Inflammatory bowel diseases(IBDs)are increasingly recognized as a pressing global health concern.The gut microbiome emerges as both a potential therapeutic target and a repository for pharmacological interventions in ...Inflammatory bowel diseases(IBDs)are increasingly recognized as a pressing global health concern.The gut microbiome emerges as both a potential therapeutic target and a repository for pharmacological interventions in IBDs management.This perspective aims to elucidate the pivotal findings from recent studies concerning the anti-inflammatory properties of gut microbiota-derived metabolites(GMDMs),dissect the strengths and challenges of GMDMs as treatment strategies for IBDs,and highlight the integral role of nuclear receptors in mediating the interplay between IBD pathogenesis and GMDMs.Through the integration of these perspectives,our objective is to deepen the understanding of the therapeutic promise of nuclear receptor-targeted GMDMs,thus propelling forward the exploration and formulation of new pharmacological treatments for IBDs.展开更多
Silicon offers a high theoretical specific capacity for anodic lithium storage.However,its applications are hindered by the electrode instability caused by the sharp volume change,and the limited rate performance resu...Silicon offers a high theoretical specific capacity for anodic lithium storage.However,its applications are hindered by the electrode instability caused by the sharp volume change,and the limited rate performance resulted from the insulating property.Herein,we introduce a facile and fast method of preparing honeycomb‐like silicon‐based anodes(MXene‐Si@C)with porous structure using MXene and carbon‐coated silicon.The dual protection from both the surface coating and as‐formed interlayered vacant spaces ameliorate the volume expansion of the silicon and thus reinforce the mechanical stability of the electrode.In addition,the highly conducting MXene and the surface carbon coating form a hierarchical and consecutive electron‐conducting network with evidently reduced resistance.With this proposed composite,a high average Coulombic efficiency of 99.73%and high capacity retention of 82.4%after 300 cycles at 1 A/g can be achieved even with an areal loading around 1.5 mg/cm^(2).Coupled with an NCM523 cathode,the proof‐of‐concept full cell delivers a high capacity of 164.2mAh/g with an extremely high energy density of 574Wh/kg(based on the mass of the electrode materials)at 0.2 C and an excellent cyclability at 0.5 C of 100 cycles with decent capacity retention(80.28%).展开更多
基金supported by the National Natural Science Foundation of China(82373940&82104238).
文摘Inflammatory bowel diseases(IBDs)are increasingly recognized as a pressing global health concern.The gut microbiome emerges as both a potential therapeutic target and a repository for pharmacological interventions in IBDs management.This perspective aims to elucidate the pivotal findings from recent studies concerning the anti-inflammatory properties of gut microbiota-derived metabolites(GMDMs),dissect the strengths and challenges of GMDMs as treatment strategies for IBDs,and highlight the integral role of nuclear receptors in mediating the interplay between IBD pathogenesis and GMDMs.Through the integration of these perspectives,our objective is to deepen the understanding of the therapeutic promise of nuclear receptor-targeted GMDMs,thus propelling forward the exploration and formulation of new pharmacological treatments for IBDs.
基金supported by a grant from the Research Grants Council of the Hong Kong Special Administrative Region,China(Project No.T23‐601/17‐R).
文摘Silicon offers a high theoretical specific capacity for anodic lithium storage.However,its applications are hindered by the electrode instability caused by the sharp volume change,and the limited rate performance resulted from the insulating property.Herein,we introduce a facile and fast method of preparing honeycomb‐like silicon‐based anodes(MXene‐Si@C)with porous structure using MXene and carbon‐coated silicon.The dual protection from both the surface coating and as‐formed interlayered vacant spaces ameliorate the volume expansion of the silicon and thus reinforce the mechanical stability of the electrode.In addition,the highly conducting MXene and the surface carbon coating form a hierarchical and consecutive electron‐conducting network with evidently reduced resistance.With this proposed composite,a high average Coulombic efficiency of 99.73%and high capacity retention of 82.4%after 300 cycles at 1 A/g can be achieved even with an areal loading around 1.5 mg/cm^(2).Coupled with an NCM523 cathode,the proof‐of‐concept full cell delivers a high capacity of 164.2mAh/g with an extremely high energy density of 574Wh/kg(based on the mass of the electrode materials)at 0.2 C and an excellent cyclability at 0.5 C of 100 cycles with decent capacity retention(80.28%).
