Pepper(Capsicum annuum L.)is a typical self-pollinating crop with obvious heterosis in hybrids.Consequently,the use of morphological markers during the pepper seedling stage is crucial for pepper breeding.The color of...Pepper(Capsicum annuum L.)is a typical self-pollinating crop with obvious heterosis in hybrids.Consequently,the use of morphological markers during the pepper seedling stage is crucial for pepper breeding.The color of hypocotyl is widely used as a phenotypic marker in crossing studies of pepper.Pepper accessions generally have purple hypocotyls,which are mainly due to the anthocyanin accumulation in seedlings,and green hypocotyls are rarely observed in pepper.Here we reported the characterization of a green hypocotyl mutant of pepper,Cha1,which was identified from a pepper ethyl methanesulfonate(EMS)mutant library.Fine mapping revealed that the causal gene,CaTTG1,belonging to the WD40 repeat family,controlled the green hypocotyl phenotype of the mutant.Virus-induced gene silencing(VIGS)confirmed that CaTTG1 regulated anthocyanin accumulation.RNA-seq data showed that expression of structural genes CaDFR,CaANS,and CaUF3GT in the anthocyanin biosynthetic pathway was significantly decreased in Cha1 compared to the wild type.Yeast two-hybrid(Y2H)experiments also confirmed that CaTTG1 activated the synthesis of anthocyanin structural genes by forming a MBW complex with CaAN1 and CaGL3.In summary,this study provided a green hypocotyl mutant of pepper,and the Kompetitive Allele Specific PCR(KASP)marker developed based on the mutation site of the underlying gene would be helpful for pepper breeding.展开更多
With the rapid development of modern science and technology,the era of artificial intelligence has quietly come.Against the background of the new era,students’learning needs,learning resource acquisition methods,teac...With the rapid development of modern science and technology,the era of artificial intelligence has quietly come.Against the background of the new era,students’learning needs,learning resource acquisition methods,teachers’teaching concepts,teaching tools,and so on have changed significantly.How to carry out teaching reform based on this change has become one of the important issues facing educators,and the same is true for the teaching of computer programming courses.This paper focuses on the teaching reform of AI-enabled computer programming courses,analyzes its basic problems,and puts forward corresponding reform countermeasures to provide a useful reference for front-line teachers.展开更多
Internet of Things(IoT)technology is rapidly evolving,but there is no trusted platform to protect user privacy,protect information between different IoT domains,and promote edge processing.Therefore,we integrate the b...Internet of Things(IoT)technology is rapidly evolving,but there is no trusted platform to protect user privacy,protect information between different IoT domains,and promote edge processing.Therefore,we integrate the blockchain technology into constructing trusted IoT platforms.However,the application of blockchain in IoT is hampered by the challenges posed by heavy computing processes.To solve the problem,we put forward a blockchain framework based on mobile edge computing,in which the blockchain mining tasks can be offloaded to nearby nodes or the edge computing service providers and the encrypted hashes of blocks can be cached in the edge computing service providers.Moreover,we model the process of offloading and caching to ensure that both edge nodes and edge computing service providers obtain the maximum profit based on game theory and auction theory.Finally,the proposed mechanism is compared with the centralized mode,mode A(all the miners offload their tasks to the edge computing service providers),and mode B(all the miners offload their tasks to a group of neighbor devices).Simulation results show that under our mechanism,mining networks obtain more profits and consume less time on average.展开更多
Dynamic controls of pressure-swing distillation with an intermediate connection(PSDIC) process of ethyl acetate and ethanol separation were investigated.The double temperature/composition cascade control structure can...Dynamic controls of pressure-swing distillation with an intermediate connection(PSDIC) process of ethyl acetate and ethanol separation were investigated.The double temperature/composition cascade control structure can perfectly implement effective control when ±20% feed disturbances were introduced.This control structure did not require the control of the flowrate of the side stream.The dynamic controllability of PSDIC with partial heat integration(PHIPSDIC) was also explored.The improved control structure can effectively control ±20% feed disturbances.However,in industrial production,simple controller,sensitive and easy to operate,is the optimal target.To avoid the use of component controllers or complex control structure,the original product purities could be maintained using the basic control structure for the PSDIC process if the product purities in steady state were properly increased,albeit by incurring a slight rise in the total annual cost(TAC).This alternative method without a composition controller combined with the energy-saving PSDIC process provides a simple and effective control scheme in industrial production.展开更多
