A colorimetric and fluorometric dual probe based on a water-soluble polythiophene derivative(PMTPBA)was designed and synthesized.It can be applied to determination of picric acid(PA) in 100% aqueous solution.The appro...A colorimetric and fluorometric dual probe based on a water-soluble polythiophene derivative(PMTPBA)was designed and synthesized.It can be applied to determination of picric acid(PA) in 100% aqueous solution.The approach relies on the formation of supramolecular polythiophene assemblies in the presence of PA through electrostatic,charge transfer and π-π stacking interactions.This probe could be utilized for the rapid and visual detection of PA both in aqueous solution and solid support with high specificity and sensitivity.The detection limit of this sensor is as low as 5.0 × 10^-8 mol/L.展开更多
Microglia activation and white matter injury coexist after repeated episodes of mild brain trauma and ischemic stroke. Axon degeneration and demyelination can activate microglia; however, it is unclear whether early m...Microglia activation and white matter injury coexist after repeated episodes of mild brain trauma and ischemic stroke. Axon degeneration and demyelination can activate microglia; however, it is unclear whether early microglia activation can impair the function of white matter tracts and lead to injury. Rat corpus callosum（CC） slices were treated with lipopolysaccharide（LPS） or LPS ＋ Rhodobacter sphaeroides（RS）-LPS that is a toll-like receptor 4（TLR-4） antagonist. Functional changes reflected by the change of axon compound action potentials（CAPs） and the accumulation of β-amyloid precursor protein（β-APP） in CC nerve fibers. Microglia activation was monitored by ionized calcium binding adaptor-1 immunofluorescent stain, based on well-established morphological criteria and paralleled proportional area measurement. Input-output（I/O） curves of CAPs in response to increased stimuli were significantly downshifted in a dose-dependent manner in LPS（0.2, 0.5 and 1.0μg/mL）-treated slices, implying that axons neurophysiological function was undermined. LPS caused significant β-APP accumulation in CC tissues,reflecting the deterioration of fast axon transport. LPS-induced I/O curve downshift and P-APP accumulation were significantly reversed by the pre-treatment or co-incubation with RS-LPS. RS-LPS alone did not change the I/O curve.The degree of malfunction was correlated with microglia activation, as was shown by the measurements of proportional areas. Function of CC nerve fibers was evidently impaired by microglia activation and reversed by a TLP-4 antagonist, suggesting that the TLP-4 pathway lead to microglia activation.展开更多
Objective: The target prediction and molecular mechanism of compound Honggencao in the treatment of upper respiratory tract infection were investigated based on network pharmacology. Methods: In the database of Tradit...Objective: The target prediction and molecular mechanism of compound Honggencao in the treatment of upper respiratory tract infection were investigated based on network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, chemical composition and potential targets of compound Honggencao were mined, and the target gene of upper respiratory tract infection of compound Honggencao was extracted from GeneCards databases. The protein-protein interaction of target genes was constructed. Then, the essential genes of enrichment of KEGG pathway analysis and functional analysis were analysed. Results: Compound Honggencao had 69 kinds of active ingredients. The upper respiratory tract infection of the target gene was 186 that built compound Honggencao on the relationship between upper respiratory tract infections of protein interaction networks, which had a total of 186 nodes, 3515 sides. Fifty-six essential genes were including IL-17, EGFR and CDND1, and so on. Gene ontology analysis had 2567 items, and pathway analysis was 166 items. The main signaling pathways involved with IL-17 signaling pathways, tumour necrosis factor signal pathway and human cytomegalovirus infection, and so on. Conclusion: The pharmacological action of compound Honggencao on upper respiratory tract infection was characterized by the synergistic effect of multiple components and multiple targets, which provided an absolute theoretical basis for the research on the pharmacological direction of molecular signaling pathway and a specific theoretical basis for clinical use.展开更多
