Recently,Jayabalan et al published an important study.The authors defined the liver outcome score as a novel biomarker for predicting liver-related mortality in patients with autoimmune hepatitis-primary biliary chola...Recently,Jayabalan et al published an important study.The authors defined the liver outcome score as a novel biomarker for predicting liver-related mortality in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome.After thoroughly reviewing their work,we offer insights that primarily relate to their study design to enhance the medical community’s understanding of this complex disease.展开更多
This article discusses the findings presented by Zhang et al.They analyzed the risk factors and clinical characteristics associated with Klebsiella pneumoniae infection in patients with liver cirrhosis treated at a ho...This article discusses the findings presented by Zhang et al.They analyzed the risk factors and clinical characteristics associated with Klebsiella pneumoniae infection in patients with liver cirrhosis treated at a hospital in Beijing.In this article,we focus on the connection between chronic kidney disease and the intestinal microbiota,and propose microbiota transplantation as a potential treatment for this patient group.We also examine an intriguing phenomenon related to hepatic encephalopathy,and provide insights into the future research.展开更多
Microwave–optical entanglement is essential for efficient quantum communication,secure information transfer,and integrating microwave and optical quantum systems to advance hybrid quantum technologies.In this work,we...Microwave–optical entanglement is essential for efficient quantum communication,secure information transfer,and integrating microwave and optical quantum systems to advance hybrid quantum technologies.In this work,we demonstrate how the magnon Kerr effect can be harnessed to generate and control nonreciprocal entanglement in cavity optomagnomechanics(COMM).This effect induces magnon frequency shifts and introduces pair-magnon interactions,both of which are tunable through the magnetic field direction,enabling nonreciprocal behavior.By adjusting system parameters such as magnon frequency detuning,we show that magnon–phonon,microwave–optical photon–photon,and optical photon–magnon entanglement can be nonreciprocally enhanced and rendered more robust against thermal noise.Additionally,the nonreciprocity of entanglement can be selectively controlled,and ideal nonreciprocal entanglement is achievable.This work paves the way for designing nonreciprocal quantum devices across the microwave and optical regimes,leveraging the unique properties of the magnon Kerr effect in COMM.展开更多
BACKGROUND Ralstonia is a Gram-negative non-fermentative bacterium widespread in nature,and includes four species,Ralstonia pickettii,Ralstonia solanacearum,Ralstonia mannitolilytica,and Ralstonia insidiosa,which were...BACKGROUND Ralstonia is a Gram-negative non-fermentative bacterium widespread in nature,and includes four species,Ralstonia pickettii,Ralstonia solanacearum,Ralstonia mannitolilytica,and Ralstonia insidiosa,which were proposed in 2003.Ralstonia is mainly found in the external water environment,including municipal and medical water purification systems.This bacterium has low toxicity and is a conditional pathogen.It has been reported in recent years that infections due to Ralstonia are increasing.Previous studies have shown that most cases of infection are caused by Ralstonia pickettii,a few by Ralstonia mannitolilytica,and infections caused by Ralstonia insidiosa are rare.CASE SUMMARY A 2-year-old Chinese child suffered from intermittent fever and cough for 20 d and was admitted to hospital with bronchial pneumonia.Bronchoscopy and alveolar lavage fluid culture confirmed Ralstonia insidiosa pneumonia.The infection was well controlled after treatment with meropenem and azithromycin.CONCLUSION Ralstonia infections are increasing,and we report a rare case of Ralstonia insidiosa infection in a child.Clinicians should be vigilant about Ralstonia infections.展开更多
