Blades are essential components of wind turbines.Reducing their fatigue loads during operation helps to extend their lifespan,but it is difficult to quickly and accurately calculate the fatigue loads of blades.To solv...Blades are essential components of wind turbines.Reducing their fatigue loads during operation helps to extend their lifespan,but it is difficult to quickly and accurately calculate the fatigue loads of blades.To solve this problem,this paper innovatively designs a data-driven blade load modeling method based on a deep learning framework through mechanism analysis,feature selection,and model construction.In the mechanism analysis part,the generation mechanism of blade loads and the load theoretical calculationmethod based on material damage theory are analyzed,and four measurable operating state parameters related to blade loads are screened;in the feature extraction part,15 characteristic indicators of each screened parameter are extracted in the time and frequency domain,and feature selection is completed through correlation analysis with blade loads to determine the input parameters of data-driven modeling;in the model construction part,a deep neural network based on feedforward and feedback propagation is designed to construct the nonlinear coupling relationship between the unit operating parameter characteristics and blade loads.The results show that the proposed method mines the wind turbine operating state characteristics highly correlated with the blade load,such as the standard deviation of wind speed.The model built using these characteristics has reasonable calculation and fitting capabilities for the blade load and shows a better fitting level for untrained out-of-sample data than the traditional scheme.Based on the mean absolute percentage error calculation,the modeling accuracy of the two blade loads can reach more than 90%and 80%,respectively,providing a good foundation for the subsequent optimization control to suppress the blade load.展开更多
Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate un...Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate unknown molecular mechanisms.Building upon the close alignment of their biological functions with the observed health effects of PFASs,this study innovatively focuses on proteomic insights from EVs into the molecular mechanisms underlying the systemic health effects of PFASs.Through rat exposure experiments and proteomics technology,it not only demonstrated the occurrence of PFASs in EVs but also revealed the alterations in the serum EVs and the expression of their protein cargos following mixed exposure to PFASs,leading to changes in related pathways.These changes encompass various biological processes,including proteasome activity,immune response,cytoskeletal organization,oxidative stress,cell signaling,and nervous system function.Particularly noteworthy is the uncovering of the activation of the proteasome pathway,highlighting significant key contributing proteins.These novel findings provide a new perspective for exploring the molecularmechanism underlying the systemic health effects of PFASs and offer reliable screening for potential biomarkers.Additionally,comparisons with serum confirmed the potential of serum EVs as biological responders and measurable endpoints for evaluating PFASs-induced toxicity.展开更多
Black phosphorus(BP)is recognized as a promising anode for sodium-ion batteries(SIBs)due to its high safety and theoretical capacity.However,traditional ball milling methodologies for fabricating BP composite anodes h...Black phosphorus(BP)is recognized as a promising anode for sodium-ion batteries(SIBs)due to its high safety and theoretical capacity.However,traditional ball milling methodologies for fabricating BP composite anodes have not satisfactorily addressed the challenges of poor rate performance and short cycle life.To fill this scientific gap,we herein pioneer incorporating the sodium fast ionic conductorβ"-Al_(2)O_(3)into ball-milled BP with carbon,which facilitates the formation of three-dimensional mass transfer channels in the resulting composite.To stabilize these channels,we develop a novel and environmentally friendly functional binder that outperforms traditional binders in thermal stability,wettability,and mechanical properties.The newly established binder is capable of remarkably mitigating volume expansion and interfacial side reactions in the BP/β"-Al_(2)O_(3)/C composite anode.Additionally,we identify synergistic effects of the binder interacting with the BP/β"-Al_(2)O_(3)/C composite during cycling,characterized by the in-situ formation of P-O-C bonds,which is the first instance of a strong,durable chemical bond between the binder and the active material to the best of our knowledge.These advancements allow the composite electrode to exhibit exceptional sodium storage,including high initial Coulombic efficiency and long-term cycling stability,which surpasses most previous phosphorus-based anodes fabricated via traditional approaches.Notably,when paired with a Na_(4)Fe_(3)(PO_(4))_(2)P_(2)O_7(NFPP)cathode,the full cell exhibits unexpectedly high energy and power densities,highlighting the BP potential in SIBs.The findings presented in the present work contribute to the promotion of economical and efficient applications of phosphorus-based anode materials.展开更多