Inflammation plays an important role in atherosclerosis.Inflammasomes play a crucial role in innate immunity,which mediates the body’s response to various pathogens.Of the different types of inflammasomes,NLRP3 has b...Inflammation plays an important role in atherosclerosis.Inflammasomes play a crucial role in innate immunity,which mediates the body’s response to various pathogens.Of the different types of inflammasomes,NLRP3 has been implicated in atherosclerosis through the production of proinfl ammatory cytokines,IL-1β and IL-18.This review describes the role of the NLRP3 infl ammasome in atherosclerosis and discusses potential therapeutic targets in the infl ammasome pathway.展开更多
Metal(Li,Na,K,Al)-ion batteries and lithium-sulfur and lithium-tellurium batteries are gaining recognition for their eco-friendly characteristics,substantial energy density,and sustainable attributes.However,the overa...Metal(Li,Na,K,Al)-ion batteries and lithium-sulfur and lithium-tellurium batteries are gaining recognition for their eco-friendly characteristics,substantial energy density,and sustainable attributes.However,the overall performance of rechargeable batteries heavily depends on their electrode materials.Transition metal tellurides have recently gained significant attention due to their high electrical conductivity and density.Cobalt telluride has received the most extensive research due to its catalytic activity,unique magnetic properties,and diverse composition and crystal structure.Nevertheless,its limited conductivity and significant volume variation contribute to electrode structural deterioration and rapid capacity decline.This review comprehensively summarizes recent advances in rational design and synthesis of modified cobalt telluride-based electrodes,encompassing defect engineering(Te vacancies,cation vacancies,heterointerfaces,and homogeneous interfaces)and composite engineering(derived carbon from precursors,carbon fibers,Mxene,graphene nanosheets,etc.).Particularly,the intricate evolution mechanisms of the conversion reaction process during cycling are elucidated.Furthermore,these modified strategies applied to other transitional metal tellurides,such as iron telluride,nickel telluride,zinc telluride,copper telluride,molybdenum telluride,etc.,are also thoroughly summarized.Additionally,their application extends to emerging aqueous zinc-ion batteries.Finally,potential challenges and prospects are discussed to further propel the development of transition metal tellurides electrode materials for next-generation rechargeable batteries.展开更多
The crack tip fields are investigated for a cracked functionally graded material （FGM） plate by Reissner＇s linear plate theory with the consideration of the transverse shear deformation generated by bending. The el...The crack tip fields are investigated for a cracked functionally graded material （FGM） plate by Reissner＇s linear plate theory with the consideration of the transverse shear deformation generated by bending. The elastic modulus and Poisson＇s ratio of the functionally graded plates are assumed to vary continuously through the coordinate y, according to a linear law and a constant, respectively. The governing equations, i.e., the 6th-order partial differential equations with variable coefficients, are derived in the polar coordinate system based on Reissner＇s plate theory. Furthermore, the generalized displacements are treated in a separation-of-variable form, and the higher-order crack tip fields of the cracked FGM plate are obtained by the eigen-expansion method. It is found that the analytic solutions degenerate to the corresponding fields of the isotropic homogeneous plate with Reissner＇s effect when the in-homogeneity parameter approaches zero.展开更多
Most existing star-galaxy classifiers depend on the reduced information from catalogs,necessitating careful data processing and feature extraction.In this study,we employ a supervised machine learning method(GoogLeNet...Most existing star-galaxy classifiers depend on the reduced information from catalogs,necessitating careful data processing and feature extraction.In this study,we employ a supervised machine learning method(GoogLeNet)to automatically classify stars and galaxies in the COSMOS field.Unlike traditional machine learning methods,we introduce several preprocessing techniques,including noise reduction and the unwrapping of denoised images in polar coordinates,applied to our carefully selected samples of stars and galaxies.By dividing the selected samples into training and validation sets in an 8:2 ratio,we evaluate the performance of the GoogLeNet model in distinguishing between stars and galaxies.The results indicate that the GoogLeNet model is highly effective,achieving accuracies of 99.6% and 99.9% for stars and galaxies,respectively.Furthermore,by comparing the results with and without preprocessing,we find that preprocessing can significantly improve classification accuracy(by approximately 2.0% to 6.0%)when the images are rotated.In preparation for the future launch of the China Space Station Telescope(CSST),we also evaluate the performance of the GoogLeNet model on the CSST simulation data.These results demonstrate a high level of accuracy(approximately 99.8%),indicating that this model can be effectively utilized for future observations with the CSST.展开更多
