Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have diffe...Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have different degrees of adverse reactions, which will cause damage to the patient’s body once they occur. This paper retrospectively analyzed the clinical data of patients with severe allergic reactions such as fecal incontinence and numbness of hands and feet caused by the use of paclitaxel liposome during postoperative chemotherapy in a case of ovarian cancer admitted to our hospital. The causes and corresponding treatment measures were analyzed, in order to provide the reference for medical staff to take effective countermeasures in advance in the future.展开更多
Objective:To evaluate the efficacy and safety of QL1206(a denosumab biosimilar to Xgeva■)in breast cancer patients with bone metastasis(BM)through subgroup analysis of a randomized,double-blind phaseⅢtrial(No.NCT045...Objective:To evaluate the efficacy and safety of QL1206(a denosumab biosimilar to Xgeva■)in breast cancer patients with bone metastasis(BM)through subgroup analysis of a randomized,double-blind phaseⅢtrial(No.NCT04550949).Methods:This subgroup analysis included patients with BM from breast cancer enrolled in a phaseⅢtrial.Patients were randomized(1:1)to receive either three cycles of QL1206 or denosumab(120 mg subcutaneously every 4 weeks).Subsequently,they received 10 cycles of QL1206(120 mg)over 40 weeks,followed by a 20-week safety follow-up.The primary endpoint was the percentage changes from baseline to week 13 in urinary Ntelopeptide corrected for creatinine(u NTx/Cr).Results:The breast cancer cohort consisted of 311 patients.Vertebral involvement(66.4%)was the most prevalent BM site at enrollment,while 27.7%of patients presented with≥3 metastatic bone lesions.At week 13,QL1206 demonstrated a median u NTx/Cr reduction of-69.9%(range:-98.1%-568.0%)vs.-74.3%(range:-97.7%-386.3%)for denosumab.The analysis of covariance revealed comparable least-square means for log-transformed changes:-1.416[95%confidence interval(95%CI):-1.736 to-1.096]vs.-1.501(95%CI:-1.824 to-1.178),yielding an between-group difference of 0.085(90%CI:-0.062-0.232;P=0.343).After a 53-week treatment period,83.6%achieved bone density improvement/disease stabilization.Safety profiles were comparable between groups.Conclusions:QL1206 demonstrated similar efficacy and safety to the reference denosumab in patients with BM from breast cancer,supporting QL1206 as a new option for management of BM from breast cancer.展开更多
Chronic kidney disease (CKD) is characterized by high morbidity, high mortality, and poor prognosis, while health literacy is the goal of health education and an important outcome of health promotion, crucial for impr...Chronic kidney disease (CKD) is characterized by high morbidity, high mortality, and poor prognosis, while health literacy is the goal of health education and an important outcome of health promotion, crucial for improving health outcomes. Therefore, this paper reviews the conceptual evolution, theoretical models, and assessment tools of health literacy, as well as the current status, influencing factors, and intervention strategies of health literacy in CKD patients. The aim is to raise awareness among healthcare professionals regarding health literacy in CKD and to provide a reference for further research on health literacy in CKD patients.展开更多
Objective: To explore the real experience and nursing needs of patients with gynecological malignant tumors during their illness, in order to provide reference for the formulation of clinical nursing paths for this po...Objective: To explore the real experience and nursing needs of patients with gynecological malignant tumors during their illness, in order to provide reference for the formulation of clinical nursing paths for this population. Methods: Using descriptive phenomenological research method, 9 cases of gynecological malignant tumor patients treated in a tertiary A hospital in Baoding City, Hebei Province were selected according to the objective sampling method. Semi-structured in-depth interviews were conducted on them, and the interview data were analyzed by Colaizzi 7-step method. Results: Four themes were extracted: the disturbing and beneficial effects of the disease on life, the lack of knowledge about gynecological malignancies, the attitude towards the disease, and the nursing needs of women in reproductive health. Conclusion: Medical workers can take a variety of ways to carry out health education in the community and hospital, choose effective pain management for patients, help patients with gynecological malignant tumor to establish a mature psychological defense mechanism and positive coping style, so that they pay attention to disease prevention awareness, get sufficient social support, so as to improve the quality of life and comfort of patients with gynecological malignant tumor.展开更多
Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-d...Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-dwelling older adults using the Social Isolation Scale for the Elderly(C-SIS),the 10-item Brief Psychological Resilience Scale,and the Comprehensive Happiness Questionnaire(MHQ).The results were statistically analyzed using SPSS 27.0.Results:The highest score on the Social Isolation Scale for Community Elderly was 23,with a mean entry score of 2.36±0.62.A score of 14 was the cut-off point,with scores of≤14 classified as social isolation.There were 136 cases with scores below 14,resulting in a social isolation incidence rate of 51.3%.The median(P50)psychological resilience score was 27,indicating a higher level of resilience.The total score on the Psychological Well-being Scale was 161,suggesting a moderate to slightly higher level of well-being.Social isolation had a direct negative effect on psychological well-being,while psychological resilience had a positive effect.Conclusion:Older adults should be supported in reducing the incidence of social isolation and increasing psychological resilience to enhance psychological well-being and promote successful aging.展开更多