Due to the neglect of the retrieval of communication parameters(including the symbol rate,the symbol timing offset,and the carrier frequency),the existing non-cooperative communication mode recognizers suffer from the...Due to the neglect of the retrieval of communication parameters(including the symbol rate,the symbol timing offset,and the carrier frequency),the existing non-cooperative communication mode recognizers suffer from the generality ability degradation and severe difficulty in distinguishing a large number of modulation modes,etc.To overcome these drawbacks,this paper proposes an efficient communication mode recognizer consisting of communication parameter estimation,the constellation diagram retrieval,and a classification network.In particular,we define a 2-D symbol synchronization metric to retrieve both the symbol rate and the symbol timing offset,whereas a constellation dispersity annealing procedure is devised to correct the carrier frequency accurately.Owing to the accurate estimation of these crucial parameters,high-regularity constellation maps can be retrieved and thus simplify the subsequent classification work.Numerical results show that the proposed communication mode recognizer acquires higher classification accuracy,stronger anti-noise robustness,and higher applicability of distinguishing multiple types,which presents the proposed scheme with vast applicable potentials in non-cooperative scenarios.展开更多
In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control （FTC） design problem of actuator fault and perturbation compensations for linear time-invariant...In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control （FTC） design problem of actuator fault and perturbation compensations for linear time-invariant systems.A more general and practical model of actuator faults is presented.While both eventual faults on actuators and perturbations are unknown,the adaptive schemes are addressed to estimate the lower and upper bounds of actuator-stuck faults and perturbations online,as well as to estimate control effectiveness on actuators.Thus,on the basis of the information from adaptive schemes,an adaptive robust state feed-back controller is designed to compensate the effects of faults and perturbations automatically.According to Lyapunov stability theory,it is shown that the robust adaptive closed-loop systems can be ensured to be asymptotically stable under the influence of actuator faults and bounded perturbations.An example is provided to further illustrate the fault compensation effectiveness.展开更多
Excessive N-acetyl-p-benzoquinone imine(NAPQI)formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen(APAP)overdose caused acute liver failure(ALF).S-glutathion...Excessive N-acetyl-p-benzoquinone imine(NAPQI)formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen(APAP)overdose caused acute liver failure(ALF).S-glutathionylation is a reversible redox post-translational modification and a prospective mechanism of APAP hepatotoxicity.Glutaredoxin-1(Glrx1),a glutathione-specific thioltransferase,is a primary enzyme to catalyze deglutathionylation.The objective of this study was to explored whether and how Glrx1 is associated with the development of ALF induced by APAP.The Glrx1 knockout mice(Glrx1^(-/-))and liver-specific overexpression of Glrx1(AAV8-Glrx1)mice were produced and underwent APAPinduced ALF.Pirfenidone(PFD),a potential inducer of Glrx1,was administrated preceding APAP to assess its protective effects.Our results revealed that the hepatic total protein S-glutathionylation(PSSG)increased and the Glrx1 level reduced in mice after APAP toxicity.Glrx1^(-/-)mice were more sensitive to APAP overdose,with higher oxidative stress and more toxic metabolites of APAP.This was attributed to Glrx1 deficiency increasing the total hepatic PSSG and the S-glutathionylation of cytochrome p4503a11(Cyp3a11),which likely increased the activity of Cyp3a11.Conversely,AAV8-Glrx1 mice were defended against liver damage caused by APAP overdose by inhibiting the S-glutathionylation and activity of Cyp3a11,which reduced the toxic metabolites of APAP and oxidative stress.PFD precede administration upregulated Glrx1 expression and alleviated APAP-induced ALF by decreasing oxidative stress.We have identified the function of Glrx1 mediated PSSG in liver injury caused by APAP overdose.Increasing Glrx1 expression may be investigated for the medical treatment of APAP-caused hepatic injury.展开更多
