Conversational agents have emerged as promising tools for depression-diagnosis-oriented chats. However, the integration of task-oriented dialogues with empathetic chit-chat in diagnostic interactions presents signific...Conversational agents have emerged as promising tools for depression-diagnosis-oriented chats. However, the integration of task-oriented dialogues with empathetic chit-chat in diagnostic interactions presents significant challenges. Such unique requirements demand professional expertise and empathetic communication, pushing beyond the capabilities of traditional dialogue frameworks designed for single optimization objectives. To bridge this gap, we propose a novel ontology-driven framework specifically designed for depression diagnosis dialogues. Our approach unifies the precision of task-oriented interactions with the empathetic nuance of chit-chat, enabling a more balanced and effective diagnostic exchange. We apply this framework to D4, the only publicly available Chinese dialogue dataset focused on depression diagnosis. Extensive experimental results demonstrate notable improvements in all tasks, highlighting the potential of our approach to advance task-oriented dialogue systems in digital mental health applications.展开更多
Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell ...Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 62572320, U23B2018)the Shanghai Shenkang Hospital Development Center Project (Grant No.SHDC12025118)。
文摘Conversational agents have emerged as promising tools for depression-diagnosis-oriented chats. However, the integration of task-oriented dialogues with empathetic chit-chat in diagnostic interactions presents significant challenges. Such unique requirements demand professional expertise and empathetic communication, pushing beyond the capabilities of traditional dialogue frameworks designed for single optimization objectives. To bridge this gap, we propose a novel ontology-driven framework specifically designed for depression diagnosis dialogues. Our approach unifies the precision of task-oriented interactions with the empathetic nuance of chit-chat, enabling a more balanced and effective diagnostic exchange. We apply this framework to D4, the only publicly available Chinese dialogue dataset focused on depression diagnosis. Extensive experimental results demonstrate notable improvements in all tasks, highlighting the potential of our approach to advance task-oriented dialogue systems in digital mental health applications.
基金supported by the National Natural Science Foundation of China(No.U2004101 for Peng-xing He,No.U21A20416 for Hong-min Liu).
文摘Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear.
