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多项临床指标与肺结节良恶性的相关性
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作者 林荣梅 刘邦燕 +4 位作者 陈杨君 杨艳 金媛 杨永锐 陆霓虹 《昆明医科大学学报》 2025年第7期101-109,共9页
目的探究肺结节良恶性与血清炎症因子、肿瘤指标、影像学特征的相关性。方法收集2023年1月至2024年1月在昆明市第三人民医院行肺穿刺活检的肺结节患者209例,根据病理结果分为良性肺结节组(n=106)、恶性肺结节组(n=103)。收集所有研究对... 目的探究肺结节良恶性与血清炎症因子、肿瘤指标、影像学特征的相关性。方法收集2023年1月至2024年1月在昆明市第三人民医院行肺穿刺活检的肺结节患者209例,根据病理结果分为良性肺结节组(n=106)、恶性肺结节组(n=103)。收集所有研究对象的一般资料和临床指标,分析两组间不同指标的差异。结果血清炎症因子方面:两组研究对象的LYMPH、NLR、LMR、IL-2、IL-6、IL-17、IFN-γ、HsCRP、SAA、PCT差异存在统计学意义(P<0.05),WBC、NETU、MONO、PLT、SII、IL-1β、IL-5、IL-8、IL-10、IL-12P70、IFN-α差异无统计学意义(P>0.05)。血清肿瘤标志物方面:两组研究对象的CEA、CA125、CA199、CYFRA21-1、ProGRP、NSE差异存在统计学意义(P<0.05),TNF-α、TSGF、AFP、CA153差异无统计学意义(P>0.05)。影像学特征方面:两组患者在结节数量、直径、边界、分叶征、毛刺征、胸膜凹陷征等方面差异有统计学意义(P<0.05),在结节是否钙化、结节密度、结节位置方面差异无统计学意义(P>0.05)。二元Logistic-向后-Wald条件法回归分析显示,患者年龄、分叶征、CEA、NSE、ProGRP、IL-6都是恶性肺结节的独立危险因素(P<0.05),以上指标联合诊断,预测恶性肺结节模型的AUC为0.965(P<0.05)。结论肺结节患者高龄、影像学表现有分叶、血清中NSE、ProGRP、IL-6、CEA增高时,恶性概率更高;联合上述指标检测,可以预测肺结节的性质,为恶性结节早期诊断提供指导。 展开更多
关键词 肺结节 炎症因子 肿瘤标志物 影像学特征 相关性
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Statistical properties of hot flow anomalies around Mars
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作者 MingYu Wu HeYin Wang +7 位作者 Lei Wang GuoQiang Wang SuDong Xiao yangjun chen Qi Lü Peng E AiMin Du TieLong Zhang 《Earth and Planetary Physics》 2025年第4期891-903,共13页
Hot flow anomalies(HFAs)are not only a terrestrial phenomenon,but also a solar-system-wide phenomenon,one that can cause significant perturbations in planetary magnetospheres and ionospheres.In this study,based on the... Hot flow anomalies(HFAs)are not only a terrestrial phenomenon,but also a solar-system-wide phenomenon,one that can cause significant perturbations in planetary magnetospheres and ionospheres.In this study,based on the observations of Mars Atmosphere and Volatile EvolutioN(MAVEN)mission in the region upstream of the Martian bow shock from the year 2014 to 2020,we have investigated the statistical properties of HFAs around Mars.Our results show that HFAs can be found in a wide region of Mars,from the dayside to the terminator region.On average,these HFAs last 63 seconds,with a thickness of 28 local proton gyroradii.They are more prevalent when the ambient solar wind is denser and faster,and usually occur when the interplanetary magnetic field magnitude is between 1-4 nT.Martian HFAs can also lead to solar wind dynamics multiplying in pressure by factors of ten within only tens of seconds,which could significantly influence the heights of the Martian ionopause and induced magnetosphere boundary.By comparing HFAs around Earth,we suggest that these phenomena are primarily governed by solar wind dynamics rather than local planetary conditions. 展开更多
关键词 magnetic fields MARS solar wind hot flow anomaly
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Sources and transformations of nitrite in the Amundsen Sea in summer 2019 and 2020 as revealed by nitrogen and oxygen isotopes 被引量:3
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作者 yangjun chen Jinxu chen +4 位作者 Yi Wang You Jiang Minfang Zheng Yusheng Qiu Min chen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2023年第4期16-24,共9页
