[1,2,4]-Triazole-[4,3-a]-quinoxaline is an important component of many drugs.The yield of the reported methods for triazole cyclization step was usually as low as 20%.In this article,the triazole cyclization step was ...[1,2,4]-Triazole-[4,3-a]-quinoxaline is an important component of many drugs.The yield of the reported methods for triazole cyclization step was usually as low as 20%.In this article,the triazole cyclization step was successfully done by using microwave method with a high yield of 75%for the first time.展开更多
The overall heat transfer coefficient(OHTC)of rock fractures is a fundamental parameter for characterizing the heat transfer behavior of rock fractures in hot dry rock(HDR)geothermal mining.Although a number of practi...The overall heat transfer coefficient(OHTC)of rock fractures is a fundamental parameter for characterizing the heat transfer behavior of rock fractures in hot dry rock(HDR)geothermal mining.Although a number of practical formulae for heat transfer coefficients have been developed in the literature,there is still no widely accepted analytical solution.This paper constructs highly accurate analytical solutions for the temperatures of the inner fracture wall and the fluid.Then they are employed to develop new definition-based formulae(formula A and its simplification formula B)of the OHTC,which are well validated by the experimental and numerical simulation results.An empirical correlation formula of heat transfer coefficient is proposed based on the definition-based formulae which can be directly used in the numerical simulations of heat transfer in rock fractures.A site-scale application example of numerical simulation also demonstrates the effectiveness of the empirical correlation formula.展开更多
Mechanically interlocked molecules (MIMs) have unique properties with broad applications, yet constructing both knotted and linked topologies from the same ligand remains challenging due to their distinct geometric de...Mechanically interlocked molecules (MIMs) have unique properties with broad applications, yet constructing both knotted and linked topologies from the same ligand remains challenging due to their distinct geometric demands. To address this, we design and synthesize a conformationally adaptive ligand 4,7-bis(3-(pyridin-4-yl) phenyl) benzo[c][1,2,5]thiadiazole (L1) with a tunable torsional angle θ of N1C1C2N2 ranging from 7.5° to 108.9°. Utilizing coordination-driven self-assembly at ambient temperature, L1 selectively assembles with binuclear half-sandwich units RhB1, RhB2, RhB3, and RhB4 featuring Cp*^(Rh^(Ⅲ)) (Cp* = η^(5)-pentam-ethylcyclopentadienyl) into distinct topologies: Solomon links Rh-1, trefoil knots Rh-2, molecular tweezers Rh 3, and Rh-4, respectively. Crucially, the self-adaptability of ligand L1 directs topology formation through pro-gramming different combination of noncovalent interactions (π-x stacking, CH..π interaction, and lone pair-π interaction), thus navigating divergent assembly pathways by conformational switching, as evidenced by X-ray crystallography analysis, independent gradient model (IGM) analysis, detailed nuclear magnetic resonance (NMR) spectroscopy and electrospray ionization time-of-flight/mass spectrometry (ESI-TOF/MS). This strategy can also be extended to construct Cp*^(Irl^(Ⅲ)) analogs (Solomon links Ir-1, trefoil knots Ir-2, molecular tweezers Ir-3 and Ir-4), demonstrating metal-independent control and achieving intricate topologies in a high yield.展开更多
Urban geological information platforms have traditionally focused on static data provision for public service,constrained by funding and limited engagement with engineering applications.This study takes Hangzhou-a maj...Urban geological information platforms have traditionally focused on static data provision for public service,constrained by funding and limited engagement with engineering applications.This study takes Hangzhou-a major Chinese megacity-as a model to propose a technically integrated platform that aligns with urban infrastructure development,particularly underground space engineering.Through the adoption of the large-scale relational database system Oracle,we first established a comprehensive storage framework for fundamental urban geological and underground infrastructure information,thereby completed the construction of the core databases.To ensure spatial consistency across multi-source data and to meet the platform’s high computational demands while improving overall server responsiveness,we introduced three critical innovations:voxel-based model encoding,distributed computing,and frontend-backend separation with asynchronous processing.To align with urban engineering projects and enhance economic returns,the platform was initially developed through the integration of foundational geological data,including borehole records and aboveground-underground spatial information.Based on this foundation,its practical application in Hangzhou’s Qiantang New Town further demonstrated the platform’s potential in supporting subway routing,underground structure planning,and engineering cost analysis.Consequently,the construction of the Hangzhou geological information platform not only offers robust support for urban decision-making and smart city development but also provides a replicable model for addressing the technical and institutional challenges commonly encountered in the development of urban geological platforms.展开更多
