Thermoelectric water spitting to hydrogen systems has great potential in the production of environment-friendly fuel using renewable solar energy in the future.In this work,we prepared porous nanosheet Mo doping Ni_(5...Thermoelectric water spitting to hydrogen systems has great potential in the production of environment-friendly fuel using renewable solar energy in the future.In this work,we prepared porous nanosheet Mo doping Ni_(5)P_(4)catalysts on nickel foam with efficient hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)performance in alkaline media.Density Functional Theory(DFT)calculations and experimental studies have shown that Mo doping deadeneds the interaction between H and O atomic orbitals of transition state water molecules,effectively weakening the activation energy of H_(2)O dissociation.Therefore,Mo doping is favorable for enhancing HER activity with overpotential at 10 mA cm^(-2)of 93 mV and Tafel slope of 40.1 mV dec^(-1)in 1 M KOH.Besides,it exhibits high alkaline OER activity with an ultra-low overpotential of 200 mV at 10 mA cm^(-2).Moreover,this catalyst only needs 1.537 V in a dual-electrode configuration of the electrolytic cell,which is much lower than the commercial Pt/C-RuO_(2)couple(1.614 V).In addition,we have developed and constructed a solar thermoelectric generator(TEG)that is capable of floating on water.This TEG has a continuous power output and an exceptionally long lifespan,providing a stable power supply to the synthesized catalyst electrolyzer.It can produce a maximum power output of over 90 mW,meeting the requirement of converting solar radiation heat into usable electricity.As a result,the system achieves productivity of 0.11 mL min^(-1)H_(2).This solar thermal energy conversion technology shows the possibility of large-scale industrial production of H_(2)and provides a new idea for exploring heat source utilization.展开更多
Polyamines(PAs)and ethylene are involved in the modulation of plant growth and development.However,their roles in fruit-set,especially in exogenous gibberellin(GA_(3))-induced grape parthenocarpic berries,and the rela...Polyamines(PAs)and ethylene are involved in the modulation of plant growth and development.However,their roles in fruit-set,especially in exogenous gibberellin(GA_(3))-induced grape parthenocarpic berries,and the related competitive action mode are poorly understood.For this,we,here performed their content determination,bioinformatics and expression pattern analysis of genes to identify the key ones in the competitive network of polyamines metabolic and ethylene biosynthesis(PMEB)pathways.The content of putrescine(Put)significantly increased;while 1-aminocyclopropanecarboxylic acid(ACC)sharply decreased during the fruit-set process of GA_(3)-induced grape parthenocarpic seedless berries.Totally,twenty-five genes in PMEB pathways,including 20 polyamines metabolic(PM)genes and 5 ethylene biosynthesis(EB)ones were identified in grape,of which 8 PM and 2 EB genes possessed the motifs responsive to phytohormone GA.The expression levels of most PMEB genes kept changing during grape fruit-set generating a competitive action mode of GA_(3)-mediated two metabolic fluxes toward PAs and ethylene synthesis.Exogenous GA_(3)might enhance grape fruit-set of parthenocarpic berries via up-regulation of VvSAMS4,VvSAMDC1/2,VvODC1,VvSPDS1,and VvPAO1 to promote PAs accumulation,whereby repressing the ethylene synthesis by down-regulation of VvACS1 and VvACO_(2).Our findings provide novel insights into GA_(3)-mediated competitive inhibition of ethylene by PAs to promote the fruit-set of parthenocarpic berries in grape,which has important implications for molecular breeding of seedless grape with high fruit-setting rate.展开更多
Avian metapneumovirus(aMPV),a paramyxovirus,causes acute respiratory diseases in turkeys and swollen head syndrome in chickens.This study established a reverse genetics system for aMPV subtype B LN16-A strain based on...Avian metapneumovirus(aMPV),a paramyxovirus,causes acute respiratory diseases in turkeys and swollen head syndrome in chickens.This study established a reverse genetics system for aMPV subtype B LN16-A strain based on T7 RNA polymerase.Full-length cDNA of the LN16-A strain was constructed by assembling 5 cDNA fragments between the T7 promoter and hepatitis delta virus ribozyme.Transfection of this plasmid,along with the supporting plasmids encoding the N,P,M2-1,and L proteins of LN16-A into BSR-T7/5 cells,resulted in the recovery of aMPV subtype B.To identify an effective insertion site,the enhanced green fluorescent protein(EGFP)gene was inserted into different sites of the LN16-A genome to generate recombinant LN16-As.The results showed that the expression levels of EGFP at the site between the G and L genes of LN16-A were significantly higher than those at the other two sites(between the leader and N genes or replacing the SH gene).To verify the availability of the site between G and L for foreign gene expression,the VP2 gene of very virulent infectious bursal disease virus(vvIBDV)was inserted into this site,and recombinant LN16-A(rLN16A-vvVP2)was successfully rescued.Single immunization of specificpathogen-free chickens with rLN16A-vvVP2 induced high levels of neutralizing antibodies and provided 100%protection against the virulent aMPV subtype B and vvIBDV.Establishing a reverse genetics system here provides an important foundation for understanding aMPV pathogenesis and developing novel vector vaccines.展开更多