The coupling of reaction and diffusion between neighboring active sites in the catalyst pore leads to the spatiotemporal fluctuation in component concentration,which is very importa nt to catalyst performance and henc...The coupling of reaction and diffusion between neighboring active sites in the catalyst pore leads to the spatiotemporal fluctuation in component concentration,which is very importa nt to catalyst performance and hence its optimal design.Molecular dynamics simulation with hard-sphere and pseudo-particle modeling has previously revealed the non-stochastic concentration fluctuation of the reactant/product near isolated active site due to such coupling,using a simple model reaction of A→B in 2D pores.The topic is further developed in this work by studying the concentration fluctuation due to such coupling between neighboring active sites in 3D pores.Two 3D pore models containing an isolated active site and two adjacent active sites were constructed,respectively.For the isolated site,the concentration fluctuation intensifies for larger pores,but the product yield decreases,and for a given pore size,the product yield reaches a peak at a certain reactant concentration.For two neighboring sites,their distance(d)is found to have little effect on the reaction,but significant to the diffusion.For the same reaction competing at both sites,larger d leads to more efficient diffusion and better overall performance.However,for sequential reactions at the two sites,higher overall performance presents at a smaller d.The results should be helpful to the catalyst design and reaction control in the relevant processes.展开更多
The national Air Pollution Prevention and Control Action Plan required significant decreases in PM_（2.5） levels over China.To explore more effective emission abatement strategies in industrial cities,a case study wa...The national Air Pollution Prevention and Control Action Plan required significant decreases in PM_（2.5） levels over China.To explore more effective emission abatement strategies in industrial cities,a case study was conducted in Baotou to evaluate the current national control measures.The total emissions of SO_2,NO_X,PM_（2.5） and NMVOC（non-methane volatile organic compounds） in Baotou were 211.2 Gg,156.1 Gg,28.8 Gg,and 48.5 Gg,respectively in 2013,and they would experience a reduction of 30.4%,26.6%,15.1%,and 8.7%,respectively in 2017 and 39.0%,32.0%,24.4%,and 12.9%,respectively in2020.The SO_2,NO_Xand PM_（2.5） emissions from the industrial sector would experience a greater decrease,with reductions of 37%,32.7 and 24.3%,respectively.From 2013 to 2020,the concentrations of SO_2,NO_2,and PM_（2.5） are expected to decline by approximately 30%,10% and 14.5%,respectively.The reduction rate of SNA（sulfate,nitrate and ammonium）concentrations was significantly higher than that of PM_（2.5） in 2017,implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA.Although air pollution control measures implemented in the industrial sector could greatly reduce total emissions,constraining the emissions from lower sources such as residential coal combustion would be more effective in decreasing the concentration of PM_（2.5） from 2017 to 2020.These results suggest that even for a typical industrial city,the reduction of PM_（2.5） concentrations not only requires decreases in emissions from the industrial sector,but also from the low emission sources.The seasonal variation in sulfate concentration also showed that emission from coal-burning is the key factor to control during the heating season.展开更多
Acetaminophen(APAP), a classic nonsteroidal anti-inflammatory drug(NSAID), has attracted much attention due to the overdose-induced hepatotoxicity in the past several decades. N-Acetyl-p-benzoquinone imine(NAPQI), the...Acetaminophen(APAP), a classic nonsteroidal anti-inflammatory drug(NSAID), has attracted much attention due to the overdose-induced hepatotoxicity in the past several decades. N-Acetyl-p-benzoquinone imine(NAPQI), the P450-dependent metabolism of APAP, leads to GSH depletion, protein binding, mitochondrial oxidative stress, and eventually the liver injury. Herein, we develop a Fe-based metal-organic framework(MOF) to deliver and transform acetaminophen into toxic “chemo” drug through the cascade reaction for enhanced cancer therapy. In the acidic tumor microenvironment, the Fe-based MOF collapses and releases abundant Fe ions to generate hydroxyl radicals(·OH) via Fenton reaction, subsequently catalyzing nontoxic APAP into toxic NAPQI. Meanwhile, NAPQI depletes intracellular glutathione(GSH) rapidly, leading to alleviating the antioxidant ability of cancer cells and amplifying Fenton activity. The intracellular oxidative stress and the toxic metabolite of APAP can provide a synergistic effect on antitumor activity.展开更多
Taking Chengde Summer Mountain Resort for example, agricultural development and application in gardening practices in the flourishing ages of Kangxi and Qianlong, and cultural connotations of valuing the fundamental r...Taking Chengde Summer Mountain Resort for example, agricultural development and application in gardening practices in the flourishing ages of Kangxi and Qianlong, and cultural connotations of valuing the fundamental role of agriculture in national economy were analyzed.展开更多
The authors regret that a mistake occurred during the presentation of Supporting Information Fig.S1B,in which we put the wrong picture during submission.This correction does not significantly impact the findings and c...The authors regret that a mistake occurred during the presentation of Supporting Information Fig.S1B,in which we put the wrong picture during submission.This correction does not significantly impact the findings and conclusions of the paper.The authors would like to assure readers that the corrected image does not alter the validity of the research.The original data of these figures have been provided to the Editorial Office,and the corresponding author can be contacted for original data access.展开更多