Hypoxia has been identified as a common environmental stress factor associated with therapeutic resistance and metastasis in human cancers. A major player in regulating the response to hypoxia is the transcriptional f...Hypoxia has been identified as a common environmental stress factor associated with therapeutic resistance and metastasis in human cancers. A major player in regulating the response to hypoxia is the transcriptional factor hypoxia-inducible factor 1 alpha （HIF-1α）.展开更多
Acute myeloid leukemia(AML)is an aging-related malignancy,with patients aged≥60 years old facing significantly poorer prognosis.Umbilical cord blood(UCB)has emerged as a promising source with effective anti-aging rol...Acute myeloid leukemia(AML)is an aging-related malignancy,with patients aged≥60 years old facing significantly poorer prognosis.Umbilical cord blood(UCB)has emerged as a promising source with effective anti-aging roles.Here,we conducted a prospective,phase 2,single-arm trial of UCB infusion as an adjuvant consolidation therapy in elderly AML patients(ChiCTR-OPC15006492).A total of 51 patients were enrolled(median age 66 years;range,60-75)and received two cycles of consolidation chemotherapy combined with UCB infusion.At a median follow-up of 27.3 months(range,9.3-100),the median overall survival(OS)was not yet reached and the median event-free survival(EFS)was 72.2 months(range,5.4-100).The 2-year OS and EFS rates were 76.9%and 62.8%,respectively.No acute graft-versus-host disease(aGVHD)or toxicity-related death occurred in any patient.The median times to platelet and neutrophil recovery were 11.5 days(range,6-17)and 12.2 days(range,0-21),respectively.Singlecell RNA sequencing(scRNA-seq)identified enhanced anti-tumor and anti-aging properties of UCB,manifested through activation of immune responses and telomere synthesis/maintenance.Thesefindings suggest that UCB infusion is an effective and safe postremission adjuvant therapy for elderly AML patients.This study provides evidence that anti-aging therapy may serve as a new and promising dimension in combined cancer treatment.展开更多
With the recent ongoing autumn/winter 2022 COVID-19 wave and the adjustment of public health control measures,there have been widespread SARS-CoV-2 infections in Chinese mainland.Here we have analyzed 369 viral genome...With the recent ongoing autumn/winter 2022 COVID-19 wave and the adjustment of public health control measures,there have been widespread SARS-CoV-2 infections in Chinese mainland.Here we have analyzed 369 viral genomes from recently diagnosed COVID-19 patients in Shanghai,identifying a large number of sublineages of the SARS-CoV-2 Omicron family.Phylogenetic analysis,coupled with contact history tracing,revealed simultaneous community transmission of two Omicron sublineages dominating the infections in some areas of China(BA.5.2 mainly in Guangzhou and Shanghai,and BF.7 mainly in Beijing)and two highly infectious sublineages recently imported from abroad(XBB and BQ.1).Publicly available data from August 31 to November 29,2022 indicated an overall severe/critical case rate of 0.035%nationwide,while analysis of 5706 symptomatic patients treated at the Shanghai Public Health Center between September 1 and December 26,2022 showed that 20 cases(0.35%)without comorbidities progressed into severe/critical conditions and 153 cases(2.68%)with COVID-19-exacerbated comorbidities progressed into severe/critical conditions.These observations shall alert healthcare providers to place more resources for the treatment of severe/critical cases.Furthermore,mathematical modeling predicts this autumn/winter wave might pass through major cities in China by the end of the year,whereas some middle and western provinces and rural areas would be hit by the upcoming infection wave in mid-to-late January 2023,and the duration and magnitude of upcoming outbreak could be dramatically enhanced by the extensive travels during the Spring Festival(January 21,2023).Altogether,these preliminary data highlight the needs to allocate resources to early diagnosis and effective treatment of severe cases and the protection of vulnerable population,especially in the rural areas,to ensure the country’s smooth exit from the ongoing pandemic and accelerate socio-economic recovery.展开更多