The paper is proposed to explore the potential effects of Shufeng Jiedu Capsule against COVID-19. The ingredients and targets of Shufeng Jiedu Capsule were collected by the Traditional Chinese Medicine Systems Pharmac...The paper is proposed to explore the potential effects of Shufeng Jiedu Capsule against COVID-19. The ingredients and targets of Shufeng Jiedu Capsule were collected by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the gene names of potential targets were extracted by UniProtKB. Then we did protein-protein interaction networks functional enrichment analysis by the STRING platform, reconstructed drug-target pathways and networks to predict the likely protein targets of the capsule against COVID-19 with software Cytoscape 3.6.1, and carried out GO enrichment analysis and KEGG analysis with R 5.3.2 software. At last we validated our predictions on molecular docking. The results suggested that Shufeng Jiedu Capsule contained 155 ingredients and 237 targets, including 26 main active ingredients and 45 key targets. There were 2334 biological processes (BP), 103 cell composition (CC) and 198 molecular functions (MF) in GO Enrichment Analysis, and 177 pathways in the KEGG analysis. The molecular docking analysis showed that binding energy for 26 main active ingredients ranged from -32.21 to -25.94 kJ·mol-1, and the main targets bind to SARS-CoV-2 3CL hydrolase by acting on CASP9, PRKCA, RELA and others. Our study suggested that Shufeng Jiedu Capsule has potential therapeutic effects on COVID-19.展开更多
Neovascular age-related macular degeneration(nAMD)and diabetic macular edema are leading causes of vision loss in aging populations,correlating closely with elevated vascular endothelial growth factor(VEGF)levels that...Neovascular age-related macular degeneration(nAMD)and diabetic macular edema are leading causes of vision loss in aging populations,correlating closely with elevated vascular endothelial growth factor(VEGF)levels that raise the permeability of capillaries,leading to the disruption of the blood-retinal barrier and detachment of the retinal neuroepithelial layer.The profound success of anti-VEGF treatments has spurred extensive pharmaceutical research and development.展开更多
The family Ajellomycetaceae(Onygenales)includes mammal-associated pathogens within the genera Blastomyces,Emmonsia,Histoplasma and Paracoccidioides,as well as the recently described genera,Emergomyces that causes dis...The family Ajellomycetaceae(Onygenales)includes mammal-associated pathogens within the genera Blastomyces,Emmonsia,Histoplasma and Paracoccidioides,as well as the recently described genera,Emergomyces that causes disease in immunocompromised hosts,and Emmonsiellopsis,known only from soil.To further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species,we sequenced and analyzed the DNA-directed RNA polymerase II(rPB2),translation elongation factor 3-a(TEF3),b-tubulin(TUB2),28S large subunit rDNA(LSU)and the internal transcribed spacer regions(ITS)in 68 strains,in addition to morphological and physiological investigations.To better understand the thermal dimorphism among these fungi,the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures(6–42C).Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus level.Emmonsia,typified by Emmonsia parva,is a synonym of Blastomyces that also accommodates Blastomyces helicus(formerly Emmonsia helica).Emmonsia crescens is phylogenetically distinct,and found closely related to a single strain from soil without known etiology.Blastomyces silverae,Emergomyces canadensis,Emergomyces europaeus and Emmonsia sola are newly described.Almost all of the taxa are associated with human and animal disease.Emmonsia crescens,B.dermatitidis and B.parvus are prevalently associated with pulmonary disease in humans or animals.Blastomyces helicus,B.percursus,Emergomyces africanus,Es.canadensis,Es.europaeus,Es.orientalis and Es.pasteurianus(formerly Emmonsia pasteuriana)are predominantly found in human hosts with immune disorders;no animal hosts are known for these species except B.helicus.展开更多
The polycrystalline strontium ferrate titanate(SrFe_(0.1)Ti_(0.9)O_(3),SFTO)thin films have been successfully prepared by chemical solution method.By analyzing the current-voltage(I-V)characteristics,we discuss the co...The polycrystalline strontium ferrate titanate(SrFe_(0.1)Ti_(0.9)O_(3),SFTO)thin films have been successfully prepared by chemical solution method.By analyzing the current-voltage(I-V)characteristics,we discuss the conduction mechanism of SFTO.It is found that the number of oxygen vacancy defects is increased by Fe ion doping,making SFTO be with better resistive switching property.Fe ion doping can also enhance the absorption of strontium titanate to be exposed to visible light,which is associated with the change of energy band.The band gap width(2.84 eV)of SFTO films is figured out,which is less than that of pure strontium titanate.Due to more oxygen vacancy defects caused by Fe ion doping,the band gap width of strontium titanate was reduced slightly.The defect types of SFTO thin films can be determined by electron paramagnetic resonance spectroscopy.In addition,we analyzed the energy band and state density of SFTO by first-principles calculation based on density functional theory,and found that Fe ion doping can reduce the band gap width of strontium titanate with micro-regulation on the band structure.A chemical state of SFTO was analyzed by X-ray photo electron spectroscopy.At the same time,the structure and morphology of SFTO were characterized by X-ray diffraction and scanning electron microscope.This study deepens further understanding of the influence of Fe ion doping on the structure and properties of strontium ferrate titanate,which is expected to be a functional thin film material for memristor devices.展开更多