Herein,a recrystallization approach was used to produce anhydrous sodium sulfate(ASS)microparticles,which are highly efficient and reusable for separating surfactant-stabilized water from water-in-oil emulsions.The AS...Herein,a recrystallization approach was used to produce anhydrous sodium sulfate(ASS)microparticles,which are highly efficient and reusable for separating surfactant-stabilized water from water-in-oil emulsions.The ASS microparticles exhibit distinct morphologies and crystal structures.Remarkably,0.1 g of ASS170 enables the separation of 10 m L of emulsion(water content:0.1 g)with a high separation efficiency of 98.63%.A stepwise separation mechanism,including demulsification and water immobilization in the crystal lattice of ASS,is proposed.The superhydrophilicity of ASS particles enables tiny water droplets to aggregate and merge into larger droplets on their surfaces.This process facilitates the phase transition from ASS to sodium sulfate decahydrate(SSD),during which water molecules are immobilized in the expanded crystal lattice of ASS.SSD particles can be collected to regenerate ASS,retaining the high performance of the original ASS.This unique renewable feature reduces the cost of utilizing ASS and simultaneously prevents secondary pollution.Further economic evaluation reveals that it only costs 66.51USD/m3to purify emulsion with a water content of 10 g/L,significantly lower than previously reported materials.Coupled with a facile and environmentally friendly preparation strategy,this method shows great application potential for water-in-oil emulsion separation and oil purification.展开更多
BACKGROUND The application of perioperative disinfection and isolation measures to patients undergoing gastrointestinal surgery with postoperative infection can provide a data reference for reducing the postoperative ...BACKGROUND The application of perioperative disinfection and isolation measures to patients undergoing gastrointestinal surgery with postoperative infection can provide a data reference for reducing the postoperative infection rate,improving post-operative biochemical markers,and enhancing postoperative recovery outcomes.AIM To explore the effectiveness of perioperative disinfection and isolation measures in controlling postoperative infection following gastrointestinal surgery.It also sought to compare infection rates and biochemical markers between the obser-vation and control groups and evaluate the impact of disinfection and isolation measures on reducing postoperative complications.METHODS A retrospective analysis was conducted.Ninety-six patients who underwent gastrointestinal surgery between January 2022 and December 2023 were selected and divided into an observation group and a control group,with 48 cases in each.The observation group received disinfection and isolation measures during the perioperative period,whereas the control group received standard nursing care.The incidence of infection,white blood cell count,C-reactive protein levels,hemoglobin levels,and liver function markers(alanine aminotransferase,aspartate aminotransferase,creatinine,and blood urea nitrogen)were monitored postoperatively in both groups.RESULTS The postoperative infection rate in the observation group was significantly lower than that in the control group(P<0.05).White blood cell and C-reactive protein levels decreased significantly after surgery in the observation group and were significantly lower than those in the control group(P<0.05).Alanine aminotransferase,aspartate aminotransferase,creatinine,and blood urea nitrogen levels in the observation group were lower than those in the control group on postoperative days 1 and 3,showing a significant difference(P<0.05).CONCLUSION Perioperative disinfection and isolation measures effectively reduce postoperative infection rates in gastrointestinal surgery patients and improve biochemical markers,thereby enhancing recovery outcomes.This study provides a valuable basis for postoperative infection control and has significant clinical applications.展开更多
The single-molecule detection tech-nique plays a pivotal role in elucidat-ing the fundamental mechanisms of various scientific processes at the molecular level,and holds essential im-portance in multiple fields includ...The single-molecule detection tech-nique plays a pivotal role in elucidat-ing the fundamental mechanisms of various scientific processes at the molecular level,and holds essential im-portance in multiple fields including physics,biology,and chemistry.Re-cently,single-molecule detection has garnered increasing attention owing to its practical utility in medical diagno-sis,primarily due to its exceptional sensitivity and the minimal sample volume required for analysis.However,the conventional single-molecule technique,represented by total internal reflection microscopy,faces challenges such as sophisticated operation procedures and limited detection throughput,thereby impeding its broader application.To address these limitations,we have demonstrated single-molecule detection using an integrated silicon photonic chip,of-fering a cost-effective and user-friendly alternative.By employing basic optics,we efficiently introduce the excitation source for single-molecule fluorescence by harnessing the strong evanescent field of high refractive-index waveguides.Subsequently,fluorescence signals are collected using basic optics comprising a water-immersion objective,relay optics,and a digi-tal camera.Our results highlight a low-cost,high-throughput single-molecule technique achieved through the integrated silicon photonic chip.This innovative approach is promised to facilitate the widespread adoption of single-molecule fluorescence in medical diagnosis.展开更多
Accurate identification of RNA-ligand binding sites is essential for elucidating RNA function and advancing structurebased drug discovery.Here,we present RLsite,a novel deep learning framework that integrates energy-,...Accurate identification of RNA-ligand binding sites is essential for elucidating RNA function and advancing structurebased drug discovery.Here,we present RLsite,a novel deep learning framework that integrates energy-,structure-and sequence-based features to predict nucleotide-level binding sites with high accuracy.RLsite leverages energy-based threedimensional representations,obtained from atomic probe interactions using a pre-trained ITScore-NL potential,and models their contextual features through a 3D convolutional neural network(3D-CNN)augmented with self-attention.In parallel,structure-based features,including network properties,Laplacian norm,and solvent-accessible surface area,together with sequence-based evolutionary constraint scores,are mapped along the RNA sequence and used as sequential descriptors.These descriptors are modeled using a bidirectional long short-term memory(BiLSTM)network enhanced with multihead self-attention.By effectively fusing these complementary modalities,RLsite achieves robust and precise binding site prediction.Extensive evaluations across four diverse RNA-ligand benchmark datasets demonstrate that RLsite consistently outperforms state-of-the-art methods in terms of precision,recall,Matthews correlation coefficient(MCC),area under the curve(AUC),and overall robustness.Notably,on a particularly challenging test set composed of RNA structures containing junctions,RLsite surpasses the second-best method by 7.3%in precision,3.4%in recall,7.5%in MCC,and 10.8%in AUC,highlighting its potential as a powerful tool for RNA-targeted molecular design.展开更多
