The high-Mg diorites, widely occurring in western Shandong, have important implications in the study of the relationship between the Mesozoic magmatism and the nature of the lithosphere and its thinning period in the ...The high-Mg diorites, widely occurring in western Shandong, have important implications in the study of the relationship between the Mesozoic magmatism and the nature of the lithosphere and its thinning period in the eastern North China craton （NCC）. The Tietonggou and Jinling intrusions are typically representatives. LA-ICP-MS zircon U-Pb dating, major and trace element and Sr-Nd isotopic compositions of the Mesozoic intrusive rocks from western Shandong, eastern China, were analyzed. The weighted mean 106^pb/ 238^U ages from LA-ICP-MS zircon U-Pb dating results for early norite-diorite, late pyroxene-diorite from the Tietonggou intrusion and biotite-diorite from the Jinling intrusion are （131.4±4.9） Ma（n=15）, （134. 5±2.3） Ma（n=13）, and （132.8±4. 2） Ma（n=12）, respectively, implying that they were formed in the Early Cretaceous. The weighted mean 207^pb/ 204^Pb ages for round zircons from late pyroxene-diorite in the Tietonggou intrusion is （ 2 513 ± 54） Ma（ n= 8）, suggesting that the basement of the North China craton should exist in the research area. The high-Mg diorites are characterized by enrichment in MgO, Na20, and light rare earth elements （LREE）, and they are poor in heavy rare earth elements （HREE） and high field strength elements （HFSE）, being similar to adakite. The existence of the mantle peridotite xenoliths with a high-Mg feature for these intrusive rocks implies that their primary magma should be derived from the upper mantle. However, Sr-Nd isotopic composi- tions （Is： 0.704 75--0.707 15;ENd （130 Ma） values： --3.95 to -- 13.30）, depletion in HFSE, and the occurrence of Archean inherited zircons suggest that crustal materials could be involved in the derivation of the primary magma. The compositional difference between the diorites from the Tietonggou and Jinling intrusions could be attributed to those of magma sources and degrees of partial melting. The Early Cretaceous high-Mg diorites are considered to have been formed by the mixed melting of the delaminated lithosphere （lithospheric mantle ＋ crust） and asthenosphere, based on their geochemistry, the mantlederived xenoliths, and the Early Mesozoic lithospheric evolutionary history of the eastern North China craton.展开更多
背景:多西环素可用于根除幽门螺杆菌(Hp)感染,但尚缺乏大样本研究证实其有效性和安全性。目的:探讨多西环素根除Hp感染的有效性和安全性。方法:检索中国知网、万方、维普和PubMed、Embase、Web of Science、Cochrane Library等数据库,...背景:多西环素可用于根除幽门螺杆菌(Hp)感染,但尚缺乏大样本研究证实其有效性和安全性。目的:探讨多西环素根除Hp感染的有效性和安全性。方法:检索中国知网、万方、维普和PubMed、Embase、Web of Science、Cochrane Library等数据库,收集比较多西环素和其他抗菌药物根除Hp感染的相关文献,检索时间均为建库至2023年10月。采用RevMan 5.3软件行meta分析。结果:最终纳入19篇文献、共3686例Hp感染患者。含多西环素方案的意向性治疗(ITT)根除率(82.51%对73.65%;OR=1.72,95%CI:1.42~2.07,P<0.00001)和按方案治疗(PP)根除率(88.96%对78.06%;OR=1.63,95%CI:1.28~2.06,P<0.0001)均显著高于非多西环素方案。含多西环素方案的不良反应发生率显著低于非多西环素方案(8.35%对15.01%;OR=0.55,95%CI:0.42~0.71,P<0.00001)。亚组分析显示含多西环素方案的Hp根除率与含阿莫西林方案(OR=1.09,95%CI:0.78~1.52,P=0.61)、含四环素方案(OR=0.87,95%CI:0.33~2.26,P=0.77)相比无明显差异,但显著高于含克拉霉素方案(OR=2.67,95%CI:1.84~3.88,P<0.00001)和含左氧氟沙星方案(OR=2.20,95%CI:1.50~3.22,P<0.0001)。结论:含多西环素方案的Hp根除率显著高于非多西环素方案,且不良反应发生率低,值得临床推广应用。展开更多