Enhancing the availability and reliability of dielectric ceramic energy storage devices is of great importance.In this work,(1-x)Na_(0.5)Bi_(0.5)TiO_(3)-xBi(Mg_(0.5)Hf_(0.5))O_(3)(NBT-xBMH)lead-free ceramics were crea...Enhancing the availability and reliability of dielectric ceramic energy storage devices is of great importance.In this work,(1-x)Na_(0.5)Bi_(0.5)TiO_(3)-xBi(Mg_(0.5)Hf_(0.5))O_(3)(NBT-xBMH)lead-free ceramics were created utilizing a solid-state reaction technique.All NBT-xBMH ceramics have a single perovskite structure.With increasing BMH doping,the grain size shrinks drastically,which greatly enhances the breakdown electric field(310 kV/cm at x=0.25).Additionally,the relaxation behaviors of NBT-xBMH ceramics with high BMH content are more remarkable.Among all designed components,the NBT-0.25BMH ceramic exhibits the best energy storage performance with a high Wrec of 4.63 J/cm^(3) and anηof 75.1%at 310 kV/cm.The NBT-0.25BMH ceramic has exceptional resistance to fluctuations in both frequency(5-500 Hz)and temperature(30-100°C).Charge-discharge test shows that the NBT-0.25BMH ceramic has a quick discharge rate(t0.9<110 ns).With these properties,the NBT-0.25BMH ceramic may have applications in microdevices as well as in ultra-high power electronic systems.展开更多
The metastable polar orthorhombic phase is believed to be the origin of the ferroelectricity of hafnia-based films.The adjustment of stain,oxygen vacancies and dopant during film deposition and the wake-up electric cy...The metastable polar orthorhombic phase is believed to be the origin of the ferroelectricity of hafnia-based films.The adjustment of stain,oxygen vacancies and dopant during film deposition and the wake-up electric cycling are common strategies to induce the ferroelectricity in hafnia.However,none of them could independently render the ferroelectric phase to be the most stable phase from the theoretical calculation results.The exact external conditions to stabilize orthorhombic phase still remain elusive.In this paper,we investigate the effects of the type,distribution,concentration,and charge state characteristics of oxygen vacancies and the uniaxial strain on the crystal’energy,dielectric constant and spontaneous polarization(Ps);In addition,the impact of the applied electric field parallel to the Ps on the crystal’energy is explored by first-principles calculations.It is challenging to independently stabilize the ferroelectric phase of hafnia-based films by a single component owing to the rather strict conditions.Surprisingly,the ferroelectricity can be easily obtained when simultaneously considering the effects of oxygen vacancies,uniaxial strain,and applied electric fields,suggesting the extremely important mechanical-electrical-chemical coupling effects.This work provides an explanation for the typical wake-up phenomenon in hafnia and a guidance for film applications.展开更多
Service computing is an emerging and distributed computing mode in cloud service systems, and has become an interesting research direction for both academia and industry. Note that the cloud service systems always dis...Service computing is an emerging and distributed computing mode in cloud service systems, and has become an interesting research direction for both academia and industry. Note that the cloud service systems always display new characteristics, such as stochasticity, large scale, loose coupling, concurrency non-homogeneity and heterogeneity;thus their load balancing investigation has been more interesting, difficult and challenging until now. By using resource management and job scheduling, this paper proposes an integrated, real-time and dynamic control mechanism for large-scale cloud service systems and their load balancing through combining supermarket models with not only work stealing models but also scheduling of public reserved resource. To this end, this paper provides a novel stochastic model with weak interactions by means of nonlinear Markov processes. To overcome theoretical difficulties growing out of the state explosion in high-dimensional stochastic systems, this paper applies the mean-field theory to develop a macro computational technique in terms of an infinite-dimensional system of mean-field equations. Furthermore, this paper proves the asymptotic independence of the large-scale cloud service system, and show how to compute the fixed point by virtue of an infinite-dimensional system of nonlinear equations. Based on the fixed point, this paper provides effective numerical computation for performance analysis of this system under a high approximate precision. Therefore, we hope that the methodology and results given in this paper can be applicable to the study of more general large-scale cloud service systems.展开更多