Lithium/fluorinated carbon(Li/CF_(x))batteries are greatly limited in their applications mostly due to poor rate performances.In this study,N,P co-doped biomass carbon was synthesized using melamine and phytic acid as...Lithium/fluorinated carbon(Li/CF_(x))batteries are greatly limited in their applications mostly due to poor rate performances.In this study,N,P co-doped biomass carbon was synthesized using melamine and phytic acid as doping sources,and the resulting product was then utilized as a precursor for CF_(x).The resulting fluorinated biomass carbon has a high degree of fluorination,exceeding the specific capacity of commercial fluorinated graphite while also demonstrating exceptional performance at high discharge rates.During the fluorination process,N,P-containing functional groups were removed from the crystalline lattice in the basal plane.This facilitates the formation of a defect-rich carbon matrix,enhancing the F/C ratio by improving the fluorinated active sites and obtaining more highly active semi-ionic bonds.Additionally,the abundant defects and porous structure promote Li^(+)diffusion.Density functional theory calculations indicated that doping modification effectively reduces the energy barrier for Li+migration,enhancing Li+transport efficiency.The prepared CF_(x)delivers material with a maximum specific capacity of 919 mAh·g^(-1),while maintaining a specific capacity of 702 mAh·g^(-1)at a high discharge current density of 20C(with a capacity retention rate of 76.4%).In this study,fluorinated N,P co-doped biomass carbon,exhibiting ultrahigh capacity and high-rate performance,was prepared for the first time,which can potentially advance the commercialization of CF_(x).展开更多
The effects of Zn/Mg ratios on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys aged at 150℃have been investigated by using tensile tests,optical metallography,scanning electron microscopy,transmission ...The effects of Zn/Mg ratios on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys aged at 150℃have been investigated by using tensile tests,optical metallography,scanning electron microscopy,transmission electron microscopy and atom probe tomography analyses.With increasing Zn/Mg ratios,the ageing process is significantly accelerated and the time to peak ageing is reduced.T’phase predominates in alloys of lower Zn/Mg ratios whileη’phase predominates in alloys with a Zn/Mg ratio over 2.86.Co-existence of T’phase andη’phase with a large number density is beneficial to the high strength of alloys.Such precipitates together with narrow precipitate free zones cause a brittle intergranular fracture.A strength model has been established to predict the co-strengthening effect of T’phase andη’phase in Al-Zn-Mg-Cu alloys,including the factors of the grain boundary,solid solution and precipitation.展开更多
The contactin-associated protein （Caspr） family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family- CNTNA...The contactin-associated protein （Caspr） family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family- CNTNAP1 （Casprl）, CNTNAP2 （Caspr2）, CNTNAP3 （Caspr3）, CNTNAP4 （Caspr4） and CNTNAP5 （Caspr5）, Casprl-5 is not only involved in the formation of myelinated axons, but also participates in maintaining the stability of adjacent connections. Casprl participates in the formation, differentiation, and proliferation of neurons and astrocytes, and in motor control and cognitive function. We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis, and autoimmune encephalitis. However, the effects of Caspr on disease course and prognosis remain poorly understood. The effects of Caspr on disease diagnosis and treatment need further investigation.展开更多
Pericytes,as the mural cells surrounding the microvasculature,play a critical role in the regulation of microcirculation;however,how these cells respond to ischemic stroke remains unclear.To determine the temporal alt...Pericytes,as the mural cells surrounding the microvasculature,play a critical role in the regulation of microcirculation;however,how these cells respond to ischemic stroke remains unclear.To determine the temporal alterations in pericytes after ischemia/reperfusion,we used the 1-hour middle cerebral artery occlusion model,which was examined at 2,12,and 24 hours after reperfusion.Our results showed that in the reperfused regions,the cerebral blood flow decreased and the infarct volume increased with time.Furthermore,the pericytes in the infarct regions contracted and acted on the vascular endothelial cells within 24 hours after reperfusion.These effects may result in incomplete microcirculation reperfusion and a gradual worsening trend with time in the acute phase.These findings provide strong evidence for explaining the“no-reflow”phenomenon that occurs after recanalization in clinical practice.展开更多
