Background China is seeing a growing demand for rehabilitation treatments for post-stroke upper limb spastic paresis(PSSP-UL).Although acupuncture is known to be effective for PSSP-UL,there is room to enhance its effi...Background China is seeing a growing demand for rehabilitation treatments for post-stroke upper limb spastic paresis(PSSP-UL).Although acupuncture is known to be effective for PSSP-UL,there is room to enhance its efficacy.Objective This study explored a semi-personalized acupuncture approach for PSSP-UL that used three-dimensional kinematic analysis(3DKA)results to select additional acupoints,and investigated the feasibility,efficacy and safety of this approach.Design,setting,participants and interventions This single-blind,single-center,randomized,controlled trial involved 74 participants who experienced a first-ever ischemic or hemorrhagic stroke with spastic upper limb paresis.The participants were then randomly assigned to the intervention group or the control group in a 1:1 ratio.Both groups received conventional treatments and acupuncture treatment 5 days a week for 4 weeks.The main acupoints in both groups were the same,while participants in the intervention group received additional acupoints selected on the basis of 3DKA results.Follow-up assessments were conducted for 8 weeks after the treatment.Main outcome measures The primary outcome was the Fugl-Meyer Assessment for Upper Extremity(FMA-UE)response rate(≥6-point change)at week 4.Secondary outcomes included changes in motor function(FMA-UE),Brunnstrom recovery stage(BRS),manual muscle test(MMT),spasticity(Modified Ashworth Scale,MAS),and activities of daily life(Modified Barthel Index,MBI)at week 4 and week 12.Results Sixty-four participants completed the trial and underwent analyses.Compared with control group,the intervention group exhibited a significantly higher FMA-UE response rate at week 4(χ^(2)=5.479,P=0.019)and greater improvements in FMA-UE at both week 4 and week 12(both P<0.001).The intervention group also showed bigger improvements from baseline in the MMT grades for shoulder adduction and elbow flexion at weeks 4 and 12 as well as thumb adduction at week 4(P=0.007,P=0.049,P=0.019,P=0.008,P=0.029,respectively).The intervention group showed a better change in the MBI at both week 4 and week 12(P=0.004 and P=0.010,respectively).Although the intervention group had a higher BRS for the hand at week 12(P=0.041),no intergroup differences were observed at week 4(all P>0.05).The two groups showed no differences in MAS grades as well as in BRS for the arm at weeks 4 and 12(all P>0.05).Conclusion Semi-personalized acupuncture prescription based on 3DKA results significantly improved motor function,muscle strength,and activities of daily living in patients with PSSP-UL.展开更多
As a major contributor to methane production in agriculture,there is a need for a suitable methane inhibitor to reduce ruminant methane emissions and minimize the impact on the climate.This work aimed to explore the i...As a major contributor to methane production in agriculture,there is a need for a suitable methane inhibitor to reduce ruminant methane emissions and minimize the impact on the climate.This work aimed to explore the influence of cordycepin on rumen fermentation,gas production,microbiome and their metabolites.A total of 0.00,0.08,0.16,0.32,and 0.64 g L^(–1)cordycepin were added into fermentation bottles containing 2 g total mixed ration for in vitro ruminal fermentation,and then the gas produced and fermentation parameters were measured for each bottle.Samples from the 0 and 0.64 g L^(–1)cordycepin addition were selected for 16S rRNA gene sequencing and metabolome analysis.The result of this experiment indicated that the addition of cordycepin could linearly increase the concentration of total volatile fatty acid,ammonia nitrogen,the proportion of propionate,valerate,and isovalerate,and linearly reduce ruminal pH and methane,carbon dioxide,hydrogen and total gas production,as well as the methane proportion,carbon dioxide proportion and proportion of butyrate.In addition,there was a quadratic relationship between hydrogen and cordycepin addition.At the same time,the relative abundance of Succiniclasticum,Prevotella,Rikenellaceae_RC9_gut_group,NK4A214_group,Christensenellaceae_R_(7)_group,unclassified_F082,Veillonellaceae_UCG_001,Dasytricha,Ophryoscolex,Isotricha,unclassified_Eukaryota,Methanobrevibacter,and Piromyces decreased significantly after adding the maximum dose of cordycepin.In contrast,the relative abundance of Succinivibrio,unclassified_Succinivibrionaceae,Prevotellaceae_UCG_001,unclassified_Lachnospiraceae,Lachnospira,Succinivibrionaceae_UCG_002,Pseudobutyrivibrio,Entodinium,Polyplastron,unclassified_Methanomethylophilaceae,Methanosphaera,and Candidatus_Methanomethylophilus increased significantly.Metabolic pathways such as biosynthesis of unsaturated fatty acids and purine metabolism and metabolites such as arachidonic acid,adenine,and 2′-deoxyguanosine were also affected by the addition of cordycepin.Based on this,we conclude that cordycepin is an effective methane emission inhibitor that can change the rumen metabolites and fermentation parameters by influencing the rumen microbiome,thus regulating rumen methane production.This experiment may provide a potential theoretical reference for developing Cordyceps byproduct or additives containing cordycepin as methane inhibitors.展开更多
Elucidating the relationship between spin excitations and fermiology is essential for clarifying the pairing mechanism in iron-based superconductors(FeSCs).Here,we report inelastic neutron scattering results on the ho...Elucidating the relationship between spin excitations and fermiology is essential for clarifying the pairing mechanism in iron-based superconductors(FeSCs).Here,we report inelastic neutron scattering results on the hole overdoped Ba_(0.4)K_(0.6)Fe_(2)As_(2) near a Lifshitz transition,where the electron pocket at M point is nearly replaced by four hole pockets.In the normal state,the spin excitations is observed at incommensurate wave vectors with a chimney-like dispersion.By cooling down to the superconducting state,a neutron spin resonance mode emerges with a peak energy of Er=14-15 meV,weakly modulated along the L-direction.The incommensurability notably increases at low energies,giving rise to downward dispersions of the resonance mode.This behavior contrasts sharply with the upward dispersions of resonance observed in optimally doped Ba_(0.67)K_(0.33)Fe_(2)As_(2) contributed by the hole to electron scattering,but resembles those in KFe_(2)As_(2) and KCa_(2)Fe_(4)As_(4)F_(2) where the fermiology is dominated by hole pockets.These results highlight the critical role of electronic structure modifications near the Fermi level,especially in governing interband scattering under imperfect nesting conditions,which fundamentally shape the spin dynamics of FeSCs.展开更多
Rare earths,as a strategic mineral resource,play a vital role in high-tech industries such as aerospace,national defense and military,electronic information,and new energy.With the accelerated evolution of the new rou...Rare earths,as a strategic mineral resource,play a vital role in high-tech industries such as aerospace,national defense and military,electronic information,and new energy.With the accelerated evolution of the new round of technological revolution and industrial transformation,global supply chain security risks have become more prominent.The focus of major countries'resource security assurance has also shifted from bulk minerals to critical minerals.展开更多