Chronology and geochemistry of the Shangyu gabbro-diorite in western Shandong were studied to understand their petrogenesis and the nature of the Mesozoic lithospheric mantle. The Shangyu intru-sion is mainly composed...Chronology and geochemistry of the Shangyu gabbro-diorite in western Shandong were studied to understand their petrogenesis and the nature of the Mesozoic lithospheric mantle. The Shangyu intru-sion is mainly composed of a suite of gabbro-diorite. Zircons from the intrusion display eu-hedral-subhedral in shape and have high Th/U ratios (1.23―2.87), implying their magmatic origin. LA-ICP-MS zircon U-Pb dating results for two samples indicate that they were formed in the Early Cre-taceous, yielding weighted mean 206Pb/238U ages of 129±1Ma and 134±2Ma, respectively. Except for early cumulate such as sample QT-19, their SiO2 and MgO contents range from 50.12% to 56.37% and from 3.52% to 6.37%, respectively. Moreover, the gabbro-diorites are characterized by high Mg# (0.54―0.63), enrichment in Na (Na2O/K2O ratios more than 1), Cr (73×10-6―217×10-6) and Ni (34×10-6―241×10-6), and intensive enrichments in light rare earth elements (LREEs) and large ion lithophile elements (LILEs) and depletion in high field strength elements (HFSEs). Their initial 87Sr/86Sr ratios and ε Nd(t) values range from 0.70962 to 0.71081 and from-16.60 to-13.04, respectively. Taken together with the Early Creta-ceous high-Mg diorites and the mantle xenoliths from the Tietonggou and Jinling as well as basalts from the Fangcheng and Feixian, it is suggested that the primary magma for the Shangyu gab-bro-diorites should be derived from the enriched lithospheric mantle intensively modified by conti-nental crust. The Sr-Nd-Pb isotopic compositions for the Early Cretaceous high-Mg diorites in western Shandong display a trend of spatial variations, i.e., initial 87Sr/86Sr, 207Pb/204Pb and 208Pb/204Pb ratios de-creasing and ε Nd(t) values increasing from southeast to northwest in western Shandong, which is con-sistent with the tectonic model that the Yangtze Craton subducted beneath the North China Craton oriented in north-west direction in the Early Mesozoic.展开更多
文摘The high-Mg diorites, widely occurring in western Shandong, have important implications in the study of the relationship between the Mesozoic magmatism and the nature of the lithosphere and its thinning period in the eastern North China craton （NCC）. The Tietonggou and Jinling intrusions are typically representatives. LA-ICP-MS zircon U-Pb dating, major and trace element and Sr-Nd isotopic compositions of the Mesozoic intrusive rocks from western Shandong, eastern China, were analyzed. The weighted mean 106^pb/ 238^U ages from LA-ICP-MS zircon U-Pb dating results for early norite-diorite, late pyroxene-diorite from the Tietonggou intrusion and biotite-diorite from the Jinling intrusion are （131.4±4.9） Ma（n=15）, （134. 5±2.3） Ma（n=13）, and （132.8±4. 2） Ma（n=12）, respectively, implying that they were formed in the Early Cretaceous. The weighted mean 207^pb/ 204^Pb ages for round zircons from late pyroxene-diorite in the Tietonggou intrusion is （ 2 513 ± 54） Ma（ n= 8）, suggesting that the basement of the North China craton should exist in the research area. The high-Mg diorites are characterized by enrichment in MgO, Na20, and light rare earth elements （LREE）, and they are poor in heavy rare earth elements （HREE） and high field strength elements （HFSE）, being similar to adakite. The existence of the mantle peridotite xenoliths with a high-Mg feature for these intrusive rocks implies that their primary magma should be derived from the upper mantle. However, Sr-Nd isotopic composi- tions （Is： 0.704 75--0.707 15;ENd （130 Ma） values： --3.95 to -- 13.30）, depletion in HFSE, and the occurrence of Archean inherited zircons suggest that crustal materials could be involved in the derivation of the primary magma. The compositional difference between the diorites from the Tietonggou and Jinling intrusions could be attributed to those of magma sources and degrees of partial melting. The Early Cretaceous high-Mg diorites are considered to have been formed by the mixed melting of the delaminated lithosphere （lithospheric mantle ＋ crust） and asthenosphere, based on their geochemistry, the mantlederived xenoliths, and the Early Mesozoic lithospheric evolutionary history of the eastern North China craton.
