuable reference for advancing tissue optical clearing applications in large-animal biomedical research.
基金supported by the National Natural Science Foundation of China(No.82070175)the Natural Science Foundation of Hunan Province(No.2022JJ30830)the Scientific Program of the Health Commission of Hunan Province(China)(No.20201179).
文摘The hypoxic microenvironment is an essential characteristic of most malignant tu-mors.Notably,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via HIF-1a.In the intra-tumoral hypoxic environment,HIF-1αis highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in patients.Recently,it has been indicated that HiF-1αinvolves in various critical pro-cesses of life events and tumor development via regulating the expression of HiF-1a target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,etc.Apart from solid tumors,accumulating evidence has re-vealed that HiF-1αis also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple myeloma.Targeted inhibition of HiF-1a can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic agents.In the review,we elaborated on the basic structure and biological functions of HIF-1a and summarized their current role in various malignancies.It is expected that they will have future potential fortargeted therapy.
基金sponsored by the National Natural Science Foundation of China(52173120,21877023,32271391)the Youth Innovation Promotion Association CAS(2021018,China)+1 种基金the Beijing Natural Science Foundation(L222015,China)the Beijing Nova Program(20220484233,China)。
文摘As a representative chemotherapeutic drug,docetaxel(DTX)has been used for breast cancer treatment for decades.However,the poor solubility of DTX limits its efficacy,and the DTX based therapy increases the metastasis risk due to the upregulation of C-X-C chemokine receptor type 4(CXCR4)expression during the treatment.Herein,we conjugated CXCR4 antagonist peptide(CTCE)with DTX(termed CTCE-DTX)as an anti-metastasis agent to treat breast cancer.CTCE-DTX could selfassemble to nanoparticles,targeting CXCR4-upregulated metastatic tumor cells and enhancing the DTX efficacy.Thus,the CTCE-DTX NPs achieved promising efficacy on inhibiting both bonespecific metastasis and lung metastasis of triple-negative breast cancer.Our work provided a rational strategy on designing peptide-drug conjugates with synergistic anti-tumor efficacy.