Extensive evidence demonstrates that a healthy and well-balanced gut microbiota profoundly influences host nutrient absorption,immunity,and metabolism.Unlike mammals,early microbiota colonization in commercial poultry...Extensive evidence demonstrates that a healthy and well-balanced gut microbiota profoundly influences host nutrient absorption,immunity,and metabolism.Unlike mammals,early microbiota colonization in commercial poultry largely depends on the environment as chicks hatch in incubators under a relatively sterile environment(egg and incubator sterilization)without maternal-offspring interaction.The early gut microbiota remains unsaturated,providing a critical window for modulation and influencing the subsequent microbiota succession,which may have long-term health outcomes.Microbiota transplantation(MT)involves transferring the microbiota from a donor to a recipient to modulate the recipient’s microbiota toward a desired state.Successfully applied in human medicine,MT is also gaining attention in poultry production to modulate intestinal health.This review comprehensively explores factors affecting MT,its mechanisms,and its potential applications in chickens,providing insights for further research and commercial use.展开更多
When the protective and protected systems are detached,the former can be allowed to absorb the kinetic energy of the impacting projectile through large deformation without considering the back face signature of the la...When the protective and protected systems are detached,the former can be allowed to absorb the kinetic energy of the impacting projectile through large deformation without considering the back face signature of the latter.This paper presents a novel double-face knitted fabric(DFKF)designed for this very impacting scenario.Shooting tests equipped with high-speed camera were used to characterize the ballistic performance with the impact velocities ranging from 100 m/s to 450 m/s.The results showed that the ballistic limits(V_(bl))of DFKF are approximately triple and double that of its counterpart UD and plain fabrics,respectively.For mass-normalized metrics,the specific energy absorption(SEA)is 250%and 350%greater than the UD and plain fabrics at their corresponding V_(bl)s.The quasi-static tests showed that the DFKF displayed greater resilience,crease recovery properties,and flexibility,which also made it an especially better candidate than UD and plain weaves for the design of umbrella surface cloth.It was also found that DFKF is dependent on yarn count and the incorporation of spandex.A prototype anti-ballistic umbrella is manufactured using DFKF made of 200D multi-filament yarn.The ballistic performance is also sensitive to the impact site when the umbrella is subjected to impact.展开更多
Accurately forecasting ecosystem services is critical for enhancing our understanding and improving management practices within nature reserves,particularly in light of climate change,land use/cover changes,and their ...Accurately forecasting ecosystem services is critical for enhancing our understanding and improving management practices within nature reserves,particularly in light of climate change,land use/cover changes,and their complex interactions.However,existing studies often fail to fully consider vegetation response,constituting a gap in the comprehensive assessment of changes in ecosystem services.Therefore,a coupled model framework integrating climate change,land use change,and vegetation dynamics was developed to allow for the simulation of dynamic ecosystem service scenarios throughout the twenty-first century.The Jiulianshan National Nature Reserve in Jiangxi Province was considered as the study area.The results showed that ecosystem services and their synergistic effects will be optimized under scenarios that emphasize strict protection of ecological lands and incorporating the SSP1-2.6 scenario.However,sustaining optimized ecosystem services poses significant challenges in scenarios characterized by resource-intensive development and ongoing climate warming,as in the SSP5-8.5 scenario.Notably,discernible variations exist in balancing and synergizing the management of ecosystem services across diverse land uses and forest types.Our study underscores the importance of integrating vegetation response into the framework of ecosystem service forecasting,which is essential for assisting nature reserves in effectively addressing the multifaceted risks associated with climate change and rapid socio-economic development.展开更多
Gecko-inspired robots have significant potential applications;however,deviations in the yaw direction during locomotion are inevitable for legged robots that lack external sensing.These deviations cause the robot to s...Gecko-inspired robots have significant potential applications;however,deviations in the yaw direction during locomotion are inevitable for legged robots that lack external sensing.These deviations cause the robot to stray from its intended path.Therefore,a cost-effective and straightforward solution is essential for reducing this deviation.In nature,the tail is often used to maintain balance and stability.Similarly,it has been used in robots to improve manoeuvrability and stability.Our aim is to reduce this deviation using a morphological computation approach,specifically by adding a tail.To test this hypothesis,we investigated four different tails(rigid plate,rigid gecko-shaped,soft plate,and soft gecko-shaped)and assessed the deviation of the robot with these tails on different slopes.Additionally,to evaluate the influence of different tail parameters,such as material,shape,and linkage,we investigated the locomotion performance in terms of the robot's climbing speed on slopes,its ability to turn at narrow corners,and the resistance of the tails to external disturbances.A new auto-reset joint was designed to ensure that a disturbed tail could be quickly reset.Our results demonstrate that the yaw deviation of the robot can be reduced by applying a tail.Among the four tails,the soft gecko-shaped tail was the most effective for most tasks.In summary,our findings demonstrate the functional role of the tail in reducing yaw deviation,improving climbing ability and stability and provide a reference for selecting the most suitable tail for geckoinspired robots.展开更多
Multistage fracturing technology has been used to enhance tight hydrocarbon resource recovery.Determining the proper well spacing and fracturing strategy is crucial for generating a complex fracture network that facil...Multistage fracturing technology has been used to enhance tight hydrocarbon resource recovery.Determining the proper well spacing and fracturing strategy is crucial for generating a complex fracture network that facilitates oil and gas flow in reservoirs.The stress-shadow effect that occurs between multiple wells significantly affects the development of fracture networks in reservoirs.However,the quantification of the stress-shadow effect and its influence on fracture networks has not been satisfactorily resolved because of the difficulties in detecting and identifying fracture propagation and reorientation in reservoirs.In this study,based on the geological information from the Shengli oilfield,we applied a hybrid finite element-discrete element method to analyze engineering-scale three-dimensional fracture propagation and reorientation by altering well spacings and fracturing strategies.The results indicate that the fracturing area generated by the synchronous fracturing scheme is much smaller than those generated by the sequential and alternative schemes.An alternative hydrofracturing scheme is optimal with respect to fracturing area.The stress-blind area was defined to quantify the mechanical disturbance between adjacent wells.Our study improves the understanding of the effect of fracturing schemes on fracture networks and the impact of independent factors contributing to stress-shadow effects.展开更多
