Background:Allergic eosinophilic asthma(EA)and eosinophilic granulomatosis with polyangiitis(EGPA)share significant overlaps in both epidemiology and pathogenesis,suggesting a potential link between the two con-dition...Background:Allergic eosinophilic asthma(EA)and eosinophilic granulomatosis with polyangiitis(EGPA)share significant overlaps in both epidemiology and pathogenesis,suggesting a potential link between the two con-ditions.Despite these associations,the underlying molecular and cellular mechanisms driving their connection remain poorly understood.Methods:We retrieved GSE143303 of EA and GSE144302 of EGPA from the GEO database and conducted dif-ferential expression analysis as well as functional enrichment analysis to identify differentially expressed genes(DEGs)and potential pathogenic pathways.A protein-protein interaction(PPI)network was generated using the STRING database.Key hub genes were determined through cytoHubba.We added two publicly reported EA and EGPA-related transcriptome datasets,GSE117038 and GSE119136,for mutual verification.Subsequent valida-tion was performed via immune infiltration assessment utilizing CIBERSORT.Results:In total,267 DEGs were identified,in which HSP90AA1,HSPA8,CCND1,RPS20,CD74,RPL5,RPS6,RHOA,RPS3A and FLT3LG are the top 10 hub genes,while the antigen processing and presentation pathway and leukocyte cell-cell adhesion pathway were the potential influential pathways.Increased naïve B cells and M1 type of Macrophages were detected in EA patients through immune infiltration analysis.Conclusions:Utilizing bioinformatics techniques,this study is the initial investigation to uncover the shared mechanisms involving the antigen processing and presentation pathway and leukocyte adhesion pathways in the progression of both EA and EGPA.It may offer potential biomarkers for future studies on the underlying path-ogenesis and treatment of EA and EGPA as well as eosinophilia related co-morbidities.展开更多
The extensive transgression that occurred on the Yangtze Plate in Early Cambrian led to a massive organic carbon pool in the Niutitang Formation. A black shale core section from 3 251.08 to 3 436.08 m beneath the Eart...The extensive transgression that occurred on the Yangtze Plate in Early Cambrian led to a massive organic carbon pool in the Niutitang Formation. A black shale core section from 3 251.08 to 3 436.08 m beneath the Earth＇s surface was studied to estimate the contribution of oxygenic photosynthesis to organic carbon sink fluxes in Early Cambrian Upper Yangtze shallow sea. Results indicate that the oxygenic photosynthesis played the most important role in carbon fixation in Early Cambrian. Organic carbon sink was mainly contributed by photosynthetic microorganisms, e.g., cyanobacteria, algae and archaea. The Niutitang Formation was formed in a deep anoxic marine shelf sedimentary environment at a sedimentation rate of ~0.09±0.03 mm/yr. The initial TOC abundance in Niutitang shale ranged from 0.18% to 7.09%, with an average of 2.15%. In accordance with the sedimentation rate and initial TOC abundance, organic carbon sink fluxes were calculated and found to range from 0.21 to 8.10×10~3 kg/km^2·yr^（-1）, especially the organic carbon sink fluxes in depth between 3 385 and 3 470 m range from 3.80 to 8.10×10~3 kg/km^2·yr^（-1）, with an average of ~6.03×10~3 kg/km^2·yr^（-1）, which is much higher than that of contemporary marine sediments. The organic carbon sink fluxes of Niutitang shale are equal to 0.56 to 21.61×10~3 kg/km^2·yr^（-1） net oxygen emitted into the Early Cambrian ocean and atmosphere, this emitted oxygen may have significantly promoted the oxygen level of the Earth＇s surface and diversification of metazoans.展开更多
Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disabili...Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disability in young people.Currently available treatments for BD are still fairly limited in terms of efficacy,with high rates of non-adherence,non-response,and undesirable side effects.Traditional Chinese medicine(TCM) has a long history and rich experience in stabilizing mania and improving quality of life.Aiming at rebalancing Yin and Yang in BD,therapy of replenishing Yin and regulating Yang(RYRY therapy) has been in clinical use for years in China.The present prospective,double-blind,randomized controlled trial is designed to investigate the efficacy and safety of RYRY therapy for bipolar mania and its possible mechanism from the point of regulating gut microbiota and anti-inflammation.A total of 60 eligible participants will be recruited from Beijing Anding Hospital.They will be randomized to either the study group or the control group in a ratio of 1∶1.Participants allocated to the study group will receive RYRY granule,while placebo granule will be applied in the control group.Participants in both groups will be prescribed conventional therapy for manic episode in BD.Four scheduled visits will be conducted over 4 weeks.Outcome measurements include Young Mania Rating Scale,TCM Symptom Pattern Rating Scale,Treatment Emergent Symptom Scale,levels of C-reactive protein,interleukin-6 and tumor necrosis factor-α and the gut microbial community profile of stool samples.Safety outcomes and adverse events will also be recorded.In this study,we set a number of scientific and objective assessments to evaluate the efficacy of RYRY therapy and study into its possible mechanism,hopefully offering clinicians an alternative approach to BD.展开更多
