Compared to other energy sources,nuclear reactors offer several advantages as a spacecraft power source,including compact size,high power density,and long operating life.These qualities make nuclear power an ideal ene...Compared to other energy sources,nuclear reactors offer several advantages as a spacecraft power source,including compact size,high power density,and long operating life.These qualities make nuclear power an ideal energy source for future deep space exploration.A whole system model of the space nuclear reactor consisting of the reactor neutron kinetics,reactivity control,reactor heat transfer,heat exchanger,and thermoelectric converter was developed.In addition,an electrical power control system was designed based on the developed dynamic model.The GRS method was used to quantitatively calculate the uncertainty of coupling parameters of the neutronics,thermal-hydraulics,and control system for the space reactor.The Spearman correlation coefficient was applied in the sensitivity analysis of system input parameters to output parameters.The calculation results showed that the uncertainty of the output parameters caused by coupling parameters had the most considerable variation,with a relative standard deviation<2.01%.Effective delayed neutron fraction was most sensitive to electrical power.To obtain optimal control performance,the non-dominated sorting genetic algorithm method was employed to optimize the controller parameters based on the uncertainty quantification calculation.Two typical transient simulations were conducted to test the adaptive ability of the optimized controller in the uncertainty dynamic system,including 100%full power(FP)to 90%FP step load reduction transient and 5%FP/min linear variable load transient.The results showed that,considering the influence of system uncertainty,the optimized controller could improve the response speed and load following accuracy of electrical power control,in which the effectiveness and superiority have been verified.展开更多
The genus Synalpheus （Decapoda： Alpheidae） from China seas is reviewed. Thirty one species belonging to this genus are described and illustrated in the present paper, including 4 new species and 6 newly recorded sp...The genus Synalpheus （Decapoda： Alpheidae） from China seas is reviewed. Thirty one species belonging to this genus are described and illustrated in the present paper, including 4 new species and 6 newly recorded species from the China seas as following： S. brevrostrus sp. nov., S. jinqingensis sp. nov., S. liui sp. nov., S. tonkinensis sp. nov., S. biunguiculatus （Stimpson, 1860）, S. gracilirostris de Man, 1910, S. iphinoe de Man, 1909, S. lophodactylus Coutiere, 1908, S. modestus de Man, 1909 and S. mortenseni Banners, 1985. A key to 31 species of the genus Synalpheus from China seas is provided.展开更多
Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis and limited first-line treatments.This phaseⅠb/Ⅱrandomized trial(NCT05218889)investigated the efficacy and safety of surufatinib plus camrelizumab and nab-p...Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis and limited first-line treatments.This phaseⅠb/Ⅱrandomized trial(NCT05218889)investigated the efficacy and safety of surufatinib plus camrelizumab and nab-paclitaxel/S-1(NASCA)versus nab-paclitaxel and gemcitabine in patients with locally advanced or metastatic PDAC.The primary endpoints were dose-limiting toxicities and the recommended phaseⅡdose(RP2D)of surufatinib in phase lb,and the objective response rate(ORR)in phaseⅡ.PhaseⅠb used a 3+3 dose-escalation design to determine the RP2D of surufatinib in six patients,which was established at 200 mg.In phaseⅡ,patients were randomized 1∶1 to receive the NASCA(45 patients)or nab-paclitaxel and gemcitabine(45 patients).NASCA group showed an ORR of 51.1%(23/45)versus 24.4%(11/45)in the nab-paclitaxel and gemcitabine group(odds ratio 3.2,95%CI 1.3-8.2,p=0.01).The median progression-free survival(PFS)was 7.9 vs.5.3 months(HR 0.63,95%CI 0.40-0.99,p=0.045).The median overall survival was 13.0 vs.11.0 months(HR 0.77,95%CI 0.47-1.28,p=0.318).The most common Grade≥3 treatment-related adverse event was decreased neutrophil count(33.3%vs.35.6%).In the NASCA group,enrichment of CD8+and CD8+PD-1+cells,a high baseline M1/M2 macrophage ratio,and a reduction in CA19-9 levels at weeks 6 and 12 were associated with improved PFS compared to patients without these features.The NASCA regimen showed promising efficacy with tolerable safety relative to nab-paclitaxel and gemcitabine for locally advanced or metastatic PDAC.展开更多
