Iron isotopes,represented byδ^(56)Fe,serve as valuable tools for constraining the surface iron processes and as potent tracers for studying the biogeochemical cycle of iron.Nevertheless,our comprehension of iron isot...Iron isotopes,represented byδ^(56)Fe,serve as valuable tools for constraining the surface iron processes and as potent tracers for studying the biogeochemical cycle of iron.Nevertheless,our comprehension of iron isotopes in the land surface processes of the Tibetan Plateau(TP)remains limited.In this study,we present the results of iron isotopic composition(δ^(56)Fe)in the surface soils of the TP,encompassing both glacial and non-glacial regions characterized by rugged and flat topographies.Our findings reveal that soilδ^(56)Fe values ranged from-0.01‰±0.05‰to 0.14‰±0.01‰,with the highest values observed in eastern locations(0.14‰)and the lowest appeared in the northeast(-0.1‰).On a global scale,theδ^(56)Fe values observed in Tibetan soils exhibited relatively small variability compared to reservoirs marked by significant iron isotope fractionation.By contrast,the range of TP soils measured here was slightly larger than that of the Chinese Loess.Furthermore,we discerned noticeable spatial variations inδ^(56)Fe across the large-scale region of TP,indicating a gradual increase trend from the northeast to the south and from the west to the east.These regional disparities inδ^(56)Fe likely arise from a combination of constraining factors,including differences in mineralogy,lithological variations,organic matter content,and variations in chemical weathering intensity.This study is pivotal in advancing our understanding of land surface iron isotope dynamics and its role in the biogeochemical cycle within the TP region.展开更多
The carbon cycle stands as a cornerstone among the Earth's material cycles,carrying profound implications for global climate dynamics and humanity's sustenance and advancement.Additionally,nitrogen,as a vital ...The carbon cycle stands as a cornerstone among the Earth's material cycles,carrying profound implications for global climate dynamics and humanity's sustenance and advancement.Additionally,nitrogen,as a vital nutrient element,plays a pivotal role in biogeochemical processes,exerting significant influence on the ecological environment within watersheds.In this study,an analysis of the carbon(C)and nitrogen(N)components in the river water of 12 alpine basins on the eastern margin of the Tibetan Plateau(TP)reveals that the average dissolved organic carbon(DOC)concentration in the river water is 0.76±0.67 mg/L,indicating a lower level compared to the global river average organic carbon content.Specifically,the average DOC concentrations were 0.42±0.22 and 1.56±0.68 mg/L in the glacial and non-glacial basins,respectively.The average dissolved inorganic carbon(DIC)concentration in the eastern TP is 27.04±20.19 mg/L,with the lowest DIC observed at Dagu Glacier and the highest at Daxia River.Furthermore,the average dissolved total carbon(DTC)concentration in glacier river water was 18.87±12.65 mg/L,contrasting with 48.23±21.07 mg/L in non-glacial basins.The mean concentration of total nitrogen(TN)in the eastern TP averaged 0.97±0.54 mg/L,with the glacial basin registering 1.01±0.47 mg/L and the non-glacial basin at 0.89±0.70 mg/L.Evaluating the release fluxes of carbon and nitrogen across 12 river basins revealed a range of DTC emission fluxes from 0.32×10^(9)to 31.02×10^(9)g·C/a,with inorganic carbon comprising 71.0%to 99.5%.Consequently,the carbon emission flux for seven glacier basins totaled 15.91×10^(9)g·C/a,while for the five non-glacial river basins,it reached 87.37×10^(9)g·C/a.The total TN release fluxes across 12 small river basins amounted to 2.46×10^(9)g·N/a,with 0.84×10^(9)g·N/a released in glacial basins and 1.62×10^(9)g·N/a in the nonglacial basin.This study elucidates the spatial distribution and transport mechanisms of carbon and nitrogen elements within the glacial and downstream non-glacial basins,offering valuable insights into the biogeochemical cycles of carbon and nitrogen in the eastern Tibetan Plateau.展开更多
Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive disease.Proteomics is an unbiased and quantitative method that can be used to detect ...Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive disease.Proteomics is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke rs.In this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy controls.Su bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral sclerosis.Potential biomarke rs were selected based on functionality and expression specificity.To validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent assay.Eight substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle rosis.Subsequently,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and translationally-controlled tumor protein effectively distinguished early-stage amyotrophic lateral sclerosis patients from controls(AUC=0.766,P<0.0001).Moreove r,the expression of three proteins(FK506 binding protein 1A,cathelicidin-related antimicrobial peptide,and hemoglobin beta-1)was found to increase with disease progression.The proteomic signatures developed in this study may help facilitate early diagnosis and monitor the progression of sporadic amyotrophic lateral sclerosis when used in co mbination with curre nt clinical-based parameters.展开更多
In addition to the occurrence of atmospheric blocking, the climatology of the characteristics of blocking events, including duration, intensity, and extension, in four seasons over the Northern Hemisphere was analyzed...In addition to the occurrence of atmospheric blocking, the climatology of the characteristics of blocking events, including duration, intensity, and extension, in four seasons over the Northern Hemisphere was analyzed for the period 1950-2009. The seasonality and spatial variations of these characteristics were studied according to their longitudinal distributions. In general, there were sharp discrepancies in the blocking characteristics between winter and summer, and these differences were more prominent over the Atlantic and Pacific Oceans. The blocking not only occurred more frequently but also underwent stronger amplification in winter; likewise, the blocking occurred less frequently and underwent weaker amplification in summer. There are very strong interrelationships among different blocking characteristics, suggesting that they are supported by similar physical factors. In addition, the relationship between blocking over different regions and East Asian circulation was examined. Ural-Siberia is a major blocking formation region in all seasons that may exert a downstream impact on East Asia. The impact is generally weak in summer, which is due to its lower intensity and smaller duration. However, the extratropical circulation over East Asia in summer can be disturbed persistently by the frequent occurrence of blocking over the Asian continent or the Western Pacific. In particular, the blocking frequency over the Western Pacific significantly increased during the study period. This climatological information provides a background for studying the impact of blocking on East Asian circulation under both present and future climate conditions.展开更多
Heat shock factor-1(HSF-1)plays a crucial role in orchestrating stress responses across diverse organisms and disease conditions.Here,we investigate how the HSF-1 signaling pathway influences the degradation of toxic ...Heat shock factor-1(HSF-1)plays a crucial role in orchestrating stress responses across diverse organisms and disease conditions.Here,we investigate how the HSF-1 signaling pathway influences the degradation of toxic proteins and neuropathological changes in the Caenorhabditis elegans model of amyotrophic lateral sclerosis(ALS).We found that overexpressing HSF-1 improves locomotor ability and increases the survival rate of ALS C.elegans.Moreover,we observed a deceleration of motor neuron degeneration,demonstrating the protective effect of HSF-1 on neurodegenerative processes.Transcriptomic analysis revealed notable changes in genes associated with autophagy and neurodegeneration,underscoring HSF-1’s critical involvement in ALS pathology.In addition,metabolomic profiling further highlighted the involvement of this pathway in metabolic reprogramming.Overall,our study underscores the critical role of the HSF-1 signaling pathway in improving survival rate,movement velocity,cellular integrity,and metabolic adaptation,providing new insights into the mechanisms underlying ALS and potential targets for therapeutic intervention.展开更多