L-Theanine(LTA)is a non-protein amino acid mainly found in tea plants with many beneficial effects.Exercise exerts a wide range of benefits in metabolic health.Here,we show that exercise or gastric lavage intervention...L-Theanine(LTA)is a non-protein amino acid mainly found in tea plants with many beneficial effects.Exercise exerts a wide range of benefits in metabolic health.Here,we show that exercise or gastric lavage intervention on mice with LTA improves diet-induced nonalcoholic steatohepatitis(NASH)in mice.Meanwhile,combinatory therapy shows that exercise and LTA synergistically improve obesity-related metabolic disorders and NASH phenotypes,including hepatic steatosis,inflammation,cell death and oxidative stress.In vivo studies indicate that LTA inhibits free fatty acid(FFA)-induced hepatocyte injury,including steatosis,oxidative stress and apoptosis.Knockdown of Nrf2 blunts the role of LTA in inhibiting FFA-induced hepatocyte oxidative stress and dysfunction.Mechanistically,LTA increases theα-ketoglutarate(α-KG)level in hepatocytes,which increases the transcription of Nrf2 by inducing active DNA demethylation on its promoter.Moreover,LTA promote the aboveα-KG/Nrf2 axis in synergy with exercise,thereby more efficiently inhibiting hepatic oxidative stress and ameliorating diet-induced NASH in mice.Our results suggest that,through promoting theα-KG/Nrf2 axis-mediated anti-oxidative pathway,the combination of LTA and exercise may provide an effective measure for the prevention and control of NASH.展开更多
As lithium-ion batteries(LIBs)continue to evolve toward lower costs and higher energy densities,their potential safety risks have become increasingly apparent.Incidents such as explosions at energy storage facilities,...As lithium-ion batteries(LIBs)continue to evolve toward lower costs and higher energy densities,their potential safety risks have become increasingly apparent.Incidents such as explosions at energy storage facilities,fires in electric vehicles,and building fires ignited by charging two-wheeled vehicles have been occurring with alarming frequency,often resulting in significant casualties and injuries.Conducting indepth investigations into thermal runaway(TR)incidents in LIBs can significantly reduce the risk of future occurrences.However,current investigations into LIB fire and explosion incidents face challenges due to the difficulty of conducting in-depth analyses and the lack of a robust theoretical framework to guide these investigations.To enhance the effectiveness of in-depth investigations into battery fire and explosion incidents and to address the lack of theoretical guidance,this paper is the first to systematically examine the conservation and flow patterns of elements during the TR process of LIBs.The analysis reveals that during TR,the gas products generated include approximately 1.5 g of H_(2),23.6 g of CO,88.4 g of CO_(2),8.9 g of C_(2)H_(4),7.3 g of CH_(4),3.7 g of C_(2)H_(6),and 82 g of electrolyte vapor.After TR,the solid compounds formed consist of approximately 2.5 g of LiF,29–92.2 g of elemental Ni/Co/Mn,11.4 g of Li_(2)CO_(3),200.6 g of graphite,1.4 g of NiO,29.6 g of MnO,30.1 g of CoO,67 g of elemental Cu,0.03 g of LiNiO_(2),and 4.3 g of LiAlO_(2).Importantly,the energy released from reactions forming solid compounds during TR surpasses that from gas-forming reactions.This investigation represents the first application of Hess’s law to verify the conservation of elements during the TR process of lithium-ion batteries.The proposed methodology is also applicable to other types of energy storage batteries,effectively advancing techniques for comprehensively investigating lithium battery fire and explosion incidents.展开更多
Electrocatalytic carbon dioxide reduction(ECO_(2)RR)serves as a promising approach for converting CO_(2)into energy-dense fuels and high-value chemicals,garnering substantial interest across academic and industrial se...Electrocatalytic carbon dioxide reduction(ECO_(2)RR)serves as a promising approach for converting CO_(2)into energy-dense fuels and high-value chemicals,garnering substantial interest across academic and industrial sectors.Copper(Cu)-based electrocatalysts are widely acknowledged as highly effective for ECO_(2)RR,primarily due to their optimal adsorption energy for*CO.Nonetheless,significant challenges remain to be addressed in transitioning Cu-based catalysts from research settings to industrial applications,including the low stability and unavoidable side reactions.This article aims to i)systematically examine the deactivation mechanisms of Cu-based catalysts,including changes in valence states,surface poisoning,and restructuring(agglomeration,dissolution,Ostwald ripening);ii)provide a timely overview of cutting-edge strategies to enhance the stability of Cu-based catalysts,such as ligand effects,heteroatom doping,support optimization,size effect,and restructuring;iii)highlight critical areas and prospective development directions that warrant further exploration to expedite the industrial adoption of Cu-based catalysts in ECO_(2)RR.展开更多
Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing novel anti-fibrotic drugs is imperative.Isovalerylspiramycin I(ISP I)as a major component of carrimycin applied to upper resp...Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing novel anti-fibrotic drugs is imperative.Isovalerylspiramycin I(ISP I)as a major component of carrimycin applied to upper respiratory infections,was first found to possess anti-fibrotic potential.The present study aims to evaluate the functions and mechanisms of ISP I in protecting against liver fibrosis.According to our results,ISP I not only reduced the expressions of fibrogenic markers in LX-2 cells but also appeared great protective effects on liver injury and liver fibrosis in bile duct ligation(BDL)rats and carbon tetrachloride(CCl4)mice.We proved that nucleotide-binding protein 2(NUBP2)was the direct target of ISP I.ISP I through targeting NUBP2,increased the amount of vascular non-inflammatory molecule-1(VNN1)on the cell membrane,which will inhibit oxidative stress and fibrosis.Simultaneously,the original carrimycin's protective effect on liver damage and fibrosis was verified.Therefore,our study provides potential agents for patients with liver fibrosis-related diseases,and the clear mechanism supports wide application in the clinic.展开更多
Wearable electronics incorporating proteins for biocompatibility have garnered significant research attention,given their potential applications in biocompatible medical devices,artificial skin,humanoid robots,and oth...Wearable electronics incorporating proteins for biocompatibility have garnered significant research attention,given their potential applications in biocompatible medical devices,artificial skin,humanoid robots,and other fields.However,a notable challenge exists,as many wearable electronics currently lack those essential properties due to issues such as non-biological compatibility,as well as insufficient mechanical and conductive performance.Here,we have developed a hybrid keratin(KE)hydrogel by incorporating a liquid metal(LM,eutectic gallium-indium alloy)to design a wearable electronic device with excellent biocompatibility,enhanced conductivity,and good mechanical properties.The resulting keratin liquid metal(KELM)hydrogel demonstrates favorable mechanical characteristics,including good tensile strength(166 kPa),impressive stretchability(2600%),and long-term stability.Furthermore,it exhibits good conductivity(6.84 S·m^(-1))and sensitivity as a sensing material(gauge factor(GF)=7.03),rendering it suitable for constructing high-performance strain sensors.Notably,the KELM hydrogel-based wearable electronics extend their functionality to monitoring marine inhabitants'health.This innovative application provides new insights for designing the next generation of biomimetic electronic devices,with potential applications in human-machine interfaces,electronic skin,artificial intelligence,and health monitoring.展开更多