The traditional approach to solvent selction in the extractive distillation process strictly focuses on the change in the relative voltility of light-heavy components induced by the solvent.However,the total annual co...The traditional approach to solvent selction in the extractive distillation process strictly focuses on the change in the relative voltility of light-heavy components induced by the solvent.However,the total annual cost of the process may not be minimal when the solvent induces the largest change in relative volatility.This work presents a heuristic method for selecting the optimal solvent to minimize the total annual cost.The functional relationship between the relative volatility and the total annual cost is established,where the main factors,such as the relative volatility of the light-heavy components and the relative volatility of the heavy-component solvent,are taken into account.Binary azeotropic mixtures of methanol-toluene and methanol-acetone are separated to verify the feasibility of the model.The results show that using the solvent with the minimal two-column extractive distillation index,the process achieves a minimal total annual cost.The method is conducive for sustainable advancements in chemistry and engineering because a suitable solvent can be selected without simulation verification.展开更多
Nonaqueous Li metal batteries(LMBs)and aqueous Zn metal batteries(ZMBs)are promising next-generation secondary batteries owing to their high energy density.Selecting an appropriate electrolyte is critical for addressi...Nonaqueous Li metal batteries(LMBs)and aqueous Zn metal batteries(ZMBs)are promising next-generation secondary batteries owing to their high energy density.Selecting an appropriate electrolyte is critical for addressing the safety issues nonaqueous and aqueous metal batteries can encounter.Ionic liquids(ILs)have been widely used in secondary metal batteries because they are non-flammable,present good thermal stability,and have wide electrochemical windows.This review highlights the research progress on IL-based electrolytes for stable Li/Zn metal anodes.We focus particularly on these electrolytes'electrochemistry and functionalities at the electrolyte/anode interface for inhibiting dendrite growth,preventing side reactions,and enhancing electrochemical performance.It is expected that this review will shed some light on the development of ILs for nextgeneration metal batteries.展开更多
基金supported by grants from the Special Funds for Construction of Innovative Provinces in Hunan Province(Grant No.2021NK1006)the Science and Technology Innovation Program of Hunan Province(Grant No.2021JC0007)+2 种基金China Agriculture Research System of MOF and MARA(Grant No.CARS-24-A-15)National Natural Science Foundation of China(Grant No.32130097)National Natural Science Foundation of China(Grant No.U19A2028)。
文摘Pepper(Capsicum annuum L.)is a typical self-pollinating crop with obvious heterosis in hybrids.Consequently,the use of morphological markers during the pepper seedling stage is crucial for pepper breeding.The color of hypocotyl is widely used as a phenotypic marker in crossing studies of pepper.Pepper accessions generally have purple hypocotyls,which are mainly due to the anthocyanin accumulation in seedlings,and green hypocotyls are rarely observed in pepper.Here we reported the characterization of a green hypocotyl mutant of pepper,Cha1,which was identified from a pepper ethyl methanesulfonate(EMS)mutant library.Fine mapping revealed that the causal gene,CaTTG1,belonging to the WD40 repeat family,controlled the green hypocotyl phenotype of the mutant.Virus-induced gene silencing(VIGS)confirmed that CaTTG1 regulated anthocyanin accumulation.RNA-seq data showed that expression of structural genes CaDFR,CaANS,and CaUF3GT in the anthocyanin biosynthetic pathway was significantly decreased in Cha1 compared to the wild type.Yeast two-hybrid(Y2H)experiments also confirmed that CaTTG1 activated the synthesis of anthocyanin structural genes by forming a MBW complex with CaAN1 and CaGL3.In summary,this study provided a green hypocotyl mutant of pepper,and the Kompetitive Allele Specific PCR(KASP)marker developed based on the mutation site of the underlying gene would be helpful for pepper breeding.
文摘With the rapid development of modern science and technology,the era of artificial intelligence has quietly come.Against the background of the new era,students’learning needs,learning resource acquisition methods,teachers’teaching concepts,teaching tools,and so on have changed significantly.How to carry out teaching reform based on this change has become one of the important issues facing educators,and the same is true for the teaching of computer programming courses.This paper focuses on the teaching reform of AI-enabled computer programming courses,analyzes its basic problems,and puts forward corresponding reform countermeasures to provide a useful reference for front-line teachers.