Enlarging the steric hindrance to the molecular structures of extractants is a common way to improve their selectivity.To improve the separation factor of thorium(Ⅳ)and cerium(Ⅳ),cyclic groups having large steric hi...Enlarging the steric hindrance to the molecular structures of extractants is a common way to improve their selectivity.To improve the separation factor of thorium(Ⅳ)and cerium(Ⅳ),cyclic groups having large steric hindrance such as phenyl,cyclohexyl,and benzyl were introduced into theα-aminophosphonate extractant molecules.Bis(2-ethylhexyl)((phenylamino)methyl)phosphonate(PAMP),bis(2-ethylhexyl)((cyclohexylamino)methyl)phosphonate(CAMP),and bis(2-ethylhexyl)((benzylamine)methyl)phosphate(BAMP)were synthesized and applied in the separation and recovery of thorium(Ⅳ)and cerium(Ⅳ)from sulfuric acid solution.The separation ability between cerium(Ⅳ)and thorium(Ⅳ)descends in the order of CAMP>BAMP≈Cextrant230>DEHAMP>>PAMP,which is consistent with the decreasing order of steric hindrance.Nearly non-extraction of both cerium(Ⅳ)and thorium(Ⅳ)and the lowest separation ability for PAMP will be due to the conjugation of the lone pair of the amino N atom and benzene ring in PAMP.Furthermore,the extraction of REs(Ⅲ)by CAMP is lower than that of thorium(Ⅳ).Thermodynamic parameters(ΔG^(0),ΔH^(0),ΔS^(0))and extraction equilibrium constants were determined.An extraction process was developed to separate and retrieve thorium(Ⅳ)and cerium(Ⅳ)from a bastnaesite leaching solution.The final product purity of CeO2and ThO2is 99%and 98.4%,respectively,and the yields are 90.2%and 97.6%,respectively.展开更多
Schizophrenia(SZ)stands as a severe psychiatric disorder.This study applied diffusion tensor imaging(DTI)data in conjunction with graph neural networks to distinguish SZ patients from normal controls(NCs)and showcases...Schizophrenia(SZ)stands as a severe psychiatric disorder.This study applied diffusion tensor imaging(DTI)data in conjunction with graph neural networks to distinguish SZ patients from normal controls(NCs)and showcases the superior performance of a graph neural network integrating combined fractional anisotropy and fiber number brain network features,achieving an accuracy of 73.79%in distinguishing SZ patients from NCs.Beyond mere discrimination,our study delved deeper into the advantages of utilizing white matter brain network features for identifying SZ patients through interpretable model analysis and gene expression analysis.These analyses uncovered intricate interrelationships between brain imaging markers and genetic biomarkers,providing novel insights into the neuropathological basis of SZ.In summary,our findings underscore the potential of graph neural networks applied to multimodal DTI data for enhancing SZ detection through an integrated analysis of neuroimaging and genetic features.展开更多
BACKGROUND:The problem of prolonged emergency department length of stay(EDLOS) is becoming increasingly crucial.This study aims to develop a machine learning(ML) model to predict EDLOS,with EDLOS as the outcome variab...BACKGROUND:The problem of prolonged emergency department length of stay(EDLOS) is becoming increasingly crucial.This study aims to develop a machine learning(ML) model to predict EDLOS,with EDLOS as the outcome variable and demographic characteristics,triage level,and medical resource utilization as predictive factors.METHODS:A retrospective analysis was performed on the patients who visited the emergency department of the Second Affiliated Hospital of Guangzhou Medical University from March 2019to September 2021,and a total of 321,012 cases were identified.According to the inclusion and exclusion criteria,187,028 cases were finally included in the analysis.ML analysis was performed using R-squared(R^(2)),and the predictive factors and the EDLOS were used as independent variables and dependent variables,respectively,to establish models.The performance evaluation of the ML models was conducted through the utilization of the mean absolute error(MAE),root mean square error(RMSE),and R^(2),enabling an objective comparative analysis.RESULTS:In the comparative analysis of the six ML models,light gradient boosting machine(LightGBM) model demonstrated the lowest MAE(443.519) and RMSE(826.783),and the highest R^(2) value(0.48),indicating better model fit and predictive performance.Among the top 10 predictive factors associated with EDLOS according to the LightGBM model,the emergency waiting time,age,and emergency arrival time had the most significant impact on the EDLOS.CONCLUSION:The LightGBM model suggests that the emergency waiting time,age,and emergency arrival time may be used to predict the EDLOS.展开更多