Objective:The aim is to study the effects of metformin on the expression of 70 kDa ribosomal protein S6 kinase(P70S6k),insulin receptor substrate 1(IRS-1),and IRS-1Ser307 phosphorylation in human luteinized granulosa ...Objective:The aim is to study the effects of metformin on the expression of 70 kDa ribosomal protein S6 kinase(P70S6k),insulin receptor substrate 1(IRS-1),and IRS-1Ser307 phosphorylation in human luteinized granulosa cells.Methods:Granulosa cells in the experimental group were cultured in M199 medium containing 0.1 mmol/L metformin for 24 h and those in control group were cultured in M199 medium.The expression levels of P70S6k and IRS-1 mRNA were detected by reverse-transcriptiom polymerase chain reaction(RT-PCR)and real-time PCR.P70S6k,IRS-1,p-ser307-IRS-1,and p-thr389-P70S6k protein expression levels were detected by immunofluorescence and western blotting.Results:P70S6k mRNA level was higher and IRS-1 was significantly lower in the experimental group than those in the control group.IRS-1 and p-ser307-IRS-1 were expressed in cell plasma,and P70S6k and p-thr389-P70S6k were expressed in cell nucleus.The results of Western blot analysis indicated that the expression levels of P70S6k,p-thr389-P70S6k,IRS-1,and p-ser307-IRS-1 proteins had significant difference between the experimental group and the control group.Compared to the control group,the relative intensity illustrated that the expression levels of P70S6K and p-thr389-P70S6k significantly increased in the experimental group;however,those of IRS-1 and p-ser307-IRS-1 proteins significantly decreased.Conclusion:Metformin can inhibit the P70S6k mRNA and protein expression levels in the granulosa cells and improve insulin sensitivity by regulating IRS-1 expression through Akt/P70S6k/IRS-1-dependent pathway.展开更多
基金supported by the National Natural Science Foundation of China(12305185)Natural Science Foundation of Hunan Province,China(No.2023JJ50122)+1 种基金International Cooperative Research Project of the Ministry of Education,China(No.HZKY20220355)Scientific Research Foundation of the Education Department of Hunan Province,China(No.22A0307).
文摘Compared to other energy sources,nuclear reactors offer several advantages as a spacecraft power source,including compact size,high power density,and long operating life.These qualities make nuclear power an ideal energy source for future deep space exploration.A whole system model of the space nuclear reactor consisting of the reactor neutron kinetics,reactivity control,reactor heat transfer,heat exchanger,and thermoelectric converter was developed.In addition,an electrical power control system was designed based on the developed dynamic model.The GRS method was used to quantitatively calculate the uncertainty of coupling parameters of the neutronics,thermal-hydraulics,and control system for the space reactor.The Spearman correlation coefficient was applied in the sensitivity analysis of system input parameters to output parameters.The calculation results showed that the uncertainty of the output parameters caused by coupling parameters had the most considerable variation,with a relative standard deviation<2.01%.Effective delayed neutron fraction was most sensitive to electrical power.To obtain optimal control performance,the non-dominated sorting genetic algorithm method was employed to optimize the controller parameters based on the uncertainty quantification calculation.Two typical transient simulations were conducted to test the adaptive ability of the optimized controller in the uncertainty dynamic system,including 100%full power(FP)to 90%FP step load reduction transient and 5%FP/min linear variable load transient.The results showed that,considering the influence of system uncertainty,the optimized controller could improve the response speed and load following accuracy of electrical power control,in which the effectiveness and superiority have been verified.
基金supported by the National Natural Science Foundation of China(31172054)partly supported by the project of the S&T basic work from the Ministry of Science and Technology of China(2014FY110500,2015FY210300)
文摘The genus Synalpheus （Decapoda： Alpheidae） from China seas is reviewed. Thirty one species belonging to this genus are described and illustrated in the present paper, including 4 new species and 6 newly recorded species from the China seas as following： S. brevrostrus sp. nov., S. jinqingensis sp. nov., S. liui sp. nov., S. tonkinensis sp. nov., S. biunguiculatus （Stimpson, 1860）, S. gracilirostris de Man, 1910, S. iphinoe de Man, 1909, S. lophodactylus Coutiere, 1908, S. modestus de Man, 1909 and S. mortenseni Banners, 1985. A key to 31 species of the genus Synalpheus from China seas is provided.
