In vivo imaging of human iris vasculature remains a persistent challenge,limiting our understanding of its relationship with ocular disease pathogenesis.Conventional raster scan optical coherence tomography angiograph...In vivo imaging of human iris vasculature remains a persistent challenge,limiting our understanding of its relationship with ocular disease pathogenesis.Conventional raster scan optical coherence tomography angiography(OCTA)suffers from angular-dependent contrast(including blind spots),limited field of view,and prolonged imaging time—challenges that restrict its clinical utility.We introduce a circular interleaving scan OCTA method that overcomes these barriers by enabling 360 deg high-contrast iris angiography with consistent spatiotemporal sampling and optimized motion contrast.The circular scan design enables directionoptimized sampling:we configured circumferential sampling density to approximately twice the radial density,enhancing detection of radially oriented iris vasculature.A Cartesian–polar coordinate transformation was implemented for eye-motion compensation,vessel realignment,and vasculature reconstruction.Compared with raster scan OCTA,our circular scan protocol demonstrates 1.55×higher efficiency in iris vascular imaging,featuring a superior duty cycle(99.95%versus 82.00%)and eliminating redundant data acquisition from rectangular field corners(27.3%of the circular area).This method improves vessel density measurement by 39.0%and vessel count quantification by 25.2%relative to raster scans.By eliminating angular-dependent blind spots,our method significantly enhances vascular quantification reliability,paving the way to a better understanding of ocular diseases and holding promising potential for future clinical applications.展开更多
The interplay between electronic topological phase transitions and superconductivity in the field of condensed matter physics has consistently captivated researchers.Here we have succeeded in modulating the Lifshitz t...The interplay between electronic topological phase transitions and superconductivity in the field of condensed matter physics has consistently captivated researchers.Here we have succeeded in modulating the Lifshitz transition by pressure and realized superconductivity.At 25.7 GPa,superconductivity with a transition temperature of 1.9 K has been observed in 3R-NbS_(2).The Hall coefficient changes from negative to positive at 14 GPa,indicating a Lifshitz transition in 3R-NbS_(2),and the carrier concentration continues to increase with increasing pressure.X-ray diffraction results indicate that the appearance of superconductivity cannot be attributable to structural transitions.Based on theoretical calculations,the emergence of a new band is attributed to the Lifshitz transition and the new band coincides with the Fermi surface at the pressure of 30 GPa.These findings provide new insights into the relationship between the Lifshitz transition and superconductivity.展开更多
Perovskite oxynitrides AB(N,O)_(3), a crucial class in materials science, have attracted much attention. By precisely controlling A-and B-site ions and tuning the N/O ratio, new materials with exotic charge states and...Perovskite oxynitrides AB(N,O)_(3), a crucial class in materials science, have attracted much attention. By precisely controlling A-and B-site ions and tuning the N/O ratio, new materials with exotic charge states and intriguing electronic behaviors can be designed and synthesized. In this work, a novel oxynitride perovskite, CeNbO_(2)N, was prepared under high-temperature and high-pressure conditions. The compound crystallizes in an orthorhombic perovskite structure in Pnma symmetry with disordered N/O distribution. The x-ray absorption spectroscopy confirms the presence of a Nb^(4+) state with 4d^(1) electronic configuration in CeNbO_(2)N. As a result, the resistivity of CeNbO_(2)N is sharply reduced compared to its counterpart CeTa^(5+)ON_(2) and other Nb^(5+) compounds. No long-range spin order is found to occur with the temperature down to 2 K in CeNbO_(2)N, while a remarkable negative magnetoresistance effect shows up at lower temperatures, probably due to the magnetic scattering arising from short-range spin correlations.展开更多
To enhance the hydrogen release during hydrogen storage,several Pt-Ir supported on Mg-Al mixed oxide catalysts were prepared and then applied into the dehydrogenation of methylcyclohexane(MCH)in this study.The effects...To enhance the hydrogen release during hydrogen storage,several Pt-Ir supported on Mg-Al mixed oxide catalysts were prepared and then applied into the dehydrogenation of methylcyclohexane(MCH)in this study.The effects of iridium content,reduction temperature on the activity and stability of the catalysts were studied in detail.In the presence of Ir,metal particle size was decrea sed and electron transfer between Ir and Pt was observed.High reduction temperature increased the metallic Ir content but enlarged the particle size of active site s.During the dehydrogenation reaction on Pt-Ir bimetallic catalyst,MCH was efficiently converted into toluene and PtIr-5/Mg-Al-275 exhibited the highe st activity.After prolonging the residence time and raising the reaction temperature to 350℃the conversion and hydrogen evolution rate were increased to 99.9%and 578.7 mmol·(g Pt)^-1·min^-1,respectively.Moreover,no carbon deposition was observed in the spent catalyst,presenting a high anti-coking ability and good potential for industrial application.展开更多
Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate o...Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate of UC in China has increased year by year,but there is no effective cure method in Western medicine.Traditional Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity,convenience,effectiveness,and low cost.Therefore,integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment,and has made significant progress in UC.On the basis of learning from a number of consensuses at home and abroad,combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine,the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western medicine.In this consensus,the pathogenesis,etiology and pathogenesis,diagnosis,integrated traditional Chinese and Western medicine treatment,and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by experts.This article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.展开更多
Multiple phase transitions are detected in sodium amide(NaNH2), an important hydrogen storage material, upon compression in diamond anvil cells(DAC) by using Raman spectroscopy and x-ray diffraction(XRD) measurements....Multiple phase transitions are detected in sodium amide(NaNH2), an important hydrogen storage material, upon compression in diamond anvil cells(DAC) by using Raman spectroscopy and x-ray diffraction(XRD) measurements.Additional Bragg reflections appear on lower and higher angle sides of the original ones at ~1.07 GPa and 1.84 GPa,accompanied by obvious changes in Raman spectroscopy, respectively.It reveals that NaNH2 undergoes the high-pressure phase sequence(α-β-γ) up to 20 GPa at room temperature.Spectral analysis indicates an orthorhombic structure with PBAN space group for the γ phase.We also experimentally observe high pressure induced recrystallization in alkaline amide compounds for the first time.展开更多
In situ Raman spectroscopy and x-ray diffraction measurements are used to explore the structural stability of CaB6 at high pressures and room temperature. The results show no evidence of structural phase transitions u...In situ Raman spectroscopy and x-ray diffraction measurements are used to explore the structural stability of CaB6 at high pressures and room temperature. The results show no evidence of structural phase transitions up to at least 40 GPa.The obtained equation of state with smooth pressure dependencies yields a zero-pressure isothermal bulk modulus B0=170(5) GPa, which agrees well with the previous measurements. The frequency shifts for A1g, Eg, and T2g vibrational modes of polycrystalline CaB6 are obtained with pressure uploading. As the pressure increases, all the vibration modes have smooth monotonic pressure dependence. The Gr¨uneisen parameter of Eg modes is the largest, indicating its largest dependence on the volume of a crystal lattice.展开更多
Design of a robust catalyst with high activity but the low cost for the hydrodeoxygenation(HDO) of biooils is of great importance to bring the biorefinery concept into reality.In this study,density functional theory(D...Design of a robust catalyst with high activity but the low cost for the hydrodeoxygenation(HDO) of biooils is of great importance to bring the biorefinery concept into reality.In this study,density functional theory(DFT) calculation was adopted to analyze the optimal location of Ni on MoO_(3-x) containing oxygen vacancy,and the corresponding result demonstrated that metallic Ni cluster located at the neighborhood of oxygen vacancies would significantly evoke HDO activity.Enlightened by DFT results,NiMoO_(4) was first hydrothermally synthesized and then employed to fabricate Ni-MoO_(3-x) catalyst via a low-temperature reduction,where Ni escaped from NiMoO_(4) and was reduced to its metallic state.Such an evolution of Ni species also induced the formation of oxygen vacancies around metallic Ni cluster.In the HDO of p-cresol,Ni-MoO_(3-x) exhibited high activity with a complete conversion and a methylcyclohexane selectivity of 99.4% at 150℃.Moreover,the catalyst showed good versatility in catalyzing HDO of diverse lignin-derived oxygenates and lignin oil.2D HSQC NMR,gas chromatograph and elemental analysis of the lignin oil demonstrated the high deoxygenation efficiency and saturation of the benzene ring over Ni-MoO_(3-x).In the upgrading of crude lignin oil,the deoxygenation degree was up to 99%,and the overall carbon yield of the naphthenes was as high as 69.4%.Importantly,the structures and carbon numbers of the naphthene products are similar to jet fuel-range cycloalka nes,which are expected to have a high density that can be blended into jet fuel to raise the range(or payload) of airplanes.This work demonstrates the feasibility for improving the targeted catalytic reactivity by rational tailoring the catalyst structure under the guidance of theoretical analysis,and provides an energy-efficient route for the upgrading of lignin crude oil into valuable naphthenes.展开更多
Conventional theories expect that materials under pressure exhibit expanded valence and conduction bands,leading to increased electrical conductivity.Here,we report the electrical properties of the doped 1T-TiS_(2) un...Conventional theories expect that materials under pressure exhibit expanded valence and conduction bands,leading to increased electrical conductivity.Here,we report the electrical properties of the doped 1T-TiS_(2) under high pressure by electrical resistance investigations,synchrotron x-ray diffraction,Raman scattering and theoretical calculations.Up to 70 GPa,an unusual metal-semiconductor-metal transition occurs.Our first-principles calculations suggest that the observed anti-Wilson transition from metal to semiconductor at 17 GPa is due to the electron localization induced by the intercalated Ti atoms.This electron localization is attributed to the strengthened coupling between the doped Ti atoms and S atoms,and the Anderson localization arising from the disordered intercalation.At pressures exceeding 30.5 GPa,the doped TiS_(2) undergoes a re-metallization transition initiated by a crystal structure phase transition.We assign the most probable space group as P2_(1)2_(1)2_(1).Our findings suggest that materials probably will eventually undergo the Wilson transition when subjected to sufficient pressure.展开更多