In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when sim...In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when simulating biological cognition,as the overall synergy between multiple cognitive functions is difficult to represent.In this work,a high-performance heterojunction memristor is presented at first.The memristor-based neural network and functional circuit are further implemented to realize and integrate multiple cognitive functions.Specifically,the proposed photoelectric memristor has the structure of Ag/ZnO-SnO_(2)/WO_(3-x)/ITO,it exhibits various synaptic behaviors under external modulations,which are characterized by good stability and repeatability.Based on this device,a neural network is built to realize the basic recognition function in biological cognition.The recognition results are translated into different labelled voltage signals and subsequently fed into a memristor-based functional circuit.By leveraging memory characteristics and tunable conductance of the memristor,and controlling the specific circuit functionalities,the input signals are processed to produce different outputs representing various cognitive functions.This methodology allows the realization and integration of recognition,memory,learning,association,relearning,and forgetting into one single system,thereby enabling a more comprehensive and authentic simulation of biological cognition.This work presents a novel memristor and a method for achieving and integrating multiple neuromorphic computing functions within a single system,providing a successful example for achieving complete biological function.展开更多
Memristive devices based on in-memory computing architectures offer a promising strategy for overcoming the energy bottlenecks inherent in big data systems.However,uncontrolled ion migration at the material level rema...Memristive devices based on in-memory computing architectures offer a promising strategy for overcoming the energy bottlenecks inherent in big data systems.However,uncontrolled ion migration at the material level remains a key challenge,compromising device stability and hindering practical applications.Here,we employ a chemical optimization strategy that dynamically induces the precipitation of Ag atoms under applied voltage,creating fixed atomic sites to achieve precise control over ion migration,synergistically enhancing the memory and computing capabilities of the device.Compared to unoptimized samples,the proposed device exhibits an approximately 8-fold improvement in robustness,a 3-fold enhancement in stability,high mechanical endurance,and reliable multilevel data storage capability.We further construct a device array and incorporate an efficient reservoir computing model,achieving handwritten digit recognition with an accuracy of up to 90.81%.In summary,this work proposes a dynamic Ag/Ag^(+)anchoring strategy and demonstrates a memristor-based approach that integrates storage and computation to enable energy-efficient artificial intelligence processing,offering a scalable solution for sustainable intelligence in the big data era.展开更多
The limited ion/electron transport kinetics and insufficient crystalline stability of TiNb_(2)O_(7)(TNO)present significant challenges to the development of high-performance lithium-ion batteries(LIBs)with fastchargin...The limited ion/electron transport kinetics and insufficient crystalline stability of TiNb_(2)O_(7)(TNO)present significant challenges to the development of high-performance lithium-ion batteries(LIBs)with fastcharging capabilities and long cycle life.Here we propose a dual-modification strategy combining Ndoped carbon(NC)coating and Co^(2+)/W^(6+)doping,which not only enhances ionic and electronic conductivity but also effectively regulates volume expansion during electrochemical cycling.Upon Li+ion insertion,a significant reduction in the unit cell expansion coefficient of doped TNO is observed,from 7.48%(pristine TNO)to 5.37%(with 3%W^(6+)doping)and 4.65%(with 3%Co^(2+)doping),alo ng with lowered lattice distortion and improved uniformity in internal strain release.Density functional theory(DFT)simulation demonstrates that Co^(2+)and W^(6+)ions preferentially substitute Ti^(4+)sites in the TNO crystal,leading to the improved electronic conductivity by narrowing the bandgap.Moreover,Co^(2+)doping creates lower electron density and wider Li+ion transport channels than W^(6+)doping.The optimized 3Co-TNO@NC anode delivers a remarkable power density of 11.0 kW kg^(-1)at 20 C while maintaining a high reversible capacity of 150.9 mAh g^(-1)at 10 C after 2000 cycles.It also exhibits excellent compatibility in full cells,paired well with LiFePO_(4)(137.9 mAh g^(-1)after 2000 cycles)and Ni-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)(130.9 mAh g^(-1)after 500cycles)cathodes at 5 C,highlighting its potential as a high-safety,low-strain anode material for highpower LIBs.展开更多
The technology of carbon dioxide(CO_(2))enhanced hydrocarbon recovery is favored over other Carbon Capture,Utilization,and Sequestration(CCUS)methods for achieving the"double carbon"goal in China due to its ...The technology of carbon dioxide(CO_(2))enhanced hydrocarbon recovery is favored over other Carbon Capture,Utilization,and Sequestration(CCUS)methods for achieving the"double carbon"goal in China due to its ability to sequester CO_(2) geologically while enhancing the recovery rates of oil and gas resources.However,current technologies face significant challenges,such as limited recovery enhancement capacity,as well as high costs and low efficiency in carbon utilization and sequestration.To address these issues,an innovative carbon-negative technology termed Carbon Capture,Circular Utilization,and Sequestration(CCCUS)is proposed.This technology integrates CO_(2)-microbial enhanced hydrocarbon recovery,CO_(2) underground bio-methanation,and CO_(2) sequestration in depleted hydrocarbon reservoirs.Compared to conventional CCUS technologies,CCCUS stands out through both its modes of carbon utilization and the forms in which carbon exists,by cyclically biochemically converting endogenous and exogenous CO_(2) into renewable natural gas(RNG).A preliminary assessment indicates that CCCUS holds significant developmental potential in China,with 661 million tonnes of CO_(2) utilized per cycle and 3.47 billion tonnes ultimately sequestered.However,there is a significant lack of research on the core technology of CCCUS,specifically CO_(2) underground bio-methanation,in China.To bridge this gap and mitigate potential challenges during the development of CCCUS,targeted proposals have been formulated.This paper provides new insights into advancing the development of a circular carbon economy and accelerating the achievement of carbon neutrality in China.展开更多
Carbon capture,utilization,and storage(CCUS)represents a critical technological pathway for global car-bon emission reduction.CCUS-enhanced oil recovery(EOR)technology is the most feasible CCUS technol-ogy demonstrati...Carbon capture,utilization,and storage(CCUS)represents a critical technological pathway for global car-bon emission reduction.CCUS-enhanced oil recovery(EOR)technology is the most feasible CCUS technol-ogy demonstrating dual benefits of enhanced energy production and carbon reduction.This study comprehensively described the key influencing factors governing CO_(2)-EOR and geological storage and systematically analyzed reservoir properties,fluid characteristics,and operational parameters.The mech-anisms of these parameters on EOR versus CO_(2) storage performance were investigated throughout CCUS-EOR processes.This paper proposes a coupled two-stage CCUS-EOR process:CO_(2)-EOR storage stage and long-term CO_(2) storage stage after the CO_(2) injection phase is completed.In each stage,the main control factors impacting the CO_(2)-EOR and storage stages are screened and coupled with rigorous technical anal-ysis.The key factors here are reservoir properties,fluid characteristics,and operational parameter.A novel CCUS-EOR synergistic method was proposed to optimize the lifecycle performance of dual objective of EOR and storage.Furthermore,based on multi-objective optimization,considering the lifecycle,a multi-scale techno-economic evaluation method was proposed to fully assess the CCUS-EOR project per-formance.Finally,a set of recommendations for advancing CCUS-EOR technologies by deploying multi-factor/multi-field coupling methodologies,novel green intelligent injection materials,and artificial intel-ligence/machine learning technologies were visited.展开更多
基金funded by Science Foundation for Youth supported by Shanghai Municipal Health Commission(No.20204Y0313)Sailing Program with the support of Science and Technology Commission of Shanghai Municipality(No.21YF1443800).