Recently,sparse representation classification(SRC)and fisher discrimination dictionary learning(FDDL)methods have emerged as important methods for vehicle classification.In this paper,inspired by recent breakthroughs ...Recently,sparse representation classification(SRC)and fisher discrimination dictionary learning(FDDL)methods have emerged as important methods for vehicle classification.In this paper,inspired by recent breakthroughs of discrimination dictionary learning approach and multi-task joint covariate selection,we focus on the problem of vehicle classification in real-world applications by formulating it as a multi-task joint sparse representation model based on fisher discrimination dictionary learning to merge the strength of multiple features among multiple sensors.To improve the classification accuracy in complex scenes,we develop a new method,called multi-task joint sparse representation classification based on fisher discrimination dictionary learning,for vehicle classification.In our proposed method,the acoustic and seismic sensor data sets are captured to measure the same physical event simultaneously by multiple heterogeneous sensors and the multi-dimensional frequency spectrum features of sensors data are extracted using Mel frequency cepstral coefficients(MFCC).Moreover,we extend our model to handle sparse environmental noise.We experimentally demonstrate the benefits of joint information fusion based on fisher discrimination dictionary learning from different sensors in vehicle classification tasks.展开更多
Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific...Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy.展开更多
Ceria(CeO_(2))nanoparticles were successfully synthesized via a simple complex-precipitation route that employs cerium chloride as cerium source and citric acid as precipitant.The elemental analysis results of carbon,...Ceria(CeO_(2))nanoparticles were successfully synthesized via a simple complex-precipitation route that employs cerium chloride as cerium source and citric acid as precipitant.The elemental analysis results of carbon,hydrogen,oxygen,and cerium in the precursors were calculated,and the results revealed that the precursors were composed of Ce(OH)_(3),Ce(H_(2)Cit)_(3),or CeCit.X-ray diffraction analysis showed that all ceria nanoparticles had a face-centered cubic structure.With the molar ratio of citric acid to Ce^(3)+(n)of 0.25 and pH of 5.5,the specific surface area of the sample reached the maximum value of 83.17 m^(2)/g.Ceria nanoparticles were observed by scanning electron microscopy.Selected area electron diffraction patterns of several samples were obtained by transmission electron microscopy,and the crystal plane spacing of each low-exponent crystal plane was calculated.The ultraviolet(UV)–visible transmittance curve showed that ceria can absorb UV light and pass through visible light.Among all samples,the minimum average transmittance of ultraviolet radiation a(UVA)was 4.42%,and that of ultraviolet radiation b(UVB)was 1.56%.展开更多
基金supported by Science and Technology Project funding from China Southern Power Grid Corporation No.GDKJXM20230245(031700KC23020003).
文摘Blades are essential components of wind turbines.Reducing their fatigue loads during operation helps to extend their lifespan,but it is difficult to quickly and accurately calculate the fatigue loads of blades.To solve this problem,this paper innovatively designs a data-driven blade load modeling method based on a deep learning framework through mechanism analysis,feature selection,and model construction.In the mechanism analysis part,the generation mechanism of blade loads and the load theoretical calculationmethod based on material damage theory are analyzed,and four measurable operating state parameters related to blade loads are screened;in the feature extraction part,15 characteristic indicators of each screened parameter are extracted in the time and frequency domain,and feature selection is completed through correlation analysis with blade loads to determine the input parameters of data-driven modeling;in the model construction part,a deep neural network based on feedforward and feedback propagation is designed to construct the nonlinear coupling relationship between the unit operating parameter characteristics and blade loads.The results show that the proposed method mines the wind turbine operating state characteristics highly correlated with the blade load,such as the standard deviation of wind speed.The model built using these characteristics has reasonable calculation and fitting capabilities for the blade load and shows a better fitting level for untrained out-of-sample data than the traditional scheme.Based on the mean absolute percentage error calculation,the modeling accuracy of the two blade loads can reach more than 90%and 80%,respectively,providing a good foundation for the subsequent optimization control to suppress the blade load.