Hardness tests and transmission electron microscopy were used to investigate the strategy of tailoring the phase fraction of precipitates in an Al-Zn-Mg-Cu alloy strengthened by T’ and η’ phases. Different phase fr...Hardness tests and transmission electron microscopy were used to investigate the strategy of tailoring the phase fraction of precipitates in an Al-Zn-Mg-Cu alloy strengthened by T’ and η’ phases. Different phase fractions of T’ and η’ phases are presented in samples subjected to either single or two stages of ageing treatments at 120 and 150 ℃.For both types of ageing, the precipitation of η’ phase is found to be promoted by ageing at lower temperature and its phase fraction increases with prolonging ageing time at 120 ℃;whereas the phase fractions of T’ and η’ phases almost remain constant during ageing at 150 ℃. Besides, the strain fields produced by T’ and η’ phases were analyzed by using the geometric phase analysis technique, and on a macroscale the contributions of T’ and η’ phases to precipitation strengthening have been quantitatively predicted by combining the size, phase fraction and number density of precipitates.展开更多
Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one k...Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.展开更多
The high precision population forecasting and spatial distribution modeling are very important for the theory and application of population sociology,city planning and Geo-Informatics.However,the two problems need to ...The high precision population forecasting and spatial distribution modeling are very important for the theory and application of population sociology,city planning and Geo-Informatics.However,the two problems need to be solved for providing the high precision population information.One is how to improve the population forecasting precision of small area(e.g.,street scale);another is how to improve the spatial resolution of urban population distribution model.To solve the two problems,some new methods are proposed in this contribution.(1)To improve the precision of small area population forecasting,a new method is developed based on the fade factor and the slide window.(2)To improve the spatial resolution of urban population distribution model,a new method is proposed based on the land classification,public facility information and the artificial intelligence technology.For validation of the proposed methods,the real population data of 15 streets in Xicheng district,Beijing,China from 2010 to 2016,the remote sensing images and the public facility data are collected and used.A number of experiments are performed.The results show that the spatial resolution of proposed model reaches 30m*30m and the forecasting precision is better than 5%using the proposed method to forecast the population of 15 streets in Xicheng district in the next four years.展开更多
Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptid...Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptides feature a covalent cross-link of side chains, thus effectively mimicking α-helix as inhibitors of protein-protein interactions. In this review, we category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years.展开更多
Integrated multi-tropic aquaculture(IMTA)systems have been used in China for many years and have achieved significant economic,social,and ecological benefits.However,there is still a lack of benthic bioremediation spe...Integrated multi-tropic aquaculture(IMTA)systems have been used in China for many years and have achieved significant economic,social,and ecological benefits.However,there is still a lack of benthic bioremediation species that can effectively utilize the aquaculture particulate organic waste in the system.Polychaete Perinereis aibuhitensis Grube is used as an environmental remediation species for large-scale aquaculture to reduce particulate organic waste,which is of great significance to environmental protection.To improve bio-elements utilization efficiency,P.aibuhitensis was applied for IMTA indoor fish(Hexagrammos otakii)farming.Results showed that in the system,production of 1 kg of the fish discharged 2141-2338 mg of carbon and 529-532 mg of nitrogen,while in the monoculture of the fish,the figures were 3033-3390 mg and 764-794 mg,or 24.84%-35.26%and 30.35%-33.32%less,respectively.This approach promoted IMTA technology that could utilize the particulate organic waste from intensive aquaculture and reduce the adverse environmental effects.展开更多
Photocatalysis technology has been proved to be a potential strategy for removal of organic dyes,however high-power light sources are generally necessary to initiate photocatalytic reaction.In this work,we employed an...Photocatalysis technology has been proved to be a potential strategy for removal of organic dyes,however high-power light sources are generally necessary to initiate photocatalytic reaction.In this work,we employed an excellent photocatalyst of Bi_(2)WO_(6) with visible light harvest and meanwhile an intrinsic ferroelectricity,which realized the efficient degradation of organic dye via the synergetic photopiezocatalysis.Through coupling the illumination by a low-power(9 W)LED and the ultrasonic vibration(120 W)by an ultrasonic cleaner,the nano flower-like Bi_(2)WO_(6) composed of ultrathin nanosheets showed a much more enhanced photopiezocatalysis performance for purification of organic dye than the individual photocatalysis and piezocatalysis.Furthermore,the high mineralization efficiency and the good durability of the Bi_(2)WO_(6) catalyst were demonstrated.The possible mechanism of photopiezocatalysis was finally proposed,where the ultrasound-induced piezoelectric field in Bi_(2)WO_(6) drove photo-generated electrons and holes to diffuse along opposite directions,consequently promoting the separation efficiency of charge carriers.This work indicates that the synergetic photopiezocatalysis by coupling irradiation and ultrasonic vibration is a promising strategy to purify organic pollutants in wastewater.展开更多
文摘[1,2,4]-Triazole-[4,3-a]-quinoxaline is an important component of many drugs.The yield of the reported methods for triazole cyclization step was usually as low as 20%.In this article,the triazole cyclization step was successfully done by using microwave method with a high yield of 75%for the first time.
基金support of this work by the National Natural Science Foundation of China (Grant Nos.41972316 and 41672252).
