Molecular glues(MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of protein-protein...Molecular glues(MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of protein-protein interactions. By altering the surface properties of either target proteins or E3 ligases, MGs promote the formation of a ternary complex comprising the MG, an E3 ligase, and a target protein. This interaction facilitates the polyubiquitination and subsequent degradation of the target protein via the ubiquitin-proteasome system.Owing to its distinctive mechanism of action and broad therapeutic potential, MG is offering novel approaches to disease treatment. This review summarizes recent advances in MGs targeting NEK7, WEE1, CDK2, GSPT1 and VAV1, emphasizing the rational design, benefits,and potential limitations, highlighting rational design principles, advantages, and current limitations including challenges in achieving selectivity and rational design that provide critical insights for enhancing MG efficacy. These developments are crucial for advancing the application and optimization of molecular glues targeting NEK7, WEE1, CDK2, GSPT1and VAV1.展开更多
The extraction of uranium from seawater via membrane adsorption is a promising strategy for ensuring a long-term supply of uranium and the sustainability of nuclear energy.However,this approach has been hindered by th...The extraction of uranium from seawater via membrane adsorption is a promising strategy for ensuring a long-term supply of uranium and the sustainability of nuclear energy.However,this approach has been hindered by the longstanding challenge of identifying sustainable membrane materials.In response,we propose a prototypal hybridization strategy to design a novel series of aminated conjugated microporous polymer(CMPN)@collagen fiber membrane(COLM).These sustainable and low-cost membrane materials allow a rapid and high-affinity kinetic to capture 90%of the uranium in just 30 min from 50 ppm with a high selectivity of Kd>105 mL·g^(−1).They also afford a robustly reusable adsorption capacity as high as 345 mg·g^(−1)that could harvest 1.61 mg·g^(−1)of uranium in a short 7-day real marine engineering in Fujian Province,even though suffered from very low uranium concentration of 3.29μg·L^(−1)and tough influence of salts such as 10.77 g·L^(−1)of Na^(+),1.75μg·L^(−1)of VO_(3)^(−)etc.in the rough seas.The structural evidence from both experimental and theoretical studies confirmed the formation of favorable chelating motifs from the amino group on CMPN-COLM,and the intensification by the synergistic effect from the size-sieving action of CMPN and the capillary inflow effect of COLM.展开更多
This study aims to explore how the Wei River Basin can enhance the efficiency of horizontal ecological compensation to promote high-quality and sustainable development in the Yellow River Basin.To achieve this,a four-...This study aims to explore how the Wei River Basin can enhance the efficiency of horizontal ecological compensation to promote high-quality and sustainable development in the Yellow River Basin.To achieve this,a four-stage DEA(Data Envelopment Analysis)method was employed to evaluate the efficiency of ecological compensation in six prefecture-level cities within the Wei River Basin from 2001 to 2022.In addition,the K-prototype clustering analysis method was integrated to assess the regional differences in ECE(ecological compensation efficiency).The findings indicate:(1)the ecological compensation efficiency in the upstream areas of the Wei River Basin is significantly higher than in the downstream regions;(2)the influence of factors such as the proportion of the tertiary industry,population density and residents’disposable income on the efficiency of ecological compensation is significant;(3)after excluding environmental factors,the overall ecological compensation efficiency showed a significant improvement.Based on these insights,it is recommended that the provinces of Shaanxi and Gansu further establish a robust compensation fund operation mechanism,build a cross-regional ecological compensation upstream-downstream coordination system,and strengthen inter-basin economic cooperation mechanisms to promote dual-driven development through technological advancement and scale benefits,thereby advancing ecological protection and sustainable development in the Wei River Basin.展开更多
Space-filling designs with superior low-dimensional properties are highly required in computer experiments.Strong orthogonal arrays(SOAs)represent a class of such designs that outperform ordinary orthogonal arrays in ...Space-filling designs with superior low-dimensional properties are highly required in computer experiments.Strong orthogonal arrays(SOAs)represent a class of such designs that outperform ordinary orthogonal arrays in their stratification properties within low dimensions.Nevertheless,current methods for constructing high-strength SOAs are rare,and they typically rely on regular designs,thereby limiting the number of runs in the final arrays to prime powers.This study presents new construction methods for three types of SOAs:SOAs of strength three,column-orthogonal SOAs(OSOAs)of strength three and three minus.The resulting designs have run sizes of twice an odd prime power without replications,filling the gaps in run sizes left by existing constructions.The projection properties of Addelman–Kempthorne orthogonal arrays are instrumental in the development of these construction methods.展开更多
The Lower Cambrian Longwangmiao Formation shoal dolostone reservoir in Sichuan Basin is currently an exploration and research highlight in China. Reservoir rocks mainly consist of crystalline dolomite with residual gr...The Lower Cambrian Longwangmiao Formation shoal dolostone reservoir in Sichuan Basin is currently an exploration and research highlight in China. Reservoir rocks mainly consist of crystalline dolomite with residual grain texture, and dolarenite of which the arene is mainly composed of muddy to micritic dolomite with some crystalline grain directionally aligned. The trace element indicates that the dolomites of Longwangmiao Formation may be related to the high salinity of sea water. The oxygen isotope values of crystalline dolomite and dolarenite are both similar to that of the Early Cambrian marine dolomites, and the carbon isotope values of every kind of dolomites are completely overlapped with that of the seawater in Early Cambrian, indicating the dolomitization fluid is originated from the Early Cambrian sea water. The restricted marine biological communities and a small amount of gypsum pseudonodule seen in muddy to micritic dolomite indicate that the sea water in Early Cambrian was restricted and evaporated. However, the general lack of massive evaporite mineral and gypsum karst breccia indicates that the salinity of sea water during dolomitization was lower than the value of gypsum＇s precipitation. The Longwangmiao Formation consists of several high-frequency sedimentary cycles, indicating frequent sea level changes. This study indicates that massive dolomitization may also occur in underwater palaeohigh in carbonate platform through the reflux of penesaline sea water driven by a combination of high-and low-frequency sea-level changes. This kind of dolomitization can explain the generation of massive dolomites in the absence of evaporite precipitation, and further indicates that replacement dolomites can be produced by sea water with a wide range of salinity（normal, penesaline to hypersaline）.展开更多