To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport processes.However,most current CO_(2) s...To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport processes.However,most current CO_(2) sequestration models do not adequately consider multiple transport mechanisms.Moreover,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and decision-making.In this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training database.On this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and inversion.By incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion processes.Furthermore,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated scenarios.The validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise sources.This study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.展开更多
Al_(2)O_(3)-ZrO_(2)-TiO_(2)coatings were successfully prepared by plasma spraying Al_(2)O_(3)-ZrO_(2)composite powders with and without TiO_(2)addition.The effects of TiO_(2)on the phase composition,microstructure and...Al_(2)O_(3)-ZrO_(2)-TiO_(2)coatings were successfully prepared by plasma spraying Al_(2)O_(3)-ZrO_(2)composite powders with and without TiO_(2)addition.The effects of TiO_(2)on the phase composition,microstructure and properties of the Al_(2)O_(3)-ZrO_(2)coating were studied.The results show that the Al_(2)O_(3)-ZrO_(2)-TiO_(2)composite powder was composed of t-ZrO_(2),a-Al_(2)O_(3),m-ZrO_(2)and rutile,while the Al_(2)O_(3)-ZrO_(2)-TiO_(2)composite coating consisted of t-ZrO_(2),a-Al_(2)O_(3)and c-Al_(2)O_(3).The diffraction peaks of TiO_(2)could not be detected in the Al_(2)O_(3)-ZrO_(2)-TiO_(2)coating even up to10 wt%TiO_(2)addition.The reason may be that TiO_(2)was dissolved in the amorphous phase or formed solid solution with c-Al_(2)O_(3)phase in the coating during cooling.Compared with the Al_(2)O_(3)-ZrO_(2)coating,the as-prepared Al_(2)O_(3)-ZrO_(2)-TiO_(2)coating had denser microstructure,less microcracks and more amorphous phases.The density of the Al_(2)O_(3)-ZrO_(2)-TiO_(2)coating increased with the increase of TiO_(2)content.The Al_(2)O_(3)-ZrO_(2)-10 wt%TiO_(2)coating had the most uniform and dense microstructure,possessed higher toughness,adhesive strength and wear resistance compared with the Al_(2)O_(3)-ZrO_(2)coating,which was due to its lower porosity and more uniform microstructure.展开更多
The Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite coatings were prepared by plasma spraying Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)and Al−Cr2O3−SiC composite powders,respectively.The microstructure,formation mechanism and proper...The Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite coatings were prepared by plasma spraying Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)and Al−Cr2O3−SiC composite powders,respectively.The microstructure,formation mechanism and properties of the two Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite coatings obtained by plasma spraying were investigated,and the reaction mechanism of the Al−Cr_(2)O_(3)−SiC system was explored.The results show that the coating obtained by plasma spraying Al−Cr_(2)O_(3)−SiC composite powders had thinner lamella and more tortuous interlayer interface,and the in-situ synthesized Cr_(7)C_(3),CrSi_(2)and Al_(2)O_(3)in the coating were all nano-crystallines.Compared with the Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)coating prepared by plasma spraying Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite powders,the plasma-sprayed Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)coating obtained from Al−Cr_(2)O_(3)−SiC composite powders had higher density,higher microhardness(increased by 20%),better fracture toughness and lower wear rate(reduced by 28%).展开更多
By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285 with 1,2,3-triazole as linker,eight novel 6-substituted-4-aminoquinazolin derivatives...By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285 with 1,2,3-triazole as linker,eight novel 6-substituted-4-aminoquinazolin derivatives were synthesized and characterized by -1H NMR,-（13）C NMR,and high resolution mass spectrometry.Their inhibitory activities against five enzymes（VEGFR2,HER2,EGFR,HDAC1,and HDAC6） and five cancer cell lines（A549,BT-474,A431,SK-BR-3,and NCI-H1975） were evaluated.The bioassay results show that the introduction of triazole linked vorinostat-like segment dramatically changed the selectivity profiles of newly synthetic compounds relative to vandetanib,BMS-690514,neratinib,and TAK-285.Among them,compound 6b exerted outstanding enzymatic and cellular activities through its simultaneous and synergistic inhibitions on multiple pathways,which might have the great potential to confer the better benefits than single-targeted inhibitors in cancer therapy.展开更多