基金supported by the Key Research and Development Plan of Zhejiang Province(No.2021C03176)Zhejiang Provincial Natural Science Foundation of China(No.LY23B070001)+2 种基金the Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province(No.20230009)the National Natural Science Foundation of China(No.22106032)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0750000).
文摘Per-and polyfluoroalkyl substances(PFASs)can induce a range of adverse health effects,with the precise molecularmechanisms remaining elusive.Extracellular vesicles(EVs)have demonstrated their potential to elucidate unknown molecular mechanisms.Building upon the close alignment of their biological functions with the observed health effects of PFASs,this study innovatively focuses on proteomic insights from EVs into the molecular mechanisms underlying the systemic health effects of PFASs.Through rat exposure experiments and proteomics technology,it not only demonstrated the occurrence of PFASs in EVs but also revealed the alterations in the serum EVs and the expression of their protein cargos following mixed exposure to PFASs,leading to changes in related pathways.These changes encompass various biological processes,including proteasome activity,immune response,cytoskeletal organization,oxidative stress,cell signaling,and nervous system function.Particularly noteworthy is the uncovering of the activation of the proteasome pathway,highlighting significant key contributing proteins.These novel findings provide a new perspective for exploring the molecularmechanism underlying the systemic health effects of PFASs and offer reliable screening for potential biomarkers.Additionally,comparisons with serum confirmed the potential of serum EVs as biological responders and measurable endpoints for evaluating PFASs-induced toxicity.
基金supported by the National Key R&D Program of China(2022YFB3807700)the National Natural Science Foundation of China(52072217,22179071,51772169,and 52104313)+3 种基金the Hubei Provincial Natural Science Foundation of China(2023AFB618 and 2024AFB993)the Hubei Natural Science Foundation Innovation Group Project(2022CFA020)the Joint Funds of the Hubei Natural Science Foundation Innovation and Development(2022CFD034)the Major Technological Innovation Project of Hubei Science and Technology Department(2019AAA164)。
文摘Black phosphorus(BP)is recognized as a promising anode for sodium-ion batteries(SIBs)due to its high safety and theoretical capacity.However,traditional ball milling methodologies for fabricating BP composite anodes have not satisfactorily addressed the challenges of poor rate performance and short cycle life.To fill this scientific gap,we herein pioneer incorporating the sodium fast ionic conductorβ"-Al_(2)O_(3)into ball-milled BP with carbon,which facilitates the formation of three-dimensional mass transfer channels in the resulting composite.To stabilize these channels,we develop a novel and environmentally friendly functional binder that outperforms traditional binders in thermal stability,wettability,and mechanical properties.The newly established binder is capable of remarkably mitigating volume expansion and interfacial side reactions in the BP/β"-Al_(2)O_(3)/C composite anode.Additionally,we identify synergistic effects of the binder interacting with the BP/β"-Al_(2)O_(3)/C composite during cycling,characterized by the in-situ formation of P-O-C bonds,which is the first instance of a strong,durable chemical bond between the binder and the active material to the best of our knowledge.These advancements allow the composite electrode to exhibit exceptional sodium storage,including high initial Coulombic efficiency and long-term cycling stability,which surpasses most previous phosphorus-based anodes fabricated via traditional approaches.Notably,when paired with a Na_(4)Fe_(3)(PO_(4))_(2)P_(2)O_7(NFPP)cathode,the full cell exhibits unexpectedly high energy and power densities,highlighting the BP potential in SIBs.The findings presented in the present work contribute to the promotion of economical and efficient applications of phosphorus-based anode materials.
文摘Due to the neglect of the retrieval of communication parameters(including the symbol rate,the symbol timing offset,and the carrier frequency),the existing non-cooperative communication mode recognizers suffer from the generality ability degradation and severe difficulty in distinguishing a large number of modulation modes,etc.To overcome these drawbacks,this paper proposes an efficient communication mode recognizer consisting of communication parameter estimation,the constellation diagram retrieval,and a classification network.In particular,we define a 2-D symbol synchronization metric to retrieve both the symbol rate and the symbol timing offset,whereas a constellation dispersity annealing procedure is devised to correct the carrier frequency accurately.Owing to the accurate estimation of these crucial parameters,high-regularity constellation maps can be retrieved and thus simplify the subsequent classification work.Numerical results show that the proposed communication mode recognizer acquires higher classification accuracy,stronger anti-noise robustness,and higher applicability of distinguishing multiple types,which presents the proposed scheme with vast applicable potentials in non-cooperative scenarios.