Metamorphic mechanism has the advantages of variable topology and variable degrees of freedom, which can realize the requirements of multi-conditions and multi-tasks, and has a good application prospect. The configura...Metamorphic mechanism has the advantages of variable topology and variable degrees of freedom, which can realize the requirements of multi-conditions and multi-tasks, and has a good application prospect. The configuration transformation is prominent feature of the metamorphic mechanism. The number of constraints or properties of the kinematic pairs provided by the metamorphic kinematic pairs will change under certain conditions, its dynamic performance is much more complex than that of traditional kinematic pairs with immutable constraints. However, the clearance model about traditional kinematic pairs with immutable constraints established by long-term research is difficult to be directly applied to the metachromatic kinematic pairs. Referring to the experience of the traditional kinematic pairs with immutable constraints, the continuous contact model of Metamorphic Groove pin pair with clearance is established. According to the traditional continuous contact model of the kinematic pairs with immutable constraints, the forces between the elements of kinematic pair of the mechanism with clearance and the ideal mechanism without clearance are regarded as the same, and the inertia force and inertia moment of the components are also calculated according to the acceleration of the ideal mechanism. The clearance is regarded as a massless virtual bar with length r. For the rotating pair part, the massless virtual bar length r is the difference between the radius of the shaft and the hole, and for the sliding pair part, the massless virtual bar length r is half of the difference between the height of the slider and the guide groove. According to the new mechanism without gap after adding the imaginary bar, kinetic energy and potential energy of the system are calculated for the two configurations of mechanism with metamorphic Groove pin pair with clearance. The kinetic energy and potential energy of the system are calculated according to the new mechanism without clearance after adding the massless virtual bar. The kinetic energy, potential energy and generalized force are substituted into the Lagrangian equation to obtain the motion equation of the metamorphic mechanism, which lays the foundation for the dynamic performance study of the mechanism with metamorphic groove pin pair with clearance.展开更多
In this study,two wheat-derived cadmium(Cd)-immobilizing endophytic Pseudomonas paralactis M14 and Priestia megaterium R27 were evaluated for their effects on wheat tissue Cd uptake under hydroponic conditions.Then,th...In this study,two wheat-derived cadmium(Cd)-immobilizing endophytic Pseudomonas paralactis M14 and Priestia megaterium R27 were evaluated for their effects on wheat tissue Cd uptake under hydroponic conditions.Then,the impacts of the biochar(BC),M14+R27(MR),and BC+MR treatments on wheat Cd uptake and the mechanisms involved were investigated at the jointing,heading,and mature stages of wheat plants under field-plot conditions.A hydroponic experiment showed that the MR treatment significantly decreased the above-ground tissue Cd content compared with theM14 or R27 treatment.The BC+MRtreatment reduced the grain Cd content by 51.5%-67.7%and Cd translocation factor at the mature stage of wheat plants and increased the organic matter-bound Cd content by 31%-75%in the rhizosphere soils compared with the BC or MR treatment.Compared with the BC or MR treatment,the relative abundances of the biomarkers associated with Gemmatimonas,Altererythrobacter,Gammaproteobacteria,Xanthomonadaceae,Phenylobacterium,and Nocardioides in the BC+MR-treated rhizosphere microbiome decreased and negatively correlated with the organic matter-bound Cd contents.In the BC+MR-treated root interior microbiome,the relative abundance of the biomarker belonging to Exiguobacterium increased and negatively correlated with the Cd translocation factor,while the relative abundance of the biomarker belonging to Pseudonocardiaceae decreased and positively correlated with the Cd translocation factor.Our findings suggested that the BC+MR treatment reduced Cd availability and Cd transfer through affecting the abundances of these specific biomarkers in the rhizosphere soil and root interior microbiomes,leading to decreased wheat grain Cd uptake in the contaminated soil.展开更多
Fluoropolymers promise all-solid-state lithium metal batteries(ASLMBs)but suffer from two critical challenges.The first is the trade-off between ionic conductivity(σ)and lithium anode reactions,closely related to hig...Fluoropolymers promise all-solid-state lithium metal batteries(ASLMBs)but suffer from two critical challenges.The first is the trade-off between ionic conductivity(σ)and lithium anode reactions,closely related to high-content residual solvents.The second,usually consciously overlooked,is the fluoropolymer's inherent instability against alkaline lithium anodes.Here,we propose indium-based metal-organic frameworks(In-MOFs)as a multifunctional promoter to simultaneously address these two challenges,using poly(vinylidene fluoride-hexafluoropropylene)(PVH)as the typical fluoropolymer.In-MOF plays a trio:(1)adsorbing and converting free residual solvents into bonded states to prevent their side reactions with lithium anodes while retaining their advantages on Li~+transport;(2)forming inorganic-rich solid electrolyte interphase layers to prevent PVH from reacting with lithium anodes and promote uniform lithium deposition without dendrite growth;(3)reducing PVH crystallinity and promoting Li-salt dissociation.Therefore,the resulting PVH/In-MOF(PVH-IM)showcases excellent electrochemical stability against lithium anodes,delivering a 5550 h cycling at 0.2 m A cm^(-2)with a remarkable cumulative lithium deposition capacity of 1110 m Ah cm^(-2).It also exhibits an ultrahighσof 1.23×10^(-3)S cm^(-1)at 25℃.Moreover,all-solid-state LiFePO_4|PVH-IM|Li full cells show outstanding rate capability and cyclability(80.0%capacity retention after 280 cycles at 0.5C),demonstrating high potential for practical ASLMBs.展开更多
The expansion of river plumes is essential for coastal systems and inner-shelf biogeochemical processes.This investigation employs the Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST)modeling system to systema...The expansion of river plumes is essential for coastal systems and inner-shelf biogeochemical processes.This investigation employs the Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST)modeling system to systematically analyze the governing mechanisms influencing the Changjiang River plume during winter conditions.Model validation through comparison with the observational datasets demonstrates the system’s capability to accurately reproduce hydrodynamic processes and thermohaline variability.A series of sensitivity experiments was implemented to quantify the relative contributions of distinct forcing mechanisms,including tidal dynamics,wind stress,and waveinduced processes on hydrodynamic patterns and associated temperature-salinity distributions.Numerical simulations reveal that wave-induced vertical mixing generates significant nearshore thermal elevation concurrent with salinity reduction.Tidal residual currents exhibit persistent onshore and northward components,potentially facilitating northward advection of the Changjiang River plume during winter months.Conversely,wind-driven currents impose a constraining effect on plume expansion through the establishment of downwelling-favorable circulation patterns.During extreme wave events,wave-driven current contributions to salinity variance account for 30%−90%,relative to tidal mixing effects.These findings collectively establish wave-current interaction as a critical mechanistic component governing wintertime Changjiang River plume dynamics,with particular relevance to stratification modification and cross-shelf transport processes.展开更多
