Landslide susceptibility evaluation plays an important role in disaster prevention and reduction.Feature-based transfer learning(TL)is an effective method for solving landslide susceptibility mapping(LSM)in target reg...Landslide susceptibility evaluation plays an important role in disaster prevention and reduction.Feature-based transfer learning(TL)is an effective method for solving landslide susceptibility mapping(LSM)in target regions with no available samples.However,as the study area expands,the distribution of land-slide types and triggering mechanisms becomes more diverse,leading to performance degradation in models relying on landslide evaluation knowledge from a single source domain due to domain feature shift.To address this,this study proposes a Multi-source Domain Adaptation Convolutional Neural Network(MDACNN),which combines the landslide prediction knowledge learned from two source domains to perform cross-regional LSM in complex large-scale areas.The method is validated through case studies in three regions located in southeastern coastal China and compared with single-source domain TL models(TCA-based models).The results demonstrate that MDACNN effectively integrates transfer knowledge from multiple source domains to learn diverse landslide-triggering mechanisms,thereby significantly reducing prediction bias inherent to single-source domain TL models,achieving an average improvement of 16.58%across all metrics.Moreover,the landslide susceptibility maps gener-ated by MDACNN accurately quantify the spatial distribution of landslide risks in the target area,provid-ing a powerful scientific and technological tool for landslide disaster management and prevention.展开更多
Efficient siRNA delivery is highly desirable for disease treatment.However,the application of conventional nanoparticles is limited by the inability to escape from endo-lysosomes.Herein,we report a strategy using smal...Efficient siRNA delivery is highly desirable for disease treatment.However,the application of conventional nanoparticles is limited by the inability to escape from endo-lysosomes.Herein,we report a strategy using small-molecule drugs to enhance siRNA endo-lysosomal release,addressing this challenge.We encapsulated gentamicin(GM)into the marketed Onpattro■ formulation to establish LNP-siRNA/GM nanoparticles that promote siRNA endo-lysosomal escape through endosomal disruption,mechanistically exhibiting unique functionality and synergistic effects of LNP-siRNA/GM to improve cancer therapy.Besides,GM induced reactive oxygen species(ROS)and phospholipids accumulation in endolysosomes,as well as the physical characteristics of lipid nanoparticles(LNPs)were preserved.We also revealed that GM causes endo-lysosomal swelling and disrupts the endosomal membrane to enable siRNA release,as confirmed by Galectin 3 recruitment and acridine orange release.This approach achieved∼81%mRNA-EGFR silencing,which is more than LNP-siEGFR(∼56.23%)by enhancing siRNA endo-lysosomal escape efficiency.Meanwhile,LNP-siEGFR/GM exhibited significant biological activities in HepG2 cells,driven by the synergistic effects of siEGFR and GM with the VEGF and CXCL12 downregulation of,and ROS and phospholipids upregulation.Furthermore,tumor growth was notably suppressed after intravenous injection of LNP-siEGFR/GM in tumor-bearing nude mice.The combination of EGFR-siRNA and GM could also greatly inhibit angiogenesis,be antiproliferative,and induce tumor cells apoptosis.Therefore,this GM and siRNA co-delivery system would provide an efficient strategy for siRNA endosomal escape,significantly improving knockdown in various LNPs based siRNA delivery systems and efficiently enhancing cancer therapy.展开更多
To improve our understanding of the formation and evolution of the Moon, one of the payloads onboard the Chang＇e-3 （CE-3） rover is Lunar Penetrating Radar （LPR）. This investigation is the first attempt to explore...To improve our understanding of the formation and evolution of the Moon, one of the payloads onboard the Chang＇e-3 （CE-3） rover is Lunar Penetrating Radar （LPR）. This investigation is the first attempt to explore the lunar subsurface structure by using ground penetrating radar with high resolution. We have probed the subsur- face to a depth of several hundred meters using LPR. In-orbit testing, data processing and the preliminary results are presented. These observations have revealed the con- figuration of regolith where the thickness of regolith varies from about 4 m to 6 m. In addition, one layer of lunar rock, which is about 330 m deep and might have been accumulated during the depositional hiatus of mare basalts, was detected.展开更多