Two phosphorylcarboxylic acids,3-((bis(2-ethylhexyloxy))phosphoryl)propanoic acid(PPA) and 3-((bis(2-ethylhexyloxy))phosphoryl)-3-phenylpropanoic acid(PPPA),were synthesized for separating yttrium from other rare eart...Two phosphorylcarboxylic acids,3-((bis(2-ethylhexyloxy))phosphoryl)propanoic acid(PPA) and 3-((bis(2-ethylhexyloxy))phosphoryl)-3-phenylpropanoic acid(PPPA),were synthesized for separating yttrium from other rare earths in the chloride feed of ion-adsorption type rare earth concentrate.The effect of the factors such as pH_(1/2),temperature,saponification degree and phase modifiers was investigated.The separation efficiencies of PPA and PPPA are obviously better than the typical extractants such as sec-octylphenoxy acetic acid(CA-12) and naphthenic acid(NA).The extraction process of rare earths by PPA and PPPA is a cation exchanging reaction,which is similar to those of CA-12 and NA.The loaded rare earths in both PPA and PPPA systems can be effectively back-extracted by 0.5 mol/L HCl or higher concentration.A cascade extraction process for separating yttrium from other rare earths was developed using PPPA as the extractant.The yttrium product with the purity of 97.20 wt% was obtained by 35 stages of extraction and 12 stages of scrubbing.展开更多
The AKT/mTOR and NF-κB signalings are crucial pathways activated in cancers including nasopharyngeal carcinoma(NPC), which is prevalent in southern China and closely related to Epstein-Barr virus(EBV) infection.How t...The AKT/mTOR and NF-κB signalings are crucial pathways activated in cancers including nasopharyngeal carcinoma(NPC), which is prevalent in southern China and closely related to Epstein-Barr virus(EBV) infection.How these master pathways are persistently activated in EBV-associated NPC remains to be investigated. Here we demonstrated that EBV-encoded latent membrane protein 1(LMP1) promoted cyclophilin A(CYPA) expression through the activation of NF-κB. The depletion of CYPA suppressed cell proliferation and facilitated apoptosis.CYPA was able to bind to AKT1, thus activating AKT/mTOR/NF-κB signaling cascade. Moreover, the use of mTOR inhibitor, rapamycin, subverted the activation of the positive feedback loop, NF-κB/CYPA/AKT/mTOR. It is reasonable that LMP1 expression derived from initial viral infection is enough to assure the constant potentiation of AKT/mTOR and NF-κB signalings. This may partly explain the fact that EBV serves as a tumor-promoting factor with minimal expression of the viral oncoprotein LMP1 in malignancies. Our findings provide new insight into the understanding of causative role of EBV in tumorigenicity during latent infection.展开更多
Objective： To determine the capability of dynamic enhanced computed tomography（CT） to differentiate liver metastases（LMs） of well-differentiated from poorly-differentiated gastroenteropancreatic neuroendocrine ne...Objective： To determine the capability of dynamic enhanced computed tomography（CT） to differentiate liver metastases（LMs） of well-differentiated from poorly-differentiated gastroenteropancreatic neuroendocrine neoplasms（GEP-NENs）.Methods： Patients with LMs of GEP-NENs who underwent dynamic enhanced CT examination in Peking University Cancer Hospital from January 2009 to October 2015 were included and data were retrospectively analyzed. We assessed the qualitative and quantitative CT features to identify the significant differentiating CT features of LMs of poorly-differentiated GEP-NENs from those of well-differentiated GEP-NENs using univariate analysis and a multivariate logistic regression model.Results： The study included 22 patients with LMs of well-differentiated GEP-NENs and 32 patients with LMs of poorly-differentiated GEP-NENs. Univariate analysis revealed statistically significant differences between the LMs of well-and poorly-differentiated GEP-NENs in terms of feeding arteries（36.4% vs. 75.0%, χ2=8.061,P=0.005）, intratumoral neovascularity（18.2% vs. 59.4%, χ2=9.047, P=0.003）, lymphadenopathy（27.3% vs. 81.2%,χ2=15.733, P〈0.001）, tumor-to-aortic ratio in the hepatic arterial and portal venous phase（T-A/AP： 0.297±0.080 vs.0.251±0.059, t=2.437, P=0.018; T-A/PVP： 0.639±0.138 vs. 0.529±0.117, t=3.163, P=0.003） and tumor-to-liver ratio in the hepatic arterial phase（T-L/AP： 1.108±0.267 vs. 0.907±0.240, t=2.882, P=0.006）. The LMs of poorlydifferentiated GEP-NENs showed more feeding arteries, more intratumoral neovascularity, more lymphadenopathy and a lower tumor-to-aortic ratio. Multivariate analysis suggested that intratumoral neovascularity [P=0.015, OR=0.108, 95% confidence interval（95% CI）, 0.018–0.646], lymphadenopathy（P=0.001,OR=0.055, 95% CI, 0.009–0.323） and T-A/PVP（P=0.004, OR=5.3 E–5, 95% CI, 0.000–0.044） were independent factors for differentiating LMs of poorly-differentiated from well-differentiated GEP-NENs.Conclusions： Dynamic enhanced CT features（intratumoral neovascularity, lymphadenopathy and T-A/PVP）are useful in the pathological classification of LMs of GEP-NENs.展开更多
Objective:To explore the effect of case management nursing service on compliance behavior and quality of life of patients with pulmonary tuberculosis.Methods:69 cases of pulmonary tuberculosis patients in our hospital...Objective:To explore the effect of case management nursing service on compliance behavior and quality of life of patients with pulmonary tuberculosis.Methods:69 cases of pulmonary tuberculosis patients in our hospital from September 2019 to August 2020 were selected as the research objects.The 69 patients were divided into study group(35 cases)and control group(34 cases).The compliance behavior,quality of life and nursing satisfaction of pulmonary tuberculosis patients were studied and analyzed.Results:The compliance rate of the control group was 82.35%,and that of the study group was 97.14%;The quality of life in the control group was[61.32±7.66],which was significantly lower than that in the study group[71.12±7.23];The satisfaction rate of the study group was 97.14%,which was significantly higher than 73.53%of the control group.Conclusion:In the treatment of tuberculosis patients,the use of case management nursing service can effectively improve the quality of life of patients,improve the compliance behavior of patients,and improve the treatment effect of patients,which is worthy of promotion.展开更多