We conduct extensive research into the structures of Be_(x)Zn_(1-x)OO ternary alloys in a pressure range of 0-60GPa,using the ab initio total energy evolutionary algorithm and total energy calculations,finding several...We conduct extensive research into the structures of Be_(x)Zn_(1-x)OO ternary alloys in a pressure range of 0-60GPa,using the ab initio total energy evolutionary algorithm and total energy calculations,finding several metastable structures.Our pressure-composition phase diagram is constructed using the enthalpy results.In addition,we calculate the electronic structures of the Be_(x)Zn_(1-x)OO structures and investigate the bandgap values at varying pressures and Be content.The calculated results show that the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with an increase in Be content at the same pressure.Moreover,the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with the increasing pressure with fixed Be content.At the same Be content,the formation enthalpy of the Be_(x)Zn_(1-x)OO ternary alloys first decreases,then increases with the increasing pressure.展开更多
Ammonium iodine(NH4I)as an important member of hydrogen-rich compounds has attracted a great deal of attention owing to its interesting structural changes triggered by the relative orientations of adjacent ammonium io...Ammonium iodine(NH4I)as an important member of hydrogen-rich compounds has attracted a great deal of attention owing to its interesting structural changes triggered by the relative orientations of adjacent ammonium ions.Previous studies of ammonium iodide have remained in the low pressure range experimentally,which we first extended to so high pressure(250 GPa).We have investigated the structures of ammonium iodine under high pressure through ab initio evolutionary algorithm and total energy calculations based on density functional theory.The static enthalpy calculations show that phase V is stable until 85 GPa where a new phase Ibam is identified.Calculations of phonon spectra show that the Ibam phase is stable between 85 GPa and 101 GPa and the Cm phase is stable up to 130 GPa.In addition,ammonium iodine dissociates into NH3,H2,and I2 at 74 GPa.Subsequently,we analyzed phonon spectra and electronic band structures,finding that phonon softening is not the reason of dissociation and NH4I is always a semiconductor within the pressure range.展开更多
Silane(SiH4)is a promising hydrogen-rich compound for pursing high temperature superconducting.Previous high pressure measurements of Raman,x-ray diffraction and theoretical studies on SiH4 mainly focused on its polym...Silane(SiH4)is a promising hydrogen-rich compound for pursing high temperature superconducting.Previous high pressure measurements of Raman,x-ray diffraction and theoretical studies on SiH4 mainly focused on its polymorphic structures above 50 GPa,while the structure and the stability under lower pressure range are still unclear.Here we report an investigation of condensed SiH4 by Brillouin scattering measurements at high temperature up to 407 K and high pressure up to 18 GPa.Brillouin scattering frequencies of fluid SiH4 under compression are obtained under isothermal conditions of 300 K,359 K and 407 K.The SiH4 becomes unstable with increasing temperature and subsequently decomposes into silicon and H2.We find that compression at room temperature induces two velocity anomalies corresponding to a fluid-solid state transition and a phaseⅣto phase V transition,respectively.Brillouin scattering spectra has been a powerful tool to investigate the fruitful phases and structure transitions in the hydrogen-rich compound under extreme conditions.展开更多
In this paper, diversity-multiplexing tradeoff (DMT) curve for 2×2 Dual-Polarized uncorrelated Rice MIMO channels is studied. Exact expressions for statistic information of mutual information exponent are derived...In this paper, diversity-multiplexing tradeoff (DMT) curve for 2×2 Dual-Polarized uncorrelated Rice MIMO channels is studied. Exact expressions for statistic information of mutual information exponent are derived. Impacts of channel parameters such as signal to noise ratio (SNR), k-factor and cross polarization discrimination (XPD) on mutual information exponent are analyzed. Compared to conventional single-polarized (SP) Rice MIMO systems, a qualitatively different behavior is observed for DP Rice systems. The work in this paper, allows identifying quantitatively for which channels (k-factor) and SNR levels the use of dual polarization becomes beneficial. Gamma or lognormal distribution are used to describe mutual information component, and a theoretical formulation for finite-SNR DMT curve in 2×2 DP uncorrelated Rice channels is presented for the first time, which is valid in low and medium SNRs when multiplexing gain is larger than 0.75.展开更多
I.EXECUTIVE SUMMARY next-generation,high-intensity electron-positron collider"Higgs factory",such as the Circular Electron-Positron Collider(CEPC),is among the highest priorities for the global high-energy c...I.EXECUTIVE SUMMARY next-generation,high-intensity electron-positron collider"Higgs factory",such as the Circular Electron-Positron Collider(CEPC),is among the highest priorities for the global high-energy collider physics community.The CEPC can provide unprecedented opportunities for making fundamental discoveries and providing decisive insights in the quest for a"New Standard Model(SM)"of nature's fundamental interactions.The CEPC could:·Identify the origin of matter,especially the mechanism related to the first-order phase transition in the early Universe,which could produce a detectable gravitational wave signal.展开更多
