Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to ...Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPs-based nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.展开更多
Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm...Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing.展开更多
Silicon photonics has become very popular because of their compatibility with mature CMOS technologies. However, pure silicon is still very difficult to be utilized to obtain various photonic functional devices for la...Silicon photonics has become very popular because of their compatibility with mature CMOS technologies. However, pure silicon is still very difficult to be utilized to obtain various photonic functional devices for large-scale photonic integration due to intrinsic properties. Silicon-plus photonics, which pluses other materials to break the limitation of silicon, is playing a very important role currently and in the future. In this paper, we give a review and discussion on the progresses of siliconplus photonics, including the structures, devices and applications.展开更多
Silicon photonics has attracted much attention because of the advantages of CMOS （complementary- metal-oxide-semiconductor） compatibility, ultra-high integrated density, etc. Great progress has been achieved in the ...Silicon photonics has attracted much attention because of the advantages of CMOS （complementary- metal-oxide-semiconductor） compatibility, ultra-high integrated density, etc. Great progress has been achieved in the past decades. However, it is still not easy to realize active silicon photonic devices and circuits by utilizing the material system of pure silicon due to the limitation of the intrinsic properties of silicon. Graphene has been re- garded as a promising material for optoelectronics due to its unique properties and thus provides a potential option for realizing active photonic integrated devices on silicon. In this paper, we present a review on recent progress of some silicon-graphene photonic devices for photodetection, all-optical modulation, as well as thermal-tuning.展开更多
基金financially supported by the Application Fundamental Research Foundation of Sichuan Province Science and Technology Department, China (No. 2016JY0157)the State Sponsored Scholarship for Visiting Scholar from China Scholarship Council, the Outstanding Science and Technology Projects for Returned Overseas Chinese Scholars, Sichuan Province, China, theNational Natural Science Foundation of China (No. 31600811) the National Training Program of Innovation and Entrepreneurship for Undergraduates(No. 201813705025)
文摘Gold-based nanomaterials with plasmonic properties exhibit various potentials for biomedical applications. In this work, gold nanoprisms (GNPs) was synthesized and then modified with LyP-1, a tumor-homing peptide, to improve the affinity of the GNPs to tumor cells, thus, to improve the efficacy of tumor-targeted photothermal therapy. The introduction of NIR dye IR780 not only enabled the GNPs-based nanosystem with the surface-enhanced resonant Raman scattering (SERRS) property, but also enhanced the plasmonic photothermal property which delivering therapeutic heating by 660 nm laser irradiation. The obtained GNPs/IR780-LyP-1 presented significantly increased of photothermal conversion in vitro and in vivo, which resulted in enhanced tumor-targeting photothermal therapeutic efficacy after laser irradiation. Hence, the GNPs/IR780-LyP-1 prepared in this study can be served as a Raman-encoded molecular imaging candidate and photothermal therapy agents for future cancer treatment.
基金supported by the National Major Research and Development Program(No.2018YFB2200200)National Science Fund for Distinguished Young Scholars(61725503)+2 种基金National Natural Science Foundation of China(NSFC)(61905210 and 91950205)China Postdoctoral Science Foundation(2019M662041)Zhejiang Provincial Natural Science Foundation(LZ18F050001 and LD19F050001).
文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing.
基金Acknowledgements This work was supported partially by the National Natural Science Foundation of China （Grant Nos. 61422510, 11374263 and 61431166001 ）, the Doctoral Fund of Ministry of Education of China （No. 20120101110094）, the Fundamental Research Funds for the Central Universities,
文摘Silicon photonics has become very popular because of their compatibility with mature CMOS technologies. However, pure silicon is still very difficult to be utilized to obtain various photonic functional devices for large-scale photonic integration due to intrinsic properties. Silicon-plus photonics, which pluses other materials to break the limitation of silicon, is playing a very important role currently and in the future. In this paper, we give a review and discussion on the progresses of siliconplus photonics, including the structures, devices and applications.
基金Project supported by the National Major Research and Development Program(No.2016YFB0402502)the National Natural Science Foundation of China(Nos.11374263,61422510,61431166001,61474099,61674127)the National Key Research and Development Program(No.2016YFA0200200)
文摘Silicon photonics has attracted much attention because of the advantages of CMOS （complementary- metal-oxide-semiconductor） compatibility, ultra-high integrated density, etc. Great progress has been achieved in the past decades. However, it is still not easy to realize active silicon photonic devices and circuits by utilizing the material system of pure silicon due to the limitation of the intrinsic properties of silicon. Graphene has been re- garded as a promising material for optoelectronics due to its unique properties and thus provides a potential option for realizing active photonic integrated devices on silicon. In this paper, we present a review on recent progress of some silicon-graphene photonic devices for photodetection, all-optical modulation, as well as thermal-tuning.
