Pelvic floor disorders(PFDs)represent a group of common and frequentlyoccurring diseases that seriously affect the life quality of women,generally including stress urinary incontinence and pelvic organ prolapse.Surger...Pelvic floor disorders(PFDs)represent a group of common and frequentlyoccurring diseases that seriously affect the life quality of women,generally including stress urinary incontinence and pelvic organ prolapse.Surgery has been used as a treatment for PFD,but almost 30%of patients require subsequent surgery due to a high incidence of postoperative complications and high recurrence rates.Therefore,investigations of new therapeutic strategies are urgently needed.Stem cells possess strong multi-differentiation,self-renewal,immunomodulation,and angiogenesis abilities and they are able to differentiate into various cell types of pelvic floor tissues and thus provide a potential therapeutic approach for PFD.Recently,various studies using different autologous stem cells have achieved promising results by improving the pelvic ligament and muscle regeneration and conferring the tissue elasticity and strength to the damaged tissue in PFD,as well as reduced inflammatory reactions,collagen deposition,and foreign body reaction.However,with relatively high rates of complications such as bladder stone formation and wound infections,further studies are necessary to investigate the role of stem cells as maintainers of tissue homeostasis and modulators in early interventions including therapies using new stem cell sources,exosomes,and tissueengineering combined with stem cell-based implants,among others.This review describes the types of stem cells and the possible interaction mechanisms in PFD treatment,with the hope of providing more promising stem cell treatment strategies for PFD in the future.展开更多
This study investigated water samples collected from the surface water and groundwater in Wuhan City,Hubei Province,China in different stages of the outbreak of the coronavirus disease 2019(hereinafter referred to as ...This study investigated water samples collected from the surface water and groundwater in Wuhan City,Hubei Province,China in different stages of the outbreak of the coronavirus disease 2019(hereinafter referred to as COVID-19)in the city,aiming to determine the distribution characteristics of antiviral drugs in the city’s waters.The results are as follows.The main hydrochemical type of surface water and groundwater in Wuhan was Ca-HCO3.The major chemical components in the groundwater had higher concentrations and spatial variability than those in the surface water.Two antiviral drugs and two glucocorticoids were detected in the surface water,groundwater,and sewage during the COVID-19 outbreak.Among them,chloroquine phosphate and cortisone had higher detection rates of 32.26%and 25.80%,respectively in all samples.The concentrations of residual drugs in East Lake were higher than those in other waters.The main drug detected in the waters in the later stage of the COVID-19 outbreak in Wuhan was chloroquine phosphate,whose detection rates in the surface water and the groundwater were 53.85%and 28.57%,respectively.Moreover,the detection rate and concentration of chloroquine phosphate were higher in East Lake than in Huangjia Lake.The groundwater containing chloroquine phosphate was mainly distributed along the river areas where the groundwater was highly vulnerable.The residual drugs in the surface water and the groundwater had lower concentrations in the late stage of the COVID-19 outbreak than in the middle of the outbreak,and they have not yet caused any negative impacts on the ecological environment.展开更多
1.Objectives Chibi City is located along the key development axis of the Beijing-Guangzhou high-speed rail in Hubei Province,and is one of the key towns in the middle reaches of the Yangtze River in China.Karst ground...1.Objectives Chibi City is located along the key development axis of the Beijing-Guangzhou high-speed rail in Hubei Province,and is one of the key towns in the middle reaches of the Yangtze River in China.Karst ground subsidence,groundwater contamination,seasonal water shortage or water shortage are important environmental geological problems that restrict economic and social development in the region.Relying on the discovery of abundant geological heritage landscape resources of Chibi City(Ancient battlefield in the period of the Three Kingdoms,Yangloudong),geothermal resources(Wuhong Mountain hot spring),the discovery of natural mineral water rich in strontium and metasilicate provides more options for the development and utilization of geological resources in Chibi City.Strontium-rich mineral water can strengthen bones,protect hearts,soften blood vessels,and has the function of anti-oxidation,anti-aging and immunity enhancement.It is a kind of high-quality water that is very beneficial to human health.Therefore,identifying its distribution and potential is key to the development of strontium rich mineral water industry in Chibi City.展开更多
Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases...Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases.As we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex virus.In this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.展开更多
Coronaviruses are enveloped RNA viruses distinguished by their crown-like surface spikes. These viruses cause various diseases in humans and animals, including respiratory, gastrointestinal, and neurological disorders...Coronaviruses are enveloped RNA viruses distinguished by their crown-like surface spikes. These viruses cause various diseases in humans and animals, including respiratory, gastrointestinal, and neurological disorders. The health risks posed by coronaviruses are substantial, as demonstrated by severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2. SARS-CoV triggered a global outbreak of SARS in 2003, and SARS-CoV-2 has been responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic since the end of 2019. Furthermore, four human coronaviruses (HCoVs), HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, have been implicated in 15% to 30% cases of the common cold.[1] Given their prevalence and potential to cause various diseases, understanding the mechanisms underlying the invasion into cells of the coronavirus is essential for public health. By binding to specific cell receptors, the spike protein of coronaviruses undergoes conformational changes that promote membrane fusion and entry of the virus into host cells. Although significant progress has been made in elucidating the mechanisms of coronavirus entry, the detailed molecular interactions between viral proteins and host receptors remain incompletely understood.展开更多
Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, ...Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in China. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across China. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.展开更多
基金Foundation of Sichuan Provincial Science and Technology Program,No.2019YFH0147 and No.2019YFH0158Chengdu Technological Innovation Research and Development Project,No.2018-YF05-00195-SN+1 种基金West China Second University Hospital Xinya Fund,No.kx1111.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University,No.ZYJC18016.
