Traditional diagnostic techniques including visual examination,ultrasound(US),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and practicality...Traditional diagnostic techniques including visual examination,ultrasound(US),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and practicality.This pilot study,for thefirst time,evaluates a dualmodality imaging system that combines photoacoustic tomography(PAT)with the US for the multiparametric quantitative assessment of human nail.The study involved a small cohort offive healthy volunteers who underwent PAT/US imaging for acquiring the nail unit data.The PAT/US dual-modality imaging successfully revealed thefine anatomical structures and microvascular distribution within the nail and nail bed.Moreover,this system utilized multispectral PAT to analyze functional tissue parameters,including oxygenated hemoglobin,deoxyhemoglobin,oxygen saturation,and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail bed.The quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed,under simulated different physiological conditions.This pilot study highlights the potential of PAT/US dual-modality imaging as a real-time,noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.展开更多
The primary objective of organic synthesis is the utilization of inexpensive and readily available industrial chemicals in large quantities to produce valuable organic compounds.This study introduces a direct and sele...The primary objective of organic synthesis is the utilization of inexpensive and readily available industrial chemicals in large quantities to produce valuable organic compounds.This study introduces a direct and selective approach for synthesizing arylamines using readily available cyclohexanones and ammonium salts through a dehydrogenative process.A variety of arylamine structural motifs,such as N-cyclohexylanilines,diphenylamines,and N-cyclohexyl-N-phenylanilines,were successfully synthesized with moderate to high yields.In comparison to traditional methods,these approaches are characterized by the utilization of simple starting materials,efficiency in steps and atom usage,as well as high selectivity.展开更多
基金supported by the program of Chengdu Fifth people's hospital Fund,No.KYJJ 2021-29the Xinglin Scholars research program,No.YYZX2021037+1 种基金the Chengdu Medical Research Project,Nos.2022055 and 2023022,Chongqing Education Commission,Youth Fund(No.KJQN202000607)Chongqing postdoctoral research project(special funding project,No.2021XM3040).
文摘Traditional diagnostic techniques including visual examination,ultrasound(US),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and practicality.This pilot study,for thefirst time,evaluates a dualmodality imaging system that combines photoacoustic tomography(PAT)with the US for the multiparametric quantitative assessment of human nail.The study involved a small cohort offive healthy volunteers who underwent PAT/US imaging for acquiring the nail unit data.The PAT/US dual-modality imaging successfully revealed thefine anatomical structures and microvascular distribution within the nail and nail bed.Moreover,this system utilized multispectral PAT to analyze functional tissue parameters,including oxygenated hemoglobin,deoxyhemoglobin,oxygen saturation,and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail bed.The quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed,under simulated different physiological conditions.This pilot study highlights the potential of PAT/US dual-modality imaging as a real-time,noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.
基金support from the National Natural Science Foundation of China(Nos.22271244 and 21801076)the Science and Technology Innovation Program of Hunan Province(No.2023RC3196)is gratefully acknowledged.
文摘The primary objective of organic synthesis is the utilization of inexpensive and readily available industrial chemicals in large quantities to produce valuable organic compounds.This study introduces a direct and selective approach for synthesizing arylamines using readily available cyclohexanones and ammonium salts through a dehydrogenative process.A variety of arylamine structural motifs,such as N-cyclohexylanilines,diphenylamines,and N-cyclohexyl-N-phenylanilines,were successfully synthesized with moderate to high yields.In comparison to traditional methods,these approaches are characterized by the utilization of simple starting materials,efficiency in steps and atom usage,as well as high selectivity.