A new nanostructured ZrB_(2)-ZrC composite coating with ZrB_(2)-ZrC nanoscale eutectic and ZrB_(2)+Amorphous microstructure was synthesized in situ by plasma spraying Zr-B_(4)C-Al composite powder.The thermal analysis...A new nanostructured ZrB_(2)-ZrC composite coating with ZrB_(2)-ZrC nanoscale eutectic and ZrB_(2)+Amorphous microstructure was synthesized in situ by plasma spraying Zr-B_(4)C-Al composite powder.The thermal analysis,quenching experiments and microstructure characterization were investigated and the formation mechanism of the bimodal in-situ microstructure was revealed.Al contributed to the liquid phase separation of molten droplets,which is the key to forming ZrB2+Amorphous microstructure.The formation of coating followed reaction-melting-liquid separation-deposition and solidification mechanism.The nanostructured ZrB_(2)-ZrC composite coating with Al-O intergranular amorphous phase has excellent mechanical properties.The uniform nano-grains improved the hardness and the toughness of the ZrB_(2)-ZrC eutectic.The ZrB_(2)+Al-O amorphous microstructure obtained high toughness and the toughening mechanism was the crack deflection and crack branching caused by intergranular Al-O amorphous phase.展开更多
基金Supported by The Key Research and Development Project of the Science and Technology Department of Sichuan Province,China,No.2023YFS0280The High-Level Research Initiation Fund of The First Affiliated Hospital of Chengdu Medical College,China,No.CYFY-GQ43.
文摘Recently,Jayabalan et al published an important study.The authors defined the liver outcome score as a novel biomarker for predicting liver-related mortality in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome.After thoroughly reviewing their work,we offer insights that primarily relate to their study design to enhance the medical community’s understanding of this complex disease.
基金Supported by the Key Research and Development Project of the Science and Technology Department of Sichuan Province,China,No.2023YFS0280the High-level Research Initiation Fund Program of the First Affiliated Hospital of Chengdu Medical College,China,No.CYFY-GQ43.
文摘This article discusses the findings presented by Zhang et al.They analyzed the risk factors and clinical characteristics associated with Klebsiella pneumoniae infection in patients with liver cirrhosis treated at a hospital in Beijing.In this article,we focus on the connection between chronic kidney disease and the intestinal microbiota,and propose microbiota transplantation as a potential treatment for this patient group.We also examine an intriguing phenomenon related to hepatic encephalopathy,and provide insights into the future research.
基金supported by the Natural Science Foundation of Zhejiang Province(Grant No.LY24A040004)the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(Grant No.2025C01028)+2 种基金the Shenzhen International Quantum Academy(Grant No.SIQA2024KFKT010)YWW is supported by the Natural Science Foundation of Zhejiang Province(Grant No.LY23A40002)Wenzhou Science and Technology Plan Project(Grant No.L20240004).
文摘Microwave–optical entanglement is essential for efficient quantum communication,secure information transfer,and integrating microwave and optical quantum systems to advance hybrid quantum technologies.In this work,we demonstrate how the magnon Kerr effect can be harnessed to generate and control nonreciprocal entanglement in cavity optomagnomechanics(COMM).This effect induces magnon frequency shifts and introduces pair-magnon interactions,both of which are tunable through the magnetic field direction,enabling nonreciprocal behavior.By adjusting system parameters such as magnon frequency detuning,we show that magnon–phonon,microwave–optical photon–photon,and optical photon–magnon entanglement can be nonreciprocally enhanced and rendered more robust against thermal noise.Additionally,the nonreciprocity of entanglement can be selectively controlled,and ideal nonreciprocal entanglement is achievable.This work paves the way for designing nonreciprocal quantum devices across the microwave and optical regimes,leveraging the unique properties of the magnon Kerr effect in COMM.