基金This work is supported by National Natural Science Foundation of China(61702048)。
文摘Internet of Things(IoT)technology is rapidly evolving,but there is no trusted platform to protect user privacy,protect information between different IoT domains,and promote edge processing.Therefore,we integrate the blockchain technology into constructing trusted IoT platforms.However,the application of blockchain in IoT is hampered by the challenges posed by heavy computing processes.To solve the problem,we put forward a blockchain framework based on mobile edge computing,in which the blockchain mining tasks can be offloaded to nearby nodes or the edge computing service providers and the encrypted hashes of blocks can be cached in the edge computing service providers.Moreover,we model the process of offloading and caching to ensure that both edge nodes and edge computing service providers obtain the maximum profit based on game theory and auction theory.Finally,the proposed mechanism is compared with the centralized mode,mode A(all the miners offload their tasks to the edge computing service providers),and mode B(all the miners offload their tasks to a group of neighbor devices).Simulation results show that under our mechanism,mining networks obtain more profits and consume less time on average.
基金supported by the National Natural Science Foundation of China (No.21776145 and 21676152)。
文摘Dynamic controls of pressure-swing distillation with an intermediate connection(PSDIC) process of ethyl acetate and ethanol separation were investigated.The double temperature/composition cascade control structure can perfectly implement effective control when ±20% feed disturbances were introduced.This control structure did not require the control of the flowrate of the side stream.The dynamic controllability of PSDIC with partial heat integration(PHIPSDIC) was also explored.The improved control structure can effectively control ±20% feed disturbances.However,in industrial production,simple controller,sensitive and easy to operate,is the optimal target.To avoid the use of component controllers or complex control structure,the original product purities could be maintained using the basic control structure for the PSDIC process if the product purities in steady state were properly increased,albeit by incurring a slight rise in the total annual cost(TAC).This alternative method without a composition controller combined with the energy-saving PSDIC process provides a simple and effective control scheme in industrial production.
文摘Inflammation plays an important role in atherosclerosis.Inflammasomes play a crucial role in innate immunity,which mediates the body’s response to various pathogens.Of the different types of inflammasomes,NLRP3 has been implicated in atherosclerosis through the production of proinfl ammatory cytokines,IL-1β and IL-18.This review describes the role of the NLRP3 infl ammasome in atherosclerosis and discusses potential therapeutic targets in the infl ammasome pathway.
基金financially supported by the National Natural Science Foundation of China (Nos.52171202,52177208,52071073)the financial support from CSIRO+3 种基金the Department of Climate Change,Energy,the Environment and Water (DCCEEW)Australian Governmentthe Australian Hydrogen Research Network (AHRN)the Australian Research Council (DE230100327 and LP220200583)the support from the DCCEEW International Clean Innovation Researcher Networks Grant (ICIRN000011)。
文摘Metal(Li,Na,K,Al)-ion batteries and lithium-sulfur and lithium-tellurium batteries are gaining recognition for their eco-friendly characteristics,substantial energy density,and sustainable attributes.However,the overall performance of rechargeable batteries heavily depends on their electrode materials.Transition metal tellurides have recently gained significant attention due to their high electrical conductivity and density.Cobalt telluride has received the most extensive research due to its catalytic activity,unique magnetic properties,and diverse composition and crystal structure.Nevertheless,its limited conductivity and significant volume variation contribute to electrode structural deterioration and rapid capacity decline.This review comprehensively summarizes recent advances in rational design and synthesis of modified cobalt telluride-based electrodes,encompassing defect engineering(Te vacancies,cation vacancies,heterointerfaces,and homogeneous interfaces)and composite engineering(derived carbon from precursors,carbon fibers,Mxene,graphene nanosheets,etc.).Particularly,the intricate evolution mechanisms of the conversion reaction process during cycling are elucidated.Furthermore,these modified strategies applied to other transitional metal tellurides,such as iron telluride,nickel telluride,zinc telluride,copper telluride,molybdenum telluride,etc.,are also thoroughly summarized.Additionally,their application extends to emerging aqueous zinc-ion batteries.Finally,potential challenges and prospects are discussed to further propel the development of transition metal tellurides electrode materials for next-generation rechargeable batteries.
基金supported by the National Natural Science Foundation of China(Nos.90305023 and 11172332)
文摘The crack tip fields are investigated for a cracked functionally graded material （FGM） plate by Reissner＇s linear plate theory with the consideration of the transverse shear deformation generated by bending. The elastic modulus and Poisson＇s ratio of the functionally graded plates are assumed to vary continuously through the coordinate y, according to a linear law and a constant, respectively. The governing equations, i.e., the 6th-order partial differential equations with variable coefficients, are derived in the polar coordinate system based on Reissner＇s plate theory. Furthermore, the generalized displacements are treated in a separation-of-variable form, and the higher-order crack tip fields of the cracked FGM plate are obtained by the eigen-expansion method. It is found that the analytic solutions degenerate to the corresponding fields of the isotropic homogeneous plate with Reissner＇s effect when the in-homogeneity parameter approaches zero.