文摘The overall heat transfer coefficient(OHTC)of rock fractures is a fundamental parameter for characterizing the heat transfer behavior of rock fractures in hot dry rock(HDR)geothermal mining.Although a number of practical formulae for heat transfer coefficients have been developed in the literature,there is still no widely accepted analytical solution.This paper constructs highly accurate analytical solutions for the temperatures of the inner fracture wall and the fluid.Then they are employed to develop new definition-based formulae(formula A and its simplification formula B)of the OHTC,which are well validated by the experimental and numerical simulation results.An empirical correlation formula of heat transfer coefficient is proposed based on the definition-based formulae which can be directly used in the numerical simulations of heat transfer in rock fractures.A site-scale application example of numerical simulation also demonstrates the effectiveness of the empirical correlation formula.
基金Department of Chemistry,Fudan Uni-versity,the National Natural Science Foundation of China(22031003,21720102004)the Shanghai Science Technology Committee(19DZ227010O)the Alexander von Humboldt Foundation for a Humboldt Research Award.
文摘Mechanically interlocked molecules (MIMs) have unique properties with broad applications, yet constructing both knotted and linked topologies from the same ligand remains challenging due to their distinct geometric demands. To address this, we design and synthesize a conformationally adaptive ligand 4,7-bis(3-(pyridin-4-yl) phenyl) benzo[c][1,2,5]thiadiazole (L1) with a tunable torsional angle θ of N1C1C2N2 ranging from 7.5° to 108.9°. Utilizing coordination-driven self-assembly at ambient temperature, L1 selectively assembles with binuclear half-sandwich units RhB1, RhB2, RhB3, and RhB4 featuring Cp*^(Rh^(Ⅲ)) (Cp* = η^(5)-pentam-ethylcyclopentadienyl) into distinct topologies: Solomon links Rh-1, trefoil knots Rh-2, molecular tweezers Rh 3, and Rh-4, respectively. Crucially, the self-adaptability of ligand L1 directs topology formation through pro-gramming different combination of noncovalent interactions (π-x stacking, CH..π interaction, and lone pair-π interaction), thus navigating divergent assembly pathways by conformational switching, as evidenced by X-ray crystallography analysis, independent gradient model (IGM) analysis, detailed nuclear magnetic resonance (NMR) spectroscopy and electrospray ionization time-of-flight/mass spectrometry (ESI-TOF/MS). This strategy can also be extended to construct Cp*^(Irl^(Ⅲ)) analogs (Solomon links Ir-1, trefoil knots Ir-2, molecular tweezers Ir-3 and Ir-4), demonstrating metal-independent control and achieving intricate topologies in a high yield.
基金supported by the China Geological Survey,Nanjing Center,Zhejiang Geological Survey and China University of Geosciences,Wuhanfunded by the Laboratory of Geological Safety of Underground Space in Coastal Cities,Ministry of Natural Resources(Project No.BHKF2023×01)the China Geological Survey,Nanjing Center(Project No.DD20190281).
文摘Urban geological information platforms have traditionally focused on static data provision for public service,constrained by funding and limited engagement with engineering applications.This study takes Hangzhou-a major Chinese megacity-as a model to propose a technically integrated platform that aligns with urban infrastructure development,particularly underground space engineering.Through the adoption of the large-scale relational database system Oracle,we first established a comprehensive storage framework for fundamental urban geological and underground infrastructure information,thereby completed the construction of the core databases.To ensure spatial consistency across multi-source data and to meet the platform’s high computational demands while improving overall server responsiveness,we introduced three critical innovations:voxel-based model encoding,distributed computing,and frontend-backend separation with asynchronous processing.To align with urban engineering projects and enhance economic returns,the platform was initially developed through the integration of foundational geological data,including borehole records and aboveground-underground spatial information.Based on this foundation,its practical application in Hangzhou’s Qiantang New Town further demonstrated the platform’s potential in supporting subway routing,underground structure planning,and engineering cost analysis.Consequently,the construction of the Hangzhou geological information platform not only offers robust support for urban decision-making and smart city development but also provides a replicable model for addressing the technical and institutional challenges commonly encountered in the development of urban geological platforms.
基金financially supported by the High-level talent research start-up project of Chongqing Technology and Business University(No.2356007)the Science and Technology Research Program of Chongqing Municipal Education Commission(No.KJQN202400809)Special Project for Performance Incentive and Guidance of Research Institutions in Chongqing(No.CSTB2023JXJL-YFX0030)。
文摘Herein,a recrystallization approach was used to produce anhydrous sodium sulfate(ASS)microparticles,which are highly efficient and reusable for separating surfactant-stabilized water from water-in-oil emulsions.The ASS microparticles exhibit distinct morphologies and crystal structures.Remarkably,0.1 g of ASS170 enables the separation of 10 m L of emulsion(water content:0.1 g)with a high separation efficiency of 98.63%.A stepwise separation mechanism,including demulsification and water immobilization in the crystal lattice of ASS,is proposed.The superhydrophilicity of ASS particles enables tiny water droplets to aggregate and merge into larger droplets on their surfaces.This process facilitates the phase transition from ASS to sodium sulfate decahydrate(SSD),during which water molecules are immobilized in the expanded crystal lattice of ASS.SSD particles can be collected to regenerate ASS,retaining the high performance of the original ASS.This unique renewable feature reduces the cost of utilizing ASS and simultaneously prevents secondary pollution.Further economic evaluation reveals that it only costs 66.51USD/m3to purify emulsion with a water content of 10 g/L,significantly lower than previously reported materials.Coupled with a facile and environmentally friendly preparation strategy,this method shows great application potential for water-in-oil emulsion separation and oil purification.