The Moon-based Ultraviolet Telescope （MUVT） is one of the payloads on the Chang＇e-3 （CE-3） lunar lander. Because of the advantages of having no at- mospheric disturbances and the slow rotation of the Moon, we can...The Moon-based Ultraviolet Telescope （MUVT） is one of the payloads on the Chang＇e-3 （CE-3） lunar lander. Because of the advantages of having no at- mospheric disturbances and the slow rotation of the Moon, we can make long-term continuous observations of a series of important celestial objects in the near ultra- violet band （245-340 nm）, and perform a sky survey of selected areas, which can- not be completed on Earth. We can find characteristic changes in celestial brightness with time by analyzing image data from the MUVT, and deduce the radiation mech- anism and physical properties of these celestial objects after comparing with a phys- ical model. In order to explain the scientific purposes of MUVT, this article analyzes the preprocessing of MUVT image data and makes a preliminary evaluation of data quality. The results demonstrate that the methods used for data collection and prepro- cessing are effective, and the Level 2A and 2B image data satisfy the requirements of follow-up scientific researches.展开更多
Lunar Penetrating Radar （LPR） onboard the rover that is part of the Chang＇e-3 （CE-3） mission was firstly utilized to obtain in situ measurements about geological structure on the lunar surface and the thickness o...Lunar Penetrating Radar （LPR） onboard the rover that is part of the Chang＇e-3 （CE-3） mission was firstly utilized to obtain in situ measurements about geological structure on the lunar surface and the thickness of the lunar regolith, which are key elements for studying the evolutional history of lunar crust. Because penetra- tion depth and resolution of LPR are related to the scientific objectives of this mission, a series of ground-based experiments using LPR was carried out, and results of the experimental data were obtained in a glacial area located in the northwest region of China. The results show that the penetration depth of the first channel antenna used for LPR is over 79 m with a resolution of 2.8 m, and that for the second channel antenna is over 50.8 m with a resolution of 17.1 cm.展开更多
The new Wuqing 70 m radio telescope is first used for the downlink data reception in the first Mars exploration mission of China,and will be used for the other deep space communications and radio astronomical observat...The new Wuqing 70 m radio telescope is first used for the downlink data reception in the first Mars exploration mission of China,and will be used for the other deep space communications and radio astronomical observations in the future.The main specifications and measurement results of some properties in the X-band are introduced in this paper,such as pointing calibration,gain and efficiency,system noise temperature,system equivalent flux density,and variations with elevation.The 23 parameters pointing calibration model considering the atmospheric refraction correction in real time is presented in the telescope,and the pointing accuracy reaches 570 in azimuth direction and 607 in elevation direction for different weather conditions.More than 62%efficiencies are achieved at full elevation range,and more than 70%in the mid-elevation.The system equivalent flux density of the X-band in the mid-elevation reaches 26 Jy.展开更多
The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium i...The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium ions （He＋） at 30.4 nm, the EUVC images the entire plasmasphere with a time resolution of 10 min and a spatial resolution of about 0.1 Earth radius （RE） in a single frame. We first present details about the data processing from EUVC and the data acquisition in the commissioning phase, and then report some initial results, which reflect the basic features of the plas- masphere well. The photon count and emission intensity of EUVC are consistent with previous observations and models, which indicate that the EUVC works normally and can provide high quality data for future studies.展开更多
Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become...Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on site.In an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and enrofloxacin.The key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold carriers.The“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the analytes.On the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive brightness.Enlightened by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection performance.Thus,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and selectivity.Further field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.展开更多