基金supported by the Strategic Priority Research Program of Chinese Academy of Sciences(grant No.XDB41000000)the National Natural Science Foundation of China(NSFC,Grant Nos.12233008 and 11973038)+2 种基金the China Manned Space Project(No.CMS-CSST-2021-A07)the Cyrus Chun Ying Tang Foundationsthe support from Hong Kong Innovation and Technology Fund through the Research Talent Hub program(GSP028)。
文摘Most existing star-galaxy classifiers depend on the reduced information from catalogs,necessitating careful data processing and feature extraction.In this study,we employ a supervised machine learning method(GoogLeNet)to automatically classify stars and galaxies in the COSMOS field.Unlike traditional machine learning methods,we introduce several preprocessing techniques,including noise reduction and the unwrapping of denoised images in polar coordinates,applied to our carefully selected samples of stars and galaxies.By dividing the selected samples into training and validation sets in an 8:2 ratio,we evaluate the performance of the GoogLeNet model in distinguishing between stars and galaxies.The results indicate that the GoogLeNet model is highly effective,achieving accuracies of 99.6% and 99.9% for stars and galaxies,respectively.Furthermore,by comparing the results with and without preprocessing,we find that preprocessing can significantly improve classification accuracy(by approximately 2.0% to 6.0%)when the images are rotated.In preparation for the future launch of the China Space Station Telescope(CSST),we also evaluate the performance of the GoogLeNet model on the CSST simulation data.These results demonstrate a high level of accuracy(approximately 99.8%),indicating that this model can be effectively utilized for future observations with the CSST.
文摘Hypoxia has been identified as a common environmental stress factor associated with therapeutic resistance and metastasis in human cancers. A major player in regulating the response to hypoxia is the transcriptional factor hypoxia-inducible factor 1 alpha （HIF-1α）.
基金supported by the Shanghai Science and Technology Development Funds(No.20Z11900200 to R.R.)Key Project of National Natural Science Foundation of China(No.82230088 to R.R.)+5 种基金National Key Research and Development Program of China(No.2019YFA0905900 to J.L.No.2019YFA0905902 to S.W.),National Natural Science Foundation of China(No.82170147 to R.R.No.82370157 to J.L.No.81970134 and 82170111 to P.L.)Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01 to R.R.)the Samuel Waxman Cancer Research Foundation(to R.R.).
文摘Acute myeloid leukemia(AML)is an aging-related malignancy,with patients aged≥60 years old facing significantly poorer prognosis.Umbilical cord blood(UCB)has emerged as a promising source with effective anti-aging roles.Here,we conducted a prospective,phase 2,single-arm trial of UCB infusion as an adjuvant consolidation therapy in elderly AML patients(ChiCTR-OPC15006492).A total of 51 patients were enrolled(median age 66 years;range,60-75)and received two cycles of consolidation chemotherapy combined with UCB infusion.At a median follow-up of 27.3 months(range,9.3-100),the median overall survival(OS)was not yet reached and the median event-free survival(EFS)was 72.2 months(range,5.4-100).The 2-year OS and EFS rates were 76.9%and 62.8%,respectively.No acute graft-versus-host disease(aGVHD)or toxicity-related death occurred in any patient.The median times to platelet and neutrophil recovery were 11.5 days(range,6-17)and 12.2 days(range,0-21),respectively.Singlecell RNA sequencing(scRNA-seq)identified enhanced anti-tumor and anti-aging properties of UCB,manifested through activation of immune responses and telomere synthesis/maintenance.Thesefindings suggest that UCB infusion is an effective and safe postremission adjuvant therapy for elderly AML patients.This study provides evidence that anti-aging therapy may serve as a new and promising dimension in combined cancer treatment.