A rapidly deployable dense seismic monitoring system which is capable of transmitting acquired data in real time and analyzing data automatically is crucial in seismic hazard mitigation after a major earthquake.Howeve...A rapidly deployable dense seismic monitoring system which is capable of transmitting acquired data in real time and analyzing data automatically is crucial in seismic hazard mitigation after a major earthquake.However,it is rather difficult for current seismic nodal stations to transmit data in real time for an extended period of time,and it usually takes a great amount of time to process the acquired data manually.To monitor earthquakes in real time flexibly,we develop a mobile integrated seismic monitoring system consisting of newly developed nodal units with 4G telemetry and a real-time AI-assisted automatic data processing workflow.The integrated system is convenient for deployment and has been successfully applied in monitoring the aftershocks of the Yangbi M_(S) 6.4 earthquake occurred on May 21,2021 in Yangbi County,Dali,Yunnan in southwest China.The acquired seismic data are transmitted almost in real time through the 4G cellular network,and then processed automat-ically for event detection,positioning,magnitude calculation and source mechanism inversion.From tens of seconds to a couple of minutes at most,the final seismic attributes can be presented remotely to the end users through the integrated system.From May 27 to June 17,the real-time system has detected and located 7905 aftershocks in the Yangbi area before the internal batteries exhausted,far more than the catalog provided by China Earthquake Networks Center using the regional permanent stations.The initial application of this inte-grated real-time monitoring system is promising,and we anticipate the advent of a new era for Real-time Intelligent Array Seismology(RIAS),for better monitoring and understanding the subsurface dynamic pro-cesses caused by Earth's internal forces as well as anthropogenic activities.展开更多
Fengshui, one of the important factors in the layout of Chinese traditional buildings, runs through activities related to traditional Chinese architecture. In order to better interpret and reflect the relationship bet...Fengshui, one of the important factors in the layout of Chinese traditional buildings, runs through activities related to traditional Chinese architecture. In order to better interpret and reflect the relationship between traditional buildings and the surrounding natural environment, Fengshui theory is moderately applied when it comes to an environmental improvement project, so as to make the whole design more unified and the sub-design more sound. Therefore, buildings are more coordinated with the overall environment, and the essence of "culture of harmoniousness" of Chinese traditional architecture is reflected.展开更多
基金funded by National Natural Science Foundation of China(NO.82370083).
文摘Background:Allergic eosinophilic asthma(EA)and eosinophilic granulomatosis with polyangiitis(EGPA)share significant overlaps in both epidemiology and pathogenesis,suggesting a potential link between the two con-ditions.Despite these associations,the underlying molecular and cellular mechanisms driving their connection remain poorly understood.Methods:We retrieved GSE143303 of EA and GSE144302 of EGPA from the GEO database and conducted dif-ferential expression analysis as well as functional enrichment analysis to identify differentially expressed genes(DEGs)and potential pathogenic pathways.A protein-protein interaction(PPI)network was generated using the STRING database.Key hub genes were determined through cytoHubba.We added two publicly reported EA and EGPA-related transcriptome datasets,GSE117038 and GSE119136,for mutual verification.Subsequent valida-tion was performed via immune infiltration assessment utilizing CIBERSORT.Results:In total,267 DEGs were identified,in which HSP90AA1,HSPA8,CCND1,RPS20,CD74,RPL5,RPS6,RHOA,RPS3A and FLT3LG are the top 10 hub genes,while the antigen processing and presentation pathway and leukocyte cell-cell adhesion pathway were the potential influential pathways.Increased naïve B cells and M1 type of Macrophages were detected in EA patients through immune infiltration analysis.Conclusions:Utilizing bioinformatics techniques,this study is the initial investigation to uncover the shared mechanisms involving the antigen processing and presentation pathway and leukocyte adhesion pathways in the progression of both EA and EGPA.It may offer potential biomarkers for future studies on the underlying path-ogenesis and treatment of EA and EGPA as well as eosinophilia related co-morbidities.