The ineluctable introduction of lithium salt to polymer solid-state electrolytes incurs a compromise between strength,ionic conductivity,and thickness.Here,we propose Al_(2)O_(3)-coated polyimide(AO/PI)porous film as ...The ineluctable introduction of lithium salt to polymer solid-state electrolytes incurs a compromise between strength,ionic conductivity,and thickness.Here,we propose Al_(2)O_(3)-coated polyimide(AO/PI)porous film as a high-strength substrate to support fast-ion-conducting polymer-in-salt(PIS)solid-state electrolytes,aiming to suppress lithium dendrite growth and improve full-cell performance.The Al_(2)O_(3)coating layer not only refines the wettability of polyimide porous film to PIS,but also performs as a high modulus protective layer to suppress the growth of lithium dendrites.The resulting PI/AO@PIS exhibits a small thickness of only 35μm with an outstanding tensile strength of 11.3 MPa and Young's modulus of 537.6 MPa.In addition,the PI/AO@PIS delivers a high ionic conductivity of 0.1 m S/cm at 25°C.As a result,the PI/AO@PIS enables symmetric Li cells to achieve exceptional cyclability for over 1000 h at 0.1 m A/cm2without noticeable lithium dendrite formation.Moreover,the PI/AO@PIS-based LiFePO4||Li full cells demonstrate outstanding rate performance(125.7 m Ah/g at 5 C)and impressive cycling stability(96.1%capacity retention at 1 C after 200 cycles).This work highlights the efficacy of enhancing the mechanical properties of polymer matrices and extending cell performance through the incorporation of a dense inorganic interface layer.展开更多
Composite solid electrolytes(CSEs)are promising for solid-state Li metal batteries but suffer from inferior room-temperature ionic conductivity due to sluggish ion transport and high cost due to expensive active ceram...Composite solid electrolytes(CSEs)are promising for solid-state Li metal batteries but suffer from inferior room-temperature ionic conductivity due to sluggish ion transport and high cost due to expensive active ceramic fillers.Here,a host–vip inversion engineering strategy is proposed to develop superionic CSEs using cost-effective SiO_(2) nanoparticles as passive ceramic hosts and poly(vinylidene fluoride-hexafluoropropylene)(PVH)microspheres as polymer vips,forming an unprecedented“polymer vip-in-ceramic host”(i.e.,PVH-in-SiO_(2))architecture differing from the traditional“ceramic vip-in-polymer host”.The PVH-in-SiO_(2) exhibits excellent Li-salt dissociation,achieving high-concentration free Li+.Owing to the low diffusion energy barriers and high diffusion coefficient,the free Li+is thermodynamically and kinetically favorable to migrate to and transport at the SiO_(2)/PVH interfaces.Consequently,the PVH-in-SiO_(2) delivers an exceptional ionic conductivity of 1.32.10−3 S cm−1 at 25℃(vs.typically 10−5–10−4 S cm−1 using high-cost active ceramics),achieved under an ultralow residual solvent content of 2.9 wt%(vs.8–15 wt%in other CSEs).Additionally,PVH-in-SiO_(2) is electrochemically stable with Li anode and various cathodes.Therefore,the PVH-in-SiO_(2) demonstrates excellent high-rate cyclability in LiFePO4|Li full cells(92.9%capacity-retention at 3C after 300 cycles under 25℃)and outstanding stability with high-mass-loading LiFePO4(9.2 mg cm−1)and high-voltage NCM622(147.1 mAh g−1).Furthermore,we verify the versatility of the host–vip inversion engineering strategy by fabricating Na-ion and K-ion-based PVH-in-SiO_(2) CSEs with similarly excellent promotions in ionic conductivity.Our strategy offers a simple,low-cost approach to fabricating superionic CSEs for large-scale application of solid-state Li metal batteries and beyond.展开更多
Halide solid-state electrolytes(HSSEs)with excellent ionic conductivity and high voltage stability are promising for all-solid-state Li-ion batteries(ASSLBs).However,they suffer from poor processability,mechanical dur...Halide solid-state electrolytes(HSSEs)with excellent ionic conductivity and high voltage stability are promising for all-solid-state Li-ion batteries(ASSLBs).However,they suffer from poor processability,mechanical durability and humidity stability,hindering their large-scale applications.Here,we introduce a dry-processing fibrillation strategy using hydrophobic polytetrafluoroethylene(PTFE)binder to encapsulate Li_(3)InCl_(6)(LIC)particles(the most representative HSSE).By manipulating the fibrillating process,only 0.5 wt%PTFE is sufficient to prepare free-standing LIC-PTFE(LIC-P)HSSEs.Additionally,LIC-P demonstrates excellent mechanical durability and humidity resistance.They can maintain their shapes after being exposed to humid atmosphere for 30 min,meanwhile still exhibit high ionic conductivity of>0.2m S/cm at 25℃.Consequently,the LIC-P-based ASSLBs deliver a high specific capacity of 126.6 m Ah/g at0.1 C and long cyclability of 200 cycles at 0.2 C.More importantly,the ASSLBs using moisture-exposed LIC-P can still operate properly by exhibiting a high capacity-retention of 87.7%after 100 cycles under0.2 C.Furthermore,for the first time,we unravel the LIC interfacial morphology evolution upon cycling because the good mechanical durability enables a facile separation of LIC-P from ASSLBs after testing.展开更多
Objective:Diabetic Peripheral Neuropathy(DPN)is a common chronic complication of diabetes that currently has no therapeutic recourse.Advanced DPN stages are characterized by severe symptoms that place a huge burden on...Objective:Diabetic Peripheral Neuropathy(DPN)is a common chronic complication of diabetes that currently has no therapeutic recourse.Advanced DPN stages are characterized by severe symptoms that place a huge burden on patients and healthcare systems.To the best of our knowledge,research hotspots within the field of DPN are yet to be visually analyzed,and so is the exploration of developmental dynamics within the same discipline.Methods:Herein,DPN articles published between 2002 and 2022 were retrieved from the Web of Science Core Collection database.Following that,bibliometric analysis was performed on these articles using CiteSpace,VOSviewer,Microsoft Excel,and R-bibliometrix tools.Results:We retrieved 2,761 DPN articles involving 11,605 researchers from 1,140 institutions in 99 countries/regions.The United States was the country/region with the highest number of publications.The most productive author was Malik Rayaz A from the University of Manchester,which was the most productive institution.The most co-cited journals were Diabetes Care,Pain,and Neurology.On the other hand,#0 neuropathic pain,#1 neuropathic pain treatment and#2 peripheral neuropathy were the most clustered keywords in co-cited references.Based on the clustering of keywords,timeline graphs,and citation bursts,“risk”,“corneal confocal microscopy”and“systematic review”were identifi ed as the key issues for future DPN research.Conclusion:This article summarizes the current DPN research status and focus areas,reveals the future development trend,and points out potential research directions for DPN scholars.展开更多