A 3D temperature field reconstruction method using the colored background oriented schlieren(CBOS)method is proposed to address image blurring due to the different refractive index of the multi-wavelength light and si...A 3D temperature field reconstruction method using the colored background oriented schlieren(CBOS)method is proposed to address image blurring due to the different refractive index of the multi-wavelength light and significant errors produced when the traditional background oriented schlieren(BOS)method is applied to high-temperature gas.First,the traditional method is employed to reconstruct the non-uniform 3D temperature field.Second,the CBOS method is applied to correct the distortion.Then,by analyzing the correlation coefficient among different color points of the colored background pattern,the non-uniform temperature field is reconstructed much more accurately.Finally,the experimental results are verified by applying the Runge-Kutta ray-tracing method and the thermocouple contact measurement method.The maximum average temperature error of the CBOS-reconstructed temperature field is 12.92°C,compared with the thermocouples.Therefore,an accurate three-dimensional reconstruction of the temperature field can be achieved by the proposed method effectively.展开更多
Literati garden in Chinese classical garden has its own characteristics,and literature,philosophy and aesthetic values contained in literati garden have a profound impact on the gardening of later generations.Literati...Literati garden in Chinese classical garden has its own characteristics,and literature,philosophy and aesthetic values contained in literati garden have a profound impact on the gardening of later generations.Literati garden embodies the aesthetic orientation of Chinese people’s love of poetry and painting,pays attention to the creation of poetic atmosphere and creates an emotional space,making that viewers appreciate the beauty of blending feelings and scenery.In this paper,the characteristics of the literati garden in Chinese classical garden are summarized,and its gardening essence is excavated,and its enlightenment to the modern Chinese garden is explored.展开更多
Multiple studies have demonstrated that oral health quality of life(OHQOL)in patients with type 2 diabetes(T2DM)is affected by multiple factors.Therefore,during this study the related factors of OHQOL for T2DM was rev...Multiple studies have demonstrated that oral health quality of life(OHQOL)in patients with type 2 diabetes(T2DM)is affected by multiple factors.Therefore,during this study the related factors of OHQOL for T2DM was reviewed,and analyzed them from the aspects of socio-demographic factors,T2DM related factors and oral health related factors.This was to provide basis for nursing workers to develop personalized nursing measures.展开更多
The deep understanding of 4f-correlated electron motion behavior is experimentally limited due to similar physicochemical properties of rare earth elements(REEs).While the solvent extraction behavior originating from ...The deep understanding of 4f-correlated electron motion behavior is experimentally limited due to similar physicochemical properties of rare earth elements(REEs).While the solvent extraction behavior originating from the continuous occupation of 4f electrons along the lanthanide family provides a particular platform to probe the 4f electrons motion behavior and its correlations to their versatile functions.Herein,the complexation between REEs and the prototypical extractant of diethyl phosphoric acid(DEP)was substantially studied based on quantum mechanical calculation.The results firstly show that the average bond lengths between Ln and six coordinated oxygen atoms are consistent with lanthanide contraction phenomenon,and gadolinium break effect is also obviously observed.Secondly,the"tetrad effect"is figured out based on the subtle discrepancy of 4f electrons occupation,namely La-Nd,Sm-Eu,Gd-Dy and Ho-Lu.Specifically,the main composition is 4f5d6p for La-Nd,while the discrepancy is due to the increasing electrons in the 5d shell,while it is 4f5d for Pm-Eu.For Gd-Dy,their 4f orbitals accept little electrons and the donating electrons flow into 6s5d subshells due to the half-filled stability and the enhancement of shielding effect.The electrons donate into 5d6p subshells due to multiply electrons occupation of 4f orbitals for Ho-Lu.These detailed analyses obviously clarify the"tetrad effect"along the lanthanide family due to the different variation of 4f orbital occupation.It is expected that these microscopic understandings provide important guidance for the separation of REEs and the design of new extractants.展开更多
文摘Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have different degrees of adverse reactions, which will cause damage to the patient’s body once they occur. This paper retrospectively analyzed the clinical data of patients with severe allergic reactions such as fecal incontinence and numbness of hands and feet caused by the use of paclitaxel liposome during postoperative chemotherapy in a case of ovarian cancer admitted to our hospital. The causes and corresponding treatment measures were analyzed, in order to provide the reference for medical staff to take effective countermeasures in advance in the future.