基金supported by Chinese National Natural Science Foundation Project(82272643)Beijing Natural Science Foundation Project(7232163,7252130).
文摘Pancreatic ductal adenocarcinoma(PDAC)has a poor prognosis and limited first-line treatments.This phaseⅠb/Ⅱrandomized trial(NCT05218889)investigated the efficacy and safety of surufatinib plus camrelizumab and nab-paclitaxel/S-1(NASCA)versus nab-paclitaxel and gemcitabine in patients with locally advanced or metastatic PDAC.The primary endpoints were dose-limiting toxicities and the recommended phaseⅡdose(RP2D)of surufatinib in phase lb,and the objective response rate(ORR)in phaseⅡ.PhaseⅠb used a 3+3 dose-escalation design to determine the RP2D of surufatinib in six patients,which was established at 200 mg.In phaseⅡ,patients were randomized 1∶1 to receive the NASCA(45 patients)or nab-paclitaxel and gemcitabine(45 patients).NASCA group showed an ORR of 51.1%(23/45)versus 24.4%(11/45)in the nab-paclitaxel and gemcitabine group(odds ratio 3.2,95%CI 1.3-8.2,p=0.01).The median progression-free survival(PFS)was 7.9 vs.5.3 months(HR 0.63,95%CI 0.40-0.99,p=0.045).The median overall survival was 13.0 vs.11.0 months(HR 0.77,95%CI 0.47-1.28,p=0.318).The most common Grade≥3 treatment-related adverse event was decreased neutrophil count(33.3%vs.35.6%).In the NASCA group,enrichment of CD8+and CD8+PD-1+cells,a high baseline M1/M2 macrophage ratio,and a reduction in CA19-9 levels at weeks 6 and 12 were associated with improved PFS compared to patients without these features.The NASCA regimen showed promising efficacy with tolerable safety relative to nab-paclitaxel and gemcitabine for locally advanced or metastatic PDAC.
基金supported by the Science Technology Research Project of Higher Education of Ningxia Province(NGY2016125)the Open Project of Key Laboratory of Fertility Preservation and Maintenance,Ministry of Education(XY201518)。
文摘Objective:The aim is to study the effects of metformin on the expression of 70 kDa ribosomal protein S6 kinase(P70S6k),insulin receptor substrate 1(IRS-1),and IRS-1Ser307 phosphorylation in human luteinized granulosa cells.Methods:Granulosa cells in the experimental group were cultured in M199 medium containing 0.1 mmol/L metformin for 24 h and those in control group were cultured in M199 medium.The expression levels of P70S6k and IRS-1 mRNA were detected by reverse-transcriptiom polymerase chain reaction(RT-PCR)and real-time PCR.P70S6k,IRS-1,p-ser307-IRS-1,and p-thr389-P70S6k protein expression levels were detected by immunofluorescence and western blotting.Results:P70S6k mRNA level was higher and IRS-1 was significantly lower in the experimental group than those in the control group.IRS-1 and p-ser307-IRS-1 were expressed in cell plasma,and P70S6k and p-thr389-P70S6k were expressed in cell nucleus.The results of Western blot analysis indicated that the expression levels of P70S6k,p-thr389-P70S6k,IRS-1,and p-ser307-IRS-1 proteins had significant difference between the experimental group and the control group.Compared to the control group,the relative intensity illustrated that the expression levels of P70S6K and p-thr389-P70S6k significantly increased in the experimental group;however,those of IRS-1 and p-ser307-IRS-1 proteins significantly decreased.Conclusion:Metformin can inhibit the P70S6k mRNA and protein expression levels in the granulosa cells and improve insulin sensitivity by regulating IRS-1 expression through Akt/P70S6k/IRS-1-dependent pathway.