基金supported by grants from the National Natural Science Foundation of China(Nos.82100158,81890994,81770143,81970130,and 81861148030)Double First-Class Project(No.WF510162602)from the Ministry of Education+8 种基金State Key Laboratory of Medical Genomics,Overseas Expertise Introduction Project for Discipline Innovation(111 Project,No.B17029)National Key R&D Program of China(Nos.2019YFA0905902 and 2018YFA0107802)Natural Science Foundation of Shanghai(Nos.20JC1410600,21ZR1480900,and 21YF1427900)Shanghai Clinical Research Center for Hematologic Disease(No.19MC1910700)Shanghai Major Project for Clinical Medicine(No.2017ZZ01002)Shanghai Shenkang Hospital Development Center(No.SHDC2020CR5002)Innovative Research Team of High-level Local Universities in Shanghai,Shanghai Collaborative Innovation Program on Regenerative Medicine and Stem Cell Research(No.2019CXJQ01)Shanghai Jiao Tong University(No.YG2021QN19)Shanghai Guangci Translational Medical Research Development Foundation.
文摘With the recent ongoing autumn/winter 2022 COVID-19 wave and the adjustment of public health control measures,there have been widespread SARS-CoV-2 infections in Chinese mainland.Here we have analyzed 369 viral genomes from recently diagnosed COVID-19 patients in Shanghai,identifying a large number of sublineages of the SARS-CoV-2 Omicron family.Phylogenetic analysis,coupled with contact history tracing,revealed simultaneous community transmission of two Omicron sublineages dominating the infections in some areas of China(BA.5.2 mainly in Guangzhou and Shanghai,and BF.7 mainly in Beijing)and two highly infectious sublineages recently imported from abroad(XBB and BQ.1).Publicly available data from August 31 to November 29,2022 indicated an overall severe/critical case rate of 0.035%nationwide,while analysis of 5706 symptomatic patients treated at the Shanghai Public Health Center between September 1 and December 26,2022 showed that 20 cases(0.35%)without comorbidities progressed into severe/critical conditions and 153 cases(2.68%)with COVID-19-exacerbated comorbidities progressed into severe/critical conditions.These observations shall alert healthcare providers to place more resources for the treatment of severe/critical cases.Furthermore,mathematical modeling predicts this autumn/winter wave might pass through major cities in China by the end of the year,whereas some middle and western provinces and rural areas would be hit by the upcoming infection wave in mid-to-late January 2023,and the duration and magnitude of upcoming outbreak could be dramatically enhanced by the extensive travels during the Spring Festival(January 21,2023).Altogether,these preliminary data highlight the needs to allocate resources to early diagnosis and effective treatment of severe cases and the protection of vulnerable population,especially in the rural areas,to ensure the country’s smooth exit from the ongoing pandemic and accelerate socio-economic recovery.
基金This work is supported by the National Natural Science Foundation of China(Grant Nos.21776145 and 21676152).
文摘The traditional approach to solvent selction in the extractive distillation process strictly focuses on the change in the relative voltility of light-heavy components induced by the solvent.However,the total annual cost of the process may not be minimal when the solvent induces the largest change in relative volatility.This work presents a heuristic method for selecting the optimal solvent to minimize the total annual cost.The functional relationship between the relative volatility and the total annual cost is established,where the main factors,such as the relative volatility of the light-heavy components and the relative volatility of the heavy-component solvent,are taken into account.Binary azeotropic mixtures of methanol-toluene and methanol-acetone are separated to verify the feasibility of the model.The results show that using the solvent with the minimal two-column extractive distillation index,the process achieves a minimal total annual cost.The method is conducive for sustainable advancements in chemistry and engineering because a suitable solvent can be selected without simulation verification.
基金supported by the National Key Research and Development Program of China(Grant No.2019YFC1806103)the National Natural Science Foundation of China(Grant Nos.22278019,U22A20145,21975015)Fundamental Research Funds for the Central Universities(Grant No.buctrc201904).
文摘Nonaqueous Li metal batteries(LMBs)and aqueous Zn metal batteries(ZMBs)are promising next-generation secondary batteries owing to their high energy density.Selecting an appropriate electrolyte is critical for addressing the safety issues nonaqueous and aqueous metal batteries can encounter.Ionic liquids(ILs)have been widely used in secondary metal batteries because they are non-flammable,present good thermal stability,and have wide electrochemical windows.This review highlights the research progress on IL-based electrolytes for stable Li/Zn metal anodes.We focus particularly on these electrolytes'electrochemistry and functionalities at the electrolyte/anode interface for inhibiting dendrite growth,preventing side reactions,and enhancing electrochemical performance.It is expected that this review will shed some light on the development of ILs for nextgeneration metal batteries.