基金supported by the National Natural Science Foundation of China (No. 41302023)the Doctoral Program of Higher Education (Specialized Research Fund) of China (No. 20125121130001)+1 种基金the Science Foundation of Education Department of Sichuan Province (No. 13ZB0190)the Karst Dynamics Laboratory, MLR and GZAR (No. KDL2011-04)
文摘The extensive transgression that occurred on the Yangtze Plate in Early Cambrian led to a massive organic carbon pool in the Niutitang Formation. A black shale core section from 3 251.08 to 3 436.08 m beneath the Earth＇s surface was studied to estimate the contribution of oxygenic photosynthesis to organic carbon sink fluxes in Early Cambrian Upper Yangtze shallow sea. Results indicate that the oxygenic photosynthesis played the most important role in carbon fixation in Early Cambrian. Organic carbon sink was mainly contributed by photosynthetic microorganisms, e.g., cyanobacteria, algae and archaea. The Niutitang Formation was formed in a deep anoxic marine shelf sedimentary environment at a sedimentation rate of ~0.09±0.03 mm/yr. The initial TOC abundance in Niutitang shale ranged from 0.18% to 7.09%, with an average of 2.15%. In accordance with the sedimentation rate and initial TOC abundance, organic carbon sink fluxes were calculated and found to range from 0.21 to 8.10×10~3 kg/km^2·yr^（-1）, especially the organic carbon sink fluxes in depth between 3 385 and 3 470 m range from 3.80 to 8.10×10~3 kg/km^2·yr^（-1）, with an average of ~6.03×10~3 kg/km^2·yr^（-1）, which is much higher than that of contemporary marine sediments. The organic carbon sink fluxes of Niutitang shale are equal to 0.56 to 21.61×10~3 kg/km^2·yr^（-1） net oxygen emitted into the Early Cambrian ocean and atmosphere, this emitted oxygen may have significantly promoted the oxygen level of the Earth＇s surface and diversification of metazoans.
基金Supported by Beijing Municipal Administration of Hospitals Incubating Program(No.PZ2021031),which plays no role in the design of the studycollection,analysis,and interpretation of data,and in writing the manuscript。
文摘Bipolar disorder(BD) is a chronic and recurrent disorder characterized by biphasic mood episodes of mania or hypomania and depression.It affects more than 1% of the global population and is a leading cause of disability in young people.Currently available treatments for BD are still fairly limited in terms of efficacy,with high rates of non-adherence,non-response,and undesirable side effects.Traditional Chinese medicine(TCM) has a long history and rich experience in stabilizing mania and improving quality of life.Aiming at rebalancing Yin and Yang in BD,therapy of replenishing Yin and regulating Yang(RYRY therapy) has been in clinical use for years in China.The present prospective,double-blind,randomized controlled trial is designed to investigate the efficacy and safety of RYRY therapy for bipolar mania and its possible mechanism from the point of regulating gut microbiota and anti-inflammation.A total of 60 eligible participants will be recruited from Beijing Anding Hospital.They will be randomized to either the study group or the control group in a ratio of 1∶1.Participants allocated to the study group will receive RYRY granule,while placebo granule will be applied in the control group.Participants in both groups will be prescribed conventional therapy for manic episode in BD.Four scheduled visits will be conducted over 4 weeks.Outcome measurements include Young Mania Rating Scale,TCM Symptom Pattern Rating Scale,Treatment Emergent Symptom Scale,levels of C-reactive protein,interleukin-6 and tumor necrosis factor-α and the gut microbial community profile of stool samples.Safety outcomes and adverse events will also be recorded.In this study,we set a number of scientific and objective assessments to evaluate the efficacy of RYRY therapy and study into its possible mechanism,hopefully offering clinicians an alternative approach to BD.
基金supported by the National Natural Science Foundation of China (under grants 41874048,41790464,41790462).
文摘A rapidly deployable dense seismic monitoring system which is capable of transmitting acquired data in real time and analyzing data automatically is crucial in seismic hazard mitigation after a major earthquake.However,it is rather difficult for current seismic nodal stations to transmit data in real time for an extended period of time,and it usually takes a great amount of time to process the acquired data manually.To monitor earthquakes in real time flexibly,we develop a mobile integrated seismic monitoring system consisting of newly developed nodal units with 4G telemetry and a real-time AI-assisted automatic data processing workflow.The integrated system is convenient for deployment and has been successfully applied in monitoring the aftershocks of the Yangbi M_(S) 6.4 earthquake occurred on May 21,2021 in Yangbi County,Dali,Yunnan in southwest China.The acquired seismic data are transmitted almost in real time through the 4G cellular network,and then processed automat-ically for event detection,positioning,magnitude calculation and source mechanism inversion.From tens of seconds to a couple of minutes at most,the final seismic attributes can be presented remotely to the end users through the integrated system.From May 27 to June 17,the real-time system has detected and located 7905 aftershocks in the Yangbi area before the internal batteries exhausted,far more than the catalog provided by China Earthquake Networks Center using the regional permanent stations.The initial application of this inte-grated real-time monitoring system is promising,and we anticipate the advent of a new era for Real-time Intelligent Array Seismology(RIAS),for better monitoring and understanding the subsurface dynamic pro-cesses caused by Earth's internal forces as well as anthropogenic activities.
文摘Fengshui, one of the important factors in the layout of Chinese traditional buildings, runs through activities related to traditional Chinese architecture. In order to better interpret and reflect the relationship between traditional buildings and the surrounding natural environment, Fengshui theory is moderately applied when it comes to an environmental improvement project, so as to make the whole design more unified and the sub-design more sound. Therefore, buildings are more coordinated with the overall environment, and the essence of "culture of harmoniousness" of Chinese traditional architecture is reflected.