The technology of photothermal catalytic degradation of acetone and conversion of nitrogen monoxide(NO)not only reduces energy consumption compared to traditional thermal catalytic oxidation technology but also improv...The technology of photothermal catalytic degradation of acetone and conversion of nitrogen monoxide(NO)not only reduces energy consumption compared to traditional thermal catalytic oxidation technology but also improves degradation efficiency,effectively overcoming the limitations of single photocatalytic or thermal catalytic technology.This paper aims to control the lattice oxygen activity and oxygen vacancy concentration of the catalyst by optimizing the manganese-cobalt(Mn-Co)molar ratio and modifying the catalyst with Ce doping,thereby enhancing its photocatalytic and thermal catalytic performance for the degradation of acetone and NO.At 240℃,when the Mn-Co molar ratio is 4:2,the CoO_(x)/MnO_(x)@Fe_(2)O_(3)-2 catalyst exhibits good catalytic activity for both acetone and NO,with conversion rates of 52%and 63.8%for acetone and NO,respectively.Based on the optimization of the Mn-Co molar ratio,Ce was doped into the CoO_(x)/MnO_(x)@Fe_(2)O_(3)-2 sample using the co-precipitation method to synthesize samples with different Ce doping amounts.The sample of CeO_(2)/CoO_(x)/MnO_(x)@Fe_(2)O_(3)-2-0.25(nMn-Co:nCe=1:0.25)shows the highest catalytic performance compared with the other samples,with the conversion of acetone and NO reaching 60%and 70%,respectively,at 240℃.Additionally,the intrinsic mechanism under photothermal synergy is based on the Mars-van Krevelen redox cycle theory.展开更多
The CeO_(2)-TiO_(2)@MnO_(x) catalyst was prepared by the co-precipitation method and applied to the photothermocatalysis system of ethyl acetate and NO simultaneous degradation under H_(2)O at low temperature,which in...The CeO_(2)-TiO_(2)@MnO_(x) catalyst was prepared by the co-precipitation method and applied to the photothermocatalysis system of ethyl acetate and NO simultaneous degradation under H_(2)O at low temperature,which introduced Ce into TiO_(2)@MnO_(x) hollow sptrera structure.The optimum TiO_(2)/MnO_(x) ratio and Ce introducing amount were obtained in the process.Among of them,the NO and ethyl acetate conversion percentage of TiO_(2)@MnO_(x)(n_(Mn):n_(Ti)=40:40)is 74%and 62%at 240℃,respectively.CeO_(2)-TiO_(2)@MnO_(x)(n_(Mn):n_(Ce)=1:1)exhibits the best catalytic performance,its efficiency for NO conversion is 83%and the conversion of ethyl acetate reaches 72%at 240℃.In addition,it is confirmed that the Cedoped nanocomposites have more uniform dispersion through various characterization and analysis methods.Meanwhile,these catalysts have a large specific surface area as well as a large number of surface-active oxygen and oxygen vacancies.It can further improve the catalytic performance based on the adjusted ratio of active components.Moreover,this work investigated the relationship between multi-metal interactions and catalytic performance in the presence of H_(2)O.Finally,the possible reaction pathways for the simultaneous removal of NO and ethyl acetate were explored in our system.展开更多
Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the domi...Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by serial passaging in Vero cells and evaluated its safety and efficacy as a vaccine candidate. The safety test showed that after the 30th passage, the LN16-A strain was fully attenuated, as clinical signs of infection and histological lesions were absent after inoculation.The LN16-A strain did not revert to a virulent strain after five serial passages in chickens. The genomic sequence of LN16-A differed from that of the parent wild-type LN16(wtLN16) strain and had nine amino acid mutations. In chickens, a single immunization with LN16-A induced robust humoral and cellular immune responses, including the abundant production of neutralizing antibodies, CD4^(+) T lymphocytes, and the Th1(IFN-γ) and Th2(IL-4 and IL-6)cytokines. We also confirmed that LN16-A provided 100% protection against subtype B aMPV and significantly reduced viral shedding and turbinate inflammation. Our findings suggest that the LN16-A strain is a promising live attenuated vaccine candidate that can prevent infection with subtype B aMPV.展开更多
The catalytic asymmetric dipolar cycloaddition reaction is efficient for the construction of various chiral valuable carbo-and heterocycles.Thus,the design and exploration of new dipoles and the subsequent control of ...The catalytic asymmetric dipolar cycloaddition reaction is efficient for the construction of various chiral valuable carbo-and heterocycles.Thus,the design and exploration of new dipoles and the subsequent control of their reactivity for various stereoselective cycloadditions are significant aspects of modern organic synthesis.Herein,we have developed a series of vinyl cyclic carbamates containing an oxazolidine-2,4–dione fragment and used them as reactive precursors for in situ generation of amide-based aza-π-allylpalladium 1,3-dipoles,which could be applied to asymmetric decarboxylative 1,3-dipolar cycloaddition with different types of dipolarophiles containing C=C,C=N,and C=O double bonds.This strategy provides an opportunity for the synthesis of previously unusual structures,such as highly functionalized optically pure pyrrolidin-2-ones,imidazolidin-4-ones,and oxazolidin-4-ones.This protocol also has significant features including wide substrate scope,mild reaction conditions,simple operation,and good to excellent results(70 examples,up to 99%yield,>20:1 dr and 99%ee).This unique method significantly expands the reaction range of the amide-based aza-π-allylpalladium 1,3-dipoles compared to the precedents.展开更多
Objective:To explore the effect of Social Skills Training(SST)on the social function of inpatients with schizophrenia.Methods:A total of 40 patients with schizophrenia(20 in the intervention group and 20 in the contro...Objective:To explore the effect of Social Skills Training(SST)on the social function of inpatients with schizophrenia.Methods:A total of 40 patients with schizophrenia(20 in the intervention group and 20 in the control group)were selected from a psychiatric hospital in Shanghai for 10 times(once a week)of social skills training.The control group was treated with routine hospitalization(drug therapy and routine hospitalization nursing)for 10 weeks.Social Disability Screening Schedule before and after intervention for patients enrolled in the intervention group(Social Disability Screening Schedule,SDSS and Scale of Social Function in Psychosis Inpatients,SSPI).Conclusion:The results of social skills training on SDSS and SSPI were different between the two groups,and there was no statistical value(P>0.05).Observation of patients in this group,when undergoing social skills training,SSPI score was significantly better than the control group(P<0.01)and SDSS score was significantly lower than the control group(P<0.01),the differences were statistically significant.Social skills training and social work group intervention can improve psychiatric symptoms and further enhance social function in hospitalized patients with schizophrenia.展开更多