基金financially supported by the National Natural Science Foundation of China(No.31871877)Chinese Universities Scientific Fund(Nos.2018QC151,2019TC036)+1 种基金the"Talents Scheme"Program of Beijing(No.31050003)the Research Fund Program of Guangdong Provincial Key Laboratory of Radionuclides Pollution Control and Resources(No.2017B030314182)。
文摘A colorimetric and fluorometric dual probe based on a water-soluble polythiophene derivative(PMTPBA)was designed and synthesized.It can be applied to determination of picric acid(PA) in 100% aqueous solution.The approach relies on the formation of supramolecular polythiophene assemblies in the presence of PA through electrostatic,charge transfer and π-π stacking interactions.This probe could be utilized for the rapid and visual detection of PA both in aqueous solution and solid support with high specificity and sensitivity.The detection limit of this sensor is as low as 5.0 × 10^-8 mol/L.
文摘Microglia activation and white matter injury coexist after repeated episodes of mild brain trauma and ischemic stroke. Axon degeneration and demyelination can activate microglia; however, it is unclear whether early microglia activation can impair the function of white matter tracts and lead to injury. Rat corpus callosum（CC） slices were treated with lipopolysaccharide（LPS） or LPS ＋ Rhodobacter sphaeroides（RS）-LPS that is a toll-like receptor 4（TLR-4） antagonist. Functional changes reflected by the change of axon compound action potentials（CAPs） and the accumulation of β-amyloid precursor protein（β-APP） in CC nerve fibers. Microglia activation was monitored by ionized calcium binding adaptor-1 immunofluorescent stain, based on well-established morphological criteria and paralleled proportional area measurement. Input-output（I/O） curves of CAPs in response to increased stimuli were significantly downshifted in a dose-dependent manner in LPS（0.2, 0.5 and 1.0μg/mL）-treated slices, implying that axons neurophysiological function was undermined. LPS caused significant β-APP accumulation in CC tissues,reflecting the deterioration of fast axon transport. LPS-induced I/O curve downshift and P-APP accumulation were significantly reversed by the pre-treatment or co-incubation with RS-LPS. RS-LPS alone did not change the I/O curve.The degree of malfunction was correlated with microglia activation, as was shown by the measurements of proportional areas. Function of CC nerve fibers was evidently impaired by microglia activation and reversed by a TLP-4 antagonist, suggesting that the TLP-4 pathway lead to microglia activation.
文摘Objective: The target prediction and molecular mechanism of compound Honggencao in the treatment of upper respiratory tract infection were investigated based on network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, chemical composition and potential targets of compound Honggencao were mined, and the target gene of upper respiratory tract infection of compound Honggencao was extracted from GeneCards databases. The protein-protein interaction of target genes was constructed. Then, the essential genes of enrichment of KEGG pathway analysis and functional analysis were analysed. Results: Compound Honggencao had 69 kinds of active ingredients. The upper respiratory tract infection of the target gene was 186 that built compound Honggencao on the relationship between upper respiratory tract infections of protein interaction networks, which had a total of 186 nodes, 3515 sides. Fifty-six essential genes were including IL-17, EGFR and CDND1, and so on. Gene ontology analysis had 2567 items, and pathway analysis was 166 items. The main signaling pathways involved with IL-17 signaling pathways, tumour necrosis factor signal pathway and human cytomegalovirus infection, and so on. Conclusion: The pharmacological action of compound Honggencao on upper respiratory tract infection was characterized by the synergistic effect of multiple components and multiple targets, which provided an absolute theoretical basis for the research on the pharmacological direction of molecular signaling pathway and a specific theoretical basis for clinical use.
