Diabetes is an urgent health issue characterized by ethnic and regional variations,and is inseparable from the differ-ent dietary habits.It is worthy to note that the incidence of diabetes in Bai nationality has been ...Diabetes is an urgent health issue characterized by ethnic and regional variations,and is inseparable from the differ-ent dietary habits.It is worthy to note that the incidence of diabetes in Bai nationality has been reported to be much lower than Han in China.As a daily vegetable of Bai,the phytochemical and antidiabetic study of Ottelia acuminata var.acuminata had not been carried out.In this study,41 metabolites with diverse diarylheptanoid(six new ones,Otteacumienes A-F),flavone,sesquiterpenoid,coumarin,lignan,polyacetylene,and alkaloid skeletons were charac-terized from O.acuminata var.acuminata.Among them,the racemic nature of 3 was characterized by chiral resolution and calculated ECD methods.The biological study revealed diarylheptanoids showed significantα-glucosidase inhibi-tory activities with 5 as the most effective one(60-fold stronger than acarbose).Molecular docking studies indicated that these structures have different binding cavities with acarbose.This study demonstrated that O.acuminata var.acuminata might correlated with the low incidence diabetes of Bai and the diarylheptanoids may have potential therapeutic value for diabetes mellitus.展开更多
A series of dearomatized isoprenylated acylphloroglucinols derivatives,hyperhenols A-E(1-5),as well as seven known analogues(6-12),were characterized from Hypericum henryi.Their structures were determined by combinati...A series of dearomatized isoprenylated acylphloroglucinols derivatives,hyperhenols A-E(1-5),as well as seven known analogues(6-12),were characterized from Hypericum henryi.Their structures were determined by combination of NMR,ECD spectroscopy,and X-ray difraction analysis.Compounds 1 and 6-8 were tested to exhibit potential antitumor properties,of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest.In addition,these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines,as well as suppress lung cancer A549 cells metastasis in vitro.展开更多
Adamantane polycyclic polyprenylated acylphloroglucinols(PPAPs)with caged architecture,a special class of hybrid natural products,is specifically rich in the plant family Guttiferae,especially Hypericum or Garcinia ge...Adamantane polycyclic polyprenylated acylphloroglucinols(PPAPs)with caged architecture,a special class of hybrid natural products,is specifically rich in the plant family Guttiferae,especially Hypericum or Garcinia genus.Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile.Here we have chosen,screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation.Particularly,the compound,hypersamp-sone P,blunted the adipocyte differentiation dose-dependently.Moreover,hypersampsone P down-regulated the expressions of several key regulators for adipogenesis,including PPARγand FABP4.The treatment of cells at the early stage of adipo-genesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.展开更多
Six new polyphenols with diferent isoprenylated xanthones,isoprenylated acylphloroglucinols,and chromone architectures,hyperfaberols A-F(1-6),were isolated from the whole plants of Hypericum faberi along with seven ot...Six new polyphenols with diferent isoprenylated xanthones,isoprenylated acylphloroglucinols,and chromone architectures,hyperfaberols A-F(1-6),were isolated from the whole plants of Hypericum faberi along with seven other related known compounds.In which hyperfaberols A/B(1/2)and 12-13 were isoprenylated xanthones,hyperfaberols C-E(3-5)and 8-11 were seven isoprenylated acylphloroglucinol derivatives,while 6-7 were two chromones.Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data.Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line(ECA-109)and the pancreatic tumor cell line(PANC-1)in vitro,respectively.展开更多
Correction to:Natural Products and Bioprospecting(2019)9:215–221 https://doi.org/10.1007/s13659-019-0206-1 In the original publication the corresponding author appeared incorrectly as Xin-Wen Zhang.The corrected text...Correction to:Natural Products and Bioprospecting(2019)9:215–221 https://doi.org/10.1007/s13659-019-0206-1 In the original publication the corresponding author appeared incorrectly as Xin-Wen Zhang.The corrected text is given below:The corresponding author of the article is Gang Xu.Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/),which permits unrestricted use,distribution,and reproduction in any medium,provided you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.展开更多
基金supported financially by the Second Tibetan Plateau Scientific Expedition and Research program (2019QZKK0502)State Key Laboratory of Phytochemistry and Plant Resources in West China (E0230211Z1 and P2019-ZZ05).