The aim of this study was to develop and examine the morphology and distribution of mercury (Hg) in flue gas desulfurization (FGD) by-product.</span></span><span><span><span style="font...The aim of this study was to develop and examine the morphology and distribution of mercury (Hg) in flue gas desulfurization (FGD) by-product.</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mercury in the coal of coal-fired power plants is concentrated in the by-products of desulfurization process, and it is widely used as an additive in cement, building materials and other industries. Due to the different stability of various forms of mercury in the environment, subsequent use of products containing desulfurization by-product additives will continue to be released into the environment, endangering human health. Therefore, it is very necessary to study the form and distribution of mercury in the by-products of desulfurization in coal-fired power plants to provide a theoretical basis for subsequent harmless treatment.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">For content and morphology of mercury analysis, 1 sample of dry FGD ash and 6 samples of wet FGD gypsum were analyzed. The total 7 samples were extracted using a modification of sequential chemical extractions (SCE) method, which was employed for the partitioning Hg into four fractions: water soluble, acid soluble, H<sub>2</sub>O<sub>2</sub> soluble, and residual. The Hg analysis was done with United States Environmental Protection Agency (USEPA) method</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">7471B. Comparing with the wet FGD gypsums of coal-fired boilers, the total Hg content in the dry FGD by-product was as high as</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">1.22 mg/kg, while the total Hg content in the FGD gypsum is 0.23</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">0.74 mg/kg, which was 2 times over the wet FGD gypsum. The concentration of water soluble Hg in the dry FGD by-product was the highest amount (0.72 mg/kg), accounting for 59.02% of the total mercury. While residual Hg content was 0.16 mg/kg, only about 13.11% of the total mercury. Mercury content in FGD gypsum was expressed in the form of <i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(residual Hg) ></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(H</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;"> soluble Hg)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(water soluble Hg)</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(acid soluble Hg). The morphology and distribution of mercury in FGD by-products is supposed to be analyzed before utilization, and the impact of mercury on the environment should be considered.展开更多
Ultraviolet(UV)assisted zero-valent iron(ZVI)-activated sodium persulfate(PDS)oxidation(UV-ZVI-PDS)was used to treat waste activated sludge(WAS)in this study.The dewaterability performance and mechanism of WAS dewater...Ultraviolet(UV)assisted zero-valent iron(ZVI)-activated sodium persulfate(PDS)oxidation(UV-ZVI-PDS)was used to treat waste activated sludge(WAS)in this study.The dewaterability performance and mechanism of WAS dewatering were analyzed.The results showed that UV-ZVI-PDS can obtain better sludge dewatering performance in a wide pH range(2.0-8.0).When the molar ratio of ZVI/PDS was 0.6,UV was 254nm,PDS dosage was 200 mg/g TS(total solid),pH was 6.54,reaction time was 20 min,the CST(capillary suction time)and SRF(specific resistance to filtration)were decreased by 64.0%and 78.2%,respectively.The molar ratio of ZVI/PDS used in this paper is much lower than that of literatures,and the contents of total Fe and Fe^(2+) in sludge supernatant remained at a low level,as 3.7 mg/L and 0.0 mg/L.The analysis of extracellular polymeric substances(EPS),scanning electron microscope(SEM)and particle size distribution showed that the EPS could be effectively destroyed by UV-ZVI-PDS,the sludge flocs broken down into smaller particles,cracks and holes appeared,and then the bound water was released.At the same time,the highly hydrophilic tightly bound-EPS(TB-EPS)were converted into loosely bound EPS(LB-EPS)and soluble EPS(S-EPS).During sludge pretreated by UV-ZVI-PDS,positively charged ions,such as Fe^(2+),Fe^(3+) and H^(+),produced in the reaction system could reduce the electronegativity of sludge surface,promote sludge particles aggregation,and then enhanced the sludge dewaterability.展开更多
A multidisciplinary approach for the production and characterization of a series of high concentration Er3+activated SrLaGa3 O7(abbreviated as Er:SLGO)crystal fibers is shown to have a great promise for implementation...A multidisciplinary approach for the production and characterization of a series of high concentration Er3+activated SrLaGa3 O7(abbreviated as Er:SLGO)crystal fibers is shown to have a great promise for implementation in mid-infrared laser applications.The current approach includes the design and formation of unique layered tetrahedral network structures with several kinds of rare earth(RE)ions including Er ions distributing statistically between layers,such as Er:SLGO,Er,Nd:SLGO,Er,Yb,Ho:SLGO,Er,Eu:SLGO and Er,Ho:SLGO.Five kinds of Er:SLGO crystal fibers were designed to grow via a micropulling down method.Spectroscopic analyses show that Er,Yb,Ho:SLGO and Nd,Er:SLGO crystal fibers were superiorly endowed with inhomogeneous broadening absorption and strong emission.The unique structural components design enables the generation of improved absorption and emission recombination,and the inhibition of self-termination as well.Generally,the use of structural components design may warrant high-efficiency emissions in RE-doped crystal fibers.展开更多
Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling. Previous studies have addressed tracer toxicity, but whether tracers injected into an intact nerve result in func...Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling. Previous studies have addressed tracer toxicity, but whether tracers injected into an intact nerve result in functional impairment remains to be elucidated. In the present study, we examined the functions of motor, sensory and autonomic nerves following the application of 5% Fluoro-Gold, 4% True Blue and 10% Fluoro-Ruby （5 pL） to rat tibial nerves via pressure injection. A set of evaluation methods including walking track analysis, plantar test and laser Doppler perfusion imaging was used to determine the action of the fluorescent neuronal tracers. Additionally, nerve pathology and ratio of muscle wet weight were also observed. Results showed that injection of Fluoro-Gold significantly resulted in loss of motor nerve function, lower plantar sensibility, increasing blood flow volume and higher neurogenic vasodilatation. Myelinated nerve fiber degeneration, unclear boundaries in nerve fibers and high retrograde labeling efficacy were observed in the Fluoro-Gold group. The True Blue group also showed obvious neurogenic vasodilatation, but less severe loss of motor function and degeneration, and fewer labeled motor neurons were found compared with the Fluoro-Gold group. No anomalies of motor and sensory nerve function and no myelinated nerve fiber degeneration were observed in the Fluoro-Ruby group. Experimental findings indicate that Fluoro-Gold tracing could lead to significant functional impairment of motor, sensory and autonomic nerves, while functional impairment was less severe following True Blue tracing. Fluoro-Ruby injection appears to have no effect on neurological function.展开更多
Nanoimprint lithography(NIL) is an emerging micro/nano-patterning technique,which is a high-resolution,high-throughput and yet simple fabrication process.According to International Technology Roadmap for Semiconductor...Nanoimprint lithography(NIL) is an emerging micro/nano-patterning technique,which is a high-resolution,high-throughput and yet simple fabrication process.According to International Technology Roadmap for Semiconductor(ITRS),NIL has emerged as the next generation lithography candidate for the22 nm and 16 nm technological nodes.In this paper,we present an overview of nanoimprint lithography.The classfication,research focus,critical issues,and the future of nanoimprint lithography are intensively elaborated.A pattern as small as 2.4 nm has been demonstrated.Full-wafer nanoimprint lithography has been completed on a 12-inch wafer.Recently,12.5 nm pattern resolution through soft molecular scale nanoimprint lithography has been achieved by EV Group,a leading nanoimprint lithography technology supplier.展开更多
The tumor suppressor p53 transactivates the expression of multiple genes to exert its multifaceted functions and ultimately maintains genome stability.Thus,cancer cells develop various mechanisms to diminish p53 expre...The tumor suppressor p53 transactivates the expression of multiple genes to exert its multifaceted functions and ultimately maintains genome stability.Thus,cancer cells develop various mechanisms to diminish p53 expression and bypass the cell cycle checkpoint.In this study,we identified the gene encoding RNAbinding protein cytoplasmic polyadenylation element-binding protein 2(CPEB2)as a p53 target.In turn,CPEB2 decreases p53 messenger RNA stability and translation to fine-tune p53 level.Specifically,we showed that CPEB2 binds the cytoplasmic polyadenylation elements in the p5330-untranslated region,and the RNA recognition motif and zinc finger(ZF)domains of CPEB2 are required for this binding.Furthermore,we found that CPEB2 was upregulated in renal cancer tissues and promotes the renal cancer cell proliferation and migration.The oncogenic effect of CPEB2 is partially dependent on negative feedback regulation of p53.Overall,we identify a novel regulatory feedback loop between p53 and CPEB2 and demonstrate that CPEB2 promotes tumor progression by inactivating p53,suggesting that CPEB2 is a potential therapeutic target in human renal cancer.展开更多
A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as wel...A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.展开更多
The study of vehicular networks has attracted considerable interest in academia and the industry.In the broad area,connected vehicles and autonomous driving are technologies based on wireless data communication betwee...The study of vehicular networks has attracted considerable interest in academia and the industry.In the broad area,connected vehicles and autonomous driving are technologies based on wireless data communication between vehicles or between vehicles and infrastructures.A Vehicle-to-Infrastructure(V2I)system consists of communications and computing over vehicles and related infrastructures.In such a system,wireless sensors are installed in some selected points along roads or driving areas.In autonomous driving,it is crucial for a vehicle to figure out the ideal routes by the communications between its equipped sensors and infrastructures then the vehicle is automatically moving along the routes.In this paper,we propose a Bezier curve based recursive algorithm,which effectively creates routes for vehicles through the communication between the On-Board Unit(OBU)and the Road-Side Units(RSUs).In addition,this approach generates a very low overhead.We conduct simulations to test the proposed algorithm in various situations.The experiment results demonstrate that our algorithm creates almost ideal routes.展开更多
基金supported by the Hainan Provincial Natural Science Foundation of China(Nos.522MS038 and 522QN282)the National Natural Science Foundation of China(Nos.52172086 and 52301268)the Start-up Research Foundation of Hainan University(No.KYQD(ZR)-22019).