文摘The paper is proposed to explore the potential effects of Shufeng Jiedu Capsule against COVID-19. The ingredients and targets of Shufeng Jiedu Capsule were collected by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the gene names of potential targets were extracted by UniProtKB. Then we did protein-protein interaction networks functional enrichment analysis by the STRING platform, reconstructed drug-target pathways and networks to predict the likely protein targets of the capsule against COVID-19 with software Cytoscape 3.6.1, and carried out GO enrichment analysis and KEGG analysis with R 5.3.2 software. At last we validated our predictions on molecular docking. The results suggested that Shufeng Jiedu Capsule contained 155 ingredients and 237 targets, including 26 main active ingredients and 45 key targets. There were 2334 biological processes (BP), 103 cell composition (CC) and 198 molecular functions (MF) in GO Enrichment Analysis, and 177 pathways in the KEGG analysis. The molecular docking analysis showed that binding energy for 26 main active ingredients ranged from -32.21 to -25.94 kJ·mol-1, and the main targets bind to SARS-CoV-2 3CL hydrolase by acting on CASP9, PRKCA, RELA and others. Our study suggested that Shufeng Jiedu Capsule has potential therapeutic effects on COVID-19.
基金supported by the Investigator Initiated Research Fund from Beijing Novartis Pharma Co.,Ltd.(to Z.T.).
文摘Neovascular age-related macular degeneration(nAMD)and diabetic macular edema are leading causes of vision loss in aging populations,correlating closely with elevated vascular endothelial growth factor(VEGF)levels that raise the permeability of capillaries,leading to the disruption of the blood-retinal barrier and detachment of the retinal neuroepithelial layer.The profound success of anti-VEGF treatments has spurred extensive pharmaceutical research and development.
文摘The family Ajellomycetaceae(Onygenales)includes mammal-associated pathogens within the genera Blastomyces,Emmonsia,Histoplasma and Paracoccidioides,as well as the recently described genera,Emergomyces that causes disease in immunocompromised hosts,and Emmonsiellopsis,known only from soil.To further assess the phylogenetic relationships among and between members of these genera and several previously undescribed species,we sequenced and analyzed the DNA-directed RNA polymerase II(rPB2),translation elongation factor 3-a(TEF3),b-tubulin(TUB2),28S large subunit rDNA(LSU)and the internal transcribed spacer regions(ITS)in 68 strains,in addition to morphological and physiological investigations.To better understand the thermal dimorphism among these fungi,the dynamic process of transformation from mycelial to yeast-like or adiaspore-like forms was also assessed over a range of temperatures(6–42C).Molecular data resolved the relationships and recognized five major well-supported lineages that correspond largely to the genus level.Emmonsia,typified by Emmonsia parva,is a synonym of Blastomyces that also accommodates Blastomyces helicus(formerly Emmonsia helica).Emmonsia crescens is phylogenetically distinct,and found closely related to a single strain from soil without known etiology.Blastomyces silverae,Emergomyces canadensis,Emergomyces europaeus and Emmonsia sola are newly described.Almost all of the taxa are associated with human and animal disease.Emmonsia crescens,B.dermatitidis and B.parvus are prevalently associated with pulmonary disease in humans or animals.Blastomyces helicus,B.percursus,Emergomyces africanus,Es.canadensis,Es.europaeus,Es.orientalis and Es.pasteurianus(formerly Emmonsia pasteuriana)are predominantly found in human hosts with immune disorders;no animal hosts are known for these species except B.helicus.
基金supported by the National Natural Science Foundation of China(Grant No.11574057)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515012607)the Science and Technology Program of Guangdong Province of China(Grant No.2017A010104022).
文摘The polycrystalline strontium ferrate titanate(SrFe_(0.1)Ti_(0.9)O_(3),SFTO)thin films have been successfully prepared by chemical solution method.By analyzing the current-voltage(I-V)characteristics,we discuss the conduction mechanism of SFTO.It is found that the number of oxygen vacancy defects is increased by Fe ion doping,making SFTO be with better resistive switching property.Fe ion doping can also enhance the absorption of strontium titanate to be exposed to visible light,which is associated with the change of energy band.The band gap width(2.84 eV)of SFTO films is figured out,which is less than that of pure strontium titanate.Due to more oxygen vacancy defects caused by Fe ion doping,the band gap width of strontium titanate was reduced slightly.The defect types of SFTO thin films can be determined by electron paramagnetic resonance spectroscopy.In addition,we analyzed the energy band and state density of SFTO by first-principles calculation based on density functional theory,and found that Fe ion doping can reduce the band gap width of strontium titanate with micro-regulation on the band structure.A chemical state of SFTO was analyzed by X-ray photo electron spectroscopy.At the same time,the structure and morphology of SFTO were characterized by X-ray diffraction and scanning electron microscope.This study deepens further understanding of the influence of Fe ion doping on the structure and properties of strontium ferrate titanate,which is expected to be a functional thin film material for memristor devices.