文摘BACKGROUND The application of perioperative disinfection and isolation measures to patients undergoing gastrointestinal surgery with postoperative infection can provide a data reference for reducing the postoperative infection rate,improving post-operative biochemical markers,and enhancing postoperative recovery outcomes.AIM To explore the effectiveness of perioperative disinfection and isolation measures in controlling postoperative infection following gastrointestinal surgery.It also sought to compare infection rates and biochemical markers between the obser-vation and control groups and evaluate the impact of disinfection and isolation measures on reducing postoperative complications.METHODS A retrospective analysis was conducted.Ninety-six patients who underwent gastrointestinal surgery between January 2022 and December 2023 were selected and divided into an observation group and a control group,with 48 cases in each.The observation group received disinfection and isolation measures during the perioperative period,whereas the control group received standard nursing care.The incidence of infection,white blood cell count,C-reactive protein levels,hemoglobin levels,and liver function markers(alanine aminotransferase,aspartate aminotransferase,creatinine,and blood urea nitrogen)were monitored postoperatively in both groups.RESULTS The postoperative infection rate in the observation group was significantly lower than that in the control group(P<0.05).White blood cell and C-reactive protein levels decreased significantly after surgery in the observation group and were significantly lower than those in the control group(P<0.05).Alanine aminotransferase,aspartate aminotransferase,creatinine,and blood urea nitrogen levels in the observation group were lower than those in the control group on postoperative days 1 and 3,showing a significant difference(P<0.05).CONCLUSION Perioperative disinfection and isolation measures effectively reduce postoperative infection rates in gastrointestinal surgery patients and improve biochemical markers,thereby enhancing recovery outcomes.This study provides a valuable basis for postoperative infection control and has significant clinical applications.
基金supported by the National Key Research and Development Program(No.2022YFE0107400)the internal research funding from Photonic View Technology Technology Co.,Ltd.the GuangCi Deep Mind Project of Ruijin Hospital Shanghai Jiao Tong University School of Medicine.
文摘The single-molecule detection tech-nique plays a pivotal role in elucidat-ing the fundamental mechanisms of various scientific processes at the molecular level,and holds essential im-portance in multiple fields including physics,biology,and chemistry.Re-cently,single-molecule detection has garnered increasing attention owing to its practical utility in medical diagno-sis,primarily due to its exceptional sensitivity and the minimal sample volume required for analysis.However,the conventional single-molecule technique,represented by total internal reflection microscopy,faces challenges such as sophisticated operation procedures and limited detection throughput,thereby impeding its broader application.To address these limitations,we have demonstrated single-molecule detection using an integrated silicon photonic chip,of-fering a cost-effective and user-friendly alternative.By employing basic optics,we efficiently introduce the excitation source for single-molecule fluorescence by harnessing the strong evanescent field of high refractive-index waveguides.Subsequently,fluorescence signals are collected using basic optics comprising a water-immersion objective,relay optics,and a digi-tal camera.Our results highlight a low-cost,high-throughput single-molecule technique achieved through the integrated silicon photonic chip.This innovative approach is promised to facilitate the widespread adoption of single-molecule fluorescence in medical diagnosis.
基金supported by the National Natural Science Foundation of China(Grant No.12204118)the Guizhou University Talent Fund(Grant No.[2022]30).
文摘Accurate identification of RNA-ligand binding sites is essential for elucidating RNA function and advancing structurebased drug discovery.Here,we present RLsite,a novel deep learning framework that integrates energy-,structure-and sequence-based features to predict nucleotide-level binding sites with high accuracy.RLsite leverages energy-based threedimensional representations,obtained from atomic probe interactions using a pre-trained ITScore-NL potential,and models their contextual features through a 3D convolutional neural network(3D-CNN)augmented with self-attention.In parallel,structure-based features,including network properties,Laplacian norm,and solvent-accessible surface area,together with sequence-based evolutionary constraint scores,are mapped along the RNA sequence and used as sequential descriptors.These descriptors are modeled using a bidirectional long short-term memory(BiLSTM)network enhanced with multihead self-attention.By effectively fusing these complementary modalities,RLsite achieves robust and precise binding site prediction.Extensive evaluations across four diverse RNA-ligand benchmark datasets demonstrate that RLsite consistently outperforms state-of-the-art methods in terms of precision,recall,Matthews correlation coefficient(MCC),area under the curve(AUC),and overall robustness.Notably,on a particularly challenging test set composed of RNA structures containing junctions,RLsite surpasses the second-best method by 7.3%in precision,3.4%in recall,7.5%in MCC,and 10.8%in AUC,highlighting its potential as a powerful tool for RNA-targeted molecular design.