文摘Diabetes is an urgent health issue characterized by ethnic and regional variations,and is inseparable from the differ-ent dietary habits.It is worthy to note that the incidence of diabetes in Bai nationality has been reported to be much lower than Han in China.As a daily vegetable of Bai,the phytochemical and antidiabetic study of Ottelia acuminata var.acuminata had not been carried out.In this study,41 metabolites with diverse diarylheptanoid(six new ones,Otteacumienes A-F),flavone,sesquiterpenoid,coumarin,lignan,polyacetylene,and alkaloid skeletons were charac-terized from O.acuminata var.acuminata.Among them,the racemic nature of 3 was characterized by chiral resolution and calculated ECD methods.The biological study revealed diarylheptanoids showed significantα-glucosidase inhibi-tory activities with 5 as the most effective one(60-fold stronger than acarbose).Molecular docking studies indicated that these structures have different binding cavities with acarbose.This study demonstrated that O.acuminata var.acuminata might correlated with the low incidence diabetes of Bai and the diarylheptanoids may have potential therapeutic value for diabetes mellitus.
基金supported by the NSFC-Joint Foundation of Yunnan Province(U1902213)Chongqing Municipal Natural Science Foundation(cstc2018jcyjAX0388)+3 种基金the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502)Southeast Asia Biodiversity Research Institute,CAS(2017CASSEABRIQG003)State Key Laboratory of Phytochemistry and Plant Resources in West China(P2017-KF02 and P2019-ZZ05)the Natural Sciences Foundation of Yunnan Province(2019FA003).
文摘A series of dearomatized isoprenylated acylphloroglucinols derivatives,hyperhenols A-E(1-5),as well as seven known analogues(6-12),were characterized from Hypericum henryi.Their structures were determined by combination of NMR,ECD spectroscopy,and X-ray difraction analysis.Compounds 1 and 6-8 were tested to exhibit potential antitumor properties,of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest.In addition,these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines,as well as suppress lung cancer A549 cells metastasis in vitro.
基金supported by Yunnan Provincial Science and Technology Department,China(2017FA044)Chongqing Municipal Natural Science Foundation(cstc2018jcyjAX0388).
文摘Adamantane polycyclic polyprenylated acylphloroglucinols(PPAPs)with caged architecture,a special class of hybrid natural products,is specifically rich in the plant family Guttiferae,especially Hypericum or Garcinia genus.Hypersampsone P is one of Adamantane PPAPs compounds extracted from Hypericum subsessile.Here we have chosen,screened ten PPAPs and identified one of them showed an activity in inhibiting of adipocytes differentiation.Particularly,the compound,hypersamp-sone P,blunted the adipocyte differentiation dose-dependently.Moreover,hypersampsone P down-regulated the expressions of several key regulators for adipogenesis,including PPARγand FABP4.The treatment of cells at the early stage of adipo-genesis by hypersampsone P induced the greatest blunting of adipocyte differentiation and the effect might be involved in the LKB1-AMPK signaling pathway.
基金supported by the foundations from Kunming Institute of Botany(KIB2017001)Southeast Asia Biodiversity Research Institute(2017CASSEABRIQG003)CAS,and Yunnan Key Laboratory of Natural Medicinal Chemistry(S2017-ZZ11 and 2015-ZZ07).
文摘Six new polyphenols with diferent isoprenylated xanthones,isoprenylated acylphloroglucinols,and chromone architectures,hyperfaberols A-F(1-6),were isolated from the whole plants of Hypericum faberi along with seven other related known compounds.In which hyperfaberols A/B(1/2)and 12-13 were isoprenylated xanthones,hyperfaberols C-E(3-5)and 8-11 were seven isoprenylated acylphloroglucinol derivatives,while 6-7 were two chromones.Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data.Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line(ECA-109)and the pancreatic tumor cell line(PANC-1)in vitro,respectively.
文摘Correction to:Natural Products and Bioprospecting(2019)9:215–221 https://doi.org/10.1007/s13659-019-0206-1 In the original publication the corresponding author appeared incorrectly as Xin-Wen Zhang.The corrected text is given below:The corresponding author of the article is Gang Xu.Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/),which permits unrestricted use,distribution,and reproduction in any medium,provided you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons license,and indicate if changes were made.