The discrete fracture system of a rock mass plays a crucial role in controlling the stability of rock slopes.To fully account for the geometric shape and distribution characteristics of jointed rock masses,terrestrial...The discrete fracture system of a rock mass plays a crucial role in controlling the stability of rock slopes.To fully account for the geometric shape and distribution characteristics of jointed rock masses,terrestrial laser scanning(TLS)was employed to acquire high-resolution point-cloud data,and a developed automatic discontinuity-identification technology was coupled to automatically interpret and characterize geometric information such as orientation,trace length,spacing,and set number of the discontinuities.The discrete element method(DEM)was applied to study the influence of the geometric morphology and distribution characteristics of discontinuities on slope stability by generating a discrete fracture network(DFN)with the same statistical characteristics as the actual discontinuities.Based on slope data from the Yebatan Hydropower Station,a simulation was conducted to verify the applicability of the automatic discontinuity identification technology and the discrete fracture network-discrete element method(DFN-DEM).Various geological parameters,including trace length,persistence,and density,were examined to investigate the morphological evolution and response characteristics of rock slope excavation under different joint combination conditions through simulation.The simulation results indicate that joint parameters affect slope stability,with density having the most significant impact.The impact of joint parameters on stability is relatively small within a reasonable range but becomes significant beyond a certain threshold,further validating that the accuracy of field geological surveys is critical for simulation.This study provides a scientific basis for the construction of complex rock slope models,engineering assessments,and disaster prevention and mitigation,which is of great value in both theory and engineering applications.展开更多
The river plume front between the diluted ocean water and salty ocean water in the Changjiang(Yangtze)River Delta(CRD)is well studied.Comparatively,less is known about the estuarine front in the CRD,which is formed be...The river plume front between the diluted ocean water and salty ocean water in the Changjiang(Yangtze)River Delta(CRD)is well studied.Comparatively,less is known about the estuarine front in the CRD,which is formed between the riverine freshwater and the diluted ocean water and has the highest magnitude of salinity gradient(SG)in the CRD.Estuarine fronts are of great significance to the riverine material transport in the estuary.Many biogeochemical processes are enhanced in estuarine fronts,which have brought about environmental problems.In this study,the seasonal variations of the estuarine fronts in the CRD were studied in wet(July)and dry(January)seasons in 2017,based on model simulations with high spatiotemporal resolutions using the Finite-Volume Community Ocean Model(FVCOM).The estuarine front included several sharp fronts with a SG>4(/500 m),and was bottom-trapped on the submerged delta front.Seasonal changes mainly occurred off the Jiangsu coast,where a significant estuarine front was formed in July.The estuarine fronts generated around the submerged delta topography were accompanied by the offshore extension of older estuarine fronts,which were diluted and evolved into plume fronts over a tidal cycle.The simulated estuarine fronts had a salinity range of 6 to 22 in the dry season and 6 to 14 in wet season 2017.The estuarine fronts hindered the residual current by altering its flow direction to the southeast.展开更多
Spartina alterniflora's robust reproductive capacity has enabled it to spread rapidly, posing a serious threat to native ecosystems in China. Therefore, accurate quantification of Spartina alterniflora aboveground...Spartina alterniflora's robust reproductive capacity has enabled it to spread rapidly, posing a serious threat to native ecosystems in China. Therefore, accurate quantification of Spartina alterniflora aboveground biomass at a fine scale is crucial for understanding its growth dynamics and managing its invasion. This study focuses on the coastal wetlands of central Jiangsu Province, China, utilizing multispectral unmanned aerial vehicle(UAV) data to map the distribution of Spartina alterniflora. Object-based image analysis(OBIA) combined with support vector machines(SVM) was employed for classification. Additionally, multiple regression models, including univariate, band-based, vegetation index(VI)-based, and multivariate linear regression models integrating both band and VI data, were developed to estimate biomass:(1) the Bands + VIs multiple linear regression model based on fresh weight exhibited the highest estimation accuracy;(2) the optimal model achieved R^(2) values of 0.81 and 0.82 at Dafeng and Tiaozini Nature Reserve,with RMSE values of 591.78 g/m^(2) and 337.62 g/m^(2), and MAE values of 576.82 g/m^(2) and 287.71 g/m^(2), respectively;and(3) the aboveground biomass of Spartina alterniflora primarily ranged from 994.60 g/m^(2) to 5 351.48 g/m^(2) at Dafeng and from 796.05 g/m^(2) to 1 994.02 g/m^(2) in Tiaozini Nature Reserve. These findings highlight the effectiveness of multispectral UAV technology for accurately estimating Spartina alterniflora biomass, providing a robust methodology for wetland vegetation monitoring and invasive species management.展开更多
基金supported by the National Natural Science Foundation of China (No. 82304306)the Hubei Key Laboratory of Kidney Disease Occurrence and Intervention Development Fund (No. 2023SB108)+4 种基金the Huangshi City Science and Innovation Team Project of China (CXPT2023000002)the talent introduction program from Hubei Polytechnic University (No.19XJK07R)the Department of Education of Hubei Provincial Science and Technology Research Project (No. D20234502)the PostDoctoral Research Start-up Fund of Lishui People's Hospital, Zhejiang, China (2023bsh002)the Zhejiang Provincial Postdoctoral Research Project of Meritorious Support (ZJ2024007)。
文摘Molecular glues(MGs), a class of small-molecule degraders, exhibit drug-like properties that generally conform to Lipinski's rule of five, while uniquely mediating the stabilization or induction of protein-protein interactions. By altering the surface properties of either target proteins or E3 ligases, MGs promote the formation of a ternary complex comprising the MG, an E3 ligase, and a target protein. This interaction facilitates the polyubiquitination and subsequent degradation of the target protein via the ubiquitin-proteasome system.Owing to its distinctive mechanism of action and broad therapeutic potential, MG is offering novel approaches to disease treatment. This review summarizes recent advances in MGs targeting NEK7, WEE1, CDK2, GSPT1 and VAV1, emphasizing the rational design, benefits,and potential limitations, highlighting rational design principles, advantages, and current limitations including challenges in achieving selectivity and rational design that provide critical insights for enhancing MG efficacy. These developments are crucial for advancing the application and optimization of molecular glues targeting NEK7, WEE1, CDK2, GSPT1and VAV1.