文摘Objective:To evaluate the efficacy and safety of QL1206(a denosumab biosimilar to Xgeva■)in breast cancer patients with bone metastasis(BM)through subgroup analysis of a randomized,double-blind phaseⅢtrial(No.NCT04550949).Methods:This subgroup analysis included patients with BM from breast cancer enrolled in a phaseⅢtrial.Patients were randomized(1:1)to receive either three cycles of QL1206 or denosumab(120 mg subcutaneously every 4 weeks).Subsequently,they received 10 cycles of QL1206(120 mg)over 40 weeks,followed by a 20-week safety follow-up.The primary endpoint was the percentage changes from baseline to week 13 in urinary Ntelopeptide corrected for creatinine(u NTx/Cr).Results:The breast cancer cohort consisted of 311 patients.Vertebral involvement(66.4%)was the most prevalent BM site at enrollment,while 27.7%of patients presented with≥3 metastatic bone lesions.At week 13,QL1206 demonstrated a median u NTx/Cr reduction of-69.9%(range:-98.1%-568.0%)vs.-74.3%(range:-97.7%-386.3%)for denosumab.The analysis of covariance revealed comparable least-square means for log-transformed changes:-1.416[95%confidence interval(95%CI):-1.736 to-1.096]vs.-1.501(95%CI:-1.824 to-1.178),yielding an between-group difference of 0.085(90%CI:-0.062-0.232;P=0.343).After a 53-week treatment period,83.6%achieved bone density improvement/disease stabilization.Safety profiles were comparable between groups.Conclusions:QL1206 demonstrated similar efficacy and safety to the reference denosumab in patients with BM from breast cancer,supporting QL1206 as a new option for management of BM from breast cancer.
文摘Chronic kidney disease (CKD) is characterized by high morbidity, high mortality, and poor prognosis, while health literacy is the goal of health education and an important outcome of health promotion, crucial for improving health outcomes. Therefore, this paper reviews the conceptual evolution, theoretical models, and assessment tools of health literacy, as well as the current status, influencing factors, and intervention strategies of health literacy in CKD patients. The aim is to raise awareness among healthcare professionals regarding health literacy in CKD and to provide a reference for further research on health literacy in CKD patients.
文摘Objective: To explore the real experience and nursing needs of patients with gynecological malignant tumors during their illness, in order to provide reference for the formulation of clinical nursing paths for this population. Methods: Using descriptive phenomenological research method, 9 cases of gynecological malignant tumor patients treated in a tertiary A hospital in Baoding City, Hebei Province were selected according to the objective sampling method. Semi-structured in-depth interviews were conducted on them, and the interview data were analyzed by Colaizzi 7-step method. Results: Four themes were extracted: the disturbing and beneficial effects of the disease on life, the lack of knowledge about gynecological malignancies, the attitude towards the disease, and the nursing needs of women in reproductive health. Conclusion: Medical workers can take a variety of ways to carry out health education in the community and hospital, choose effective pain management for patients, help patients with gynecological malignant tumor to establish a mature psychological defense mechanism and positive coping style, so that they pay attention to disease prevention awareness, get sufficient social support, so as to improve the quality of life and comfort of patients with gynecological malignant tumor.
基金Medical Discipline Cultivation Program of Hebei University(Project No.Medicine+X 2022X01)。
文摘Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-dwelling older adults using the Social Isolation Scale for the Elderly(C-SIS),the 10-item Brief Psychological Resilience Scale,and the Comprehensive Happiness Questionnaire(MHQ).The results were statistically analyzed using SPSS 27.0.Results:The highest score on the Social Isolation Scale for Community Elderly was 23,with a mean entry score of 2.36±0.62.A score of 14 was the cut-off point,with scores of≤14 classified as social isolation.There were 136 cases with scores below 14,resulting in a social isolation incidence rate of 51.3%.The median(P50)psychological resilience score was 27,indicating a higher level of resilience.The total score on the Psychological Well-being Scale was 161,suggesting a moderate to slightly higher level of well-being.Social isolation had a direct negative effect on psychological well-being,while psychological resilience had a positive effect.Conclusion:Older adults should be supported in reducing the incidence of social isolation and increasing psychological resilience to enhance psychological well-being and promote successful aging.