The polymerase 1 and transcript release factor(PTRF)–cytoplasmic phospholipase A2(cPLA2)phospholipid remodeling pathway facilitates tumor proliferation in glioma.Nevertheless,blockade of this pathway leads to the exc...The polymerase 1 and transcript release factor(PTRF)–cytoplasmic phospholipase A2(cPLA2)phospholipid remodeling pathway facilitates tumor proliferation in glioma.Nevertheless,blockade of this pathway leads to the excessive activation of oncogenic receptors on the plasma membrane and subsequent drug resistance.Here,CD26/dipeptidyl peptidase 4(DPP4)was identified through screening of CRISPR/Cas9 libraries.Suppressing PTRF–cPLA2 signaling resulted in the activation of the epidermal growth factor receptor(EGFR)pathway through phosphatidylcholine and lysophosphatidylcholine remodeling,which ultimately increased DPP4 transcription.In turn,DPP4 interacted with EGFR and prevented its ubiquitination.Linagliptin,a DPP4 inhibitor,facilitated the degradation of EGFR by blocking its interaction with DPP4.When combined with the cPLA2 inhibitor AACOCF3,it exhibited synergistic effects and led to a decrease in energy metabolism in glioblastoma cells.Subsequent in vivo investigations provided further evidence of a synergistic impact of linagliptin by augmenting the sensitivity of AACOCF3 and strengthening the efficacy of temozolomide.DPP4 serves as a novel target and establishes a constructive feedback loop with EGFR.Linagliptin is a potent inhibitor that promotes EGFR degradation by blocking the DPP4–EGFR interaction.This study presents innovative approaches for treating glioma by combining linagliptin with AACOCF3 and temozolomide.展开更多
In this study,we employed the heavy quark expansion model with the kinetic scheme to evaluate os(m^(2)_(c)),the strong coupling constant at the chamn quark mass me,using data on inclusive semileptonic decays of charme...In this study,we employed the heavy quark expansion model with the kinetic scheme to evaluate os(m^(2)_(c)),the strong coupling constant at the chamn quark mass me,using data on inclusive semileptonic decays of charmed mesons.Using the experimental values of the semileptonic decay widths of the D^(0)and the D^(+),the value of ars(m^(2))was determined to be 0.445±0.009±0.114,where the first uncertainty is experimental and the second is systematic.This value of a,(m^(2))is in good agreement with the value of ar,(m^(2)_(c))which calculated by running as(m^(2))athe 20 bo-son mass mz with the renormalization group evolution equation.In addition,the values of a_(s)(m^(2)_(c))obtained individu-ally from each of the D,D+,and D5 mesons were consistent,as they were of the same origin.展开更多
Correction to:Radiation Detection Technology and Methods(2024)8:1-1105.https://doi.org/10.1007/s41605-024-00463-y.In this article all authors name was missing in the springer link.It has been corrected.The original ar...Correction to:Radiation Detection Technology and Methods(2024)8:1-1105.https://doi.org/10.1007/s41605-024-00463-y.In this article all authors name was missing in the springer link.It has been corrected.The original article has been corrected.展开更多
基金supported by the National Key Research and Development Program of China(Grant No.2021YFF0502900)the National Natural Science Foundation of China(Grant Nos.62575066 and 62027824)+3 种基金the Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515011344)the Innovation and Entrepreneurship Teams Project of Guangdong Pearl River Talents Program(Grant No.2019ZT08Y105)the Guangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory(Grant No.2020B1212030010)the National Institutes of Health/National Eye Institute(NIH/NEI)(Grant Nos.P30EY07551,R01EY022362,and R01EY022362).
文摘In vivo imaging of human iris vasculature remains a persistent challenge,limiting our understanding of its relationship with ocular disease pathogenesis.Conventional raster scan optical coherence tomography angiography(OCTA)suffers from angular-dependent contrast(including blind spots),limited field of view,and prolonged imaging time—challenges that restrict its clinical utility.We introduce a circular interleaving scan OCTA method that overcomes these barriers by enabling 360 deg high-contrast iris angiography with consistent spatiotemporal sampling and optimized motion contrast.The circular scan design enables directionoptimized sampling:we configured circumferential sampling density to approximately twice the radial density,enhancing detection of radially oriented iris vasculature.A Cartesian–polar coordinate transformation was implemented for eye-motion compensation,vessel realignment,and vasculature reconstruction.Compared with raster scan OCTA,our circular scan protocol demonstrates 1.55×higher efficiency in iris vascular imaging,featuring a superior duty cycle(99.95%versus 82.00%)and eliminating redundant data acquisition from rectangular field corners(27.3%of the circular area).This method improves vessel density measurement by 39.0%and vessel count quantification by 25.2%relative to raster scans.By eliminating angular-dependent blind spots,our method significantly enhances vascular quantification reliability,paving the way to a better understanding of ocular diseases and holding promising potential for future clinical applications.