基金supported by National Natural Science Foundation of China(Grant No.22378066,22108040)Collaboration&Innovation Platform Project of National Independent Innovation Demonstration Zone(Fuzhou,Xiamen&Quanzhou)(Project No:3502ZCQXT2023004).
文摘The extraction of uranium from seawater via membrane adsorption is a promising strategy for ensuring a long-term supply of uranium and the sustainability of nuclear energy.However,this approach has been hindered by the longstanding challenge of identifying sustainable membrane materials.In response,we propose a prototypal hybridization strategy to design a novel series of aminated conjugated microporous polymer(CMPN)@collagen fiber membrane(COLM).These sustainable and low-cost membrane materials allow a rapid and high-affinity kinetic to capture 90%of the uranium in just 30 min from 50 ppm with a high selectivity of Kd>105 mL·g^(−1).They also afford a robustly reusable adsorption capacity as high as 345 mg·g^(−1)that could harvest 1.61 mg·g^(−1)of uranium in a short 7-day real marine engineering in Fujian Province,even though suffered from very low uranium concentration of 3.29μg·L^(−1)and tough influence of salts such as 10.77 g·L^(−1)of Na^(+),1.75μg·L^(−1)of VO_(3)^(−)etc.in the rough seas.The structural evidence from both experimental and theoretical studies confirmed the formation of favorable chelating motifs from the amino group on CMPN-COLM,and the intensification by the synergistic effect from the size-sieving action of CMPN and the capillary inflow effect of COLM.
基金funded by the Gansu Soft Science Planning Project(Grant No.25JRZA170).
文摘This study aims to explore how the Wei River Basin can enhance the efficiency of horizontal ecological compensation to promote high-quality and sustainable development in the Yellow River Basin.To achieve this,a four-stage DEA(Data Envelopment Analysis)method was employed to evaluate the efficiency of ecological compensation in six prefecture-level cities within the Wei River Basin from 2001 to 2022.In addition,the K-prototype clustering analysis method was integrated to assess the regional differences in ECE(ecological compensation efficiency).The findings indicate:(1)the ecological compensation efficiency in the upstream areas of the Wei River Basin is significantly higher than in the downstream regions;(2)the influence of factors such as the proportion of the tertiary industry,population density and residents’disposable income on the efficiency of ecological compensation is significant;(3)after excluding environmental factors,the overall ecological compensation efficiency showed a significant improvement.Based on these insights,it is recommended that the provinces of Shaanxi and Gansu further establish a robust compensation fund operation mechanism,build a cross-regional ecological compensation upstream-downstream coordination system,and strengthen inter-basin economic cooperation mechanisms to promote dual-driven development through technological advancement and scale benefits,thereby advancing ecological protection and sustainable development in the Wei River Basin.
基金supported by the Fundamental Research Funds for the Central Universities[grant number 2025JBZX013]the National Natural Science Foundation of China[grant numbers 12001036,12271166,32030063]+1 种基金Young Elite Scientists Sponsorship Program by CAST[grant number 2022QNRC001]National Key Research and Development Program of China[grant number 2024YFA1016200].
文摘Space-filling designs with superior low-dimensional properties are highly required in computer experiments.Strong orthogonal arrays(SOAs)represent a class of such designs that outperform ordinary orthogonal arrays in their stratification properties within low dimensions.Nevertheless,current methods for constructing high-strength SOAs are rare,and they typically rely on regular designs,thereby limiting the number of runs in the final arrays to prime powers.This study presents new construction methods for three types of SOAs:SOAs of strength three,column-orthogonal SOAs(OSOAs)of strength three and three minus.The resulting designs have run sizes of twice an odd prime power without replications,filling the gaps in run sizes left by existing constructions.The projection properties of Addelman–Kempthorne orthogonal arrays are instrumental in the development of these construction methods.
基金supported by the National Natural Science Foundation of China (No.41602166)
文摘The Lower Cambrian Longwangmiao Formation shoal dolostone reservoir in Sichuan Basin is currently an exploration and research highlight in China. Reservoir rocks mainly consist of crystalline dolomite with residual grain texture, and dolarenite of which the arene is mainly composed of muddy to micritic dolomite with some crystalline grain directionally aligned. The trace element indicates that the dolomites of Longwangmiao Formation may be related to the high salinity of sea water. The oxygen isotope values of crystalline dolomite and dolarenite are both similar to that of the Early Cambrian marine dolomites, and the carbon isotope values of every kind of dolomites are completely overlapped with that of the seawater in Early Cambrian, indicating the dolomitization fluid is originated from the Early Cambrian sea water. The restricted marine biological communities and a small amount of gypsum pseudonodule seen in muddy to micritic dolomite indicate that the sea water in Early Cambrian was restricted and evaporated. However, the general lack of massive evaporite mineral and gypsum karst breccia indicates that the salinity of sea water during dolomitization was lower than the value of gypsum＇s precipitation. The Longwangmiao Formation consists of several high-frequency sedimentary cycles, indicating frequent sea level changes. This study indicates that massive dolomitization may also occur in underwater palaeohigh in carbonate platform through the reflux of penesaline sea water driven by a combination of high-and low-frequency sea-level changes. This kind of dolomitization can explain the generation of massive dolomites in the absence of evaporite precipitation, and further indicates that replacement dolomites can be produced by sea water with a wide range of salinity（normal, penesaline to hypersaline）.