Calorie restriction(CR)or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders,ameliorate autoimmune diseases,and attenuate aging.Despite effo...Calorie restriction(CR)or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders,ameliorate autoimmune diseases,and attenuate aging.Despite efforts,the mechanisms by which CR improves health,particularly brain health,are still not fully understood.Metabolic homeostasis is vital for brain function,and a detailed metabolome atlas of the brain is essential for understanding the networks connecting different brain regions.展开更多
Beijing often suffers under heavy smog.During such events which occur mostly in autumn and winter,people are desperate for fresh air.The formation of heavy smog is due to foremost human induced air pollution,but geogr...Beijing often suffers under heavy smog.During such events which occur mostly in autumn and winter,people are desperate for fresh air.The formation of heavy smog is due to foremost human induced air pollution,but geographic and meteorological conditions,especially below a surface inversion,play an important role.We propose to destroy the inversion by pumping air from above the inversion layer to the surface layer to alleviate the severity of the smog.While long-term air quality improvement depends on the reduction of air pollution emission,air pumping may provide relief in the interim for the Beijing citizens.We estimate that an air pumping at a rate 2×10~7m^3s^(–1)can lead to significantly improved air quality in Beijing,due to(1)direct clean air input;(2)increased instability and vertical mixing and(3)a positive radiation-mixing feedback.The pumping requires an energy input of 10 GW,comparable with the energy consumption in Beijing for air conditioning in summer.We propose to use wind energy from Inner Mongolia for the pumping,which has currently an installed wind energy capacity of 70GW.展开更多
基金supported by the National Natural Science Foundation of China(Nos.42201152,42371139)the Gansu Province Natural Science Foundation Key Project(No.23JRRA858)+2 种基金the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)(No.CUG240629)the“CUG Scholar”Scientific Research Funds at China University of Geosciences(Wuhan)(No.2023092)EJRP is supported by the German Research Foundation(DFG)through the Heisenberg Programme“Multiscale Simulation of Earth Surface Processes”。
文摘Iron isotopes,represented byδ^(56)Fe,serve as valuable tools for constraining the surface iron processes and as potent tracers for studying the biogeochemical cycle of iron.Nevertheless,our comprehension of iron isotopes in the land surface processes of the Tibetan Plateau(TP)remains limited.In this study,we present the results of iron isotopic composition(δ^(56)Fe)in the surface soils of the TP,encompassing both glacial and non-glacial regions characterized by rugged and flat topographies.Our findings reveal that soilδ^(56)Fe values ranged from-0.01‰±0.05‰to 0.14‰±0.01‰,with the highest values observed in eastern locations(0.14‰)and the lowest appeared in the northeast(-0.1‰).On a global scale,theδ^(56)Fe values observed in Tibetan soils exhibited relatively small variability compared to reservoirs marked by significant iron isotope fractionation.By contrast,the range of TP soils measured here was slightly larger than that of the Chinese Loess.Furthermore,we discerned noticeable spatial variations inδ^(56)Fe across the large-scale region of TP,indicating a gradual increase trend from the northeast to the south and from the west to the east.These regional disparities inδ^(56)Fe likely arise from a combination of constraining factors,including differences in mineralogy,lithological variations,organic matter content,and variations in chemical weathering intensity.This study is pivotal in advancing our understanding of land surface iron isotope dynamics and its role in the biogeochemical cycle within the TP region.