文摘BACKGROUND Ralstonia is a Gram-negative non-fermentative bacterium widespread in nature,and includes four species,Ralstonia pickettii,Ralstonia solanacearum,Ralstonia mannitolilytica,and Ralstonia insidiosa,which were proposed in 2003.Ralstonia is mainly found in the external water environment,including municipal and medical water purification systems.This bacterium has low toxicity and is a conditional pathogen.It has been reported in recent years that infections due to Ralstonia are increasing.Previous studies have shown that most cases of infection are caused by Ralstonia pickettii,a few by Ralstonia mannitolilytica,and infections caused by Ralstonia insidiosa are rare.CASE SUMMARY A 2-year-old Chinese child suffered from intermittent fever and cough for 20 d and was admitted to hospital with bronchial pneumonia.Bronchoscopy and alveolar lavage fluid culture confirmed Ralstonia insidiosa pneumonia.The infection was well controlled after treatment with meropenem and azithromycin.CONCLUSION Ralstonia infections are increasing,and we report a rare case of Ralstonia insidiosa infection in a child.Clinicians should be vigilant about Ralstonia infections.
基金This work is funded by National Natural Science Foundation of China(Nos.42202292,42141011)the Program for Jilin University(JLU)Science and Technology Innovative Research Team(No.2019TD-35).The authors would also like to thank the reviewers and editors whose critical comments are very helpful in preparing this article.
文摘To reduce CO_(2) emissions in response to global climate change,shale reservoirs could be ideal candidates for long-term carbon geo-sequestration involving multi-scale transport processes.However,most current CO_(2) sequestration models do not adequately consider multiple transport mechanisms.Moreover,the evaluation of CO_(2) storage processes usually involves laborious and time-consuming numerical simulations unsuitable for practical prediction and decision-making.In this paper,an integrated model involving gas diffusion,adsorption,dissolution,slip flow,and Darcy flow is proposed to accurately characterize CO_(2) storage in depleted shale reservoirs,supporting the establishment of a training database.On this basis,a hybrid physics-informed data-driven neural network(HPDNN)is developed as a deep learning surrogate for prediction and inversion.By incorporating multiple sources of scientific knowledge,the HPDNN can be configured with limited simulation resources,significantly accelerating the forward and inversion processes.Furthermore,the HPDNN can more intelligently predict injection performance,precisely perform reservoir parameter inversion,and reasonably evaluate the CO_(2) storage capacity under complicated scenarios.The validation and test results demonstrate that the HPDNN can ensure high accuracy and strong robustness across an extensive applicability range when dealing with field data with multiple noise sources.This study has tremendous potential to replace traditional modeling tools for predicting and making decisions about CO_(2) storage projects in depleted shale reservoirs.
基金the National Natural Science Foundation of China(Nos.51672067,51541208 and 51102074)the Natural Science Foundation of Hebei Province(Nos.E2018202034 and E2015202070)+1 种基金the Talent Training Project in Hebei Province(No.A2016002026)the Top Talents in Universities in Hebei Province(No.SLRC2017027)。
文摘Al_(2)O_(3)-ZrO_(2)-TiO_(2)coatings were successfully prepared by plasma spraying Al_(2)O_(3)-ZrO_(2)composite powders with and without TiO_(2)addition.The effects of TiO_(2)on the phase composition,microstructure and properties of the Al_(2)O_(3)-ZrO_(2)coating were studied.The results show that the Al_(2)O_(3)-ZrO_(2)-TiO_(2)composite powder was composed of t-ZrO_(2),a-Al_(2)O_(3),m-ZrO_(2)and rutile,while the Al_(2)O_(3)-ZrO_(2)-TiO_(2)composite coating consisted of t-ZrO_(2),a-Al_(2)O_(3)and c-Al_(2)O_(3).The diffraction peaks of TiO_(2)could not be detected in the Al_(2)O_(3)-ZrO_(2)-TiO_(2)coating even up to10 wt%TiO_(2)addition.The reason may be that TiO_(2)was dissolved in the amorphous phase or formed solid solution with c-Al_(2)O_(3)phase in the coating during cooling.Compared with the Al_(2)O_(3)-ZrO_(2)coating,the as-prepared Al_(2)O_(3)-ZrO_(2)-TiO_(2)coating had denser microstructure,less microcracks and more amorphous phases.The density of the Al_(2)O_(3)-ZrO_(2)-TiO_(2)coating increased with the increase of TiO_(2)content.The Al_(2)O_(3)-ZrO_(2)-10 wt%TiO_(2)coating had the most uniform and dense microstructure,possessed higher toughness,adhesive strength and wear resistance compared with the Al_(2)O_(3)-ZrO_(2)coating,which was due to its lower porosity and more uniform microstructure.