文摘Thermoelectric water spitting to hydrogen systems has great potential in the production of environment-friendly fuel using renewable solar energy in the future.In this work,we prepared porous nanosheet Mo doping Ni_(5)P_(4)catalysts on nickel foam with efficient hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)performance in alkaline media.Density Functional Theory(DFT)calculations and experimental studies have shown that Mo doping deadeneds the interaction between H and O atomic orbitals of transition state water molecules,effectively weakening the activation energy of H_(2)O dissociation.Therefore,Mo doping is favorable for enhancing HER activity with overpotential at 10 mA cm^(-2)of 93 mV and Tafel slope of 40.1 mV dec^(-1)in 1 M KOH.Besides,it exhibits high alkaline OER activity with an ultra-low overpotential of 200 mV at 10 mA cm^(-2).Moreover,this catalyst only needs 1.537 V in a dual-electrode configuration of the electrolytic cell,which is much lower than the commercial Pt/C-RuO_(2)couple(1.614 V).In addition,we have developed and constructed a solar thermoelectric generator(TEG)that is capable of floating on water.This TEG has a continuous power output and an exceptionally long lifespan,providing a stable power supply to the synthesized catalyst electrolyzer.It can produce a maximum power output of over 90 mW,meeting the requirement of converting solar radiation heat into usable electricity.As a result,the system achieves productivity of 0.11 mL min^(-1)H_(2).This solar thermal energy conversion technology shows the possibility of large-scale industrial production of H_(2)and provides a new idea for exploring heat source utilization.
基金supported by grants from Jiangsu province seed industry revitalization of the leading project(JBGS[2021]086)the National Natural Science Funds(31972373,32272647,32202433)+1 种基金the Provincial Natural Science Foundation of Jiangsu(BK20200541)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China(PAPD),and Postgraduate Research&Practice Innovation Program of Jiangsu Province,China(KYCX22_0754,SJCX23-0209).
文摘Polyamines(PAs)and ethylene are involved in the modulation of plant growth and development.However,their roles in fruit-set,especially in exogenous gibberellin(GA_(3))-induced grape parthenocarpic berries,and the related competitive action mode are poorly understood.For this,we,here performed their content determination,bioinformatics and expression pattern analysis of genes to identify the key ones in the competitive network of polyamines metabolic and ethylene biosynthesis(PMEB)pathways.The content of putrescine(Put)significantly increased;while 1-aminocyclopropanecarboxylic acid(ACC)sharply decreased during the fruit-set process of GA_(3)-induced grape parthenocarpic seedless berries.Totally,twenty-five genes in PMEB pathways,including 20 polyamines metabolic(PM)genes and 5 ethylene biosynthesis(EB)ones were identified in grape,of which 8 PM and 2 EB genes possessed the motifs responsive to phytohormone GA.The expression levels of most PMEB genes kept changing during grape fruit-set generating a competitive action mode of GA_(3)-mediated two metabolic fluxes toward PAs and ethylene synthesis.Exogenous GA_(3)might enhance grape fruit-set of parthenocarpic berries via up-regulation of VvSAMS4,VvSAMDC1/2,VvODC1,VvSPDS1,and VvPAO1 to promote PAs accumulation,whereby repressing the ethylene synthesis by down-regulation of VvACS1 and VvACO_(2).Our findings provide novel insights into GA_(3)-mediated competitive inhibition of ethylene by PAs to promote the fruit-set of parthenocarpic berries in grape,which has important implications for molecular breeding of seedless grape with high fruit-setting rate.
基金supported by the grants from the National Key Research and Development Program of China(2022YFD1800604)the China Agriculture Research System(CARS-41)the Heilongjiang Touyan Innovation Team Program,China。
文摘Avian metapneumovirus(aMPV),a paramyxovirus,causes acute respiratory diseases in turkeys and swollen head syndrome in chickens.This study established a reverse genetics system for aMPV subtype B LN16-A strain based on T7 RNA polymerase.Full-length cDNA of the LN16-A strain was constructed by assembling 5 cDNA fragments between the T7 promoter and hepatitis delta virus ribozyme.Transfection of this plasmid,along with the supporting plasmids encoding the N,P,M2-1,and L proteins of LN16-A into BSR-T7/5 cells,resulted in the recovery of aMPV subtype B.To identify an effective insertion site,the enhanced green fluorescent protein(EGFP)gene was inserted into different sites of the LN16-A genome to generate recombinant LN16-As.The results showed that the expression levels of EGFP at the site between the G and L genes of LN16-A were significantly higher than those at the other two sites(between the leader and N genes or replacing the SH gene).To verify the availability of the site between G and L for foreign gene expression,the VP2 gene of very virulent infectious bursal disease virus(vvIBDV)was inserted into this site,and recombinant LN16-A(rLN16A-vvVP2)was successfully rescued.Single immunization of specificpathogen-free chickens with rLN16A-vvVP2 induced high levels of neutralizing antibodies and provided 100%protection against the virulent aMPV subtype B and vvIBDV.Establishing a reverse genetics system here provides an important foundation for understanding aMPV pathogenesis and developing novel vector vaccines.
基金supported by the Foundation of Guangxi Science and Technology of Base&Talent Special Program(AD20159067)Central Guiding Local Development of Science and Technology Plan Project in Guigang City(2023 No.2)。
文摘The technology of photothermal catalytic degradation of acetone and conversion of nitrogen monoxide(NO)not only reduces energy consumption compared to traditional thermal catalytic oxidation technology but also improves degradation efficiency,effectively overcoming the limitations of single photocatalytic or thermal catalytic technology.This paper aims to control the lattice oxygen activity and oxygen vacancy concentration of the catalyst by optimizing the manganese-cobalt(Mn-Co)molar ratio and modifying the catalyst with Ce doping,thereby enhancing its photocatalytic and thermal catalytic performance for the degradation of acetone and NO.At 240℃,when the Mn-Co molar ratio is 4:2,the CoO_(x)/MnO_(x)@Fe_(2)O_(3)-2 catalyst exhibits good catalytic activity for both acetone and NO,with conversion rates of 52%and 63.8%for acetone and NO,respectively.Based on the optimization of the Mn-Co molar ratio,Ce was doped into the CoO_(x)/MnO_(x)@Fe_(2)O_(3)-2 sample using the co-precipitation method to synthesize samples with different Ce doping amounts.The sample of CeO_(2)/CoO_(x)/MnO_(x)@Fe_(2)O_(3)-2-0.25(nMn-Co:nCe=1:0.25)shows the highest catalytic performance compared with the other samples,with the conversion of acetone and NO reaching 60%and 70%,respectively,at 240℃.Additionally,the intrinsic mechanism under photothermal synergy is based on the Mars-van Krevelen redox cycle theory.