In this study,the nitrogen and oxygen isotope compositions of nitrite in the upper 150 m water column of the Amundsen Sea in the summer of 2019 and 2020 were measured to reveal the distribution and transformation of n... In this study,the nitrogen and oxygen isotope compositions of nitrite in the upper 150 m water column of the Amundsen Sea in the summer of 2019 and 2020 were measured to reveal the distribution and transformation of nitrite in the euphotic zone of the Southern Ocean.We found that primary nitrite maxima(PNMs)are widely present in the Amundsen Sea,where the depth of occurrence deepens from east to west and nitrite concentrations increases.Evidence from dual isotopes suggests that the formation of PNMs in all regions of the Amundsen Sea is dominated by ammonia oxidation.More importantly,the nitrogen and oxygen isotope compositions of nitrite in the Amundsen Sea mixed layer are abnormal,and their depth profiles are mirror symmetrical.Isotopic anomalies exhibit spatial variations,with central surface water having the lowest nitrogen isotope composition(−89.9‰±0.2‰)and western surface water having the highest oxygen isotope composition(63.3‰±0.3‰).Isotopic exchange reaction between nitrate and nitrite is responsible for these isotope anomalies,as both nitrogen and oxygen isotopes have large isotopic fractionation and opposite enrichment effects.This proves that isotopic exchange reaction operates extensively in different regions of the Amundsen Sea.Our study highlights the unique role of dual isotopes of nitrite in deepening the understanding of nitrogen cycle.Further studies on ammonia oxidation and isotopic exchange between nitrate and nitrite are warranted in the future to understand their roles in the nitrogen cycle in the Southern Ocean. 展开更多
关键词 nitrogen isotope oxygen isotope NITRITE Amundsen Sea
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Responses of the field-aligned currents in the plasma sheet boundary layer to a geomagnetic storm 被引量:1
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作者 YuanQiang chen MingYu Wu +3 位作者 yangjun chen SuDong Xiao GuoQiang Wang TieLong Zhang 《Earth and Planetary Physics》 CAS CSCD 2023年第5期558-564,共7页
Geomagnetic storms can result in large magnetic field disturbances and intense currents in the magnetosphere and even on the ground.As an important medium of momentum and energy transport among the solar wind,magnetos... Geomagnetic storms can result in large magnetic field disturbances and intense currents in the magnetosphere and even on the ground.As an important medium of momentum and energy transport among the solar wind,magnetosphere,and ionosphere,field-aligned currents(FACs)can also be strengthened in storm times.This study shows the responses of FACs in the plasma sheet boundary layer(PSBL)observed by the Magnetospheric Multiscale(MMS)spacecraft in different phases of a large storm that lasted from May 27,2017,to May 29,2017.Most of the FACs were carried by electrons,and several FACs in the storm time also contained sufficient ion FACs.The FAC magnitudes were larger in the storm than in the quiet period,and those in the main phase were the strongest.In this case,the direction of the FACs in the main phase showed no preference for tailward or earthward,whereas the direction of the FACs in the recovery phase was mostly tailward.The results suggest that the FACs in the PSBL are closely related to the storm and could be driven by activities in the tail region,where the energy transported from the solar wind to the magnetosphere is stored and released as the storm is evolving.Thus,the FACs are an important medium of energy transport between the tail and the ionosphere,and the PSBL is a significant magnetosphere–ionosphere coupling region in the nightside. 展开更多
关键词 field-aligned currents plasma sheet boundary layer geomagnetic storm
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Quantitative analysis of the morphing wing mechanism of raptors: Analysis methods, folding motions, and bionic design of Falco Peregrinus
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作者 Di Tang Xipeng Huang +9 位作者 Jinqi Che Weijie Jin Yahui Cui yangjun chen Yuxiao Yuan Zhongyong Fan Weiwei Lu Siyu Wang Yin Yang Dawei Liu 《Fundamental Research》 CAS CSCD 2024年第2期344-352,共9页
