Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent s...Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis.展开更多
The power law and reflection emission have been observed in the X-ray spectra of both black hole X-ray binaries(BHXRBs)and active galactic nuclei(AGNs),indicating a common physical origin of the X-ray emission from th...The power law and reflection emission have been observed in the X-ray spectra of both black hole X-ray binaries(BHXRBs)and active galactic nuclei(AGNs),indicating a common physical origin of the X-ray emission from these two types of sources.The relevant parameters describing the shape of both components and the potential correlation between these parameters can provide important clues on the geometric and physical properties of the disk and the corona in these sources.In this work,we present a positive correlation between the photon indexΓand the reflection strength R for the low-mass BHXRBs in the hard state by modeling NuSTAR data,which is qualitatively consistent with the previous studies.We compare our results with the predictions from different theoretical disk-corona models.We show that the RIT correlation found in this work seems to favor the moving corona model proposed by Beloborodov.Our results indicate that the coronal geometry varies significantly among BHXRBs.We further compare our results with that of AGNs.We find that the reflection strength R is smaller than unity in the hard state of BHXRBs,while it can be as large as~5 in AGNs,which implies that the variations of the disk-coronal geometry of AGNs are more vigorous than that of the BHXRBs in the hard state.展开更多
文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis.
基金funded by the National Aeronautics and Space Administrationsupported by the National Natural Science Foundation of China(11833007,12073023,12233007,and 12147103)+1 种基金the science research grants from the China Manned Space Project with No.CMS-CSST-2021-A06the fundamental research fund for Chinese central universities(Zhejiang University)。
文摘The power law and reflection emission have been observed in the X-ray spectra of both black hole X-ray binaries(BHXRBs)and active galactic nuclei(AGNs),indicating a common physical origin of the X-ray emission from these two types of sources.The relevant parameters describing the shape of both components and the potential correlation between these parameters can provide important clues on the geometric and physical properties of the disk and the corona in these sources.In this work,we present a positive correlation between the photon indexΓand the reflection strength R for the low-mass BHXRBs in the hard state by modeling NuSTAR data,which is qualitatively consistent with the previous studies.We compare our results with the predictions from different theoretical disk-corona models.We show that the RIT correlation found in this work seems to favor the moving corona model proposed by Beloborodov.Our results indicate that the coronal geometry varies significantly among BHXRBs.We further compare our results with that of AGNs.We find that the reflection strength R is smaller than unity in the hard state of BHXRBs,while it can be as large as~5 in AGNs,which implies that the variations of the disk-coronal geometry of AGNs are more vigorous than that of the BHXRBs in the hard state.
