The production of medical waste(MW)is a growing concern,particularly in light of the increasing annual generation and the exacerbating effects of the COVID-19 pandemic.Traditional techniques such as incineration and l...The production of medical waste(MW)is a growing concern,particularly in light of the increasing annual generation and the exacerbating effects of the COVID-19 pandemic.Traditional techniques such as incineration and landfilling present significant limitations.In this study,a self-designed 50 kW arc plasma reactor was employed to conduct gasification experiments on nitrile-butadiene rubber(NBR)which served as a model of MWand a mixture of NBR/SiO_(2) which served as a model of glass-containing MW,using CO_(2)as the working gas.The CO_(2)thermal plasma gasification process not only ensures the safe and efficient disposal of MW,but also facilitates its effective conversion into H_(2)and CO,achieving a carbon conversion efficiency of 94.52%.The yields of H2 and CO reached 98.52%and 81.83%,respectively,and the specific energy consumption was as low as 3.55 kW·h·kg^(-1).Furthermore,the addition of SiO_(2) was found to inhibit the gasification of NBR and cause damage to the reactor.Therefore,it is recommended that glass waste should be removed prior to the treatment of MW.The CO_(2)thermal plasma gasification technology can not only eliminate environmental and health risks posed by MW,but also convert it into syngas for further utilization.This provides a promising approach to the harmless and resource disposal of MW,while also contributing to the comprehensive utilization of greenhouse gases.展开更多
While alpine meadow degradation presents a significant ecological challenge,research on the complex patterns of soil property changes induced by degradation has been somewhat limited.In this study,we investigated the ...While alpine meadow degradation presents a significant ecological challenge,research on the complex patterns of soil property changes induced by degradation has been somewhat limited.In this study,we investigated the Maqu alpine meadow,meticulously categorizing it into different grassland types exhibiting varying degrees of degradation based on factors such as vegetation coverage and community,soil characteristics,and landscape features.These classifications included typical grassland,degraded grassland,desertified grassland,and sandy land.In August 2018,we established three quadrats at each sample point and collected soil samples at five depths(surface(0-2 cm),2-5 cm,5-10 cm,10-20 cm,and 20-40 cm)to analyze soil particle size distribution(PSD)and nutrients content.The results revealed a discernible trend:alpine meadow degradation led to selective loss of nutrient-rich soil fine particles,resulting in significant alterations in soil PSD and nutrients,particularly pronounced in grasslands with low degrees of degradation.Moreover,within a specific range of degradation degree,the clay content in the shallow soil of alpine meadow increased with the degradation degree,but it declined when the degradation degree exceeded a certain threshold.Degradation also disrupted the intricate relationship between soil nutrients,with notable variations in their coupling.This difference was also reflected in the influence of soil physical and chemical properties on soil nutrients,with the explanatory power of each environmental indicator on soil nutrients decreasing significantly with increasing degradation.This study systematically analyzed the variation in soil physical and chemical properties throughout the degradation process,revealing the mechanism of soil nutrient imbalance and decline caused by the degradation process.It provides crucial theoretical foundations and reference points for the preservation and rejuvenation of alpine meadows,enriching the methodology for assessing the impact of grassland degradation.展开更多
In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to p...In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to protect the security of whole system.In the proposed security defense system,the security is protected by the intelligent immunity through three functions,identification function,learning function,and regulation function,respectively.Meanwhile,a three process-based intelligent algorithm is proposed for the intelligent immunity system.Numerical simulations are given to prove the effeteness of the proposed approach.展开更多
In recent years,the desertification of alpine meadows has become a serious ecological problem and has gradually become a threat to regional economic activities in Maqu County.To reveal the mechanism for sandy desertif...In recent years,the desertification of alpine meadows has become a serious ecological problem and has gradually become a threat to regional economic activities in Maqu County.To reveal the mechanism for sandy desertification of alpine meadows,we conducted wind tunnel experiments on aeolian processes over sandy alpine meadows.Results show that the sandflux profile of mix-sized sediment decays exponentially with increasing height.However,the profile pattern of a group of uniform-sized particles depends on the experimental wind speeds.The profile pattern of all the groups studied can be expressed by exponential decay functions when the wind speed is less than or equal to 16 m/s.while that for all the groups studied can be expressed by a Gaussian distribution function when the wind speed is above 16 m/s.The average saltation heights of mixed sands at wind speeds of 12 m/s,16 m/s,20 m/s,and 24 m/s were 2.74,4.19,5.28,and 6.12 cm,respectively.The mean grain size basically first decreases and then increases with increasing height under different wind speeds.The sorting improves with increasing wind speed,while the kurtosis and skewness show relationships with only the characteristics of the parent soil.展开更多
Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-bin...Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-binding protein which can inhibit the assembly of microtubule dimer or promote depolymerization of microtubules.It was reported as a major responsive factor of paclitaxel resistance for clinical chemotherapy of tumor patients.But the function of abnormally high level of STMN1 and its regulation mechanism in cancer cells remain unclear.In this study,we used public database and tissue microarrays to analyze the expression pattern of FoxM1 and STMN1 and found a strong positive correlation between FoxM1 and STMN1 in multiple types of cancer.Lentivirus-mediated FoxM1/STMN1-knockdown cell lines were established to study the function of FoxM1/STMN1 by performing cell viability assay,plate clone formation assay,soft agar assay in vitro and xenograft mouse model in vivo.Our results showed that FoxMl promotes cell proliferation by upregulating STMN1.Further ChIP assay showed that FoxM1 upregulates STMN1 in a transcriptional level.Prognostic analysis showed that a high level of FoxM1 and STMN1 is related to poor prognosis in solid tumors.Moreover,a high co-expression of FoxM1 and STMN1 has a more significant correlation with poor prognosis.Our findings suggest that a general FoxMl-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma,gastric cancer and colorectal cancer.The combination of FoxM1 and STMN1 can be a more precise biomarker for prognostic prediction.展开更多
基金supported by the National Key Research and Development Program of China(2016YFB0301800)the National High Technology Research and Development Program of China(2015AA020201).
文摘The production of medical waste(MW)is a growing concern,particularly in light of the increasing annual generation and the exacerbating effects of the COVID-19 pandemic.Traditional techniques such as incineration and landfilling present significant limitations.In this study,a self-designed 50 kW arc plasma reactor was employed to conduct gasification experiments on nitrile-butadiene rubber(NBR)which served as a model of MWand a mixture of NBR/SiO_(2) which served as a model of glass-containing MW,using CO_(2)as the working gas.The CO_(2)thermal plasma gasification process not only ensures the safe and efficient disposal of MW,but also facilitates its effective conversion into H_(2)and CO,achieving a carbon conversion efficiency of 94.52%.The yields of H2 and CO reached 98.52%and 81.83%,respectively,and the specific energy consumption was as low as 3.55 kW·h·kg^(-1).Furthermore,the addition of SiO_(2) was found to inhibit the gasification of NBR and cause damage to the reactor.Therefore,it is recommended that glass waste should be removed prior to the treatment of MW.The CO_(2)thermal plasma gasification technology can not only eliminate environmental and health risks posed by MW,but also convert it into syngas for further utilization.This provides a promising approach to the harmless and resource disposal of MW,while also contributing to the comprehensive utilization of greenhouse gases.
基金research was supported by the National Key Research and Development Program of China(2020YFA0608403)the National Natural Science Foundation of China(42171083)the Natural Science Foundation of Gansu Province(23JRRA601).
文摘While alpine meadow degradation presents a significant ecological challenge,research on the complex patterns of soil property changes induced by degradation has been somewhat limited.In this study,we investigated the Maqu alpine meadow,meticulously categorizing it into different grassland types exhibiting varying degrees of degradation based on factors such as vegetation coverage and community,soil characteristics,and landscape features.These classifications included typical grassland,degraded grassland,desertified grassland,and sandy land.In August 2018,we established three quadrats at each sample point and collected soil samples at five depths(surface(0-2 cm),2-5 cm,5-10 cm,10-20 cm,and 20-40 cm)to analyze soil particle size distribution(PSD)and nutrients content.The results revealed a discernible trend:alpine meadow degradation led to selective loss of nutrient-rich soil fine particles,resulting in significant alterations in soil PSD and nutrients,particularly pronounced in grasslands with low degrees of degradation.Moreover,within a specific range of degradation degree,the clay content in the shallow soil of alpine meadow increased with the degradation degree,but it declined when the degradation degree exceeded a certain threshold.Degradation also disrupted the intricate relationship between soil nutrients,with notable variations in their coupling.This difference was also reflected in the influence of soil physical and chemical properties on soil nutrients,with the explanatory power of each environmental indicator on soil nutrients decreasing significantly with increasing degradation.This study systematically analyzed the variation in soil physical and chemical properties throughout the degradation process,revealing the mechanism of soil nutrient imbalance and decline caused by the degradation process.It provides crucial theoretical foundations and reference points for the preservation and rejuvenation of alpine meadows,enriching the methodology for assessing the impact of grassland degradation.