基金supported by the National Natural Science Foundation of China(Grant Nos.51604087,11904056,and 12172093)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515012607).
文摘Enhancing the availability and reliability of dielectric ceramic energy storage devices is of great importance.In this work,(1-x)Na_(0.5)Bi_(0.5)TiO_(3)-xBi(Mg_(0.5)Hf_(0.5))O_(3)(NBT-xBMH)lead-free ceramics were created utilizing a solid-state reaction technique.All NBT-xBMH ceramics have a single perovskite structure.With increasing BMH doping,the grain size shrinks drastically,which greatly enhances the breakdown electric field(310 kV/cm at x=0.25).Additionally,the relaxation behaviors of NBT-xBMH ceramics with high BMH content are more remarkable.Among all designed components,the NBT-0.25BMH ceramic exhibits the best energy storage performance with a high Wrec of 4.63 J/cm^(3) and anηof 75.1%at 310 kV/cm.The NBT-0.25BMH ceramic has exceptional resistance to fluctuations in both frequency(5-500 Hz)and temperature(30-100°C).Charge-discharge test shows that the NBT-0.25BMH ceramic has a quick discharge rate(t0.9<110 ns).With these properties,the NBT-0.25BMH ceramic may have applications in microdevices as well as in ultra-high power electronic systems.
基金supported by the National Natural Science Foundation of China(Grant nos.12172093 and 11932016)the Guangdong Basic and Applied Basic Research Foundation(Grant no.2021A1515012607).
文摘The metastable polar orthorhombic phase is believed to be the origin of the ferroelectricity of hafnia-based films.The adjustment of stain,oxygen vacancies and dopant during film deposition and the wake-up electric cycling are common strategies to induce the ferroelectricity in hafnia.However,none of them could independently render the ferroelectric phase to be the most stable phase from the theoretical calculation results.The exact external conditions to stabilize orthorhombic phase still remain elusive.In this paper,we investigate the effects of the type,distribution,concentration,and charge state characteristics of oxygen vacancies and the uniaxial strain on the crystal’energy,dielectric constant and spontaneous polarization(Ps);In addition,the impact of the applied electric field parallel to the Ps on the crystal’energy is explored by first-principles calculations.It is challenging to independently stabilize the ferroelectric phase of hafnia-based films by a single component owing to the rather strict conditions.Surprisingly,the ferroelectricity can be easily obtained when simultaneously considering the effects of oxygen vacancies,uniaxial strain,and applied electric fields,suggesting the extremely important mechanical-electrical-chemical coupling effects.This work provides an explanation for the typical wake-up phenomenon in hafnia and a guidance for film applications.
文摘Service computing is an emerging and distributed computing mode in cloud service systems, and has become an interesting research direction for both academia and industry. Note that the cloud service systems always display new characteristics, such as stochasticity, large scale, loose coupling, concurrency non-homogeneity and heterogeneity;thus their load balancing investigation has been more interesting, difficult and challenging until now. By using resource management and job scheduling, this paper proposes an integrated, real-time and dynamic control mechanism for large-scale cloud service systems and their load balancing through combining supermarket models with not only work stealing models but also scheduling of public reserved resource. To this end, this paper provides a novel stochastic model with weak interactions by means of nonlinear Markov processes. To overcome theoretical difficulties growing out of the state explosion in high-dimensional stochastic systems, this paper applies the mean-field theory to develop a macro computational technique in terms of an infinite-dimensional system of mean-field equations. Furthermore, this paper proves the asymptotic independence of the large-scale cloud service system, and show how to compute the fixed point by virtue of an infinite-dimensional system of nonlinear equations. Based on the fixed point, this paper provides effective numerical computation for performance analysis of this system under a high approximate precision. Therefore, we hope that the methodology and results given in this paper can be applicable to the study of more general large-scale cloud service systems.
