The application of aggregation-induced emission(AIE)materials in biological imaging holds multiple significances,including improving detection sensitivity and specificity,optimizing the imaging process,expanding the s...The application of aggregation-induced emission(AIE)materials in biological imaging holds multiple significances,including improving detection sensitivity and specificity,optimizing the imaging process,expanding the scope of application,and promoting advancements in biomedical research.In this work,the propeller ligand was constructed through McMurry coupling reaction and Suzuki coupling reaction by using dimethoxybenzophenone as the starting material.Then,an imine condensation reaction was carried out in chloroform solution,using a 3:2 molar ratio of precursor to tri(2-aminoethyl)amine to synthesize C3 symmetric porous organic cage CB.The structures of the compounds were determined by nuclear magnetic resonance spectroscopy(NMR),electrospray ionization mass spectrometry(ESI-MS)and Fourier transform infrared spectroscopy(FT-IR).The optical investigation results reveal that ligand L-B and the porous organic cage C_(B) demonstrate remarkable aggregation-induced emission(AIE)properties in a tetrahydrofuran/water mixed solvent system,along with a pronounced response to tetrahydrofuran vapor stimuli.Consequently,Furthermore,given its unique cage-like structure,high quantum yield,and outstanding AIE behavior,the porous organic cage C_(B) holds promise for applications in cell imaging.展开更多
A novel complex nano-structured Au@TiO2 gold catalyst has been prepared. Au precursor could be transformed into Au@TiO2/MCM-22 with the complex nano-structured using two different methods. Samples were characterized b...A novel complex nano-structured Au@TiO2 gold catalyst has been prepared. Au precursor could be transformed into Au@TiO2/MCM-22 with the complex nano-structured using two different methods. Samples were characterized by XRD, FT-IR, UV-vis, TEM, ICP-AES and N2 adsorption-desorption. It is found that gold was anchored on the TiO2/MCM-22 as small size and uniform particles with the average diameters in the range of 5 - 9 nm. Catalytic results show that such nano-gold catalysts display excellent catalytic performance for cyclohexane oxidation. Au@TiO2/MCM-22 catalyst with the gold content of 0.5 wt% exhibits extremely exceptionally catalytic activity (12.81%) and high turnover frequency (52,121 h-1), which may be ascribed to the synergistic effects of Au and TiO2 in the complex nano-structured catalyst Au@TiO2/ MCM-22. Because of the strong metal support interaction, aggregation of active sites (Au nanoparticles) during the oxidation reaction is effectively prohibited and the catalytic activity is essentially retained.展开更多
The cutaneous lymphatic system regulates tissue inflammation,fluid balance and immunological responses.Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema,immune deficiency,chronic inflammation etc.Tissu...The cutaneous lymphatic system regulates tissue inflammation,fluid balance and immunological responses.Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema,immune deficiency,chronic inflammation etc.Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing.Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction.For example,impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers,venous ulcers and bedsores.This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds.Furthermore,we review wound lymphangiogenesis processes and remodelling,especially the influence of the inflammatory phase.Finally,we outline how to control lymphangiogenesis to promote wound healing,assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.展开更多
基金funded by the National Natural Science Foundation of China(Nos.22101267 and 82103686)the Natural Science Foundation of Henan Province(202300410477 and 24230042123)the China Postdoctoral Science Foundation(Nos.2021M692905 and 2024T170832).
文摘The application of aggregation-induced emission(AIE)materials in biological imaging holds multiple significances,including improving detection sensitivity and specificity,optimizing the imaging process,expanding the scope of application,and promoting advancements in biomedical research.In this work,the propeller ligand was constructed through McMurry coupling reaction and Suzuki coupling reaction by using dimethoxybenzophenone as the starting material.Then,an imine condensation reaction was carried out in chloroform solution,using a 3:2 molar ratio of precursor to tri(2-aminoethyl)amine to synthesize C3 symmetric porous organic cage CB.The structures of the compounds were determined by nuclear magnetic resonance spectroscopy(NMR),electrospray ionization mass spectrometry(ESI-MS)and Fourier transform infrared spectroscopy(FT-IR).The optical investigation results reveal that ligand L-B and the porous organic cage C_(B) demonstrate remarkable aggregation-induced emission(AIE)properties in a tetrahydrofuran/water mixed solvent system,along with a pronounced response to tetrahydrofuran vapor stimuli.Consequently,Furthermore,given its unique cage-like structure,high quantum yield,and outstanding AIE behavior,the porous organic cage C_(B) holds promise for applications in cell imaging.
文摘A novel complex nano-structured Au@TiO2 gold catalyst has been prepared. Au precursor could be transformed into Au@TiO2/MCM-22 with the complex nano-structured using two different methods. Samples were characterized by XRD, FT-IR, UV-vis, TEM, ICP-AES and N2 adsorption-desorption. It is found that gold was anchored on the TiO2/MCM-22 as small size and uniform particles with the average diameters in the range of 5 - 9 nm. Catalytic results show that such nano-gold catalysts display excellent catalytic performance for cyclohexane oxidation. Au@TiO2/MCM-22 catalyst with the gold content of 0.5 wt% exhibits extremely exceptionally catalytic activity (12.81%) and high turnover frequency (52,121 h-1), which may be ascribed to the synergistic effects of Au and TiO2 in the complex nano-structured catalyst Au@TiO2/ MCM-22. Because of the strong metal support interaction, aggregation of active sites (Au nanoparticles) during the oxidation reaction is effectively prohibited and the catalytic activity is essentially retained.
基金supported by grants from the Collaborative Innovation Center of the Chinese Ministry of Education(Grant No.2020-39)Talents Science Cooperation Platform of Guizhou(No.2020-5012)+2 种基金Talents Science Platform of Zunyi city(Grant No.2021-3)Science and Technology Program of Guizhou Province([2020]1Y331)Scientific Research and Talent Training Funds of Kweichow Moutai Hospital(Grant No.2022-13).
文摘The cutaneous lymphatic system regulates tissue inflammation,fluid balance and immunological responses.Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema,immune deficiency,chronic inflammation etc.Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing.Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction.For example,impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers,venous ulcers and bedsores.This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds.Furthermore,we review wound lymphangiogenesis processes and remodelling,especially the influence of the inflammatory phase.Finally,we outline how to control lymphangiogenesis to promote wound healing,assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.