基金This work was supported by National Natural Science Foundation of China(No.61971026)the Fundamental Research Funds for the Central Universities(No.FRF-TP-18-008A3).
文摘In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to protect the security of whole system.In the proposed security defense system,the security is protected by the intelligent immunity through three functions,identification function,learning function,and regulation function,respectively.Meanwhile,a three process-based intelligent algorithm is proposed for the intelligent immunity system.Numerical simulations are given to prove the effeteness of the proposed approach.
基金supported by the national key research and development project of China(Grant No.2017YFC0504801)the National Natural Sciences Foundation of China(Grant No.41871016)Opening Fund of Key Laboratory of Desert and Desertification,Chinese Academy of Sciences(Grant No.KLDD-2017-007)
文摘In recent years,the desertification of alpine meadows has become a serious ecological problem and has gradually become a threat to regional economic activities in Maqu County.To reveal the mechanism for sandy desertification of alpine meadows,we conducted wind tunnel experiments on aeolian processes over sandy alpine meadows.Results show that the sandflux profile of mix-sized sediment decays exponentially with increasing height.However,the profile pattern of a group of uniform-sized particles depends on the experimental wind speeds.The profile pattern of all the groups studied can be expressed by exponential decay functions when the wind speed is less than or equal to 16 m/s.while that for all the groups studied can be expressed by a Gaussian distribution function when the wind speed is above 16 m/s.The average saltation heights of mixed sands at wind speeds of 12 m/s,16 m/s,20 m/s,and 24 m/s were 2.74,4.19,5.28,and 6.12 cm,respectively.The mean grain size basically first decreases and then increases with increasing height under different wind speeds.The sorting improves with increasing wind speed,while the kurtosis and skewness show relationships with only the characteristics of the parent soil.
基金supported by the National Natural Science Foundation of China(grantnumbers 81630069,81421003,31771439,81773262,81572763,81672751)the National Key Research and Development Program(grant number 2016YFC1303200)+1 种基金the Key Research and Development Program of Shaanxi(2019SF-010)Opening Projects of the State Key Laboratory of Cancer Biology(CBSKL201703,CBSKL201704,CBSKL201726)。
文摘Fork-head box protein M1(FoxM1)is a transcriptional factor which plays critical roles in cancer development and progression.However,the general regulatory mechanism of FoxM1 is still limited.STMN1 is a microtubule-binding protein which can inhibit the assembly of microtubule dimer or promote depolymerization of microtubules.It was reported as a major responsive factor of paclitaxel resistance for clinical chemotherapy of tumor patients.But the function of abnormally high level of STMN1 and its regulation mechanism in cancer cells remain unclear.In this study,we used public database and tissue microarrays to analyze the expression pattern of FoxM1 and STMN1 and found a strong positive correlation between FoxM1 and STMN1 in multiple types of cancer.Lentivirus-mediated FoxM1/STMN1-knockdown cell lines were established to study the function of FoxM1/STMN1 by performing cell viability assay,plate clone formation assay,soft agar assay in vitro and xenograft mouse model in vivo.Our results showed that FoxMl promotes cell proliferation by upregulating STMN1.Further ChIP assay showed that FoxM1 upregulates STMN1 in a transcriptional level.Prognostic analysis showed that a high level of FoxM1 and STMN1 is related to poor prognosis in solid tumors.Moreover,a high co-expression of FoxM1 and STMN1 has a more significant correlation with poor prognosis.Our findings suggest that a general FoxMl-STMN1 axis contributes to cell proliferation and tumorigenesis in hepatocellular carcinoma,gastric cancer and colorectal cancer.The combination of FoxM1 and STMN1 can be a more precise biomarker for prognostic prediction.