基金supported by the National Natural Science Foundation of China(Nos.42371139,42201152)the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)(No.CUG240629)+2 种基金the“CUG Scholar”Scientific Research Funds at China University of Geosciences(Wuhan)(No.2023092)the Gansu Province Natural Science Foundation Key Project(No.23JRRA858)CAS President's International Fellowship for Visiting Scientists(No.2024PVC003)。
文摘The carbon cycle stands as a cornerstone among the Earth's material cycles,carrying profound implications for global climate dynamics and humanity's sustenance and advancement.Additionally,nitrogen,as a vital nutrient element,plays a pivotal role in biogeochemical processes,exerting significant influence on the ecological environment within watersheds.In this study,an analysis of the carbon(C)and nitrogen(N)components in the river water of 12 alpine basins on the eastern margin of the Tibetan Plateau(TP)reveals that the average dissolved organic carbon(DOC)concentration in the river water is 0.76±0.67 mg/L,indicating a lower level compared to the global river average organic carbon content.Specifically,the average DOC concentrations were 0.42±0.22 and 1.56±0.68 mg/L in the glacial and non-glacial basins,respectively.The average dissolved inorganic carbon(DIC)concentration in the eastern TP is 27.04±20.19 mg/L,with the lowest DIC observed at Dagu Glacier and the highest at Daxia River.Furthermore,the average dissolved total carbon(DTC)concentration in glacier river water was 18.87±12.65 mg/L,contrasting with 48.23±21.07 mg/L in non-glacial basins.The mean concentration of total nitrogen(TN)in the eastern TP averaged 0.97±0.54 mg/L,with the glacial basin registering 1.01±0.47 mg/L and the non-glacial basin at 0.89±0.70 mg/L.Evaluating the release fluxes of carbon and nitrogen across 12 river basins revealed a range of DTC emission fluxes from 0.32×10^(9)to 31.02×10^(9)g·C/a,with inorganic carbon comprising 71.0%to 99.5%.Consequently,the carbon emission flux for seven glacier basins totaled 15.91×10^(9)g·C/a,while for the five non-glacial river basins,it reached 87.37×10^(9)g·C/a.The total TN release fluxes across 12 small river basins amounted to 2.46×10^(9)g·N/a,with 0.84×10^(9)g·N/a released in glacial basins and 1.62×10^(9)g·N/a in the nonglacial basin.This study elucidates the spatial distribution and transport mechanisms of carbon and nitrogen elements within the glacial and downstream non-glacial basins,offering valuable insights into the biogeochemical cycles of carbon and nitrogen in the eastern Tibetan Plateau.
基金supported by the grants from Shanghai Shuguang Plan Project,No.18SG15(to SC)Shanghai Outstanding Young Scholars Project+2 种基金Shanghai Talent Development Project,No.2019044(to SC)Medical-engineering cross fund of Shanghai Jiao Tong University,No.YG2022QN009(to QZ)the National Natural Science Foundation of China,No.82201558(to QZ)。
文摘Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive disease.Proteomics is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke rs.In this study,we used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients with sporadic amyotrophic lateral scle rosis compared with five healthy controls.Su bstantial upregulation of serum proteins related to multiple functional clusters was observed in patients with spo radic amyotrophic lateral sclerosis.Potential biomarke rs were selected based on functionality and expression specificity.To validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients with sporadic amyotrophic lateral sclerosis and 100 healthy controls were subjected to enzyme-linked immunosorbent assay.Eight substantially upregulated serum proteins in patients with spora dic amyotrophic lateral sclerosis were selected,of which the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability between patients with sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,P<0.0001).To further enhance diagnostic accuracy,a multi-protein combined discriminant algorithm was developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value of<0.0001,resulting in 79%sensitivity and 71%specificity for the diagnosis of sporadic amyotrophic lateral scle rosis.Subsequently,the ability of candidate biomarkers to discriminate between early-stage amyotrophic lateral sclerosis patients and controls,as well as patients with different disease severities,was examined.A two-protein panel comprising talin-1 and translationally-controlled tumor protein effectively distinguished early-stage amyotrophic lateral sclerosis patients from controls(AUC=0.766,P<0.0001).Moreove r,the expression of three proteins(FK506 binding protein 1A,cathelicidin-related antimicrobial peptide,and hemoglobin beta-1)was found to increase with disease progression.The proteomic signatures developed in this study may help facilitate early diagnosis and monitor the progression of sporadic amyotrophic lateral sclerosis when used in co mbination with curre nt clinical-based parameters.