基金Project supported by the National Key R&D Program of China(Grant No.2022YFA1405500)the National Natural Science Foundation of China(Grant Nos.52072188 and 12304072)+1 种基金Program for Science and Technology Innovation Team in Zhejiang(Grant No.2021R01004)the Natural Science Foundation of Ningbo(Grant No.2021J121)。
文摘The interplay between electronic topological phase transitions and superconductivity in the field of condensed matter physics has consistently captivated researchers.Here we have succeeded in modulating the Lifshitz transition by pressure and realized superconductivity.At 25.7 GPa,superconductivity with a transition temperature of 1.9 K has been observed in 3R-NbS_(2).The Hall coefficient changes from negative to positive at 14 GPa,indicating a Lifshitz transition in 3R-NbS_(2),and the carrier concentration continues to increase with increasing pressure.X-ray diffraction results indicate that the appearance of superconductivity cannot be attributable to structural transitions.Based on theoretical calculations,the emergence of a new band is attributed to the Lifshitz transition and the new band coincides with the Fermi surface at the pressure of 30 GPa.These findings provide new insights into the relationship between the Lifshitz transition and superconductivity.
基金Project supported by the National Key R&D Program of China (Grant No. 2021YFA1400300)the National Natural Science Foundation of China (Grant Nos. 12425403, 12261131499, 12304268, 12304159, 11934017, and 11921004)+1 种基金the China Postdoctoral Science Foundation (Grant No. 2023M743741)The synchrotron x-ray diffraction experiments were performed at SPring-8 with the approval of the Japan Synchrotron Radiation Research Institute (Grant Nos. 2023B1575, 2023B1976, 2024A1506, and 2024A1695)。
文摘Perovskite oxynitrides AB(N,O)_(3), a crucial class in materials science, have attracted much attention. By precisely controlling A-and B-site ions and tuning the N/O ratio, new materials with exotic charge states and intriguing electronic behaviors can be designed and synthesized. In this work, a novel oxynitride perovskite, CeNbO_(2)N, was prepared under high-temperature and high-pressure conditions. The compound crystallizes in an orthorhombic perovskite structure in Pnma symmetry with disordered N/O distribution. The x-ray absorption spectroscopy confirms the presence of a Nb^(4+) state with 4d^(1) electronic configuration in CeNbO_(2)N. As a result, the resistivity of CeNbO_(2)N is sharply reduced compared to its counterpart CeTa^(5+)ON_(2) and other Nb^(5+) compounds. No long-range spin order is found to occur with the temperature down to 2 K in CeNbO_(2)N, while a remarkable negative magnetoresistance effect shows up at lower temperatures, probably due to the magnetic scattering arising from short-range spin correlations.
基金supported by the National Natural Science Foundation of China(Nos.21676225 and 21776236)Natural Science Foundation of Hunan Province(2018JJ2384)+2 种基金Fund of Hunan Provincial Education Department(19A478)Collaborative Innovation Centre of New Chemical Technologies for Environmental Benignity and Efficient Resource UtilizationEngineering Research Centre of Chemical Process Simulation and Optimization of Ministry of Education。
文摘To enhance the hydrogen release during hydrogen storage,several Pt-Ir supported on Mg-Al mixed oxide catalysts were prepared and then applied into the dehydrogenation of methylcyclohexane(MCH)in this study.The effects of iridium content,reduction temperature on the activity and stability of the catalysts were studied in detail.In the presence of Ir,metal particle size was decrea sed and electron transfer between Ir and Pt was observed.High reduction temperature increased the metallic Ir content but enlarged the particle size of active site s.During the dehydrogenation reaction on Pt-Ir bimetallic catalyst,MCH was efficiently converted into toluene and PtIr-5/Mg-Al-275 exhibited the highe st activity.After prolonging the residence time and raising the reaction temperature to 350℃the conversion and hydrogen evolution rate were increased to 99.9%and 578.7 mmol·(g Pt)^-1·min^-1,respectively.Moreover,no carbon deposition was observed in the spent catalyst,presenting a high anti-coking ability and good potential for industrial application.
文摘Ulcerative colitis(UC)is a chronic nonspecific intestinal inflammatory disease of unclear etiology,characterized by continuous and diffuse inflammatory changes of colorectal mucosa.In recent years,the incidence rate of UC in China has increased year by year,but there is no effective cure method in Western medicine.Traditional Chinese medicine treatment based on syndrome differentiation has the unique advantages of simplicity,convenience,effectiveness,and low cost.Therefore,integration of Chinese and Western medicine has become an important strategy for UC diagnosis and treatment,and has made significant progress in UC.On the basis of learning from a number of consensuses at home and abroad,combined with Chinese research results and the actual clinical situation of traditional Chinese and Western medicine,the UC group of the Chinese Association of Integrative Medicine has formulated the expert consensus on the diagnosis and treatment of UC with integrated traditional Chinese and Western medicine.In this consensus,the pathogenesis,etiology and pathogenesis,diagnosis,integrated traditional Chinese and Western medicine treatment,and chronic disease management with integrated traditional Chinese and Western medicine for UC were recommended by experts.This article interprets the consensus from the perspective of nursing in order to provide reference basis for clinical nursing workers.