基金supported by the Funds for Creative Research Groups of China(No.60821063)National 973 Program of China(No.2009CB320604)+2 种基金the Funds of National Science of China(No.60974043)the 111 Project(No.B08015)the Fundamental Research Funds for the Central Universities(No.N090604001,N090604002)
文摘In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control （FTC） design problem of actuator fault and perturbation compensations for linear time-invariant systems.A more general and practical model of actuator faults is presented.While both eventual faults on actuators and perturbations are unknown,the adaptive schemes are addressed to estimate the lower and upper bounds of actuator-stuck faults and perturbations online,as well as to estimate control effectiveness on actuators.Thus,on the basis of the information from adaptive schemes,an adaptive robust state feed-back controller is designed to compensate the effects of faults and perturbations automatically.According to Lyapunov stability theory,it is shown that the robust adaptive closed-loop systems can be ensured to be asymptotically stable under the influence of actuator faults and bounded perturbations.An example is provided to further illustrate the fault compensation effectiveness.
基金supported by the National Natural Science Foundation of China(Grant Nos.:82025007,81930020,and 82170874)China Postdoctoral Science Foundation(Grant No.:2022M710099).
文摘Excessive N-acetyl-p-benzoquinone imine(NAPQI)formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen(APAP)overdose caused acute liver failure(ALF).S-glutathionylation is a reversible redox post-translational modification and a prospective mechanism of APAP hepatotoxicity.Glutaredoxin-1(Glrx1),a glutathione-specific thioltransferase,is a primary enzyme to catalyze deglutathionylation.The objective of this study was to explored whether and how Glrx1 is associated with the development of ALF induced by APAP.The Glrx1 knockout mice(Glrx1^(-/-))and liver-specific overexpression of Glrx1(AAV8-Glrx1)mice were produced and underwent APAPinduced ALF.Pirfenidone(PFD),a potential inducer of Glrx1,was administrated preceding APAP to assess its protective effects.Our results revealed that the hepatic total protein S-glutathionylation(PSSG)increased and the Glrx1 level reduced in mice after APAP toxicity.Glrx1^(-/-)mice were more sensitive to APAP overdose,with higher oxidative stress and more toxic metabolites of APAP.This was attributed to Glrx1 deficiency increasing the total hepatic PSSG and the S-glutathionylation of cytochrome p4503a11(Cyp3a11),which likely increased the activity of Cyp3a11.Conversely,AAV8-Glrx1 mice were defended against liver damage caused by APAP overdose by inhibiting the S-glutathionylation and activity of Cyp3a11,which reduced the toxic metabolites of APAP and oxidative stress.PFD precede administration upregulated Glrx1 expression and alleviated APAP-induced ALF by decreasing oxidative stress.We have identified the function of Glrx1 mediated PSSG in liver injury caused by APAP overdose.Increasing Glrx1 expression may be investigated for the medical treatment of APAP-caused hepatic injury.
基金supported by the National Natural Science Foundation of China(92034302,22178347)the Dalian National Laboratory for Clean Energy(DNL)Cooperation Fund,the Chinese Academy of Sciences(DNL201905)+1 种基金the“Transformational Technologies for Clean Energy and Demonstration”,Strategic Priority Research Program of the Chinese Academy of Sciences(XDA21030700)the National Science and Technology Major Project(2017-I-0004-0005)。
文摘The coupling of reaction and diffusion between neighboring active sites in the catalyst pore leads to the spatiotemporal fluctuation in component concentration,which is very importa nt to catalyst performance and hence its optimal design.Molecular dynamics simulation with hard-sphere and pseudo-particle modeling has previously revealed the non-stochastic concentration fluctuation of the reactant/product near isolated active site due to such coupling,using a simple model reaction of A→B in 2D pores.The topic is further developed in this work by studying the concentration fluctuation due to such coupling between neighboring active sites in 3D pores.Two 3D pore models containing an isolated active site and two adjacent active sites were constructed,respectively.For the isolated site,the concentration fluctuation intensifies for larger pores,but the product yield decreases,and for a given pore size,the product yield reaches a peak at a certain reactant concentration.For two neighboring sites,their distance(d)is found to have little effect on the reaction,but significant to the diffusion.For the same reaction competing at both sites,larger d leads to more efficient diffusion and better overall performance.However,for sequential reactions at the two sites,higher overall performance presents at a smaller d.The results should be helpful to the catalyst design and reaction control in the relevant processes.