The radio-occultation observations taken by Tianwen-1 are aiming to study the properties of solar wind.A new method of frequency fluctuation(FF)estimation is presented for processing the down-link signals of Tianwen-1...The radio-occultation observations taken by Tianwen-1 are aiming to study the properties of solar wind.A new method of frequency fluctuation(FF)estimation is presented for processing the down-link signals of Tianwen-1 during the occultation period to study the properties of the coronal plasma at the heliocentric distances of 4.48–19 R_(⊙).Because of low S/N as well as the phase fluctuation phenomena caused by solar activity,a Kalman based on polynomial prediction methods is proposed to avoid the phase locked loop loss lock.A new detrend method based on multi-level iteration correction is proposed to estimate Doppler shift to get more accurate power density spectra of FF in the low frequency region.The data analyze procedure is used to get the properties of the solar corona during the occultation.The method was finally verified at the point when the solar offset is 5.7 R_(⊙),frequency tracking was successfully performed on data with a carrier-to-noise ratio of about 28 dBHz.The density spectra obtained by the improved method are basically the same when the frequency is greater than 2 mHz,the uncertainty in the result of the rms of the FF obtained by removing the trend term with different order polynomials is less than 3.3%.The data without eliminating interference show a large error for different detrending orders,which justifies the need for an improved approach.Finally,the frequency fluctuation results combined with the information on intensity fluctuation obtained by the new method are compared with the results of the integrated Space Weather Analysis system and theoretical formula,which verifies that the processing results in this paper have a certain degree of credibility.展开更多
To solve the problem of time-consuming measurement and correction of large antennas’reflector deformation,a new microwave holography methodology based on a Phased Array Feed(PAF)is proposed.Starting from the known ex...To solve the problem of time-consuming measurement and correction of large antennas’reflector deformation,a new microwave holography methodology based on a Phased Array Feed(PAF)is proposed.Starting from the known expression of receiving signals in microwave holography,the theory of PAF holography is derived through Geometrical Optics.Reflector deformation,as well as pointing deviation and subreflector offset,can be calculated out by applying the derived equations.A measurement and correction system based on PAF holography is depicted,and two kinds of measurement methods are illustrated.The proposed measurement methodology is verified by numerical simulation,and its measurement error is analyzed.The results indicate that our proposed methodology is feasible,especially for Cassegrain antennas.展开更多
为了提高图像拼接速度并满足高分辨率图像的实时拼接需求,提出了一种基于ORB(Oriented Fast and Rotated Brief)算法和MSAC(M-estimator Sample Consensus)算法的快速图像拼接方法。ORB算法特征匹配速度快,能够满足实时性要求。首先采用...为了提高图像拼接速度并满足高分辨率图像的实时拼接需求,提出了一种基于ORB(Oriented Fast and Rotated Brief)算法和MSAC(M-estimator Sample Consensus)算法的快速图像拼接方法。ORB算法特征匹配速度快,能够满足实时性要求。首先采用ORB算法进行图像特征点提取;然后,采用MSAC算法对匹配点对进行优化,剔除图像拼接中的伪匹配点对,通过正确的匹配点对求解图像变换矩阵;最后,采用双线性插值融合算法消除可见接缝并去除拼接痕迹。实验结果表明,本文方法在保证图像拼接质量的同时具有更快的拼接速度。展开更多
基金the National Natural Science Foundation of China(Grant No.42301002,and 52109118)Fujian Provincial Water Resources Science and Technology Project(Grant No.MSK202524)Guidance fund for Science and Technology Program,Fujian province(Grant No.2024Y0002).
文摘Landslide susceptibility evaluation plays an important role in disaster prevention and reduction.Feature-based transfer learning(TL)is an effective method for solving landslide susceptibility mapping(LSM)in target regions with no available samples.However,as the study area expands,the distribution of land-slide types and triggering mechanisms becomes more diverse,leading to performance degradation in models relying on landslide evaluation knowledge from a single source domain due to domain feature shift.To address this,this study proposes a Multi-source Domain Adaptation Convolutional Neural Network(MDACNN),which combines the landslide prediction knowledge learned from two source domains to perform cross-regional LSM in complex large-scale areas.The method is validated through case studies in three regions located in southeastern coastal China and compared with single-source domain TL models(TCA-based models).The results demonstrate that MDACNN effectively integrates transfer knowledge from multiple source domains to learn diverse landslide-triggering mechanisms,thereby significantly reducing prediction bias inherent to single-source domain TL models,achieving an average improvement of 16.58%across all metrics.Moreover,the landslide susceptibility maps gener-ated by MDACNN accurately quantify the spatial distribution of landslide risks in the target area,provid-ing a powerful scientific and technological tool for landslide disaster management and prevention.
基金supported by National Natural Science Foundation of China(81502688)Cooperation Research Funding of Capital Medical University(2020KJ000514)+1 种基金Cooperation Research Funding of Capital Medical University(2023KJ000814)R&D Program of Beijing Municipal Education Commission(KM202210025024).