文摘Background China is seeing a growing demand for rehabilitation treatments for post-stroke upper limb spastic paresis(PSSP-UL).Although acupuncture is known to be effective for PSSP-UL,there is room to enhance its efficacy.Objective This study explored a semi-personalized acupuncture approach for PSSP-UL that used three-dimensional kinematic analysis(3DKA)results to select additional acupoints,and investigated the feasibility,efficacy and safety of this approach.Design,setting,participants and interventions This single-blind,single-center,randomized,controlled trial involved 74 participants who experienced a first-ever ischemic or hemorrhagic stroke with spastic upper limb paresis.The participants were then randomly assigned to the intervention group or the control group in a 1:1 ratio.Both groups received conventional treatments and acupuncture treatment 5 days a week for 4 weeks.The main acupoints in both groups were the same,while participants in the intervention group received additional acupoints selected on the basis of 3DKA results.Follow-up assessments were conducted for 8 weeks after the treatment.Main outcome measures The primary outcome was the Fugl-Meyer Assessment for Upper Extremity(FMA-UE)response rate(≥6-point change)at week 4.Secondary outcomes included changes in motor function(FMA-UE),Brunnstrom recovery stage(BRS),manual muscle test(MMT),spasticity(Modified Ashworth Scale,MAS),and activities of daily life(Modified Barthel Index,MBI)at week 4 and week 12.Results Sixty-four participants completed the trial and underwent analyses.Compared with control group,the intervention group exhibited a significantly higher FMA-UE response rate at week 4(χ^(2)=5.479,P=0.019)and greater improvements in FMA-UE at both week 4 and week 12(both P<0.001).The intervention group also showed bigger improvements from baseline in the MMT grades for shoulder adduction and elbow flexion at weeks 4 and 12 as well as thumb adduction at week 4(P=0.007,P=0.049,P=0.019,P=0.008,P=0.029,respectively).The intervention group showed a better change in the MBI at both week 4 and week 12(P=0.004 and P=0.010,respectively).Although the intervention group had a higher BRS for the hand at week 12(P=0.041),no intergroup differences were observed at week 4(all P>0.05).The two groups showed no differences in MAS grades as well as in BRS for the arm at weeks 4 and 12(all P>0.05).Conclusion Semi-personalized acupuncture prescription based on 3DKA results significantly improved motor function,muscle strength,and activities of daily living in patients with PSSP-UL.
基金financially supported by the National Key Research and Development Program of China(2023YFD2000701)the Natural Science Foundation of Heilongjiang Province,China(YQ2023C011)+1 种基金the Key Research and Development Program of Heilongjiang Province,China(Grant no.2022ZX01A24)the Key Laboratory of Low-carbon Green Agriculture in Northeastern China,Ministry of Agriculture and Rural Affairs of China(LCGANE14)。
文摘As a major contributor to methane production in agriculture,there is a need for a suitable methane inhibitor to reduce ruminant methane emissions and minimize the impact on the climate.This work aimed to explore the influence of cordycepin on rumen fermentation,gas production,microbiome and their metabolites.A total of 0.00,0.08,0.16,0.32,and 0.64 g L^(–1)cordycepin were added into fermentation bottles containing 2 g total mixed ration for in vitro ruminal fermentation,and then the gas produced and fermentation parameters were measured for each bottle.Samples from the 0 and 0.64 g L^(–1)cordycepin addition were selected for 16S rRNA gene sequencing and metabolome analysis.The result of this experiment indicated that the addition of cordycepin could linearly increase the concentration of total volatile fatty acid,ammonia nitrogen,the proportion of propionate,valerate,and isovalerate,and linearly reduce ruminal pH and methane,carbon dioxide,hydrogen and total gas production,as well as the methane proportion,carbon dioxide proportion and proportion of butyrate.In addition,there was a quadratic relationship between hydrogen and cordycepin addition.At the same time,the relative abundance of Succiniclasticum,Prevotella,Rikenellaceae_RC9_gut_group,NK4A214_group,Christensenellaceae_R_(7)_group,unclassified_F082,Veillonellaceae_UCG_001,Dasytricha,Ophryoscolex,Isotricha,unclassified_Eukaryota,Methanobrevibacter,and Piromyces decreased significantly after adding the maximum dose of cordycepin.In contrast,the relative abundance of Succinivibrio,unclassified_Succinivibrionaceae,Prevotellaceae_UCG_001,unclassified_Lachnospiraceae,Lachnospira,Succinivibrionaceae_UCG_002,Pseudobutyrivibrio,Entodinium,Polyplastron,unclassified_Methanomethylophilaceae,Methanosphaera,and Candidatus_Methanomethylophilus increased significantly.Metabolic pathways such as biosynthesis of unsaturated fatty acids and purine metabolism and metabolites such as arachidonic acid,adenine,and 2′-deoxyguanosine were also affected by the addition of cordycepin.Based on this,we conclude that cordycepin is an effective methane emission inhibitor that can change the rumen metabolites and fermentation parameters by influencing the rumen microbiome,thus regulating rumen methane production.This experiment may provide a potential theoretical reference for developing Cordyceps byproduct or additives containing cordycepin as methane inhibitors.
基金supported by the National Key Research and Development Program of China(Grant Nos.2023YFA1406100,2018YFA0704200,2022YFA1403400 and 2021YFA1400400)the National Natural Science Foundation of China(Grant Nos.11822411 and 12274444)+2 种基金the Strategic Priority Research Program(B)of the CAS(Grant Nos.XDB25000000 and XDB33000000)K.C.Wong Education Foundation(GJTD-2020-01)AP by HBNI-RRCAT and MPCST under the FTYS program。
文摘Elucidating the relationship between spin excitations and fermiology is essential for clarifying the pairing mechanism in iron-based superconductors(FeSCs).Here,we report inelastic neutron scattering results on the hole overdoped Ba_(0.4)K_(0.6)Fe_(2)As_(2) near a Lifshitz transition,where the electron pocket at M point is nearly replaced by four hole pockets.In the normal state,the spin excitations is observed at incommensurate wave vectors with a chimney-like dispersion.By cooling down to the superconducting state,a neutron spin resonance mode emerges with a peak energy of Er=14-15 meV,weakly modulated along the L-direction.The incommensurability notably increases at low energies,giving rise to downward dispersions of the resonance mode.This behavior contrasts sharply with the upward dispersions of resonance observed in optimally doped Ba_(0.67)K_(0.33)Fe_(2)As_(2) contributed by the hole to electron scattering,but resembles those in KFe_(2)As_(2) and KCa_(2)Fe_(4)As_(4)F_(2) where the fermiology is dominated by hole pockets.These results highlight the critical role of electronic structure modifications near the Fermi level,especially in governing interband scattering under imperfect nesting conditions,which fundamentally shape the spin dynamics of FeSCs.
文摘Rare earths,as a strategic mineral resource,play a vital role in high-tech industries such as aerospace,national defense and military,electronic information,and new energy.With the accelerated evolution of the new round of technological revolution and industrial transformation,global supply chain security risks have become more prominent.The focus of major countries'resource security assurance has also shifted from bulk minerals to critical minerals.
基金Haoran Zhao would like to acknowledge the support provided by China Scholarship Council(CSC)of the Ministry of Education,P.R.China(CSC No.202206850006)supported by funding from VLAIO with project number(HBC.2023.0172),HEPPY Markers-Establishment of biomarkers of Health and Eubiosis in Pigs and Poultry.