基金Project supported by the National Key R&D Program of China(Grant Nos.2018YFA0305900 and 2016YFB0201204)the National Natural Science Foundation of China(Grant Nos.51632002,51572108,11504127,91745203,and 11634004)+1 种基金Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT 15R23)National Fund for Fostering Talents of Basic Science,China(Grant No.J1103202)
文摘Multiple phase transitions are detected in sodium amide(NaNH2), an important hydrogen storage material, upon compression in diamond anvil cells(DAC) by using Raman spectroscopy and x-ray diffraction(XRD) measurements.Additional Bragg reflections appear on lower and higher angle sides of the original ones at ~1.07 GPa and 1.84 GPa,accompanied by obvious changes in Raman spectroscopy, respectively.It reveals that NaNH2 undergoes the high-pressure phase sequence(α-β-γ) up to 20 GPa at room temperature.Spectral analysis indicates an orthorhombic structure with PBAN space group for the γ phase.We also experimentally observe high pressure induced recrystallization in alkaline amide compounds for the first time.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.51572108,51632002,11504127,11674122,11574112,11474127,and11634004)the 111 Project,China(Grant No.B12011)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT 15R23)the National Found for Fostering Talents of Basic Science,China(Grant No.J1103202)
文摘In situ Raman spectroscopy and x-ray diffraction measurements are used to explore the structural stability of CaB6 at high pressures and room temperature. The results show no evidence of structural phase transitions up to at least 40 GPa.The obtained equation of state with smooth pressure dependencies yields a zero-pressure isothermal bulk modulus B0=170(5) GPa, which agrees well with the previous measurements. The frequency shifts for A1g, Eg, and T2g vibrational modes of polycrystalline CaB6 are obtained with pressure uploading. As the pressure increases, all the vibration modes have smooth monotonic pressure dependence. The Gr¨uneisen parameter of Eg modes is the largest, indicating its largest dependence on the volume of a crystal lattice.
基金supported by the National Key R&D Program of China (2022YFB3805401, 2019YFC1905300)the National Natural Science Foundation of China (22178297)+1 种基金the Hunan Provincial Natural Science Foundation (2022JJ40425, 2022JJ40432)the Process Intensification and Green Chemical Engineering Innovation Team of Hunan Province。
文摘Design of a robust catalyst with high activity but the low cost for the hydrodeoxygenation(HDO) of biooils is of great importance to bring the biorefinery concept into reality.In this study,density functional theory(DFT) calculation was adopted to analyze the optimal location of Ni on MoO_(3-x) containing oxygen vacancy,and the corresponding result demonstrated that metallic Ni cluster located at the neighborhood of oxygen vacancies would significantly evoke HDO activity.Enlightened by DFT results,NiMoO_(4) was first hydrothermally synthesized and then employed to fabricate Ni-MoO_(3-x) catalyst via a low-temperature reduction,where Ni escaped from NiMoO_(4) and was reduced to its metallic state.Such an evolution of Ni species also induced the formation of oxygen vacancies around metallic Ni cluster.In the HDO of p-cresol,Ni-MoO_(3-x) exhibited high activity with a complete conversion and a methylcyclohexane selectivity of 99.4% at 150℃.Moreover,the catalyst showed good versatility in catalyzing HDO of diverse lignin-derived oxygenates and lignin oil.2D HSQC NMR,gas chromatograph and elemental analysis of the lignin oil demonstrated the high deoxygenation efficiency and saturation of the benzene ring over Ni-MoO_(3-x).In the upgrading of crude lignin oil,the deoxygenation degree was up to 99%,and the overall carbon yield of the naphthenes was as high as 69.4%.Importantly,the structures and carbon numbers of the naphthene products are similar to jet fuel-range cycloalka nes,which are expected to have a high density that can be blended into jet fuel to raise the range(or payload) of airplanes.This work demonstrates the feasibility for improving the targeted catalytic reactivity by rational tailoring the catalyst structure under the guidance of theoretical analysis,and provides an energy-efficient route for the upgrading of lignin crude oil into valuable naphthenes.
基金supported by the National Natural Science Foundation of China (Grant No. 12304072)Program for Science and Technology Innovation Team in Zhejiang (Grant No. 2021R01004)+1 种基金Natural Science Foundation of Ningbo(Grant No. 2021J121)supported by the User Experiment Assist System of Shanghai Synchrotron Radiation Facility (SSRF)。
文摘Conventional theories expect that materials under pressure exhibit expanded valence and conduction bands,leading to increased electrical conductivity.Here,we report the electrical properties of the doped 1T-TiS_(2) under high pressure by electrical resistance investigations,synchrotron x-ray diffraction,Raman scattering and theoretical calculations.Up to 70 GPa,an unusual metal-semiconductor-metal transition occurs.Our first-principles calculations suggest that the observed anti-Wilson transition from metal to semiconductor at 17 GPa is due to the electron localization induced by the intercalated Ti atoms.This electron localization is attributed to the strengthened coupling between the doped Ti atoms and S atoms,and the Anderson localization arising from the disordered intercalation.At pressures exceeding 30.5 GPa,the doped TiS_(2) undergoes a re-metallization transition initiated by a crystal structure phase transition.We assign the most probable space group as P2_(1)2_(1)2_(1).Our findings suggest that materials probably will eventually undergo the Wilson transition when subjected to sufficient pressure.