基金Project supported by the National Natural Science Foundation of China(92262301)。
文摘Enlarging the steric hindrance to the molecular structures of extractants is a common way to improve their selectivity.To improve the separation factor of thorium(Ⅳ)and cerium(Ⅳ),cyclic groups having large steric hindrance such as phenyl,cyclohexyl,and benzyl were introduced into theα-aminophosphonate extractant molecules.Bis(2-ethylhexyl)((phenylamino)methyl)phosphonate(PAMP),bis(2-ethylhexyl)((cyclohexylamino)methyl)phosphonate(CAMP),and bis(2-ethylhexyl)((benzylamine)methyl)phosphate(BAMP)were synthesized and applied in the separation and recovery of thorium(Ⅳ)and cerium(Ⅳ)from sulfuric acid solution.The separation ability between cerium(Ⅳ)and thorium(Ⅳ)descends in the order of CAMP>BAMP≈Cextrant230>DEHAMP>>PAMP,which is consistent with the decreasing order of steric hindrance.Nearly non-extraction of both cerium(Ⅳ)and thorium(Ⅳ)and the lowest separation ability for PAMP will be due to the conjugation of the lone pair of the amino N atom and benzene ring in PAMP.Furthermore,the extraction of REs(Ⅲ)by CAMP is lower than that of thorium(Ⅳ).Thermodynamic parameters(ΔG^(0),ΔH^(0),ΔS^(0))and extraction equilibrium constants were determined.An extraction process was developed to separate and retrieve thorium(Ⅳ)and cerium(Ⅳ)from a bastnaesite leaching solution.The final product purity of CeO2and ThO2is 99%and 98.4%,respectively,and the yields are 90.2%and 97.6%,respectively.
基金supported by the National Natural Science Foundation of China(62276049,61701078,61872068,and 62006038)the Natural Science Foundation of Sichuan Province(2025ZNSFSC0487)+3 种基金the Science and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project(2021ZD0200200)the National Key R&D Program of China(2023YFE0118600)Sichuan Province Science and Technology Support Program(2019YJ0193,2021YFG0126,2021YFG0366,and 2022YFS0180)Medico-Engineering Cooperation Funds from the University of Electronic Science and Technology of China(ZYGX2021YGLH014).
文摘Schizophrenia(SZ)stands as a severe psychiatric disorder.This study applied diffusion tensor imaging(DTI)data in conjunction with graph neural networks to distinguish SZ patients from normal controls(NCs)and showcases the superior performance of a graph neural network integrating combined fractional anisotropy and fiber number brain network features,achieving an accuracy of 73.79%in distinguishing SZ patients from NCs.Beyond mere discrimination,our study delved deeper into the advantages of utilizing white matter brain network features for identifying SZ patients through interpretable model analysis and gene expression analysis.These analyses uncovered intricate interrelationships between brain imaging markers and genetic biomarkers,providing novel insights into the neuropathological basis of SZ.In summary,our findings underscore the potential of graph neural networks applied to multimodal DTI data for enhancing SZ detection through an integrated analysis of neuroimaging and genetic features.
基金supported by Guangzhou Municipal Health Science and Technology General Program (20221A011083)the Key Medical Disciplines and Specialties Program of Guangzhou(2021-2023)Guangdong University Innovation Team Project(2024KCXTD029)。
文摘BACKGROUND:The problem of prolonged emergency department length of stay(EDLOS) is becoming increasingly crucial.This study aims to develop a machine learning(ML) model to predict EDLOS,with EDLOS as the outcome variable and demographic characteristics,triage level,and medical resource utilization as predictive factors.METHODS:A retrospective analysis was performed on the patients who visited the emergency department of the Second Affiliated Hospital of Guangzhou Medical University from March 2019to September 2021,and a total of 321,012 cases were identified.According to the inclusion and exclusion criteria,187,028 cases were finally included in the analysis.ML analysis was performed using R-squared(R^(2)),and the predictive factors and the EDLOS were used as independent variables and dependent variables,respectively,to establish models.The performance evaluation of the ML models was conducted through the utilization of the mean absolute error(MAE),root mean square error(RMSE),and R^(2),enabling an objective comparative analysis.RESULTS:In the comparative analysis of the six ML models,light gradient boosting machine(LightGBM) model demonstrated the lowest MAE(443.519) and RMSE(826.783),and the highest R^(2) value(0.48),indicating better model fit and predictive performance.Among the top 10 predictive factors associated with EDLOS according to the LightGBM model,the emergency waiting time,age,and emergency arrival time had the most significant impact on the EDLOS.CONCLUSION:The LightGBM model suggests that the emergency waiting time,age,and emergency arrival time may be used to predict the EDLOS.