文摘Extensive evidence demonstrates that a healthy and well-balanced gut microbiota profoundly influences host nutrient absorption,immunity,and metabolism.Unlike mammals,early microbiota colonization in commercial poultry largely depends on the environment as chicks hatch in incubators under a relatively sterile environment(egg and incubator sterilization)without maternal-offspring interaction.The early gut microbiota remains unsaturated,providing a critical window for modulation and influencing the subsequent microbiota succession,which may have long-term health outcomes.Microbiota transplantation(MT)involves transferring the microbiota from a donor to a recipient to modulate the recipient’s microbiota toward a desired state.Successfully applied in human medicine,MT is also gaining attention in poultry production to modulate intestinal health.This review comprehensively explores factors affecting MT,its mechanisms,and its potential applications in chickens,providing insights for further research and commercial use.
基金support from the following for aspects of the research,authorship,and/or publication of this article:National Natural Science Foundation of China(Grant No.12302187)Innovation Program of Wuhan-Shuguang Project(Grant No.202201080102).
文摘When the protective and protected systems are detached,the former can be allowed to absorb the kinetic energy of the impacting projectile through large deformation without considering the back face signature of the latter.This paper presents a novel double-face knitted fabric(DFKF)designed for this very impacting scenario.Shooting tests equipped with high-speed camera were used to characterize the ballistic performance with the impact velocities ranging from 100 m/s to 450 m/s.The results showed that the ballistic limits(V_(bl))of DFKF are approximately triple and double that of its counterpart UD and plain fabrics,respectively.For mass-normalized metrics,the specific energy absorption(SEA)is 250%and 350%greater than the UD and plain fabrics at their corresponding V_(bl)s.The quasi-static tests showed that the DFKF displayed greater resilience,crease recovery properties,and flexibility,which also made it an especially better candidate than UD and plain weaves for the design of umbrella surface cloth.It was also found that DFKF is dependent on yarn count and the incorporation of spandex.A prototype anti-ballistic umbrella is manufactured using DFKF made of 200D multi-filament yarn.The ballistic performance is also sensitive to the impact site when the umbrella is subjected to impact.
基金supported by the National Natural Science Foundation of China (32160292, 32471681, and 32201575)Jiangxi “Double Thousand Plan”(jxsq2020101080)+1 种基金the Natural Science Foundation of Jiangxi Province (20224BAB205008, 20224BAB213033, and 20242BAB2538)Jiangxi Province Science and Technology+Water Resources” Joint Plan Project (2023KSG01001 and 2022KSG01010)
文摘Accurately forecasting ecosystem services is critical for enhancing our understanding and improving management practices within nature reserves,particularly in light of climate change,land use/cover changes,and their complex interactions.However,existing studies often fail to fully consider vegetation response,constituting a gap in the comprehensive assessment of changes in ecosystem services.Therefore,a coupled model framework integrating climate change,land use change,and vegetation dynamics was developed to allow for the simulation of dynamic ecosystem service scenarios throughout the twenty-first century.The Jiulianshan National Nature Reserve in Jiangxi Province was considered as the study area.The results showed that ecosystem services and their synergistic effects will be optimized under scenarios that emphasize strict protection of ecological lands and incorporating the SSP1-2.6 scenario.However,sustaining optimized ecosystem services poses significant challenges in scenarios characterized by resource-intensive development and ongoing climate warming,as in the SSP5-8.5 scenario.Notably,discernible variations exist in balancing and synergizing the management of ecosystem services across diverse land uses and forest types.Our study underscores the importance of integrating vegetation response into the framework of ecosystem service forecasting,which is essential for assisting nature reserves in effectively addressing the multifaceted risks associated with climate change and rapid socio-economic development.
基金supported by the National Key Research&Development Program of China(Grant No.2020YFB1313504)the State Key Laboratory of Mechanics and Control for Aerospace Structures of Nanjing University of Aeronautics and Astronautics.
文摘Gecko-inspired robots have significant potential applications;however,deviations in the yaw direction during locomotion are inevitable for legged robots that lack external sensing.These deviations cause the robot to stray from its intended path.Therefore,a cost-effective and straightforward solution is essential for reducing this deviation.In nature,the tail is often used to maintain balance and stability.Similarly,it has been used in robots to improve manoeuvrability and stability.Our aim is to reduce this deviation using a morphological computation approach,specifically by adding a tail.To test this hypothesis,we investigated four different tails(rigid plate,rigid gecko-shaped,soft plate,and soft gecko-shaped)and assessed the deviation of the robot with these tails on different slopes.Additionally,to evaluate the influence of different tail parameters,such as material,shape,and linkage,we investigated the locomotion performance in terms of the robot's climbing speed on slopes,its ability to turn at narrow corners,and the resistance of the tails to external disturbances.A new auto-reset joint was designed to ensure that a disturbed tail could be quickly reset.Our results demonstrate that the yaw deviation of the robot can be reduced by applying a tail.Among the four tails,the soft gecko-shaped tail was the most effective for most tasks.In summary,our findings demonstrate the functional role of the tail in reducing yaw deviation,improving climbing ability and stability and provide a reference for selecting the most suitable tail for geckoinspired robots.
基金supported in part by the National Key Research and Development Project of China(No.2022YFC3004602)in part by the National Natural Science Foundation of China(Nos.52121003 and 52342403).
文摘Multistage fracturing technology has been used to enhance tight hydrocarbon resource recovery.Determining the proper well spacing and fracturing strategy is crucial for generating a complex fracture network that facilitates oil and gas flow in reservoirs.The stress-shadow effect that occurs between multiple wells significantly affects the development of fracture networks in reservoirs.However,the quantification of the stress-shadow effect and its influence on fracture networks has not been satisfactorily resolved because of the difficulties in detecting and identifying fracture propagation and reorientation in reservoirs.In this study,based on the geological information from the Shengli oilfield,we applied a hybrid finite element-discrete element method to analyze engineering-scale three-dimensional fracture propagation and reorientation by altering well spacings and fracturing strategies.The results indicate that the fracturing area generated by the synchronous fracturing scheme is much smaller than those generated by the sequential and alternative schemes.An alternative hydrofracturing scheme is optimal with respect to fracturing area.The stress-blind area was defined to quantify the mechanical disturbance between adjacent wells.Our study improves the understanding of the effect of fracturing schemes on fracture networks and the impact of independent factors contributing to stress-shadow effects.
基金supported by the National Natural Science Foundation of China(82571021,32070751 and 31871435)the Shanghai Natural Science Foundation(25ZR1401328)the Program for Overseas High-level talents at Shanghai Institutions of Higher Learning(TP2022100)。
文摘L-Theanine(LTA)is a non-protein amino acid mainly found in tea plants with many beneficial effects.Exercise exerts a wide range of benefits in metabolic health.Here,we show that exercise or gastric lavage intervention on mice with LTA improves diet-induced nonalcoholic steatohepatitis(NASH)in mice.Meanwhile,combinatory therapy shows that exercise and LTA synergistically improve obesity-related metabolic disorders and NASH phenotypes,including hepatic steatosis,inflammation,cell death and oxidative stress.In vivo studies indicate that LTA inhibits free fatty acid(FFA)-induced hepatocyte injury,including steatosis,oxidative stress and apoptosis.Knockdown of Nrf2 blunts the role of LTA in inhibiting FFA-induced hepatocyte oxidative stress and dysfunction.Mechanistically,LTA increases theα-ketoglutarate(α-KG)level in hepatocytes,which increases the transcription of Nrf2 by inducing active DNA demethylation on its promoter.Moreover,LTA promote the aboveα-KG/Nrf2 axis in synergy with exercise,thereby more efficiently inhibiting hepatic oxidative stress and ameliorating diet-induced NASH in mice.Our results suggest that,through promoting theα-KG/Nrf2 axis-mediated anti-oxidative pathway,the combination of LTA and exercise may provide an effective measure for the prevention and control of NASH.