基金Project supported by the Foundation of Guangxi Science and Technology of Base&Talent Special Program(AD20159067)Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology(2101Z002)。
文摘The CeO_(2)-TiO_(2)@MnO_(x) catalyst was prepared by the co-precipitation method and applied to the photothermocatalysis system of ethyl acetate and NO simultaneous degradation under H_(2)O at low temperature,which introduced Ce into TiO_(2)@MnO_(x) hollow sptrera structure.The optimum TiO_(2)/MnO_(x) ratio and Ce introducing amount were obtained in the process.Among of them,the NO and ethyl acetate conversion percentage of TiO_(2)@MnO_(x)(n_(Mn):n_(Ti)=40:40)is 74%and 62%at 240℃,respectively.CeO_(2)-TiO_(2)@MnO_(x)(n_(Mn):n_(Ce)=1:1)exhibits the best catalytic performance,its efficiency for NO conversion is 83%and the conversion of ethyl acetate reaches 72%at 240℃.In addition,it is confirmed that the Cedoped nanocomposites have more uniform dispersion through various characterization and analysis methods.Meanwhile,these catalysts have a large specific surface area as well as a large number of surface-active oxygen and oxygen vacancies.It can further improve the catalytic performance based on the adjusted ratio of active components.Moreover,this work investigated the relationship between multi-metal interactions and catalytic performance in the presence of H_(2)O.Finally,the possible reaction pathways for the simultaneous removal of NO and ethyl acetate were explored in our system.
基金supported by the National Key Research and Development Program of China (2022YFD1800604)the China Agricultural Research System (CARS-41)the Heilongjiang Touyan Innovation Team Program of China
文摘Avian metapneumovirus(aMPV) is a highly contagious pathogen that causes acute upper respiratory tract diseases in chickens and turkeys, resulting in serious economic losses. Subtype B aMPV has recently become the dominant epidemic strain in China. We developed an attenuated aMPV subtype B strain by serial passaging in Vero cells and evaluated its safety and efficacy as a vaccine candidate. The safety test showed that after the 30th passage, the LN16-A strain was fully attenuated, as clinical signs of infection and histological lesions were absent after inoculation.The LN16-A strain did not revert to a virulent strain after five serial passages in chickens. The genomic sequence of LN16-A differed from that of the parent wild-type LN16(wtLN16) strain and had nine amino acid mutations. In chickens, a single immunization with LN16-A induced robust humoral and cellular immune responses, including the abundant production of neutralizing antibodies, CD4^(+) T lymphocytes, and the Th1(IFN-γ) and Th2(IL-4 and IL-6)cytokines. We also confirmed that LN16-A provided 100% protection against subtype B aMPV and significantly reduced viral shedding and turbinate inflammation. Our findings suggest that the LN16-A strain is a promising live attenuated vaccine candidate that can prevent infection with subtype B aMPV.
基金the National Natural Science Foundation of China(Nos.22271027,22171029,21901024,21871252,21801024,and 21801026)the Sichuan Science and Technology Program(No.2021YFS0315)the Talent Program of Chengdu University(Nos.2081919035 and 2081921038)。
文摘The catalytic asymmetric dipolar cycloaddition reaction is efficient for the construction of various chiral valuable carbo-and heterocycles.Thus,the design and exploration of new dipoles and the subsequent control of their reactivity for various stereoselective cycloadditions are significant aspects of modern organic synthesis.Herein,we have developed a series of vinyl cyclic carbamates containing an oxazolidine-2,4–dione fragment and used them as reactive precursors for in situ generation of amide-based aza-π-allylpalladium 1,3-dipoles,which could be applied to asymmetric decarboxylative 1,3-dipolar cycloaddition with different types of dipolarophiles containing C=C,C=N,and C=O double bonds.This strategy provides an opportunity for the synthesis of previously unusual structures,such as highly functionalized optically pure pyrrolidin-2-ones,imidazolidin-4-ones,and oxazolidin-4-ones.This protocol also has significant features including wide substrate scope,mild reaction conditions,simple operation,and good to excellent results(70 examples,up to 99%yield,>20:1 dr and 99%ee).This unique method significantly expands the reaction range of the amide-based aza-π-allylpalladium 1,3-dipoles compared to the precedents.
基金Hospital-level project of Shanghai Jinshan Mental Health Center,“Effects of SST Social Skills Training Group on Social Function of Schizophrenia Patients”(Project No.:JZX-2022-002)。
文摘Objective:To explore the effect of Social Skills Training(SST)on the social function of inpatients with schizophrenia.Methods:A total of 40 patients with schizophrenia(20 in the intervention group and 20 in the control group)were selected from a psychiatric hospital in Shanghai for 10 times(once a week)of social skills training.The control group was treated with routine hospitalization(drug therapy and routine hospitalization nursing)for 10 weeks.Social Disability Screening Schedule before and after intervention for patients enrolled in the intervention group(Social Disability Screening Schedule,SDSS and Scale of Social Function in Psychosis Inpatients,SSPI).Conclusion:The results of social skills training on SDSS and SSPI were different between the two groups,and there was no statistical value(P>0.05).Observation of patients in this group,when undergoing social skills training,SSPI score was significantly better than the control group(P<0.01)and SDSS score was significantly lower than the control group(P<0.01),the differences were statistically significant.Social skills training and social work group intervention can improve psychiatric symptoms and further enhance social function in hospitalized patients with schizophrenia.
