Diabetic peripheral neuropathy is a common complication of diabetes mellitus.Elucidating the pathophysiological metabolic mechanism impels the generation of ideal therapies.However,existing limited treatments for diab...Diabetic peripheral neuropathy is a common complication of diabetes mellitus.Elucidating the pathophysiological metabolic mechanism impels the generation of ideal therapies.However,existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism research.Given the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy,it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment methods.This review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment methods.Various metabolic mechanisms(e.g.,polyol,hexosamine,protein kinase C pathway)are associated with diabetic peripheral neuropathy,and researchers are looking for more effective treatments through these pathways.展开更多
After peripheral nerve injury,disruption of immune homeostasis retards the repair process of peripheral nerves.Piezoelectric materials are the latest paradigm used to address the electrical and energy deficiencies of ...After peripheral nerve injury,disruption of immune homeostasis retards the repair process of peripheral nerves.Piezoelectric materials are the latest paradigm used to address the electrical and energy deficiencies of peripheral nerves.However,the effects and mechanism by which piezoelectric materials regulate immune homeostasis and promote peripheral nerve regeneration remain unclear.We developed a self-powered nerve-bridging scaffold by adding polyvinylidene fluoride-trifluoroethylene(P(VDF-TrFE))and reduced graphene oxide(rGO)nanoparticles to a polycaprolactone(PCL)substrate.This electrical stimulation reduces high levels of inflammatory cytokines in damaged nerve tissue,controls abnormal neutrophil activity,and promotes quick revascularization.By providing energy,immune balance,and angiogenesis,this electroactive scaffold significantly enhances peripheral nerve regeneration.The recovery of the disintegrated myelin sheath was comparable to that observed after autologous nerve transplantation,and neuromuscular function was significantly restored after implantation of the self-generating electrical stimulation material.This multifunctional fibrous material has promise for clinical translation for the treatment of peripheral nerve injuries.展开更多
基金supported by the Projects of the National Key R&D Program of China,Nos.2021YFC2400803(to YO),2021YFC2400801(to YQ)the National Natural Science Foundation of China,Nos.82002290(to YQ),82072452(to YO),82272475(to YO)+5 种基金the Young Elite Scientist Sponsorship Program by Cast,No.YESS20200153(to YQ)the Sino-German Mobility Programme,No.M-0699(to YQ)the Excellent Youth Cultivation Program of Shanghai Sixth People’s Hospital,No.ynyq202201(to YQ)the Shanghai Sailing Program,No.20YF1436000(to YQ)the Medical Engineering Co-Project of University of Shanghai for Science and Technology,10-22-310-520(to YO)a grant from Shanghai Municipal Health Commission,No.202040399(to YO).
文摘Diabetic peripheral neuropathy is a common complication of diabetes mellitus.Elucidating the pathophysiological metabolic mechanism impels the generation of ideal therapies.However,existing limited treatments for diabetic peripheral neuropathy expose the urgent need for cell metabolism research.Given the lack of comprehensive understanding of energy metabolism changes and related signaling pathways in diabetic peripheral neuropathy,it is essential to explore energy changes and metabolic changes in diabetic peripheral neuropathy to develop suitable treatment methods.This review summarizes the pathophysiological mechanism of diabetic peripheral neuropathy from the perspective of cellular metabolism and the specific interventions for different metabolic pathways to develop effective treatment methods.Various metabolic mechanisms(e.g.,polyol,hexosamine,protein kinase C pathway)are associated with diabetic peripheral neuropathy,and researchers are looking for more effective treatments through these pathways.
基金supported by the National Key R&D Program of China(No.2021YFC2400800)the Projects of the National Natural Science Foundation of China(Nos.82072452,82272475,and 82372409)+5 种基金the Science and Technology Commission of Shanghai Municipality(No.20DZ2254900)the Sino-German Mobility Programme(No.M-0699)the Excellent Youth Cultivation Program of Shanghai Sixth People’s Hospital(No.ynyq202201)the Medical Engineering Co-Project of University of Shanghai for Science and Technology(10-22-310-520)a grant from the Shanghai Municipal Health Commission(No.202040399)the Laboratory Open Fund of Key Technology and Materials in Minimally Invasive Spine Surgery(2024JZWC-ZDA05).
文摘After peripheral nerve injury,disruption of immune homeostasis retards the repair process of peripheral nerves.Piezoelectric materials are the latest paradigm used to address the electrical and energy deficiencies of peripheral nerves.However,the effects and mechanism by which piezoelectric materials regulate immune homeostasis and promote peripheral nerve regeneration remain unclear.We developed a self-powered nerve-bridging scaffold by adding polyvinylidene fluoride-trifluoroethylene(P(VDF-TrFE))and reduced graphene oxide(rGO)nanoparticles to a polycaprolactone(PCL)substrate.This electrical stimulation reduces high levels of inflammatory cytokines in damaged nerve tissue,controls abnormal neutrophil activity,and promotes quick revascularization.By providing energy,immune balance,and angiogenesis,this electroactive scaffold significantly enhances peripheral nerve regeneration.The recovery of the disintegrated myelin sheath was comparable to that observed after autologous nerve transplantation,and neuromuscular function was significantly restored after implantation of the self-generating electrical stimulation material.This multifunctional fibrous material has promise for clinical translation for the treatment of peripheral nerve injuries.