基金supported by Fujian Science and Technology Planning Projects of China(Nos.2022T3067 and 2023H0045)the Self-deployment Project Research Programs of Haixi Institutes,Chinese Academy of Sciences(No.CXZX-2022-JQ12)the Self-deployment project of XIREM(No.2023GG02).
文摘Lithium/fluorinated carbon(Li/CF_(x))batteries are greatly limited in their applications mostly due to poor rate performances.In this study,N,P co-doped biomass carbon was synthesized using melamine and phytic acid as doping sources,and the resulting product was then utilized as a precursor for CF_(x).The resulting fluorinated biomass carbon has a high degree of fluorination,exceeding the specific capacity of commercial fluorinated graphite while also demonstrating exceptional performance at high discharge rates.During the fluorination process,N,P-containing functional groups were removed from the crystalline lattice in the basal plane.This facilitates the formation of a defect-rich carbon matrix,enhancing the F/C ratio by improving the fluorinated active sites and obtaining more highly active semi-ionic bonds.Additionally,the abundant defects and porous structure promote Li^(+)diffusion.Density functional theory calculations indicated that doping modification effectively reduces the energy barrier for Li+migration,enhancing Li+transport efficiency.The prepared CF_(x)delivers material with a maximum specific capacity of 919 mAh·g^(-1),while maintaining a specific capacity of 702 mAh·g^(-1)at a high discharge current density of 20C(with a capacity retention rate of 76.4%).In this study,fluorinated N,P co-doped biomass carbon,exhibiting ultrahigh capacity and high-rate performance,was prepared for the first time,which can potentially advance the commercialization of CF_(x).
基金supported by the National Natural Science Foundation of China(No.51871033)the National Key Research and Development Program of China(2016YFB0700401)the Opening Project of State Key Laboratory for Advanced Metals and Materials(No.2020-ZD02)。
文摘The effects of Zn/Mg ratios on microstructure and mechanical properties of Al-Zn-Mg-Cu alloys aged at 150℃have been investigated by using tensile tests,optical metallography,scanning electron microscopy,transmission electron microscopy and atom probe tomography analyses.With increasing Zn/Mg ratios,the ageing process is significantly accelerated and the time to peak ageing is reduced.T’phase predominates in alloys of lower Zn/Mg ratios whileη’phase predominates in alloys with a Zn/Mg ratio over 2.86.Co-existence of T’phase andη’phase with a large number density is beneficial to the high strength of alloys.Such precipitates together with narrow precipitate free zones cause a brittle intergranular fracture.A strength model has been established to predict the co-strengthening effect of T’phase andη’phase in Al-Zn-Mg-Cu alloys,including the factors of the grain boundary,solid solution and precipitation.
基金supported by a grant from the Instructional Program of Science and Technology Bureau of Wuxi City of China,No.0302B010507130039PB
文摘The contactin-associated protein （Caspr） family participates in nerve excitation and conduction, and neurotransmitter release in myelinated axons. We analyzed the structures and functions of the Caspr family- CNTNAP1 （Casprl）, CNTNAP2 （Caspr2）, CNTNAP3 （Caspr3）, CNTNAP4 （Caspr4） and CNTNAP5 （Caspr5）, Casprl-5 is not only involved in the formation of myelinated axons, but also participates in maintaining the stability of adjacent connections. Casprl participates in the formation, differentiation, and proliferation of neurons and astrocytes, and in motor control and cognitive function. We also analyzed the relationship between the Caspr family and neurodegenerative diseases, multiple sclerosis, and autoimmune encephalitis. However, the effects of Caspr on disease course and prognosis remain poorly understood. The effects of Caspr on disease diagnosis and treatment need further investigation.
基金financially supported by the China Academy of Chinese Medical Sciences Innovation Fund,No.CI2021A03407(to WZB)the National Natural Science Foundation of China,No.81973789(to FFC).
文摘Pericytes,as the mural cells surrounding the microvasculature,play a critical role in the regulation of microcirculation;however,how these cells respond to ischemic stroke remains unclear.To determine the temporal alterations in pericytes after ischemia/reperfusion,we used the 1-hour middle cerebral artery occlusion model,which was examined at 2,12,and 24 hours after reperfusion.Our results showed that in the reperfused regions,the cerebral blood flow decreased and the infarct volume increased with time.Furthermore,the pericytes in the infarct regions contracted and acted on the vascular endothelial cells within 24 hours after reperfusion.These effects may result in incomplete microcirculation reperfusion and a gradual worsening trend with time in the acute phase.These findings provide strong evidence for explaining the“no-reflow”phenomenon that occurs after recanalization in clinical practice.
基金supports from the National Natural Science Foundation of China(No.51871033).