基金Supported by the National Key Research and Development Program of China(Grant Nos.2016YFB0201204,2018YFA0703404,and 2017YFA0403704)the National Natural Science Foundation of China(Grant Nos.11574109 and 91745203)the Program for Changjiang Scholars and Innovative Research Team in Universities(Grant No.IRT_15R23).
文摘We conduct extensive research into the structures of Be_(x)Zn_(1-x)OO ternary alloys in a pressure range of 0-60GPa,using the ab initio total energy evolutionary algorithm and total energy calculations,finding several metastable structures.Our pressure-composition phase diagram is constructed using the enthalpy results.In addition,we calculate the electronic structures of the Be_(x)Zn_(1-x)OO structures and investigate the bandgap values at varying pressures and Be content.The calculated results show that the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with an increase in Be content at the same pressure.Moreover,the bandgap of the Be_(x)Zn_(1-x)OO ternary alloys increases with the increasing pressure with fixed Be content.At the same Be content,the formation enthalpy of the Be_(x)Zn_(1-x)OO ternary alloys first decreases,then increases with the increasing pressure.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11574109,51632002,51572108,91745203,and 11574112)the National Key Research and Development Program of China(Grant Nos.2016YFB0201204 and 2018YFA0305900)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University,China(Grant No.IRT 15R23)the National Fund for Fostering Talents of Basic Science of China(Grant No.J1103202).
文摘Ammonium iodine(NH4I)as an important member of hydrogen-rich compounds has attracted a great deal of attention owing to its interesting structural changes triggered by the relative orientations of adjacent ammonium ions.Previous studies of ammonium iodide have remained in the low pressure range experimentally,which we first extended to so high pressure(250 GPa).We have investigated the structures of ammonium iodine under high pressure through ab initio evolutionary algorithm and total energy calculations based on density functional theory.The static enthalpy calculations show that phase V is stable until 85 GPa where a new phase Ibam is identified.Calculations of phonon spectra show that the Ibam phase is stable between 85 GPa and 101 GPa and the Cm phase is stable up to 130 GPa.In addition,ammonium iodine dissociates into NH3,H2,and I2 at 74 GPa.Subsequently,we analyzed phonon spectra and electronic band structures,finding that phonon softening is not the reason of dissociation and NH4I is always a semiconductor within the pressure range.
基金Supported by the National Key Research and Development Program(Grant No.2017YFA0403704)the National Natural Science Foundation of China(Grant Nos.11474127,11574112,11274137,and 11504127)+1 种基金the Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT1132)China Postdoctoral Science Foundation(Grant No.2015M570265)。
文摘Silane(SiH4)is a promising hydrogen-rich compound for pursing high temperature superconducting.Previous high pressure measurements of Raman,x-ray diffraction and theoretical studies on SiH4 mainly focused on its polymorphic structures above 50 GPa,while the structure and the stability under lower pressure range are still unclear.Here we report an investigation of condensed SiH4 by Brillouin scattering measurements at high temperature up to 407 K and high pressure up to 18 GPa.Brillouin scattering frequencies of fluid SiH4 under compression are obtained under isothermal conditions of 300 K,359 K and 407 K.The SiH4 becomes unstable with increasing temperature and subsequently decomposes into silicon and H2.We find that compression at room temperature induces two velocity anomalies corresponding to a fluid-solid state transition and a phaseⅣto phase V transition,respectively.Brillouin scattering spectra has been a powerful tool to investigate the fruitful phases and structure transitions in the hydrogen-rich compound under extreme conditions.
文摘In this paper, diversity-multiplexing tradeoff (DMT) curve for 2×2 Dual-Polarized uncorrelated Rice MIMO channels is studied. Exact expressions for statistic information of mutual information exponent are derived. Impacts of channel parameters such as signal to noise ratio (SNR), k-factor and cross polarization discrimination (XPD) on mutual information exponent are analyzed. Compared to conventional single-polarized (SP) Rice MIMO systems, a qualitatively different behavior is observed for DP Rice systems. The work in this paper, allows identifying quantitatively for which channels (k-factor) and SNR levels the use of dual polarization becomes beneficial. Gamma or lognormal distribution are used to describe mutual information component, and a theoretical formulation for finite-SNR DMT curve in 2×2 DP uncorrelated Rice channels is presented for the first time, which is valid in low and medium SNRs when multiplexing gain is larger than 0.75.
