CD32a contributes to inflammation by interacting with CD137L to induce inflammatory dendritic cell differentiation.CD137 ligand(CD137L)is a costimulatory ligand that is expressed on antigen-presenting cells(APCs)and i...CD32a contributes to inflammation by interacting with CD137L to induce inflammatory dendritic cell differentiation.CD137 ligand(CD137L)is a costimulatory ligand that is expressed on antigen-presenting cells(APCs)and is important for enhancing T cell activation by crosslinking CD137 on activated T cells.1–3 While CD137 triggers a costimulatory signal in T cells,CD137L has been reported to trigger reverse signaling in APCs.4 In human monocytes,reverse CD137L signaling leads to the differentiation of dendritic cells(DCs),which are termed CD137L-DCs.展开更多
基金supported by a grant(NMRC/BnB/018b/2015)from the National Medical Research Council of Singapore.
文摘CD32a contributes to inflammation by interacting with CD137L to induce inflammatory dendritic cell differentiation.CD137 ligand(CD137L)is a costimulatory ligand that is expressed on antigen-presenting cells(APCs)and is important for enhancing T cell activation by crosslinking CD137 on activated T cells.1–3 While CD137 triggers a costimulatory signal in T cells,CD137L has been reported to trigger reverse signaling in APCs.4 In human monocytes,reverse CD137L signaling leads to the differentiation of dendritic cells(DCs),which are termed CD137L-DCs.