文摘Pelvic floor disorders(PFDs)represent a group of common and frequentlyoccurring diseases that seriously affect the life quality of women,generally including stress urinary incontinence and pelvic organ prolapse.Surgery has been used as a treatment for PFD,but almost 30%of patients require subsequent surgery due to a high incidence of postoperative complications and high recurrence rates.Therefore,investigations of new therapeutic strategies are urgently needed.Stem cells possess strong multi-differentiation,self-renewal,immunomodulation,and angiogenesis abilities and they are able to differentiate into various cell types of pelvic floor tissues and thus provide a potential therapeutic approach for PFD.Recently,various studies using different autologous stem cells have achieved promising results by improving the pelvic ligament and muscle regeneration and conferring the tissue elasticity and strength to the damaged tissue in PFD,as well as reduced inflammatory reactions,collagen deposition,and foreign body reaction.However,with relatively high rates of complications such as bladder stone formation and wound infections,further studies are necessary to investigate the role of stem cells as maintainers of tissue homeostasis and modulators in early interventions including therapies using new stem cell sources,exosomes,and tissueengineering combined with stem cell-based implants,among others.This review describes the types of stem cells and the possible interaction mechanisms in PFD treatment,with the hope of providing more promising stem cell treatment strategies for PFD in the future.
基金This research was jointly by the China Geological Survey Project Multi-Factor Urban Geological Survey of Wuhan(DD20190282)Survey and Evaluation of Riverside Urban Geological Safety in Wuhan(DD20221734).
文摘This study investigated water samples collected from the surface water and groundwater in Wuhan City,Hubei Province,China in different stages of the outbreak of the coronavirus disease 2019(hereinafter referred to as COVID-19)in the city,aiming to determine the distribution characteristics of antiviral drugs in the city’s waters.The results are as follows.The main hydrochemical type of surface water and groundwater in Wuhan was Ca-HCO3.The major chemical components in the groundwater had higher concentrations and spatial variability than those in the surface water.Two antiviral drugs and two glucocorticoids were detected in the surface water,groundwater,and sewage during the COVID-19 outbreak.Among them,chloroquine phosphate and cortisone had higher detection rates of 32.26%and 25.80%,respectively in all samples.The concentrations of residual drugs in East Lake were higher than those in other waters.The main drug detected in the waters in the later stage of the COVID-19 outbreak in Wuhan was chloroquine phosphate,whose detection rates in the surface water and the groundwater were 53.85%and 28.57%,respectively.Moreover,the detection rate and concentration of chloroquine phosphate were higher in East Lake than in Huangjia Lake.The groundwater containing chloroquine phosphate was mainly distributed along the river areas where the groundwater was highly vulnerable.The residual drugs in the surface water and the groundwater had lower concentrations in the late stage of the COVID-19 outbreak than in the middle of the outbreak,and they have not yet caused any negative impacts on the ecological environment.
基金This study was supported by China Geological Survey projects“Multi-Element Urban Geological Survey of Wuhan Project”(DD20190282)“1∶50000 Environmental Geological Survey Along the High-speed Rail Line in Xianning-Yueyang and Nanchang-Huaihua Sections of the Middle Reaches of the Yangtze River Project”(DD20160248).