基金supported by the Special Scientific Research Fund of the Environmental Protection Commonwealth Section(Nos.201409003,201509020)
文摘The national Air Pollution Prevention and Control Action Plan required significant decreases in PM_（2.5） levels over China.To explore more effective emission abatement strategies in industrial cities,a case study was conducted in Baotou to evaluate the current national control measures.The total emissions of SO_2,NO_X,PM_（2.5） and NMVOC（non-methane volatile organic compounds） in Baotou were 211.2 Gg,156.1 Gg,28.8 Gg,and 48.5 Gg,respectively in 2013,and they would experience a reduction of 30.4%,26.6%,15.1%,and 8.7%,respectively in 2017 and 39.0%,32.0%,24.4%,and 12.9%,respectively in2020.The SO_2,NO_Xand PM_（2.5） emissions from the industrial sector would experience a greater decrease,with reductions of 37%,32.7 and 24.3%,respectively.From 2013 to 2020,the concentrations of SO_2,NO_2,and PM_（2.5） are expected to decline by approximately 30%,10% and 14.5%,respectively.The reduction rate of SNA（sulfate,nitrate and ammonium）concentrations was significantly higher than that of PM_（2.5） in 2017,implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA.Although air pollution control measures implemented in the industrial sector could greatly reduce total emissions,constraining the emissions from lower sources such as residential coal combustion would be more effective in decreasing the concentration of PM_（2.5） from 2017 to 2020.These results suggest that even for a typical industrial city,the reduction of PM_（2.5） concentrations not only requires decreases in emissions from the industrial sector,but also from the low emission sources.The seasonal variation in sulfate concentration also showed that emission from coal-burning is the key factor to control during the heating season.
基金financial support of this work by the National Natural Science Foundation of China (No. 81872813)the Outstanding Youth Fund of Jiangsu Province of China (No. BK20190029)+1 种基金the China Postdoctoral Science Foundation (No. 2021M703597)the Program of State Key Laboratory of Natural Medicines-China Pharmaceutical University (No. SKLNMZZ202031)。
文摘Acetaminophen(APAP), a classic nonsteroidal anti-inflammatory drug(NSAID), has attracted much attention due to the overdose-induced hepatotoxicity in the past several decades. N-Acetyl-p-benzoquinone imine(NAPQI), the P450-dependent metabolism of APAP, leads to GSH depletion, protein binding, mitochondrial oxidative stress, and eventually the liver injury. Herein, we develop a Fe-based metal-organic framework(MOF) to deliver and transform acetaminophen into toxic “chemo” drug through the cascade reaction for enhanced cancer therapy. In the acidic tumor microenvironment, the Fe-based MOF collapses and releases abundant Fe ions to generate hydroxyl radicals(·OH) via Fenton reaction, subsequently catalyzing nontoxic APAP into toxic NAPQI. Meanwhile, NAPQI depletes intracellular glutathione(GSH) rapidly, leading to alleviating the antioxidant ability of cancer cells and amplifying Fenton activity. The intracellular oxidative stress and the toxic metabolite of APAP can provide a synergistic effect on antitumor activity.
基金Supported by Research Program of Henan Provincial Social Science Development(200802007)
文摘Taking Chengde Summer Mountain Resort for example, agricultural development and application in gardening practices in the flourishing ages of Kangxi and Qianlong, and cultural connotations of valuing the fundamental role of agriculture in national economy were analyzed.
文摘The authors regret that a mistake occurred during the presentation of Supporting Information Fig.S1B,in which we put the wrong picture during submission.This correction does not significantly impact the findings and conclusions of the paper.The authors would like to assure readers that the corrected image does not alter the validity of the research.The original data of these figures have been provided to the Editorial Office,and the corresponding author can be contacted for original data access.
基金This work was supported by National Natural Science Foundation of China(NSFC)under Grant No.61771299,No.61771322,No.61375015,No.61301027.