基金supported by the National Natural Science Foundation of China(52106284,52422609)the Natural Science Foundation of Hebei Province(B2021507001)Key Research Special Project of CPPU(ZDZX202501)。
文摘As lithium-ion batteries(LIBs)continue to evolve toward lower costs and higher energy densities,their potential safety risks have become increasingly apparent.Incidents such as explosions at energy storage facilities,fires in electric vehicles,and building fires ignited by charging two-wheeled vehicles have been occurring with alarming frequency,often resulting in significant casualties and injuries.Conducting indepth investigations into thermal runaway(TR)incidents in LIBs can significantly reduce the risk of future occurrences.However,current investigations into LIB fire and explosion incidents face challenges due to the difficulty of conducting in-depth analyses and the lack of a robust theoretical framework to guide these investigations.To enhance the effectiveness of in-depth investigations into battery fire and explosion incidents and to address the lack of theoretical guidance,this paper is the first to systematically examine the conservation and flow patterns of elements during the TR process of LIBs.The analysis reveals that during TR,the gas products generated include approximately 1.5 g of H_(2),23.6 g of CO,88.4 g of CO_(2),8.9 g of C_(2)H_(4),7.3 g of CH_(4),3.7 g of C_(2)H_(6),and 82 g of electrolyte vapor.After TR,the solid compounds formed consist of approximately 2.5 g of LiF,29–92.2 g of elemental Ni/Co/Mn,11.4 g of Li_(2)CO_(3),200.6 g of graphite,1.4 g of NiO,29.6 g of MnO,30.1 g of CoO,67 g of elemental Cu,0.03 g of LiNiO_(2),and 4.3 g of LiAlO_(2).Importantly,the energy released from reactions forming solid compounds during TR surpasses that from gas-forming reactions.This investigation represents the first application of Hess’s law to verify the conservation of elements during the TR process of lithium-ion batteries.The proposed methodology is also applicable to other types of energy storage batteries,effectively advancing techniques for comprehensively investigating lithium battery fire and explosion incidents.
基金support from the Technology Project of the State Grid Zhejiang Electric Power Company,Ltd.(No.B311DS230005).
文摘Electrocatalytic carbon dioxide reduction(ECO_(2)RR)serves as a promising approach for converting CO_(2)into energy-dense fuels and high-value chemicals,garnering substantial interest across academic and industrial sectors.Copper(Cu)-based electrocatalysts are widely acknowledged as highly effective for ECO_(2)RR,primarily due to their optimal adsorption energy for*CO.Nonetheless,significant challenges remain to be addressed in transitioning Cu-based catalysts from research settings to industrial applications,including the low stability and unavoidable side reactions.This article aims to i)systematically examine the deactivation mechanisms of Cu-based catalysts,including changes in valence states,surface poisoning,and restructuring(agglomeration,dissolution,Ostwald ripening);ii)provide a timely overview of cutting-edge strategies to enhance the stability of Cu-based catalysts,such as ligand effects,heteroatom doping,support optimization,size effect,and restructuring;iii)highlight critical areas and prospective development directions that warrant further exploration to expedite the industrial adoption of Cu-based catalysts in ECO_(2)RR.
基金supported by the Beijing Natural Science Foundation,China(Grant No.:7222118)the National Natural Science Foundation of China(Grant No.:82073900)the CAMS Innovation Fund for Medical Sciences,China(CIFMS,Grant Nos.:2021-I2M-1-030,and 2021-I2M-1-028).
文摘Liver fibrosis is a vital cause of morbidity in patients with liver diseases and developing novel anti-fibrotic drugs is imperative.Isovalerylspiramycin I(ISP I)as a major component of carrimycin applied to upper respiratory infections,was first found to possess anti-fibrotic potential.The present study aims to evaluate the functions and mechanisms of ISP I in protecting against liver fibrosis.According to our results,ISP I not only reduced the expressions of fibrogenic markers in LX-2 cells but also appeared great protective effects on liver injury and liver fibrosis in bile duct ligation(BDL)rats and carbon tetrachloride(CCl4)mice.We proved that nucleotide-binding protein 2(NUBP2)was the direct target of ISP I.ISP I through targeting NUBP2,increased the amount of vascular non-inflammatory molecule-1(VNN1)on the cell membrane,which will inhibit oxidative stress and fibrosis.Simultaneously,the original carrimycin's protective effect on liver damage and fibrosis was verified.Therefore,our study provides potential agents for patients with liver fibrosis-related diseases,and the clear mechanism supports wide application in the clinic.
基金supported by the National Natural Science Foundation of China(22176221 and 22273045)the Central Public-interest Scientific Institution Basal Research Fund,Chinese Academy of Fishery Sciences(2024XT09)+1 种基金the Tsinghua University Independent Scientific Research Plan for Young Investigatorthe Tsinghua University Initiative Scientific Research Program。
文摘Wearable electronics incorporating proteins for biocompatibility have garnered significant research attention,given their potential applications in biocompatible medical devices,artificial skin,humanoid robots,and other fields.However,a notable challenge exists,as many wearable electronics currently lack those essential properties due to issues such as non-biological compatibility,as well as insufficient mechanical and conductive performance.Here,we have developed a hybrid keratin(KE)hydrogel by incorporating a liquid metal(LM,eutectic gallium-indium alloy)to design a wearable electronic device with excellent biocompatibility,enhanced conductivity,and good mechanical properties.The resulting keratin liquid metal(KELM)hydrogel demonstrates favorable mechanical characteristics,including good tensile strength(166 kPa),impressive stretchability(2600%),and long-term stability.Furthermore,it exhibits good conductivity(6.84 S·m^(-1))and sensitivity as a sensing material(gauge factor(GF)=7.03),rendering it suitable for constructing high-performance strain sensors.Notably,the KELM hydrogel-based wearable electronics extend their functionality to monitoring marine inhabitants'health.This innovative application provides new insights for designing the next generation of biomimetic electronic devices,with potential applications in human-machine interfaces,electronic skin,artificial intelligence,and health monitoring.
基金supported in part by the Shandong Provincial Natural Science Foundation of China under Grant ZR2023ZD03 and ZR2024QF183in part by the Taishan Scholars Project Special Funds under Grant tsqn202312035.