文摘The aim of this study was to develop and examine the morphology and distribution of mercury (Hg) in flue gas desulfurization (FGD) by-product.</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Mercury in the coal of coal-fired power plants is concentrated in the by-products of desulfurization process, and it is widely used as an additive in cement, building materials and other industries. Due to the different stability of various forms of mercury in the environment, subsequent use of products containing desulfurization by-product additives will continue to be released into the environment, endangering human health. Therefore, it is very necessary to study the form and distribution of mercury in the by-products of desulfurization in coal-fired power plants to provide a theoretical basis for subsequent harmless treatment.</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">For content and morphology of mercury analysis, 1 sample of dry FGD ash and 6 samples of wet FGD gypsum were analyzed. The total 7 samples were extracted using a modification of sequential chemical extractions (SCE) method, which was employed for the partitioning Hg into four fractions: water soluble, acid soluble, H<sub>2</sub>O<sub>2</sub> soluble, and residual. The Hg analysis was done with United States Environmental Protection Agency (USEPA) method</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">7471B. Comparing with the wet FGD gypsums of coal-fired boilers, the total Hg content in the dry FGD by-product was as high as</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">1.22 mg/kg, while the total Hg content in the FGD gypsum is 0.23</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">0.74 mg/kg, which was 2 times over the wet FGD gypsum. The concentration of water soluble Hg in the dry FGD by-product was the highest amount (0.72 mg/kg), accounting for 59.02% of the total mercury. While residual Hg content was 0.16 mg/kg, only about 13.11% of the total mercury. Mercury content in FGD gypsum was expressed in the form of <i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(residual Hg) ></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(H</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">O</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;"> soluble Hg)</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(water soluble Hg)</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"><i></span><i><span style="font-family:Verdana;">ρ</span></i><span style="font-family:Verdana;"></i></span></span></span></span><span><span><i><span style="font-family:""> </span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">(acid soluble Hg). The morphology and distribution of mercury in FGD by-products is supposed to be analyzed before utilization, and the impact of mercury on the environment should be considered.
基金This work was supported by the National Natural Science Foundation of China(No.51608166)the China Scholarship Council(No.201906705003).
文摘Ultraviolet(UV)assisted zero-valent iron(ZVI)-activated sodium persulfate(PDS)oxidation(UV-ZVI-PDS)was used to treat waste activated sludge(WAS)in this study.The dewaterability performance and mechanism of WAS dewatering were analyzed.The results showed that UV-ZVI-PDS can obtain better sludge dewatering performance in a wide pH range(2.0-8.0).When the molar ratio of ZVI/PDS was 0.6,UV was 254nm,PDS dosage was 200 mg/g TS(total solid),pH was 6.54,reaction time was 20 min,the CST(capillary suction time)and SRF(specific resistance to filtration)were decreased by 64.0%and 78.2%,respectively.The molar ratio of ZVI/PDS used in this paper is much lower than that of literatures,and the contents of total Fe and Fe^(2+) in sludge supernatant remained at a low level,as 3.7 mg/L and 0.0 mg/L.The analysis of extracellular polymeric substances(EPS),scanning electron microscope(SEM)and particle size distribution showed that the EPS could be effectively destroyed by UV-ZVI-PDS,the sludge flocs broken down into smaller particles,cracks and holes appeared,and then the bound water was released.At the same time,the highly hydrophilic tightly bound-EPS(TB-EPS)were converted into loosely bound EPS(LB-EPS)and soluble EPS(S-EPS).During sludge pretreated by UV-ZVI-PDS,positively charged ions,such as Fe^(2+),Fe^(3+) and H^(+),produced in the reaction system could reduce the electronegativity of sludge surface,promote sludge particles aggregation,and then enhanced the sludge dewaterability.
基金Project supported by National Natural Science Foundation of China(51832007,51472240,51872286,61675204)Science and Technology Plan Leading Project of Fujian Province(2018H0046)+1 种基金State Key Laboratory of Rare Earth Resource Utilization(RERU2018004,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences)the National Key Research and Development Program of China(2016YFB0701002)。
文摘A multidisciplinary approach for the production and characterization of a series of high concentration Er3+activated SrLaGa3 O7(abbreviated as Er:SLGO)crystal fibers is shown to have a great promise for implementation in mid-infrared laser applications.The current approach includes the design and formation of unique layered tetrahedral network structures with several kinds of rare earth(RE)ions including Er ions distributing statistically between layers,such as Er:SLGO,Er,Nd:SLGO,Er,Yb,Ho:SLGO,Er,Eu:SLGO and Er,Ho:SLGO.Five kinds of Er:SLGO crystal fibers were designed to grow via a micropulling down method.Spectroscopic analyses show that Er,Yb,Ho:SLGO and Nd,Er:SLGO crystal fibers were superiorly endowed with inhomogeneous broadening absorption and strong emission.The unique structural components design enables the generation of improved absorption and emission recombination,and the inhibition of self-termination as well.Generally,the use of structural components design may warrant high-efficiency emissions in RE-doped crystal fibers.