文摘1.Objectives Chibi City is located along the key development axis of the Beijing-Guangzhou high-speed rail in Hubei Province,and is one of the key towns in the middle reaches of the Yangtze River in China.Karst ground subsidence,groundwater contamination,seasonal water shortage or water shortage are important environmental geological problems that restrict economic and social development in the region.Relying on the discovery of abundant geological heritage landscape resources of Chibi City(Ancient battlefield in the period of the Three Kingdoms,Yangloudong),geothermal resources(Wuhong Mountain hot spring),the discovery of natural mineral water rich in strontium and metasilicate provides more options for the development and utilization of geological resources in Chibi City.Strontium-rich mineral water can strengthen bones,protect hearts,soften blood vessels,and has the function of anti-oxidation,anti-aging and immunity enhancement.It is a kind of high-quality water that is very beneficial to human health.Therefore,identifying its distribution and potential is key to the development of strontium rich mineral water industry in Chibi City.
基金supported by the National Key Research and Development Program of China(2022YFC3400900)the National Natural Science Foundation of China(82030046,82402614)+3 种基金the Postdoctoral Fellowship Program of CPSF(GZB20230886)the Chinese Postdoctoral Science Foundation(2023M743998,2024T171080)Fundamental Research Funds for the Central Universities(24qnpy278)Shenzhen Medical Research Fund(A2302028)。
文摘Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human diseases.As we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex virus.In this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.
基金supported by grants from the Key Technologies Research and Development Program(2022YFC3400900)Postdoctoral Fellowship Program of CPSF(GZB20230886)+3 种基金China Postdoctoral Science Foundation(2023M743998)National Natural Science Foundation of China(82030046)the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2019BT02Y198)Guangdong Science and Technology Department(2020B1212030004).
文摘Coronaviruses are enveloped RNA viruses distinguished by their crown-like surface spikes. These viruses cause various diseases in humans and animals, including respiratory, gastrointestinal, and neurological disorders. The health risks posed by coronaviruses are substantial, as demonstrated by severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-CoV-2. SARS-CoV triggered a global outbreak of SARS in 2003, and SARS-CoV-2 has been responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic since the end of 2019. Furthermore, four human coronaviruses (HCoVs), HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, have been implicated in 15% to 30% cases of the common cold.[1] Given their prevalence and potential to cause various diseases, understanding the mechanisms underlying the invasion into cells of the coronavirus is essential for public health. By binding to specific cell receptors, the spike protein of coronaviruses undergoes conformational changes that promote membrane fusion and entry of the virus into host cells. Although significant progress has been made in elucidating the mechanisms of coronavirus entry, the detailed molecular interactions between viral proteins and host receptors remain incompletely understood.
文摘Background： Over the years, the mechanical ventilation （MV） strategy has changed worldwide. The aim of the present study was to describe the ventilation practices, particularly lung-protective ventilation （LPV）, among brain-injured patients in China. Methods： This study was a multicenter, 1-day, cross-sectional study in 47 Intensive Care Units （ICUs） across China. Mechanically ventilated patients （18 years and older） with brain injury in a participating ICU during the time of the study, including traumatic brain injury, stroke, postoperation with intracranial tumor, hypoxic-ischemic encephalopathy, intracranial infection, and idiopathic epilepsy, were enrolled. Demographic data, primary diagnoses, indications for MV, MV modes and settings, and prognoses on the 60th day were collected. Multivariable logistic analysis was used to assess factors that might affect the use of LPV. Results： A total of 104 patients were enrolled in the present study, 87 （83.7%） of whom were identified with severe brain injury based on a Glasgow Coma Scale 〈8 points. Synchronized intermittent mandatory ventilation （SIMV） was the most frequent ventilator mode, accounting for 46.2% of the entire cohort. The median tidal volume was set to 8.0 ml/kg （interquartile range [IQR], 7.0-8.9 ml/kg） of the predicted body weight; 50 （48.1%） patients received LPV. The median positive end-expiratory pressure （PEEP） was set to 5 cmH20 （IQR, 5-5 cmH20）. No PEEP values were higher than 10 cmH20. Compared with partially mandatory ventilation, supportive and spontaneous ventilation practices were associated with LPV. There were no significant differences in mortality and MV duration between patients subjected to LPV and those were not. Conclusions： Among brain-injured patients in China, SIMV was the most frequent ventilation mode. Nearly one-half of the brain-injured patients received LPV. Patients under supportive and spontaneous ventilation were more likely to receive LPV.