文摘Metamorphic mechanism has the advantages of variable topology and variable degrees of freedom, which can realize the requirements of multi-conditions and multi-tasks, and has a good application prospect. The configuration transformation is prominent feature of the metamorphic mechanism. The number of constraints or properties of the kinematic pairs provided by the metamorphic kinematic pairs will change under certain conditions, its dynamic performance is much more complex than that of traditional kinematic pairs with immutable constraints. However, the clearance model about traditional kinematic pairs with immutable constraints established by long-term research is difficult to be directly applied to the metachromatic kinematic pairs. Referring to the experience of the traditional kinematic pairs with immutable constraints, the continuous contact model of Metamorphic Groove pin pair with clearance is established. According to the traditional continuous contact model of the kinematic pairs with immutable constraints, the forces between the elements of kinematic pair of the mechanism with clearance and the ideal mechanism without clearance are regarded as the same, and the inertia force and inertia moment of the components are also calculated according to the acceleration of the ideal mechanism. The clearance is regarded as a massless virtual bar with length r. For the rotating pair part, the massless virtual bar length r is the difference between the radius of the shaft and the hole, and for the sliding pair part, the massless virtual bar length r is half of the difference between the height of the slider and the guide groove. According to the new mechanism without gap after adding the imaginary bar, kinetic energy and potential energy of the system are calculated for the two configurations of mechanism with metamorphic Groove pin pair with clearance. The kinetic energy and potential energy of the system are calculated according to the new mechanism without clearance after adding the massless virtual bar. The kinetic energy, potential energy and generalized force are substituted into the Lagrangian equation to obtain the motion equation of the metamorphic mechanism, which lays the foundation for the dynamic performance study of the mechanism with metamorphic groove pin pair with clearance.
基金supported by the National Natural Science Foundation of China(No.41977199).
文摘In this study,two wheat-derived cadmium(Cd)-immobilizing endophytic Pseudomonas paralactis M14 and Priestia megaterium R27 were evaluated for their effects on wheat tissue Cd uptake under hydroponic conditions.Then,the impacts of the biochar(BC),M14+R27(MR),and BC+MR treatments on wheat Cd uptake and the mechanisms involved were investigated at the jointing,heading,and mature stages of wheat plants under field-plot conditions.A hydroponic experiment showed that the MR treatment significantly decreased the above-ground tissue Cd content compared with theM14 or R27 treatment.The BC+MRtreatment reduced the grain Cd content by 51.5%-67.7%and Cd translocation factor at the mature stage of wheat plants and increased the organic matter-bound Cd content by 31%-75%in the rhizosphere soils compared with the BC or MR treatment.Compared with the BC or MR treatment,the relative abundances of the biomarkers associated with Gemmatimonas,Altererythrobacter,Gammaproteobacteria,Xanthomonadaceae,Phenylobacterium,and Nocardioides in the BC+MR-treated rhizosphere microbiome decreased and negatively correlated with the organic matter-bound Cd contents.In the BC+MR-treated root interior microbiome,the relative abundance of the biomarker belonging to Exiguobacterium increased and negatively correlated with the Cd translocation factor,while the relative abundance of the biomarker belonging to Pseudonocardiaceae decreased and positively correlated with the Cd translocation factor.Our findings suggested that the BC+MR treatment reduced Cd availability and Cd transfer through affecting the abundances of these specific biomarkers in the rhizosphere soil and root interior microbiomes,leading to decreased wheat grain Cd uptake in the contaminated soil.
基金the financial support from the 261 Project of MIITNatural Science Foundation of Jiangsu Province(No.BK20240179)。
文摘Fluoropolymers promise all-solid-state lithium metal batteries(ASLMBs)but suffer from two critical challenges.The first is the trade-off between ionic conductivity(σ)and lithium anode reactions,closely related to high-content residual solvents.The second,usually consciously overlooked,is the fluoropolymer's inherent instability against alkaline lithium anodes.Here,we propose indium-based metal-organic frameworks(In-MOFs)as a multifunctional promoter to simultaneously address these two challenges,using poly(vinylidene fluoride-hexafluoropropylene)(PVH)as the typical fluoropolymer.In-MOF plays a trio:(1)adsorbing and converting free residual solvents into bonded states to prevent their side reactions with lithium anodes while retaining their advantages on Li~+transport;(2)forming inorganic-rich solid electrolyte interphase layers to prevent PVH from reacting with lithium anodes and promote uniform lithium deposition without dendrite growth;(3)reducing PVH crystallinity and promoting Li-salt dissociation.Therefore,the resulting PVH/In-MOF(PVH-IM)showcases excellent electrochemical stability against lithium anodes,delivering a 5550 h cycling at 0.2 m A cm^(-2)with a remarkable cumulative lithium deposition capacity of 1110 m Ah cm^(-2).It also exhibits an ultrahighσof 1.23×10^(-3)S cm^(-1)at 25℃.Moreover,all-solid-state LiFePO_4|PVH-IM|Li full cells show outstanding rate capability and cyclability(80.0%capacity retention after 280 cycles at 0.5C),demonstrating high potential for practical ASLMBs.
基金The Strategic Priority Research Program of the Chinese Academy of Sciences under contract No.XDC0190102the National Key Research and Development Program of China under contract No.2022YFC3105005the Guangdong Key Project under contract No.2019BT02H594.