文摘In current memristor-based neuromorphic computing research,several studies face the challenge of realizing only a single function at a time or having isolated functions.This limitation is particularly evident when simulating biological cognition,as the overall synergy between multiple cognitive functions is difficult to represent.In this work,a high-performance heterojunction memristor is presented at first.The memristor-based neural network and functional circuit are further implemented to realize and integrate multiple cognitive functions.Specifically,the proposed photoelectric memristor has the structure of Ag/ZnO-SnO_(2)/WO_(3-x)/ITO,it exhibits various synaptic behaviors under external modulations,which are characterized by good stability and repeatability.Based on this device,a neural network is built to realize the basic recognition function in biological cognition.The recognition results are translated into different labelled voltage signals and subsequently fed into a memristor-based functional circuit.By leveraging memory characteristics and tunable conductance of the memristor,and controlling the specific circuit functionalities,the input signals are processed to produce different outputs representing various cognitive functions.This methodology allows the realization and integration of recognition,memory,learning,association,relearning,and forgetting into one single system,thereby enabling a more comprehensive and authentic simulation of biological cognition.This work presents a novel memristor and a method for achieving and integrating multiple neuromorphic computing functions within a single system,providing a successful example for achieving complete biological function.
基金supported by the National Natural Science Foundation of China(NSFC,no.61804063)the Natural Science Foundation of Jilin Province(nos.YDZJ202401307ZYTS and 20220201070GX)。
文摘Memristive devices based on in-memory computing architectures offer a promising strategy for overcoming the energy bottlenecks inherent in big data systems.However,uncontrolled ion migration at the material level remains a key challenge,compromising device stability and hindering practical applications.Here,we employ a chemical optimization strategy that dynamically induces the precipitation of Ag atoms under applied voltage,creating fixed atomic sites to achieve precise control over ion migration,synergistically enhancing the memory and computing capabilities of the device.Compared to unoptimized samples,the proposed device exhibits an approximately 8-fold improvement in robustness,a 3-fold enhancement in stability,high mechanical endurance,and reliable multilevel data storage capability.We further construct a device array and incorporate an efficient reservoir computing model,achieving handwritten digit recognition with an accuracy of up to 90.81%.In summary,this work proposes a dynamic Ag/Ag^(+)anchoring strategy and demonstrates a memristor-based approach that integrates storage and computation to enable energy-efficient artificial intelligence processing,offering a scalable solution for sustainable intelligence in the big data era.
基金support from the BRICS STI Framework Programme(No.52261145703)National Research Foundation+2 种基金Singapore under Award No.NRF-CRP24-2020-0002the Italy-Singapore Science and Technology Cooperation(Grant No.R23101R040)the use of computing resources at the A*STAR Computational Centre and National Supercomputer Centre,Singapore。
文摘The limited ion/electron transport kinetics and insufficient crystalline stability of TiNb_(2)O_(7)(TNO)present significant challenges to the development of high-performance lithium-ion batteries(LIBs)with fastcharging capabilities and long cycle life.Here we propose a dual-modification strategy combining Ndoped carbon(NC)coating and Co^(2+)/W^(6+)doping,which not only enhances ionic and electronic conductivity but also effectively regulates volume expansion during electrochemical cycling.Upon Li+ion insertion,a significant reduction in the unit cell expansion coefficient of doped TNO is observed,from 7.48%(pristine TNO)to 5.37%(with 3%W^(6+)doping)and 4.65%(with 3%Co^(2+)doping),alo ng with lowered lattice distortion and improved uniformity in internal strain release.Density functional theory(DFT)simulation demonstrates that Co^(2+)and W^(6+)ions preferentially substitute Ti^(4+)sites in the TNO crystal,leading to the improved electronic conductivity by narrowing the bandgap.Moreover,Co^(2+)doping creates lower electron density and wider Li+ion transport channels than W^(6+)doping.The optimized 3Co-TNO@NC anode delivers a remarkable power density of 11.0 kW kg^(-1)at 20 C while maintaining a high reversible capacity of 150.9 mAh g^(-1)at 10 C after 2000 cycles.It also exhibits excellent compatibility in full cells,paired well with LiFePO_(4)(137.9 mAh g^(-1)after 2000 cycles)and Ni-rich LiNi_(0.8)Co_(0.1)Mn_(0.1)(130.9 mAh g^(-1)after 500cycles)cathodes at 5 C,highlighting its potential as a high-safety,low-strain anode material for highpower LIBs.
基金funded by the European Union's“Horizon Europe programme”-LOC3G(Grant No.101129729)the Henan Center for Outstanding Overseas Scientists(Grant No.GZS2024001).
文摘The technology of carbon dioxide(CO_(2))enhanced hydrocarbon recovery is favored over other Carbon Capture,Utilization,and Sequestration(CCUS)methods for achieving the"double carbon"goal in China due to its ability to sequester CO_(2) geologically while enhancing the recovery rates of oil and gas resources.However,current technologies face significant challenges,such as limited recovery enhancement capacity,as well as high costs and low efficiency in carbon utilization and sequestration.To address these issues,an innovative carbon-negative technology termed Carbon Capture,Circular Utilization,and Sequestration(CCCUS)is proposed.This technology integrates CO_(2)-microbial enhanced hydrocarbon recovery,CO_(2) underground bio-methanation,and CO_(2) sequestration in depleted hydrocarbon reservoirs.Compared to conventional CCUS technologies,CCCUS stands out through both its modes of carbon utilization and the forms in which carbon exists,by cyclically biochemically converting endogenous and exogenous CO_(2) into renewable natural gas(RNG).A preliminary assessment indicates that CCCUS holds significant developmental potential in China,with 661 million tonnes of CO_(2) utilized per cycle and 3.47 billion tonnes ultimately sequestered.However,there is a significant lack of research on the core technology of CCCUS,specifically CO_(2) underground bio-methanation,in China.To bridge this gap and mitigate potential challenges during the development of CCCUS,targeted proposals have been formulated.This paper provides new insights into advancing the development of a circular carbon economy and accelerating the achievement of carbon neutrality in China.
基金the financial support from the National Key Research and Development Program of China(2022YFE0206700)the Science Foundation of China University of Petroleum,Beijing(2462021YJRC012).
文摘Carbon capture,utilization,and storage(CCUS)represents a critical technological pathway for global car-bon emission reduction.CCUS-enhanced oil recovery(EOR)technology is the most feasible CCUS technol-ogy demonstrating dual benefits of enhanced energy production and carbon reduction.This study comprehensively described the key influencing factors governing CO_(2)-EOR and geological storage and systematically analyzed reservoir properties,fluid characteristics,and operational parameters.The mech-anisms of these parameters on EOR versus CO_(2) storage performance were investigated throughout CCUS-EOR processes.This paper proposes a coupled two-stage CCUS-EOR process:CO_(2)-EOR storage stage and long-term CO_(2) storage stage after the CO_(2) injection phase is completed.In each stage,the main control factors impacting the CO_(2)-EOR and storage stages are screened and coupled with rigorous technical anal-ysis.The key factors here are reservoir properties,fluid characteristics,and operational parameter.A novel CCUS-EOR synergistic method was proposed to optimize the lifecycle performance of dual objective of EOR and storage.Furthermore,based on multi-objective optimization,considering the lifecycle,a multi-scale techno-economic evaluation method was proposed to fully assess the CCUS-EOR project per-formance.Finally,a set of recommendations for advancing CCUS-EOR technologies by deploying multi-factor/multi-field coupling methodologies,novel green intelligent injection materials,and artificial intel-ligence/machine learning technologies were visited.
