The primary objective of Cartilage Tissue Engineering(CTE)involves repairing or rebuilding impaired cartilage in an effort to restore joint functionality and enhance patients'quality of life.In this field,research...The primary objective of Cartilage Tissue Engineering(CTE)involves repairing or rebuilding impaired cartilage in an effort to restore joint functionality and enhance patients'quality of life.In this field,researchers are constantly exploring new materials and technologies to address the challenges posed by cartilage damage.Biomimetic hydrogels present several distinct advantages in articular cartilage repair when compared to conventional treatment methods like minimally invasive surgery,joint replacement,and drug therapies.These hydrogels effectively mimic the mechanical characteristics of natural cartilage while also promoting cell adhesion,proliferation,and differentiation through the inclusion of bioactive factors.This results in the creation of high-performance biomaterials,positioning them as a particularly promising therapeutic option.Recently,researchers have drawn inspiration from the intricate structures found in soft tissues to develop various types of biomimetic hydrogels.These innovative hydrogels find applications across various fields,such as biomedicine,tissue engineering,and flexible electronics.In tissue engineering,these materials serve as optimal scaffolds for cartilage regeneration and aid in restoring tissue function.Nevertheless,creating and manufacturing biomimetic hydrogels with complex designs,strong mechanical properties,and multifunctionality poses significant challenges.This paper reviews existing studies on natural and synthetic matrices for biomimetic hydrogels,explores the similarities between these hydrogels and natural cartilage,examines their biological and physical characteristics,discusses their advantages and limitations,and suggests future research avenues.展开更多
Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usual...Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment failure.In this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during surgery.Briefly,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in SOG.Once applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like phenotype.Meanwhile,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell activation.Our data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single administration.MSL@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers.展开更多
Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial interest.We employ a precision muffle furnace...Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial interest.We employ a precision muffle furnace at a series of increasing temperatures up to 340℃to study the oxidation behavior of continuous MoS_(2)films by either directly growing mono-and fewlayer MoS_(2)on SiO_(2)/Si substrate,or by mechanically transferring monolayer MoS_(2)or hexagonal boron nitride(h-BN)onto monolayer MoS_(2)substrate.Results show that monolayer MoS_(2)can withstand high temperature at 340℃with less oxidation while the few-layer MoS_(2)films are completely oxidized just at 280℃,resulting from the growth-induced tensile strain in few-layer MoS_(2).When the tensile strain of films is released by transfer method,the stacked few-layer MoS_(2)films exhibit superior thermal stability and typical layer-by-layer oxidation behavior at similarly high temperature.Counterintuitively,for the MoS_(2)/h-BN heterostructure,the h-BN film itself stacked on top is not damaged and forms many bubbles at 340℃,whereas the underlying monolayer MoS_(2)film is oxidized completely.By comprehensively using various experimental characterization and molecular dynamics calculations,such anomalous oxidation behavior of MoS_(2)/h-BN heterostructure is mainly due to the increased tensile strain in MoS_(2)film at elevated temperature.展开更多
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at t...Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in carcinogenesis.Therefore,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures.In this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise nanomedicine.Additionally,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.展开更多
Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical...Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical medicine of food and medicine continuum.It has a long history of medicinal applications and edible food in China.In this paper,the origin,biological active components,pharmacological action and clinical application of leek roots were introduced.We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications,as well as related health products.展开更多
In the domain of medical image analysis,there is a burgeoning recognition and adoption of large models distinguished by their extensive parameter count and intricate neural network architecture that is predominantly d...In the domain of medical image analysis,there is a burgeoning recognition and adoption of large models distinguished by their extensive parameter count and intricate neural network architecture that is predominantly due to their outstanding performance.This review article seeks to concisely explore the historical evolution,specific applications,and training methodologies associated with these large models considering their current prominence in medical image analysis.Moreover,we delve into the prevailing challenges and prospective opportunities related to the utilization of large models in the context of medical image analysis.Through a comprehensive analysis of these substantial models,this study aspires to provide valuable insights and guidance to researchers in the field of radiology,fostering further advances and optimizations in their incorporation into medical image analysis practices,in accordance with the submission requirements.展开更多
基金supported by the Shandong Provincial Natural Science Foundation(for the preparation of bionic scaffolds for bone and cartilage repair and their osteogenic wear resistance study)(ZR2022ME086).
文摘The primary objective of Cartilage Tissue Engineering(CTE)involves repairing or rebuilding impaired cartilage in an effort to restore joint functionality and enhance patients'quality of life.In this field,researchers are constantly exploring new materials and technologies to address the challenges posed by cartilage damage.Biomimetic hydrogels present several distinct advantages in articular cartilage repair when compared to conventional treatment methods like minimally invasive surgery,joint replacement,and drug therapies.These hydrogels effectively mimic the mechanical characteristics of natural cartilage while also promoting cell adhesion,proliferation,and differentiation through the inclusion of bioactive factors.This results in the creation of high-performance biomaterials,positioning them as a particularly promising therapeutic option.Recently,researchers have drawn inspiration from the intricate structures found in soft tissues to develop various types of biomimetic hydrogels.These innovative hydrogels find applications across various fields,such as biomedicine,tissue engineering,and flexible electronics.In tissue engineering,these materials serve as optimal scaffolds for cartilage regeneration and aid in restoring tissue function.Nevertheless,creating and manufacturing biomimetic hydrogels with complex designs,strong mechanical properties,and multifunctionality poses significant challenges.This paper reviews existing studies on natural and synthetic matrices for biomimetic hydrogels,explores the similarities between these hydrogels and natural cartilage,examines their biological and physical characteristics,discusses their advantages and limitations,and suggests future research avenues.
