AIM: To study the relationship between microvessel density(MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC).METHODS: S-P immunohistochemical method and telomeric repeat amplif...AIM: To study the relationship between microvessel density(MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC).METHODS: S-P immunohistochemical method and telomeric repeat amplification protocol (TRAP) were respectively used to analyze the MVD and telomerase activity in 58 HCC and adjacent normal tissues.RESULTS: The MVD in HCC with metastasis, lower differentiation or without intact capsule was significantly higher than that in HCC with intact capsule, higher differentiation, or without metastasis. While MVD had no relationship with tumor size, hepatic virus infection and other clinical factors. Telomerase activity was related to differentiation degree, but not to tumor size or histological grade. MVD in HCC with telomerase activity was higher than that in HCC without telomerase activity.CONCLUSION: MVD and telomerase activity may serve as diagnostic criteria of HCC in earlier stage. Meanwhile,there may be a cooperative effect between MVD and telomerase on the growth and metastasis of HCC.展开更多
Reducing the overall vehicle weight is an efficient,system-level approach to increase the drive range of electric vehicle,for which structural parts in auto-frame may be replaced by battery modules.Such battery module...Reducing the overall vehicle weight is an efficient,system-level approach to increase the drive range of electric vehicle,for which structural parts in auto-frame may be replaced by battery modules.Such battery modules must be structurally functional,e.g.,energy absorbing,while the battery cells are not necessarily loading–carrying.We designed and tested a butterfly-shaped battery module of prismatic cells,which could self-unfold when subjected to a compressive loading.Angle guides and frictionless joints were employed to facilitate the large deformation.Desired resistance to external loading was offered by additional energy absorption elements.The battery-module behavior and the battery-cell performance were controlled separately.Numerical simulation verified the experimental results.展开更多
Taking ordinary secondary vocational students as teaching objects, combining with the actual teaching situation of momentum theorem, through careful analysis of textbook content, self-made collision experimental model...Taking ordinary secondary vocational students as teaching objects, combining with the actual teaching situation of momentum theorem, through careful analysis of textbook content, self-made collision experimental model, introduction of life collision examples into teaching content, micro-lesson +PPT teaching mode, timely selection of precise examples to consolidate teaching results, and introduction of ideological and political education into the classroom, the characteristics, teaching experience and shortcomings in the teaching organization process of section 1, chapter 4 of physics, volume I are summarized and analyzed.展开更多
文摘AIM: To study the relationship between microvessel density(MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC).METHODS: S-P immunohistochemical method and telomeric repeat amplification protocol (TRAP) were respectively used to analyze the MVD and telomerase activity in 58 HCC and adjacent normal tissues.RESULTS: The MVD in HCC with metastasis, lower differentiation or without intact capsule was significantly higher than that in HCC with intact capsule, higher differentiation, or without metastasis. While MVD had no relationship with tumor size, hepatic virus infection and other clinical factors. Telomerase activity was related to differentiation degree, but not to tumor size or histological grade. MVD in HCC with telomerase activity was higher than that in HCC without telomerase activity.CONCLUSION: MVD and telomerase activity may serve as diagnostic criteria of HCC in earlier stage. Meanwhile,there may be a cooperative effect between MVD and telomerase on the growth and metastasis of HCC.
基金supported by the Advanced Research Projects Agency-Energy(ARPA-E) under Grant No.DEAR0000396
文摘Reducing the overall vehicle weight is an efficient,system-level approach to increase the drive range of electric vehicle,for which structural parts in auto-frame may be replaced by battery modules.Such battery modules must be structurally functional,e.g.,energy absorbing,while the battery cells are not necessarily loading–carrying.We designed and tested a butterfly-shaped battery module of prismatic cells,which could self-unfold when subjected to a compressive loading.Angle guides and frictionless joints were employed to facilitate the large deformation.Desired resistance to external loading was offered by additional energy absorption elements.The battery-module behavior and the battery-cell performance were controlled separately.Numerical simulation verified the experimental results.
文摘Taking ordinary secondary vocational students as teaching objects, combining with the actual teaching situation of momentum theorem, through careful analysis of textbook content, self-made collision experimental model, introduction of life collision examples into teaching content, micro-lesson +PPT teaching mode, timely selection of precise examples to consolidate teaching results, and introduction of ideological and political education into the classroom, the characteristics, teaching experience and shortcomings in the teaching organization process of section 1, chapter 4 of physics, volume I are summarized and analyzed.