文摘Efficient siRNA delivery is highly desirable for disease treatment.However,the application of conventional nanoparticles is limited by the inability to escape from endo-lysosomes.Herein,we report a strategy using small-molecule drugs to enhance siRNA endo-lysosomal release,addressing this challenge.We encapsulated gentamicin(GM)into the marketed Onpattro■ formulation to establish LNP-siRNA/GM nanoparticles that promote siRNA endo-lysosomal escape through endosomal disruption,mechanistically exhibiting unique functionality and synergistic effects of LNP-siRNA/GM to improve cancer therapy.Besides,GM induced reactive oxygen species(ROS)and phospholipids accumulation in endolysosomes,as well as the physical characteristics of lipid nanoparticles(LNPs)were preserved.We also revealed that GM causes endo-lysosomal swelling and disrupts the endosomal membrane to enable siRNA release,as confirmed by Galectin 3 recruitment and acridine orange release.This approach achieved∼81%mRNA-EGFR silencing,which is more than LNP-siEGFR(∼56.23%)by enhancing siRNA endo-lysosomal escape efficiency.Meanwhile,LNP-siEGFR/GM exhibited significant biological activities in HepG2 cells,driven by the synergistic effects of siEGFR and GM with the VEGF and CXCL12 downregulation of,and ROS and phospholipids upregulation.Furthermore,tumor growth was notably suppressed after intravenous injection of LNP-siEGFR/GM in tumor-bearing nude mice.The combination of EGFR-siRNA and GM could also greatly inhibit angiogenesis,be antiproliferative,and induce tumor cells apoptosis.Therefore,this GM and siRNA co-delivery system would provide an efficient strategy for siRNA endosomal escape,significantly improving knockdown in various LNPs based siRNA delivery systems and efficiently enhancing cancer therapy.
基金Supported by the National Natural Science Foundation of China
文摘To improve our understanding of the formation and evolution of the Moon, one of the payloads onboard the Chang＇e-3 （CE-3） rover is Lunar Penetrating Radar （LPR）. This investigation is the first attempt to explore the lunar subsurface structure by using ground penetrating radar with high resolution. We have probed the subsur- face to a depth of several hundred meters using LPR. In-orbit testing, data processing and the preliminary results are presented. These observations have revealed the con- figuration of regolith where the thickness of regolith varies from about 4 m to 6 m. In addition, one layer of lunar rock, which is about 330 m deep and might have been accumulated during the depositional hiatus of mare basalts, was detected.
文摘The Moon-based Ultraviolet Telescope （MUVT） is one of the payloads on the Chang＇e-3 （CE-3） lunar lander. Because of the advantages of having no at- mospheric disturbances and the slow rotation of the Moon, we can make long-term continuous observations of a series of important celestial objects in the near ultra- violet band （245-340 nm）, and perform a sky survey of selected areas, which can- not be completed on Earth. We can find characteristic changes in celestial brightness with time by analyzing image data from the MUVT, and deduce the radiation mech- anism and physical properties of these celestial objects after comparing with a phys- ical model. In order to explain the scientific purposes of MUVT, this article analyzes the preprocessing of MUVT image data and makes a preliminary evaluation of data quality. The results demonstrate that the methods used for data collection and prepro- cessing are effective, and the Level 2A and 2B image data satisfy the requirements of follow-up scientific researches.
基金Supported by the National Natural Science Foundation of China
文摘Lunar Penetrating Radar （LPR） onboard the rover that is part of the Chang＇e-3 （CE-3） mission was firstly utilized to obtain in situ measurements about geological structure on the lunar surface and the thickness of the lunar regolith, which are key elements for studying the evolutional history of lunar crust. Because penetra- tion depth and resolution of LPR are related to the scientific objectives of this mission, a series of ground-based experiments using LPR was carried out, and results of the experimental data were obtained in a glacial area located in the northwest region of China. The results show that the penetration depth of the first channel antenna used for LPR is over 79 m with a resolution of 2.8 m, and that for the second channel antenna is over 50.8 m with a resolution of 17.1 cm.
基金funded by the Astronomical Joint Fund of the National Natural Science Foundation of China and Chinese Academy of Sciences(U1831114)。
文摘The new Wuqing 70 m radio telescope is first used for the downlink data reception in the first Mars exploration mission of China,and will be used for the other deep space communications and radio astronomical observations in the future.The main specifications and measurement results of some properties in the X-band are introduced in this paper,such as pointing calibration,gain and efficiency,system noise temperature,system equivalent flux density,and variations with elevation.The 23 parameters pointing calibration model considering the atmospheric refraction correction in real time is presented in the telescope,and the pointing accuracy reaches 570 in azimuth direction and 607 in elevation direction for different weather conditions.More than 62%efficiencies are achieved at full elevation range,and more than 70%in the mid-elevation.The system equivalent flux density of the X-band in the mid-elevation reaches 26 Jy.