基金Project supported by the National Key Research and Development Project of China(2019YFC0605003)the Strategic Priority Research Program of CAS(XDA02030100)。
文摘Two phosphorylcarboxylic acids,3-((bis(2-ethylhexyloxy))phosphoryl)propanoic acid(PPA) and 3-((bis(2-ethylhexyloxy))phosphoryl)-3-phenylpropanoic acid(PPPA),were synthesized for separating yttrium from other rare earths in the chloride feed of ion-adsorption type rare earth concentrate.The effect of the factors such as pH_(1/2),temperature,saponification degree and phase modifiers was investigated.The separation efficiencies of PPA and PPPA are obviously better than the typical extractants such as sec-octylphenoxy acetic acid(CA-12) and naphthenic acid(NA).The extraction process of rare earths by PPA and PPPA is a cation exchanging reaction,which is similar to those of CA-12 and NA.The loaded rare earths in both PPA and PPPA systems can be effectively back-extracted by 0.5 mol/L HCl or higher concentration.A cascade extraction process for separating yttrium from other rare earths was developed using PPPA as the extractant.The yttrium product with the purity of 97.20 wt% was obtained by 35 stages of extraction and 12 stages of scrubbing.
基金supported by the Natural Science Foundations of China(81974427)Graduate Research and Innovation Projects of Central South University(2021zzts0931)
文摘The AKT/mTOR and NF-κB signalings are crucial pathways activated in cancers including nasopharyngeal carcinoma(NPC), which is prevalent in southern China and closely related to Epstein-Barr virus(EBV) infection.How these master pathways are persistently activated in EBV-associated NPC remains to be investigated. Here we demonstrated that EBV-encoded latent membrane protein 1(LMP1) promoted cyclophilin A(CYPA) expression through the activation of NF-κB. The depletion of CYPA suppressed cell proliferation and facilitated apoptosis.CYPA was able to bind to AKT1, thus activating AKT/mTOR/NF-κB signaling cascade. Moreover, the use of mTOR inhibitor, rapamycin, subverted the activation of the positive feedback loop, NF-κB/CYPA/AKT/mTOR. It is reasonable that LMP1 expression derived from initial viral infection is enough to assure the constant potentiation of AKT/mTOR and NF-κB signalings. This may partly explain the fact that EBV serves as a tumor-promoting factor with minimal expression of the viral oncoprotein LMP1 in malignancies. Our findings provide new insight into the understanding of causative role of EBV in tumorigenicity during latent infection.
基金funding by the National Natural Science Foundation of China (No. 61520106004 and No. 81471640)
文摘Objective： To determine the capability of dynamic enhanced computed tomography（CT） to differentiate liver metastases（LMs） of well-differentiated from poorly-differentiated gastroenteropancreatic neuroendocrine neoplasms（GEP-NENs）.Methods： Patients with LMs of GEP-NENs who underwent dynamic enhanced CT examination in Peking University Cancer Hospital from January 2009 to October 2015 were included and data were retrospectively analyzed. We assessed the qualitative and quantitative CT features to identify the significant differentiating CT features of LMs of poorly-differentiated GEP-NENs from those of well-differentiated GEP-NENs using univariate analysis and a multivariate logistic regression model.Results： The study included 22 patients with LMs of well-differentiated GEP-NENs and 32 patients with LMs of poorly-differentiated GEP-NENs. Univariate analysis revealed statistically significant differences between the LMs of well-and poorly-differentiated GEP-NENs in terms of feeding arteries（36.4% vs. 75.0%, χ2=8.061,P=0.005）, intratumoral neovascularity（18.2% vs. 59.4%, χ2=9.047, P=0.003）, lymphadenopathy（27.3% vs. 81.2%,χ2=15.733, P〈0.001）, tumor-to-aortic ratio in the hepatic arterial and portal venous phase（T-A/AP： 0.297±0.080 vs.0.251±0.059, t=2.437, P=0.018; T-A/PVP： 0.639±0.138 vs. 0.529±0.117, t=3.163, P=0.003） and tumor-to-liver ratio in the hepatic arterial phase（T-L/AP： 1.108±0.267 vs. 0.907±0.240, t=2.882, P=0.006）. The LMs of poorlydifferentiated GEP-NENs showed more feeding arteries, more intratumoral neovascularity, more lymphadenopathy and a lower tumor-to-aortic ratio. Multivariate analysis suggested that intratumoral neovascularity [P=0.015, OR=0.108, 95% confidence interval（95% CI）, 0.018–0.646], lymphadenopathy（P=0.001,OR=0.055, 95% CI, 0.009–0.323） and T-A/PVP（P=0.004, OR=5.3 E–5, 95% CI, 0.000–0.044） were independent factors for differentiating LMs of poorly-differentiated from well-differentiated GEP-NENs.Conclusions： Dynamic enhanced CT features（intratumoral neovascularity, lymphadenopathy and T-A/PVP）are useful in the pathological classification of LMs of GEP-NENs.
