Pseudolaric acids are a family of diterpenoid natural products that exhibit a broad spectrum of biological activities.The main structural feature of their framework is a trans-fused perhydroazulene bearing a bridged l...Pseudolaric acids are a family of diterpenoid natural products that exhibit a broad spectrum of biological activities.The main structural feature of their framework is a trans-fused perhydroazulene bearing a bridged lactone positioned at the junction of the rings.Herein,we have developed a radical cyclization strategy that allows flexible tuning of the cyclization process through diverse silicon substitutions on the substrates.This strategy can assist in constructing a series of skeletons with structural resemblance to pseudolaric acids and expedites the construction of the bridged lactone.Finally,it facilitates the synthesis of the entire skeletal structure of the pseudolaric acidfamily of natural products,excludingthe B-ringfunctionalization.展开更多
基金the National Natural Science Foundation of China(Nos.22071205,22301251 and 21772164)China Postdoctoral Science Foundation(2023M732942),NFFTBS(J1310024)+1 种基金NCETFJ,and PCSIRT is acknowledgedthe financial support(No.202005)from State Key Laboratory of Elemento-Organic Chemistry,Nankai University.
文摘Pseudolaric acids are a family of diterpenoid natural products that exhibit a broad spectrum of biological activities.The main structural feature of their framework is a trans-fused perhydroazulene bearing a bridged lactone positioned at the junction of the rings.Herein,we have developed a radical cyclization strategy that allows flexible tuning of the cyclization process through diverse silicon substitutions on the substrates.This strategy can assist in constructing a series of skeletons with structural resemblance to pseudolaric acids and expedites the construction of the bridged lactone.Finally,it facilitates the synthesis of the entire skeletal structure of the pseudolaric acidfamily of natural products,excludingthe B-ringfunctionalization.