基金financially supported by the National High-Tech Research and Development Program of China(863 Program),No.2012AA020502the National Natural Science Foundation of China,No.81100939 and 81130080+2 种基金the Collegiate Natural Science Foundation of Jiangsu Province,No.10KJB310009the Innovation Program for Collegiate Postgraduates of Jiangsu Province,No.CXZZ12_0872the Qinglan Project of Jiangsu Province
文摘Fluorescent neuronal tracers should not be toxic to the nervous system when used in long-term labeling. Previous studies have addressed tracer toxicity, but whether tracers injected into an intact nerve result in functional impairment remains to be elucidated. In the present study, we examined the functions of motor, sensory and autonomic nerves following the application of 5% Fluoro-Gold, 4% True Blue and 10% Fluoro-Ruby （5 pL） to rat tibial nerves via pressure injection. A set of evaluation methods including walking track analysis, plantar test and laser Doppler perfusion imaging was used to determine the action of the fluorescent neuronal tracers. Additionally, nerve pathology and ratio of muscle wet weight were also observed. Results showed that injection of Fluoro-Gold significantly resulted in loss of motor nerve function, lower plantar sensibility, increasing blood flow volume and higher neurogenic vasodilatation. Myelinated nerve fiber degeneration, unclear boundaries in nerve fibers and high retrograde labeling efficacy were observed in the Fluoro-Gold group. The True Blue group also showed obvious neurogenic vasodilatation, but less severe loss of motor function and degeneration, and fewer labeled motor neurons were found compared with the Fluoro-Gold group. No anomalies of motor and sensory nerve function and no myelinated nerve fiber degeneration were observed in the Fluoro-Ruby group. Experimental findings indicate that Fluoro-Gold tracing could lead to significant functional impairment of motor, sensory and autonomic nerves, while functional impairment was less severe following True Blue tracing. Fluoro-Ruby injection appears to have no effect on neurological function.
基金supported by Natural Science Foundation of Shanghai(No.11ZR1432100)Shanghai Postdoctoral Science Foundation(11R21420900)
文摘Nanoimprint lithography(NIL) is an emerging micro/nano-patterning technique,which is a high-resolution,high-throughput and yet simple fabrication process.According to International Technology Roadmap for Semiconductor(ITRS),NIL has emerged as the next generation lithography candidate for the22 nm and 16 nm technological nodes.In this paper,we present an overview of nanoimprint lithography.The classfication,research focus,critical issues,and the future of nanoimprint lithography are intensively elaborated.A pattern as small as 2.4 nm has been demonstrated.Full-wafer nanoimprint lithography has been completed on a 12-inch wafer.Recently,12.5 nm pattern resolution through soft molecular scale nanoimprint lithography has been achieved by EV Group,a leading nanoimprint lithography technology supplier.
基金supported by grants from the National Natural Science Foundation of China(81972377,82025027,31301131,81972723)the Science and Technology Project of Xuzhou(KC19064)+1 种基金the Social Development Project of Jiangsu Province(BE2019644)the Natural Science Foundation of the Jiangsu Higher Education Institutions(18KJA320012)。
文摘The tumor suppressor p53 transactivates the expression of multiple genes to exert its multifaceted functions and ultimately maintains genome stability.Thus,cancer cells develop various mechanisms to diminish p53 expression and bypass the cell cycle checkpoint.In this study,we identified the gene encoding RNAbinding protein cytoplasmic polyadenylation element-binding protein 2(CPEB2)as a p53 target.In turn,CPEB2 decreases p53 messenger RNA stability and translation to fine-tune p53 level.Specifically,we showed that CPEB2 binds the cytoplasmic polyadenylation elements in the p5330-untranslated region,and the RNA recognition motif and zinc finger(ZF)domains of CPEB2 are required for this binding.Furthermore,we found that CPEB2 was upregulated in renal cancer tissues and promotes the renal cancer cell proliferation and migration.The oncogenic effect of CPEB2 is partially dependent on negative feedback regulation of p53.Overall,we identify a novel regulatory feedback loop between p53 and CPEB2 and demonstrate that CPEB2 promotes tumor progression by inactivating p53,suggesting that CPEB2 is a potential therapeutic target in human renal cancer.
文摘A series of novel benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids were designed, synthesized and evaluated for their in vitro anti-TB activities against drug-sensitive MTB H_(37)Rv and MDR-TB isolates as well as cytotoxicity. All benzofuran-isatin-hydroxylimine/thiosemicarbazide hybrids exhibited considerable in vitro anti-mycobacterial activities against the tested three MTB strains, and all of them also showed acceptable cytotoxicity. The most active hybrid 7f was >4.8 and >51 folds more potent than the first line anti-TB agents RIF and INH against both drug-sensitive MTB H_(37)Rv and MDR-TB isolates, respectively. The results demonstrated the potential utility of benzofuran-isatin-hydroxylimine/-thiosemicarbazide hybrids as anti-TB agents.
基金the Presidential Incentive Awards(No.1103 and No.1105)MCCB summer research award in the University of North Georgia.
文摘The study of vehicular networks has attracted considerable interest in academia and the industry.In the broad area,connected vehicles and autonomous driving are technologies based on wireless data communication between vehicles or between vehicles and infrastructures.A Vehicle-to-Infrastructure(V2I)system consists of communications and computing over vehicles and related infrastructures.In such a system,wireless sensors are installed in some selected points along roads or driving areas.In autonomous driving,it is crucial for a vehicle to figure out the ideal routes by the communications between its equipped sensors and infrastructures then the vehicle is automatically moving along the routes.In this paper,we propose a Bezier curve based recursive algorithm,which effectively creates routes for vehicles through the communication between the On-Board Unit(OBU)and the Road-Side Units(RSUs).In addition,this approach generates a very low overhead.We conduct simulations to test the proposed algorithm in various situations.The experiment results demonstrate that our algorithm creates almost ideal routes.