文摘The expansion of river plumes is essential for coastal systems and inner-shelf biogeochemical processes.This investigation employs the Coupled Ocean-Atmosphere-Wave-Sediment Transport(COAWST)modeling system to systematically analyze the governing mechanisms influencing the Changjiang River plume during winter conditions.Model validation through comparison with the observational datasets demonstrates the system’s capability to accurately reproduce hydrodynamic processes and thermohaline variability.A series of sensitivity experiments was implemented to quantify the relative contributions of distinct forcing mechanisms,including tidal dynamics,wind stress,and waveinduced processes on hydrodynamic patterns and associated temperature-salinity distributions.Numerical simulations reveal that wave-induced vertical mixing generates significant nearshore thermal elevation concurrent with salinity reduction.Tidal residual currents exhibit persistent onshore and northward components,potentially facilitating northward advection of the Changjiang River plume during winter months.Conversely,wind-driven currents impose a constraining effect on plume expansion through the establishment of downwelling-favorable circulation patterns.During extreme wave events,wave-driven current contributions to salinity variance account for 30%−90%,relative to tidal mixing effects.These findings collectively establish wave-current interaction as a critical mechanistic component governing wintertime Changjiang River plume dynamics,with particular relevance to stratification modification and cross-shelf transport processes.
基金the financial support from the 261Project of MIIT and Natural Science Foundation of Jiangsu Province(No.BK20240179)。
文摘The ineluctable introduction of lithium salt to polymer solid-state electrolytes incurs a compromise between strength,ionic conductivity,and thickness.Here,we propose Al_(2)O_(3)-coated polyimide(AO/PI)porous film as a high-strength substrate to support fast-ion-conducting polymer-in-salt(PIS)solid-state electrolytes,aiming to suppress lithium dendrite growth and improve full-cell performance.The Al_(2)O_(3)coating layer not only refines the wettability of polyimide porous film to PIS,but also performs as a high modulus protective layer to suppress the growth of lithium dendrites.The resulting PI/AO@PIS exhibits a small thickness of only 35μm with an outstanding tensile strength of 11.3 MPa and Young's modulus of 537.6 MPa.In addition,the PI/AO@PIS delivers a high ionic conductivity of 0.1 m S/cm at 25°C.As a result,the PI/AO@PIS enables symmetric Li cells to achieve exceptional cyclability for over 1000 h at 0.1 m A/cm2without noticeable lithium dendrite formation.Moreover,the PI/AO@PIS-based LiFePO4||Li full cells demonstrate outstanding rate performance(125.7 m Ah/g at 5 C)and impressive cycling stability(96.1%capacity retention at 1 C after 200 cycles).This work highlights the efficacy of enhancing the mechanical properties of polymer matrices and extending cell performance through the incorporation of a dense inorganic interface layer.
基金financial support from the National Natural Science Foundation of China(Nos.52250010 and 52201242)the 261 Project of MIIT,Natural Science Foundation of Jiangsu Province(No.BK20240179)the Young Elite Scientists Sponsorship Program by CAST(No.2021QNRC001).
文摘Composite solid electrolytes(CSEs)are promising for solid-state Li metal batteries but suffer from inferior room-temperature ionic conductivity due to sluggish ion transport and high cost due to expensive active ceramic fillers.Here,a host–vip inversion engineering strategy is proposed to develop superionic CSEs using cost-effective SiO_(2) nanoparticles as passive ceramic hosts and poly(vinylidene fluoride-hexafluoropropylene)(PVH)microspheres as polymer vips,forming an unprecedented“polymer vip-in-ceramic host”(i.e.,PVH-in-SiO_(2))architecture differing from the traditional“ceramic vip-in-polymer host”.The PVH-in-SiO_(2) exhibits excellent Li-salt dissociation,achieving high-concentration free Li+.Owing to the low diffusion energy barriers and high diffusion coefficient,the free Li+is thermodynamically and kinetically favorable to migrate to and transport at the SiO_(2)/PVH interfaces.Consequently,the PVH-in-SiO_(2) delivers an exceptional ionic conductivity of 1.32.10−3 S cm−1 at 25℃(vs.typically 10−5–10−4 S cm−1 using high-cost active ceramics),achieved under an ultralow residual solvent content of 2.9 wt%(vs.8–15 wt%in other CSEs).Additionally,PVH-in-SiO_(2) is electrochemically stable with Li anode and various cathodes.Therefore,the PVH-in-SiO_(2) demonstrates excellent high-rate cyclability in LiFePO4|Li full cells(92.9%capacity-retention at 3C after 300 cycles under 25℃)and outstanding stability with high-mass-loading LiFePO4(9.2 mg cm−1)and high-voltage NCM622(147.1 mAh g−1).Furthermore,we verify the versatility of the host–vip inversion engineering strategy by fabricating Na-ion and K-ion-based PVH-in-SiO_(2) CSEs with similarly excellent promotions in ionic conductivity.Our strategy offers a simple,low-cost approach to fabricating superionic CSEs for large-scale application of solid-state Li metal batteries and beyond.
基金supported by the 261 Project of MIITthe National Natural Science Foundation of China(Nos.52250010,52201242,U23A20574)the Young Elite Scientists Sponsorship Program by CAST(No.2021QNRC001)。
文摘Halide solid-state electrolytes(HSSEs)with excellent ionic conductivity and high voltage stability are promising for all-solid-state Li-ion batteries(ASSLBs).However,they suffer from poor processability,mechanical durability and humidity stability,hindering their large-scale applications.Here,we introduce a dry-processing fibrillation strategy using hydrophobic polytetrafluoroethylene(PTFE)binder to encapsulate Li_(3)InCl_(6)(LIC)particles(the most representative HSSE).By manipulating the fibrillating process,only 0.5 wt%PTFE is sufficient to prepare free-standing LIC-PTFE(LIC-P)HSSEs.Additionally,LIC-P demonstrates excellent mechanical durability and humidity resistance.They can maintain their shapes after being exposed to humid atmosphere for 30 min,meanwhile still exhibit high ionic conductivity of>0.2m S/cm at 25℃.Consequently,the LIC-P-based ASSLBs deliver a high specific capacity of 126.6 m Ah/g at0.1 C and long cyclability of 200 cycles at 0.2 C.More importantly,the ASSLBs using moisture-exposed LIC-P can still operate properly by exhibiting a high capacity-retention of 87.7%after 100 cycles under0.2 C.Furthermore,for the first time,we unravel the LIC interfacial morphology evolution upon cycling because the good mechanical durability enables a facile separation of LIC-P from ASSLBs after testing.