文摘背景:多西环素可用于根除幽门螺杆菌(Hp)感染,但尚缺乏大样本研究证实其有效性和安全性。目的:探讨多西环素根除Hp感染的有效性和安全性。方法:检索中国知网、万方、维普和PubMed、Embase、Web of Science、Cochrane Library等数据库,收集比较多西环素和其他抗菌药物根除Hp感染的相关文献,检索时间均为建库至2023年10月。采用RevMan 5.3软件行meta分析。结果:最终纳入19篇文献、共3686例Hp感染患者。含多西环素方案的意向性治疗(ITT)根除率(82.51%对73.65%;OR=1.72,95%CI:1.42~2.07,P<0.00001)和按方案治疗(PP)根除率(88.96%对78.06%;OR=1.63,95%CI:1.28~2.06,P<0.0001)均显著高于非多西环素方案。含多西环素方案的不良反应发生率显著低于非多西环素方案(8.35%对15.01%;OR=0.55,95%CI:0.42~0.71,P<0.00001)。亚组分析显示含多西环素方案的Hp根除率与含阿莫西林方案(OR=1.09,95%CI:0.78~1.52,P=0.61)、含四环素方案(OR=0.87,95%CI:0.33~2.26,P=0.77)相比无明显差异,但显著高于含克拉霉素方案(OR=2.67,95%CI:1.84~3.88,P<0.00001)和含左氧氟沙星方案(OR=2.20,95%CI:1.50~3.22,P<0.0001)。结论:含多西环素方案的Hp根除率显著高于非多西环素方案,且不良反应发生率低,值得临床推广应用。
基金the National Natural Science Foundation of China (Grant No. 40472033)the State Key Laboratory of Continental Dynamics, Northwest Uni-versity
文摘Chronology and geochemistry of the Shangyu gabbro-diorite in western Shandong were studied to understand their petrogenesis and the nature of the Mesozoic lithospheric mantle. The Shangyu intru-sion is mainly composed of a suite of gabbro-diorite. Zircons from the intrusion display eu-hedral-subhedral in shape and have high Th/U ratios (1.23―2.87), implying their magmatic origin. LA-ICP-MS zircon U-Pb dating results for two samples indicate that they were formed in the Early Cre-taceous, yielding weighted mean 206Pb/238U ages of 129±1Ma and 134±2Ma, respectively. Except for early cumulate such as sample QT-19, their SiO2 and MgO contents range from 50.12% to 56.37% and from 3.52% to 6.37%, respectively. Moreover, the gabbro-diorites are characterized by high Mg# (0.54―0.63), enrichment in Na (Na2O/K2O ratios more than 1), Cr (73×10-6―217×10-6) and Ni (34×10-6―241×10-6), and intensive enrichments in light rare earth elements (LREEs) and large ion lithophile elements (LILEs) and depletion in high field strength elements (HFSEs). Their initial 87Sr/86Sr ratios and ε Nd(t) values range from 0.70962 to 0.71081 and from-16.60 to-13.04, respectively. Taken together with the Early Creta-ceous high-Mg diorites and the mantle xenoliths from the Tietonggou and Jinling as well as basalts from the Fangcheng and Feixian, it is suggested that the primary magma for the Shangyu gab-bro-diorites should be derived from the enriched lithospheric mantle intensively modified by conti-nental crust. The Sr-Nd-Pb isotopic compositions for the Early Cretaceous high-Mg diorites in western Shandong display a trend of spatial variations, i.e., initial 87Sr/86Sr, 207Pb/204Pb and 208Pb/204Pb ratios de-creasing and ε Nd(t) values increasing from southeast to northwest in western Shandong, which is con-sistent with the tectonic model that the Yangtze Craton subducted beneath the North China Craton oriented in north-west direction in the Early Mesozoic.