基金the Natural Science Foundation of China(NSFC)(11905162,12035008,12075097,12075123,12090060,12090064,12105248,12135006,12175039,12205227,12205312,12205387,12205171,12235008,12321005,12235001,12305094,12305115,12335005,12375091,12375094,12375096,11975129,12375194,12447167,12475094,12475101,12475106,12475111,12425506,12375101,12405119,12405101,12505121,12135007,12175218,12075213,12335005,12175243,12533001,12125503,12305103,12505120,12575099,12505122,12342502,12575106,12147214,W2432006,W2441004)the National Key R&D Program of China(2024YFA1610603)+22 种基金the China Postdoctoral Science Foundation(2023M732255,2025M773403,GZC20231613)the Natural Science Foundation of Jiangsu Province(BK20210201)the Natural Science Foundation of Henan(Distinguished Young Scholars of Henan Province)(242300421046)the Natural Science Foundation of Sichuan Province(2025ZNSFSC0880)the Guangdong Major Project of Basic and Applied Basic Research(2020B0301030008)the Department of Science and Technology of Shandong province(tsqn202312052,2024HWYQ-005)the Startup Research Fund of Henan Academy of Sciences(20251820001)the Excellent Young Talents Program of Wuhan University of Technology(40122102)the research program of the Wuhan University of Technology(3120625397,2020IB024)the Fundamental Research Funds for the Central Universities(JZ2023HGTB0222,WUT:2022IVA052)the Excellent Scholar Project of Southeast University(Class A)the Big Data Computing Center of Southeast University,National Science and Technology Council,the Ministry of Education(Higher Education Sprout Project NTU-114L104022-1)the Center for Theoretical Sciences of Taiwan,and Vietnam National Foundation for Science and Technology Development(NAFOSTED)(103.01-2023.50)the Research Office of the University of the Witwatersrand and South African Department of Science and Innovation through the SA-CERN programthe self-determined research funds of Central China Normal University from the colleges'basic research and operation of MOE(CCNU24AI003)SJTU Double First Class start-up fund(WF220442604)the Innovation Capability Support Program of Shaanxi(2021KJXX-47)the Slovenian Research Agency under the research core funding No.P1-0035,the research grants J1-3013,N1-0253,CONICET,ANPCyT under project(PICT-2021-00374)Higher Education Sprout Project(NTU-114L104022-1)KIAS Individual Grants(PG086002)at the Korea Institute for Advanced Study,FAPESP(2021/09547-9)the Slovenian Research Agency under the research core funding(P1-0035)research grants J1-3013,N1-0253the bilateral project Proteus PR-12696/Projet 50194VC。
文摘I.EXECUTIVE SUMMARY next-generation,high-intensity electron-positron collider"Higgs factory",such as the Circular Electron-Positron Collider(CEPC),is among the highest priorities for the global high-energy collider physics community.The CEPC can provide unprecedented opportunities for making fundamental discoveries and providing decisive insights in the quest for a"New Standard Model(SM)"of nature's fundamental interactions.The CEPC could:·Identify the origin of matter,especially the mechanism related to the first-order phase transition in the early Universe,which could produce a detectable gravitational wave signal.
基金supported by the National Key R&D Program of China,MOST(2023YFC2510000)the Key-Area Research and Development Program of Guangdong Province(2023B1111020008)the National Natural Science Foundation of China(82373147 and 82473379).
文摘The polymerase 1 and transcript release factor(PTRF)–cytoplasmic phospholipase A2(cPLA2)phospholipid remodeling pathway facilitates tumor proliferation in glioma.Nevertheless,blockade of this pathway leads to the excessive activation of oncogenic receptors on the plasma membrane and subsequent drug resistance.Here,CD26/dipeptidyl peptidase 4(DPP4)was identified through screening of CRISPR/Cas9 libraries.Suppressing PTRF–cPLA2 signaling resulted in the activation of the epidermal growth factor receptor(EGFR)pathway through phosphatidylcholine and lysophosphatidylcholine remodeling,which ultimately increased DPP4 transcription.In turn,DPP4 interacted with EGFR and prevented its ubiquitination.Linagliptin,a DPP4 inhibitor,facilitated the degradation of EGFR by blocking its interaction with DPP4.When combined with the cPLA2 inhibitor AACOCF3,it exhibited synergistic effects and led to a decrease in energy metabolism in glioblastoma cells.Subsequent in vivo investigations provided further evidence of a synergistic impact of linagliptin by augmenting the sensitivity of AACOCF3 and strengthening the efficacy of temozolomide.DPP4 serves as a novel target and establishes a constructive feedback loop with EGFR.Linagliptin is a potent inhibitor that promotes EGFR degradation by blocking the DPP4–EGFR interaction.This study presents innovative approaches for treating glioma by combining linagliptin with AACOCF3 and temozolomide.
基金Supported by the National Natural Science Foundation of China(12247119,12042507)。
文摘In this study,we employed the heavy quark expansion model with the kinetic scheme to evaluate os(m^(2)_(c)),the strong coupling constant at the chamn quark mass me,using data on inclusive semileptonic decays of charmed mesons.Using the experimental values of the semileptonic decay widths of the D^(0)and the D^(+),the value of ars(m^(2))was determined to be 0.445±0.009±0.114,where the first uncertainty is experimental and the second is systematic.This value of a,(m^(2))is in good agreement with the value of ar,(m^(2)_(c))which calculated by running as(m^(2))athe 20 bo-son mass mz with the renormalization group evolution equation.In addition,the values of a_(s)(m^(2)_(c))obtained individu-ally from each of the D,D+,and D5 mesons were consistent,as they were of the same origin.
文摘Correction to:Radiation Detection Technology and Methods(2024)8:1-1105.https://doi.org/10.1007/s41605-024-00463-y.In this article all authors name was missing in the springer link.It has been corrected.The original article has been corrected.