基金supported by the Anhui Provincial Key Research and Development PlanThis study was supported by National Key Research and Development Program of China(No.2023YFF0724803)Yunnan Province“Xingdian Talent Support Program”Yunling Scholar Special Project(No.XDYC-YLXZ-2022-0027)Scientific Research Fund Project of Yunnan Provincial Education Department(No.2025Y0634,No.2025Y0627).
文摘Objective:Diabetic Peripheral Neuropathy(DPN)is a common chronic complication of diabetes that currently has no therapeutic recourse.Advanced DPN stages are characterized by severe symptoms that place a huge burden on patients and healthcare systems.To the best of our knowledge,research hotspots within the field of DPN are yet to be visually analyzed,and so is the exploration of developmental dynamics within the same discipline.Methods:Herein,DPN articles published between 2002 and 2022 were retrieved from the Web of Science Core Collection database.Following that,bibliometric analysis was performed on these articles using CiteSpace,VOSviewer,Microsoft Excel,and R-bibliometrix tools.Results:We retrieved 2,761 DPN articles involving 11,605 researchers from 1,140 institutions in 99 countries/regions.The United States was the country/region with the highest number of publications.The most productive author was Malik Rayaz A from the University of Manchester,which was the most productive institution.The most co-cited journals were Diabetes Care,Pain,and Neurology.On the other hand,#0 neuropathic pain,#1 neuropathic pain treatment and#2 peripheral neuropathy were the most clustered keywords in co-cited references.Based on the clustering of keywords,timeline graphs,and citation bursts,“risk”,“corneal confocal microscopy”and“systematic review”were identifi ed as the key issues for future DPN research.Conclusion:This article summarizes the current DPN research status and focus areas,reveals the future development trend,and points out potential research directions for DPN scholars.
基金We acknowledge the funding support from the National Key R&D Program of China(Grant No.2022YFC3080100)the National Natural Science Foundation of China(Grant No.42102316)the opening fund of State Key Laboratory of Hydraulics and Mountain River Engineering,Sichuan University(Grant No.SKHL2306).
文摘The discrete fracture system of a rock mass plays a crucial role in controlling the stability of rock slopes.To fully account for the geometric shape and distribution characteristics of jointed rock masses,terrestrial laser scanning(TLS)was employed to acquire high-resolution point-cloud data,and a developed automatic discontinuity-identification technology was coupled to automatically interpret and characterize geometric information such as orientation,trace length,spacing,and set number of the discontinuities.The discrete element method(DEM)was applied to study the influence of the geometric morphology and distribution characteristics of discontinuities on slope stability by generating a discrete fracture network(DFN)with the same statistical characteristics as the actual discontinuities.Based on slope data from the Yebatan Hydropower Station,a simulation was conducted to verify the applicability of the automatic discontinuity identification technology and the discrete fracture network-discrete element method(DFN-DEM).Various geological parameters,including trace length,persistence,and density,were examined to investigate the morphological evolution and response characteristics of rock slope excavation under different joint combination conditions through simulation.The simulation results indicate that joint parameters affect slope stability,with density having the most significant impact.The impact of joint parameters on stability is relatively small within a reasonable range but becomes significant beyond a certain threshold,further validating that the accuracy of field geological surveys is critical for simulation.This study provides a scientific basis for the construction of complex rock slope models,engineering assessments,and disaster prevention and mitigation,which is of great value in both theory and engineering applications.
基金Supported by the National Natural Science Foundation of China(No.U2240220)。
文摘The river plume front between the diluted ocean water and salty ocean water in the Changjiang(Yangtze)River Delta(CRD)is well studied.Comparatively,less is known about the estuarine front in the CRD,which is formed between the riverine freshwater and the diluted ocean water and has the highest magnitude of salinity gradient(SG)in the CRD.Estuarine fronts are of great significance to the riverine material transport in the estuary.Many biogeochemical processes are enhanced in estuarine fronts,which have brought about environmental problems.In this study,the seasonal variations of the estuarine fronts in the CRD were studied in wet(July)and dry(January)seasons in 2017,based on model simulations with high spatiotemporal resolutions using the Finite-Volume Community Ocean Model(FVCOM).The estuarine front included several sharp fronts with a SG>4(/500 m),and was bottom-trapped on the submerged delta front.Seasonal changes mainly occurred off the Jiangsu coast,where a significant estuarine front was formed in July.The estuarine fronts generated around the submerged delta topography were accompanied by the offshore extension of older estuarine fronts,which were diluted and evolved into plume fronts over a tidal cycle.The simulated estuarine fronts had a salinity range of 6 to 22 in the dry season and 6 to 14 in wet season 2017.The estuarine fronts hindered the residual current by altering its flow direction to the southeast.
基金Postgraduate Research&Practice Innovation Program of Jiangsu Province under contract Nos KYCX23_1067 and KYCX25_1231the National Natural Science Foundation of China under contract No.42476157。
文摘Spartina alterniflora's robust reproductive capacity has enabled it to spread rapidly, posing a serious threat to native ecosystems in China. Therefore, accurate quantification of Spartina alterniflora aboveground biomass at a fine scale is crucial for understanding its growth dynamics and managing its invasion. This study focuses on the coastal wetlands of central Jiangsu Province, China, utilizing multispectral unmanned aerial vehicle(UAV) data to map the distribution of Spartina alterniflora. Object-based image analysis(OBIA) combined with support vector machines(SVM) was employed for classification. Additionally, multiple regression models, including univariate, band-based, vegetation index(VI)-based, and multivariate linear regression models integrating both band and VI data, were developed to estimate biomass:(1) the Bands + VIs multiple linear regression model based on fresh weight exhibited the highest estimation accuracy;(2) the optimal model achieved R^(2) values of 0.81 and 0.82 at Dafeng and Tiaozini Nature Reserve,with RMSE values of 591.78 g/m^(2) and 337.62 g/m^(2), and MAE values of 576.82 g/m^(2) and 287.71 g/m^(2), respectively;and(3) the aboveground biomass of Spartina alterniflora primarily ranged from 994.60 g/m^(2) to 5 351.48 g/m^(2) at Dafeng and from 796.05 g/m^(2) to 1 994.02 g/m^(2) in Tiaozini Nature Reserve. These findings highlight the effectiveness of multispectral UAV technology for accurately estimating Spartina alterniflora biomass, providing a robust methodology for wetland vegetation monitoring and invasive species management.