文摘Recently,sparse representation classification(SRC)and fisher discrimination dictionary learning(FDDL)methods have emerged as important methods for vehicle classification.In this paper,inspired by recent breakthroughs of discrimination dictionary learning approach and multi-task joint covariate selection,we focus on the problem of vehicle classification in real-world applications by formulating it as a multi-task joint sparse representation model based on fisher discrimination dictionary learning to merge the strength of multiple features among multiple sensors.To improve the classification accuracy in complex scenes,we develop a new method,called multi-task joint sparse representation classification based on fisher discrimination dictionary learning,for vehicle classification.In our proposed method,the acoustic and seismic sensor data sets are captured to measure the same physical event simultaneously by multiple heterogeneous sensors and the multi-dimensional frequency spectrum features of sensors data are extracted using Mel frequency cepstral coefficients(MFCC).Moreover,we extend our model to handle sparse environmental noise.We experimentally demonstrate the benefits of joint information fusion based on fisher discrimination dictionary learning from different sensors in vehicle classification tasks.
基金supported by The Radiation Therapy Major Project of the Ministry of Science and Technology of China(No.2016YFC0105711)supported partly by Natural Science Foundation of China(No.81401913)。
文摘Objective:For locally advanced nasopharyngeal carcinoma(LA-NPC)patients,high incidences of distant metastases and severe treatment related toxicities are the main obstacles needed to be overcome.Raltitrexed,a specific thymidylate synthase inhibitor with a convenient administration schedule,has an acceptable and manageable toxicity,and possesses radio-sensitizing properties.To investigate the efficacy and safety of raltitrexed and cisplatin induction chemotherapy and concurrent chemoradiotherapy(IC+CCRT)in patients with LA-NPC,a phaseⅡclinical study was conducted.Methods:Sixty eligible patients with LA-NPC were enrolled into this study.A raltitrexed-cisplatin combination was used as part of an IC+CCRT regimen.Raltitrexed-cisplatin IC was given once every 3 weeks(q3 w)for two cycles,followed by raltitrexed-cisplatin based CCRT q3 w for two cycles.Intensity-modulated radiotherapy(IMRT)was given for all enrolled patients.Results:All patients were included in survival analysis according to the intent-to-treat principle.The objective response rate(ORR)3 months after treatment was 98%.The 2-year overall survival(OS)rate was 92%.The median relapse-free survival(RFS)time was 30.5[95%confidence interval(95%CI),28.4-32.3]months.The 2-year RFS rate was 85%.The 2-year local failure-free survival(LFFS)rate was 97%and the 2-year distant metastasis-free survival(DMFS)rate was 88%.Acute toxicities were mostly grade 2 and 3 reactions in bone marrow suppression,gastrointestinal side effect and oropharyngeal mucositis.Only two patients occurred grade 4 acute toxicities,one was bone marrow suppression and the other was dermatitis radiation.Conclusions:The combination of raltitrexed and cisplatin has a comparable efficacy to those in standard firstline therapy.
基金financially supported by the Major State Basic Research Development Program of China(No.2012CBA01205)the National Natural Science Foundation of China(No.51274060)。
文摘Ceria(CeO_(2))nanoparticles were successfully synthesized via a simple complex-precipitation route that employs cerium chloride as cerium source and citric acid as precipitant.The elemental analysis results of carbon,hydrogen,oxygen,and cerium in the precursors were calculated,and the results revealed that the precursors were composed of Ce(OH)_(3),Ce(H_(2)Cit)_(3),or CeCit.X-ray diffraction analysis showed that all ceria nanoparticles had a face-centered cubic structure.With the molar ratio of citric acid to Ce^(3)+(n)of 0.25 and pH of 5.5,the specific surface area of the sample reached the maximum value of 83.17 m^(2)/g.Ceria nanoparticles were observed by scanning electron microscopy.Selected area electron diffraction patterns of several samples were obtained by transmission electron microscopy,and the crystal plane spacing of each low-exponent crystal plane was calculated.The ultraviolet(UV)–visible transmittance curve showed that ceria can absorb UV light and pass through visible light.Among all samples,the minimum average transmittance of ultraviolet radiation a(UVA)was 4.42%,and that of ultraviolet radiation b(UVB)was 1.56%.