文摘The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium ions （He＋） at 30.4 nm, the EUVC images the entire plasmasphere with a time resolution of 10 min and a spatial resolution of about 0.1 Earth radius （RE） in a single frame. We first present details about the data processing from EUVC and the data acquisition in the commissioning phase, and then report some initial results, which reflect the basic features of the plas- masphere well. The photon count and emission intensity of EUVC are consistent with previous observations and models, which indicate that the EUVC works normally and can provide high quality data for future studies.
基金supported by National Natural Science Foundation of China(Nos.21874071 and 22204077)China Postdoctoral Science Foundation(No.2021M701722)Fundamental Research Funds for the Central Universities(Nos.30921013112 and 30922010501)。
文摘Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on site.In an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and enrofloxacin.The key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold carriers.The“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the analytes.On the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive brightness.Enlightened by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection performance.Thus,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and selectivity.Further field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.
基金funded by the Astronomical Joint Fund of the National Natural Science Foundation of ChinaChinese Academy of Sciences(Grant Nos.U1831114,11941002,and 12073048)。
文摘The radio-occultation observations taken by Tianwen-1 are aiming to study the properties of solar wind.A new method of frequency fluctuation(FF)estimation is presented for processing the down-link signals of Tianwen-1 during the occultation period to study the properties of the coronal plasma at the heliocentric distances of 4.48–19 R_(⊙).Because of low S/N as well as the phase fluctuation phenomena caused by solar activity,a Kalman based on polynomial prediction methods is proposed to avoid the phase locked loop loss lock.A new detrend method based on multi-level iteration correction is proposed to estimate Doppler shift to get more accurate power density spectra of FF in the low frequency region.The data analyze procedure is used to get the properties of the solar corona during the occultation.The method was finally verified at the point when the solar offset is 5.7 R_(⊙),frequency tracking was successfully performed on data with a carrier-to-noise ratio of about 28 dBHz.The density spectra obtained by the improved method are basically the same when the frequency is greater than 2 mHz,the uncertainty in the result of the rms of the FF obtained by removing the trend term with different order polynomials is less than 3.3%.The data without eliminating interference show a large error for different detrending orders,which justifies the need for an improved approach.Finally,the frequency fluctuation results combined with the information on intensity fluctuation obtained by the new method are compared with the results of the integrated Space Weather Analysis system and theoretical formula,which verifies that the processing results in this paper have a certain degree of credibility.
基金funded by the Astronomical Joint Fund of the National Natural Science Foundation of China and Chinese Academy of Sciences under Nos.12373103,12073048 and 62227901。
文摘To solve the problem of time-consuming measurement and correction of large antennas’reflector deformation,a new microwave holography methodology based on a Phased Array Feed(PAF)is proposed.Starting from the known expression of receiving signals in microwave holography,the theory of PAF holography is derived through Geometrical Optics.Reflector deformation,as well as pointing deviation and subreflector offset,can be calculated out by applying the derived equations.A measurement and correction system based on PAF holography is depicted,and two kinds of measurement methods are illustrated.The proposed measurement methodology is verified by numerical simulation,and its measurement error is analyzed.The results indicate that our proposed methodology is feasible,especially for Cassegrain antennas.
文摘为了提高图像拼接速度并满足高分辨率图像的实时拼接需求,提出了一种基于ORB(Oriented Fast and Rotated Brief)算法和MSAC(M-estimator Sample Consensus)算法的快速图像拼接方法。ORB算法特征匹配速度快,能够满足实时性要求。首先采用ORB算法进行图像特征点提取;然后,采用MSAC算法对匹配点对进行优化,剔除图像拼接中的伪匹配点对,通过正确的匹配点对求解图像变换矩阵;最后,采用双线性插值融合算法消除可见接缝并去除拼接痕迹。实验结果表明,本文方法在保证图像拼接质量的同时具有更快的拼接速度。