文摘Hardness tests and transmission electron microscopy were used to investigate the strategy of tailoring the phase fraction of precipitates in an Al-Zn-Mg-Cu alloy strengthened by T’ and η’ phases. Different phase fractions of T’ and η’ phases are presented in samples subjected to either single or two stages of ageing treatments at 120 and 150 ℃.For both types of ageing, the precipitation of η’ phase is found to be promoted by ageing at lower temperature and its phase fraction increases with prolonging ageing time at 120 ℃;whereas the phase fractions of T’ and η’ phases almost remain constant during ageing at 150 ℃. Besides, the strain fields produced by T’ and η’ phases were analyzed by using the geometric phase analysis technique, and on a macroscale the contributions of T’ and η’ phases to precipitation strengthening have been quantitatively predicted by combining the size, phase fraction and number density of precipitates.
基金financially supported by the National Natural Science Foundation of China(Nos.81422046 and 21762048)the Yunnan Applicative and Basic Research Program(Nos.2015BC002,2018FY001 and 2018FA048)+4 种基金the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_17R94)the Key Program of Natural Science of Yunnan Province to W.L.Xiaothe Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education(No.2017KF02)the Natural Science Foundation of Yunnan University(No.2017YDQN03)the Foundation of Yunnan Educational Committee(No.2018JS002)。
文摘Callica rpabodinieri is a Chinese traditional medicine herb with anti-inflammatory activity in clinic.Herein,we report two new 9,10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2) and one known compound(3) isolated from the leaves and twigs of this plant.Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+NMR calculation methods.Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated.Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.
文摘The high precision population forecasting and spatial distribution modeling are very important for the theory and application of population sociology,city planning and Geo-Informatics.However,the two problems need to be solved for providing the high precision population information.One is how to improve the population forecasting precision of small area(e.g.,street scale);another is how to improve the spatial resolution of urban population distribution model.To solve the two problems,some new methods are proposed in this contribution.(1)To improve the precision of small area population forecasting,a new method is developed based on the fade factor and the slide window.(2)To improve the spatial resolution of urban population distribution model,a new method is proposed based on the land classification,public facility information and the artificial intelligence technology.For validation of the proposed methods,the real population data of 15 streets in Xicheng district,Beijing,China from 2010 to 2016,the remote sensing images and the public facility data are collected and used.A number of experiments are performed.The results show that the spatial resolution of proposed model reaches 30m*30m and the forecasting precision is better than 5%using the proposed method to forecast the population of 15 streets in Xicheng district in the next four years.
文摘Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptides feature a covalent cross-link of side chains, thus effectively mimicking α-helix as inhibitors of protein-protein interactions. In this review, we category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years.
基金Supported by the National Natural Science Foundation of China(No.41876185)the Major Agricultural Applied Technological Innovation program in Shandong Province(No.SD2019YY007)the Central Public-interest Scientifi c Institution Basal Research Fund,Chinese Academy of Fishery Sciences(No.2018GH15)。
文摘Integrated multi-tropic aquaculture(IMTA)systems have been used in China for many years and have achieved significant economic,social,and ecological benefits.However,there is still a lack of benthic bioremediation species that can effectively utilize the aquaculture particulate organic waste in the system.Polychaete Perinereis aibuhitensis Grube is used as an environmental remediation species for large-scale aquaculture to reduce particulate organic waste,which is of great significance to environmental protection.To improve bio-elements utilization efficiency,P.aibuhitensis was applied for IMTA indoor fish(Hexagrammos otakii)farming.Results showed that in the system,production of 1 kg of the fish discharged 2141-2338 mg of carbon and 529-532 mg of nitrogen,while in the monoculture of the fish,the figures were 3033-3390 mg and 764-794 mg,or 24.84%-35.26%and 30.35%-33.32%less,respectively.This approach promoted IMTA technology that could utilize the particulate organic waste from intensive aquaculture and reduce the adverse environmental effects.
基金financially supported from the National Key Research and Development Program of China(No.2017YFE0127400)the Zhejiang Provincial Natural Science Foundation of China(No.LY17B010004)。
文摘Photocatalysis technology has been proved to be a potential strategy for removal of organic dyes,however high-power light sources are generally necessary to initiate photocatalytic reaction.In this work,we employed an excellent photocatalyst of Bi_(2)WO_(6) with visible light harvest and meanwhile an intrinsic ferroelectricity,which realized the efficient degradation of organic dye via the synergetic photopiezocatalysis.Through coupling the illumination by a low-power(9 W)LED and the ultrasonic vibration(120 W)by an ultrasonic cleaner,the nano flower-like Bi_(2)WO_(6) composed of ultrathin nanosheets showed a much more enhanced photopiezocatalysis performance for purification of organic dye than the individual photocatalysis and piezocatalysis.Furthermore,the high mineralization efficiency and the good durability of the Bi_(2)WO_(6) catalyst were demonstrated.The possible mechanism of photopiezocatalysis was finally proposed,where the ultrasound-induced piezoelectric field in Bi_(2)WO_(6) drove photo-generated electrons and holes to diffuse along opposite directions,consequently promoting the separation efficiency of charge carriers.This work indicates that the synergetic photopiezocatalysis by coupling irradiation and ultrasonic vibration is a promising strategy to purify organic pollutants in wastewater.