Raptors can change the shape and area of their wings to an exceptional degree in a fast and efficient manner,surpassing other birds,insects,or bats.Some researchers have focused on the functional properties of muscle ... Raptors can change the shape and area of their wings to an exceptional degree in a fast and efficient manner,surpassing other birds,insects,or bats.Some researchers have focused on the functional properties of muscle skeletons,mechanics,and flapping robot design.However,the wing motion of the birds of prey has not been measured quantitatively,and synthetic bionic wings with morphing abilities similar to raptors are far from reality.Therefore,in the current study,a 3D suspension system for holding bird carcasses was designed and fabricated to fasten the wings of Falco Peregrinus with a series of morphing postures.Subsequently,the wing skeleton of the falcon was scanned during extending motions using the computed tomography(CT)approach to obtain three consecutive poses.Subsequently,the skeleton was reconstructed to identify the contribution of the forelimb bones to the extending/folding motions.Inspired by these findings,we propose a simple mechanical model with four bones to form a wing-morphing mechanism using the proposed pose optimisation method.Finally,a bionic wing mechanism was implemented to imitate the motion of the falcon wing—divided into inner and outer wings with folding and twisting motions.The results show that the proposed four-bar mechanism can track bone motion paths with high fidelity. 展开更多
关键词 Falco Peregrinus RAPTOR Suspension system CT scan Bionic wings Four-bar mechanism
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Biomimetic hybrid hydrogel for hemostasis,adhesion prevention and promoting regeneration after partial liver resection 被引量:1
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作者 Zuhong Li Yalei Zhao +7 位作者 Xiaoxi Ouyang Ya Yang yangjun chen Qixia Luo Yanhong Zhang Danhua Zhu Xiaopeng Yu Lanjuan Li 《Bioactive Materials》 SCIE 2022年第5期41-51,共11页
Partial liver resection is an established treatment for hepatic disorders.However,surgical bleeding,intra-abdominal adhesion and rapid liver regeneration are still major challenges after partial liver resection,associ... Partial liver resection is an established treatment for hepatic disorders.However,surgical bleeding,intra-abdominal adhesion and rapid liver regeneration are still major challenges after partial liver resection,associated with morbidity and mortality.Herein,a biomimetic hybrid hydrogel,composed of oxidized hyaluronic acid,glycol chitosan and MenSCs-derived conditioned medium(CM),is presented to address these issues.The hybrid hydrogel is formed through reversible Schiff base,and possesses injectability and self-healing capability.Moreover,hybrid hydrogel exhibits the capabilities of hemostasis,anti-infection,tissue adhesion and controllable release of cargoes.Based on in vivo studies of the multifunctional hybrid hydrogel,it is demonstrated that acute bleeding in partial liver resection can be ceased immediately by virtue of the hemostasis features of hybrid hydrogel.Also,a significant reduction of intra-abdominal adhesion is confirmed in hybrid hydrogel-treated resection surface.Furthermore,upon the treatment of hybrid hydrogel,hepatic cell proliferation and tissue regeneration can be significantly improved due to the controllably released cytokines from MenSCs-derived CM,exerting the effects of mitogenesis and anti-inflammation in vivo.Thus,the biomimetic hybrid hydrogel can be a promising candidate with great potential for application in partial liver resection. 展开更多
关键词 Hybrid hydrogel Partial liver resection HEMOSTASIS Adhesion prevention Liver regeneration
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