Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminar...Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminary progress has been made in enhancing their stability,loading efficiency,and targeted delivery effi-ciency.These advancements have led to their wide use in disease prevention,nutritional intervention,and improvement of functional foods.This review provides a comprehensive overview of the recent development of EXOs in functional foods and precision nutrition,with a specific focus on their encapsulation,protection,and delivery performance for various bioactive phenolic compounds.Additionally,the advanced surface function-alization strategies using polysaccharides and small bioactive molecules,aiming at improving the targeted ability of EXOs,are discussed.It has been shown that EXOs possess a unique constellation of advantages,including biocompatibility and safety,inherent stability with a robust lipid bilayer that protects cargo from enzymatic degradation and harsh pH conditions,and innate bio-interactivity allowing them to be recognized and inter-nalized by human cells.However,the research on EXOs is still in its infancy due to the difficulty in scalability and clinical translation,and little information on the in vivo biodistribution,metabolic destiny,and long-term safety profiles of EXOs.展开更多
Liposome has the ability to co-encapsulate hydrophobic and hydrophilic bioactive compounds due to its unique structure consisting of both aqueous core and lipid bilayer.The simultaneous delivery of bioactive compounds...Liposome has the ability to co-encapsulate hydrophobic and hydrophilic bioactive compounds due to its unique structure consisting of both aqueous core and lipid bilayer.The simultaneous delivery of bioactive compounds often brings synergistic effects and more health benefits.This article discusses the recent progress on the liposomal co-delivery systems for various combinations of bioactive compounds,including two hydrophobic bioactives,two hydrophilic bioactives,and hydrophobic/hydrophilic bioactives,as well as to combine biopolymer modification.The co-encapsulation mechanisms,influencing factors,and functional food applications are illustrated.The liposomal co-encapsulation has shown the synergistic effects on the stability,antioxidant activity,anti-inflammatory activity,and controlled release of bioactive compounds.The advantages and limitations associated with the co-delivery efficiency of liposomes are also highlighted.展开更多
基金supported by the National Key Research and Develop-ment Program of China(2022YFF1100205)National Science Foundation of China for Young Scholars(32101879).
文摘Food-derived exosomes(EXOs)are emerging as natural nanocarriers that overcome the poor stability and bioavailability of dietary bioactive compounds.With the development of functional modification techniques,preliminary progress has been made in enhancing their stability,loading efficiency,and targeted delivery effi-ciency.These advancements have led to their wide use in disease prevention,nutritional intervention,and improvement of functional foods.This review provides a comprehensive overview of the recent development of EXOs in functional foods and precision nutrition,with a specific focus on their encapsulation,protection,and delivery performance for various bioactive phenolic compounds.Additionally,the advanced surface function-alization strategies using polysaccharides and small bioactive molecules,aiming at improving the targeted ability of EXOs,are discussed.It has been shown that EXOs possess a unique constellation of advantages,including biocompatibility and safety,inherent stability with a robust lipid bilayer that protects cargo from enzymatic degradation and harsh pH conditions,and innate bio-interactivity allowing them to be recognized and inter-nalized by human cells.However,the research on EXOs is still in its infancy due to the difficulty in scalability and clinical translation,and little information on the in vivo biodistribution,metabolic destiny,and long-term safety profiles of EXOs.
基金supported by the National Key Research and Development Program of China(2023YFF1103601)National Natural Sci-ence Foundation of China for Young Scholars(32101879).
文摘Liposome has the ability to co-encapsulate hydrophobic and hydrophilic bioactive compounds due to its unique structure consisting of both aqueous core and lipid bilayer.The simultaneous delivery of bioactive compounds often brings synergistic effects and more health benefits.This article discusses the recent progress on the liposomal co-delivery systems for various combinations of bioactive compounds,including two hydrophobic bioactives,two hydrophilic bioactives,and hydrophobic/hydrophilic bioactives,as well as to combine biopolymer modification.The co-encapsulation mechanisms,influencing factors,and functional food applications are illustrated.The liposomal co-encapsulation has shown the synergistic effects on the stability,antioxidant activity,anti-inflammatory activity,and controlled release of bioactive compounds.The advantages and limitations associated with the co-delivery efficiency of liposomes are also highlighted.