基金supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region (Grant No. 104410)a grant from Germany/Hong Kong Joint Research Scheme (Grant No.G HK023/09)The figures were prepared by the NCAR Command Language (Version 6.0.0) [Software] (2012),Boulder,Colorado:UCAR/NCAR/CLSL/VETS
文摘In addition to the occurrence of atmospheric blocking, the climatology of the characteristics of blocking events, including duration, intensity, and extension, in four seasons over the Northern Hemisphere was analyzed for the period 1950-2009. The seasonality and spatial variations of these characteristics were studied according to their longitudinal distributions. In general, there were sharp discrepancies in the blocking characteristics between winter and summer, and these differences were more prominent over the Atlantic and Pacific Oceans. The blocking not only occurred more frequently but also underwent stronger amplification in winter; likewise, the blocking occurred less frequently and underwent weaker amplification in summer. There are very strong interrelationships among different blocking characteristics, suggesting that they are supported by similar physical factors. In addition, the relationship between blocking over different regions and East Asian circulation was examined. Ural-Siberia is a major blocking formation region in all seasons that may exert a downstream impact on East Asia. The impact is generally weak in summer, which is due to its lower intensity and smaller duration. However, the extratropical circulation over East Asia in summer can be disturbed persistently by the frequent occurrence of blocking over the Asian continent or the Western Pacific. In particular, the blocking frequency over the Western Pacific significantly increased during the study period. This climatological information provides a background for studying the impact of blocking on East Asian circulation under both present and future climate conditions.
基金supported by the National Natural Science Foundation of China(NSFC 31700853,32220103006,82271524,32271326)and Dalian Medical University Interdisciplinary Research Cooperation Project Team Funding(JCHZ2023023)provided by the Caenorhabditis Genetics Center,which is funded by the NIH Office of Research Infrastructure Programs(P40 OD010440).
文摘Heat shock factor-1(HSF-1)plays a crucial role in orchestrating stress responses across diverse organisms and disease conditions.Here,we investigate how the HSF-1 signaling pathway influences the degradation of toxic proteins and neuropathological changes in the Caenorhabditis elegans model of amyotrophic lateral sclerosis(ALS).We found that overexpressing HSF-1 improves locomotor ability and increases the survival rate of ALS C.elegans.Moreover,we observed a deceleration of motor neuron degeneration,demonstrating the protective effect of HSF-1 on neurodegenerative processes.Transcriptomic analysis revealed notable changes in genes associated with autophagy and neurodegeneration,underscoring HSF-1’s critical involvement in ALS pathology.In addition,metabolomic profiling further highlighted the involvement of this pathway in metabolic reprogramming.Overall,our study underscores the critical role of the HSF-1 signaling pathway in improving survival rate,movement velocity,cellular integrity,and metabolic adaptation,providing new insights into the mechanisms underlying ALS and potential targets for therapeutic intervention.
基金This work was supported by the National Natural Science Foundation of China(NSFC 22004013,82271524,and 21934006)Doctoral Scientific Research Foundation of the Liaoning Science and Technology Department(2020-BS-200)the Central Guidance on Local Science and Technology Development Fund of Dalian Science and Technology Bureau.
文摘Calorie restriction(CR)or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders,ameliorate autoimmune diseases,and attenuate aging.Despite efforts,the mechanisms by which CR improves health,particularly brain health,are still not fully understood.Metabolic homeostasis is vital for brain function,and a detailed metabolome atlas of the brain is essential for understanding the networks connecting different brain regions.
基金supported by the National Natural Science Foundation of China(Grant No.91537211)
文摘Beijing often suffers under heavy smog.During such events which occur mostly in autumn and winter,people are desperate for fresh air.The formation of heavy smog is due to foremost human induced air pollution,but geographic and meteorological conditions,especially below a surface inversion,play an important role.We propose to destroy the inversion by pumping air from above the inversion layer to the surface layer to alleviate the severity of the smog.While long-term air quality improvement depends on the reduction of air pollution emission,air pumping may provide relief in the interim for the Beijing citizens.We estimate that an air pumping at a rate 2×10~7m^3s^(–1)can lead to significantly improved air quality in Beijing,due to(1)direct clean air input;(2)increased instability and vertical mixing and(3)a positive radiation-mixing feedback.The pumping requires an energy input of 10 GW,comparable with the energy consumption in Beijing for air conditioning in summer.We propose to use wind energy from Inner Mongolia for the pumping,which has currently an installed wind energy capacity of 70GW.