基金the National Natural Science Foundation of China(No.52072110)the Natural Science Foundation of Hebei Province,China(No.E2018202034).
文摘The Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite coatings were prepared by plasma spraying Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)and Al−Cr2O3−SiC composite powders,respectively.The microstructure,formation mechanism and properties of the two Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite coatings obtained by plasma spraying were investigated,and the reaction mechanism of the Al−Cr_(2)O_(3)−SiC system was explored.The results show that the coating obtained by plasma spraying Al−Cr_(2)O_(3)−SiC composite powders had thinner lamella and more tortuous interlayer interface,and the in-situ synthesized Cr_(7)C_(3),CrSi_(2)and Al_(2)O_(3)in the coating were all nano-crystallines.Compared with the Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)coating prepared by plasma spraying Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)composite powders,the plasma-sprayed Cr_(7)C_(3)−CrSi_(2)−Al_(2)O_(3)coating obtained from Al−Cr_(2)O_(3)−SiC composite powders had higher density,higher microhardness(increased by 20%),better fracture toughness and lower wear rate(reduced by 28%).
基金supported by funding from the National Natural Science Foundation of China(No.21272134)Shenzhen Municipal Government(No.CXB201104210014A and20150113A0410006)
文摘By combining the core pharmacophores of HDAC inhibitor vorinostat and kinase inhibitors vandetanib,BMS-690514,neratinib,and TAK-285 with 1,2,3-triazole as linker,eight novel 6-substituted-4-aminoquinazolin derivatives were synthesized and characterized by -1H NMR,-（13）C NMR,and high resolution mass spectrometry.Their inhibitory activities against five enzymes（VEGFR2,HER2,EGFR,HDAC1,and HDAC6） and five cancer cell lines（A549,BT-474,A431,SK-BR-3,and NCI-H1975） were evaluated.The bioassay results show that the introduction of triazole linked vorinostat-like segment dramatically changed the selectivity profiles of newly synthetic compounds relative to vandetanib,BMS-690514,neratinib,and TAK-285.Among them,compound 6b exerted outstanding enzymatic and cellular activities through its simultaneous and synergistic inhibitions on multiple pathways,which might have the great potential to confer the better benefits than single-targeted inhibitors in cancer therapy.
基金supports of the National Natural Science Foundation of China(Nos.52371063 and 52072110)the Natural Science Foundation of Hebei Province(No.E2018202034)the Central Funds Guiding the Local Science and Technology Development of Hebei Province(No.236Z7610G).
文摘A new nanostructured ZrB_(2)-ZrC composite coating with ZrB_(2)-ZrC nanoscale eutectic and ZrB_(2)+Amorphous microstructure was synthesized in situ by plasma spraying Zr-B_(4)C-Al composite powder.The thermal analysis,quenching experiments and microstructure characterization were investigated and the formation mechanism of the bimodal in-situ microstructure was revealed.Al contributed to the liquid phase separation of molten droplets,which is the key to forming ZrB2+Amorphous microstructure.The formation of coating followed reaction-melting-liquid separation-deposition and solidification mechanism.The nanostructured ZrB_(2)-ZrC composite coating with Al-O intergranular amorphous phase has excellent mechanical properties.The uniform nano-grains improved the hardness and the toughness of the ZrB_(2)-ZrC eutectic.The ZrB_(2)+Al-O amorphous microstructure obtained high toughness and the toughening mechanism was the crack deflection and crack branching caused by intergranular Al-O amorphous phase.