基金supported by the National Natural Science Foundation of China[grant numbers 21873057,22373059]the Natural Science Foundation of Shandong Province[grant numbers ZR2023MB082]。
文摘Despite standard treatment for non-small cell lung cancer(NSCLC)being surgical resection,cancer recurrence and complications,such as induction of malignant pleural effusion(MPE)and significant postoperative pain,usually result in treatment failure.In this study,an alginate-based hybrid hydrogel(SOG)is developed that can be injected into the resection surface of the lungs during surgery.Briefly,endoplasmic reticulum-modified liposomes(MSLs)pre-loaded with the signal transducer and activator of transcription 3(STAT3)small interfering RNA and lidocaine hydrochloride are encapsulated in SOG.Once applied,MSLs strongly downregulated STAT3 expression in the tumor microenvironment,resulting in the apoptosis of lung cancer cells and polarization of tumor-associated macrophages towards the M1-like phenotype.Meanwhile,the release of lidocaine hydrochloride(LID)was beneficial for pain relief and natural killer cell activation.Our data demonstrated MSL@LID@SOG not only efficiently inhibited tumor growth but also potently improved the quality of life,including reduced MPE volume and pain relief in orthotopic NSCLC mouse models,even with a single administration.MSL@LID@SOG shows potential for comprehensive clinical management upon tumor resection in NSCLC,and may alter the treatment paradigms for other cancers.
基金the National Natural Science Foundation of China(No.52005489)Ningbo 3315 Innovation Team(No.2020A-03-C)+1 种基金the China Postdoctoral Science Fund(Nos.2021T140685 and 2019M662126)the Natural Science Foundation of Zhejiang Province(No.LR20E050001).
文摘Because of profound applications of two-dimensional molybdenum disulfide(MoS_(2))and its heterostructures in electronics,its thermal stability has been spurred substantial interest.We employ a precision muffle furnace at a series of increasing temperatures up to 340℃to study the oxidation behavior of continuous MoS_(2)films by either directly growing mono-and fewlayer MoS_(2)on SiO_(2)/Si substrate,or by mechanically transferring monolayer MoS_(2)or hexagonal boron nitride(h-BN)onto monolayer MoS_(2)substrate.Results show that monolayer MoS_(2)can withstand high temperature at 340℃with less oxidation while the few-layer MoS_(2)films are completely oxidized just at 280℃,resulting from the growth-induced tensile strain in few-layer MoS_(2).When the tensile strain of films is released by transfer method,the stacked few-layer MoS_(2)films exhibit superior thermal stability and typical layer-by-layer oxidation behavior at similarly high temperature.Counterintuitively,for the MoS_(2)/h-BN heterostructure,the h-BN film itself stacked on top is not damaged and forms many bubbles at 340℃,whereas the underlying monolayer MoS_(2)film is oxidized completely.By comprehensively using various experimental characterization and molecular dynamics calculations,such anomalous oxidation behavior of MoS_(2)/h-BN heterostructure is mainly due to the increased tensile strain in MoS_(2)film at elevated temperature.
基金supported by the National Natural Science Foundation of China(Grant No.21873057)Shandong Provincial Natural Science Foundation of China(Grant No.ZR2019MB041)+1 种基金the Major Basic Research Project of Shandong Natural Science Foundation,P.R.China(Grant No.ZR2018ZC0232)the Fundamental Research Funds of Shandong University(Grant No.2018JC006).
文摘Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets.The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level,which play a key role in carcinogenesis.Therefore,to improve the therapeutic efficiency of drugs,researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures.In this review,we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations,aiming at providing guidance in the overall design of precise nanomedicine.Additionally,future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.
基金supported by grants from Key project of Natural Science Foundation of Gansu Province(No.22JR5RA407)Lanzhou Science and Technology Planning Project(No.2020-XG-33)。
文摘Some Chinese herbs have been used to prevent and treat diseases,and are also used as common food ingredients.These Chinese herbs are potential resource for research and development of new drugs.Leek roots is a typical medicine of food and medicine continuum.It has a long history of medicinal applications and edible food in China.In this paper,the origin,biological active components,pharmacological action and clinical application of leek roots were introduced.We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications,as well as related health products.
基金funding from the National Key Research and Development Program of China under Grant Nos.2021YFC2500402,2017YFA0700401,2022YFC2503700,and 2022YFC2503705the Ministry of Science and Technology of China under Grant No.2017YFA0205200+1 种基金the National Natural Science Foundation of China under Grant Nos.82001917,81930053,82090052,62027901,81227901,92159202,U22A2023,U22A20343,and 82172039the Project of High-Level Talents Team Introduction in Zhuhai City(Zhuhai HLHPTP201703).
文摘In the domain of medical image analysis,there is a burgeoning recognition and adoption of large models distinguished by their extensive parameter count and intricate neural network architecture that is predominantly due to their outstanding performance.This review article seeks to concisely explore the historical evolution,specific applications,and training methodologies associated with these large models considering their current prominence in medical image analysis.Moreover,we delve into the prevailing challenges and prospective opportunities related to the utilization of large models in the context of medical image analysis.Through a comprehensive analysis of these substantial models,this study aspires to provide valuable insights and guidance to researchers in the field of radiology,fostering further advances and optimizations in their incorporation into medical image analysis practices,in accordance with the submission requirements.