基金Medical science research key project plan of Hebei health and Family Planning Commission in 2018.Subject name:Evaluation of application effect of case management model in newly treated smear positive pulmonary tuberculosis patients,Question number:20180720.
文摘Objective:To explore the effect of case management nursing service on compliance behavior and quality of life of patients with pulmonary tuberculosis.Methods:69 cases of pulmonary tuberculosis patients in our hospital from September 2019 to August 2020 were selected as the research objects.The 69 patients were divided into study group(35 cases)and control group(34 cases).The compliance behavior,quality of life and nursing satisfaction of pulmonary tuberculosis patients were studied and analyzed.Results:The compliance rate of the control group was 82.35%,and that of the study group was 97.14%;The quality of life in the control group was[61.32±7.66],which was significantly lower than that in the study group[71.12±7.23];The satisfaction rate of the study group was 97.14%,which was significantly higher than 73.53%of the control group.Conclusion:In the treatment of tuberculosis patients,the use of case management nursing service can effectively improve the quality of life of patients,improve the compliance behavior of patients,and improve the treatment effect of patients,which is worthy of promotion.
基金Supported by the National Natural Science Foundation of China(52005500)Foundation of Tianjin Educational Committee(2018KJ242)Basic Science-Research Funds of National University(3122019088)。
文摘A 3D temperature field reconstruction method using the colored background oriented schlieren(CBOS)method is proposed to address image blurring due to the different refractive index of the multi-wavelength light and significant errors produced when the traditional background oriented schlieren(BOS)method is applied to high-temperature gas.First,the traditional method is employed to reconstruct the non-uniform 3D temperature field.Second,the CBOS method is applied to correct the distortion.Then,by analyzing the correlation coefficient among different color points of the colored background pattern,the non-uniform temperature field is reconstructed much more accurately.Finally,the experimental results are verified by applying the Runge-Kutta ray-tracing method and the thermocouple contact measurement method.The maximum average temperature error of the CBOS-reconstructed temperature field is 12.92°C,compared with the thermocouples.Therefore,an accurate three-dimensional reconstruction of the temperature field can be achieved by the proposed method effectively.
文摘Literati garden in Chinese classical garden has its own characteristics,and literature,philosophy and aesthetic values contained in literati garden have a profound impact on the gardening of later generations.Literati garden embodies the aesthetic orientation of Chinese people’s love of poetry and painting,pays attention to the creation of poetic atmosphere and creates an emotional space,making that viewers appreciate the beauty of blending feelings and scenery.In this paper,the characteristics of the literati garden in Chinese classical garden are summarized,and its gardening essence is excavated,and its enlightenment to the modern Chinese garden is explored.
基金supported by Hebei Provincial Administration of Traditional Chineseit was used in the research project of Chinese medicine in 2019,the item number:2019178.
文摘Multiple studies have demonstrated that oral health quality of life(OHQOL)in patients with type 2 diabetes(T2DM)is affected by multiple factors.Therefore,during this study the related factors of OHQOL for T2DM was reviewed,and analyzed them from the aspects of socio-demographic factors,T2DM related factors and oral health related factors.This was to provide basis for nursing workers to develop personalized nursing measures.
基金Project supported by the National Key Research and Development Project of China(2019YFC0605003)the StrategicPriority Research Program of Chinese Academy of Sciences(XDA02030100)。
文摘The deep understanding of 4f-correlated electron motion behavior is experimentally limited due to similar physicochemical properties of rare earth elements(REEs).While the solvent extraction behavior originating from the continuous occupation of 4f electrons along the lanthanide family provides a particular platform to probe the 4f electrons motion behavior and its correlations to their versatile functions.Herein,the complexation between REEs and the prototypical extractant of diethyl phosphoric acid(DEP)was substantially studied based on quantum mechanical calculation.The results firstly show that the average bond lengths between Ln and six coordinated oxygen atoms are consistent with lanthanide contraction phenomenon,and gadolinium break effect is also obviously observed.Secondly,the"tetrad effect"is figured out based on the subtle discrepancy of 4f electrons occupation,namely La-Nd,Sm-Eu,Gd-Dy and Ho-Lu.Specifically,the main composition is 4f5d6p for La-Nd,while the discrepancy is due to the increasing electrons in the 5d shell,while it is 4f5d for Pm-Eu.For Gd-Dy,their 4f orbitals accept little electrons and the donating electrons flow into 6s5d subshells due to the half-filled stability and the enhancement of shielding effect.The electrons donate into 5d6p subshells due to multiply electrons occupation of 4f orbitals for Ho-Lu.These detailed analyses obviously clarify the"tetrad effect"along the lanthanide family due to the different variation of 4f orbital occupation.It is expected that these microscopic understandings provide important guidance for the separation of REEs and the design of new extractants.
