The mafic dykes(dolerites)during the Early Paleozoic are widely spread in Langao-Ziyang,southern Qiling Block,and the investigation on these dykes are very important.Previous studies have mainly focused on the Siluria...The mafic dykes(dolerites)during the Early Paleozoic are widely spread in Langao-Ziyang,southern Qiling Block,and the investigation on these dykes are very important.Previous studies have mainly focused on the Silurian mafic dykes;however,research on the Earlier Paleozoic mafic dykes is relatively weak at present.Therefore,the overall understanding of the mantle source and genetic dynamic setting during the Early Paleozoic in this area is lacking.To study the accurate age and origin of the Early Paleozoic mafic dykes in Ziyang,southern Shaanxi Province,the mafic dykes from dabacunand Qinmingzhai were selected and the petrology,zircon U-Pb chronology,geochemistry,and Sr-Nd-Hf isotopes were studied.Analysis indicates that the mafic dykes studied are mainly composed of dolerite,and they are the products of the Early Ordovician(475.8-480.7 Ma).Furthermore,the dolerites belong to alkaline rock series,and they are characterized by enrichment in LREE,Rb,Ba,Sr,Nb,(87Sr/86Sr)i=0.7020-0.7050,εNd(t)=3.0-4.0),εHf(t)=4.5-12.1,176Hf/177Hf=0.282681-0.282844.This suggests that the mafic dyke were derived from the partial melting of a depleted lithospheric mantle,and the genetic process is mainly controlled by the mantle plume based on the discussion of the genetic model.Furthermore,the genetic process experienced the separation and crystallization of olivine and clinopyroxene at the same time,with little crustal contamination.展开更多
Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN...Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN15),a novel ultra-short cyclic heptapeptide recently shown to promote skin repair,diabetic wound healing,and follicle neogenesis,was evaluated for its therapeutic potential in mucosal repair.Using a rat OU model and a primary oral epithelial cell inflammation model,Cy_(RL-QN15)significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk,including suppression of inflammatory cytokine release from macrophages and neutrophils,reduction of pro-inflammatory factor secretion by oral epithelial cells,and enhancement of their proliferation and migration.Mechanistic studies employing alanine scanning mutagenesis and microscale thermophoresis revealed that Cy_(RL-QN15)directly interacted with Toll-like receptor 4(TLR4)via a methionine-dependent binding interface(K_(d)=2.64μmol/L),thereby inhibiting downstream MyD88/NF-κB signaling.As the first ultra-short cyclic heptapeptide identified to antagonize TLR4,Cy_(RL-QN15)represents a mechanistically distinct immunomodulatory scaffold that restores mucosal homeostasis and offers a promising therapeutic candidate for TLR4-based OU intervention.展开更多
Herein,a simple and effective outer-surface interactions assisted supramolecular hierarchical assembly has been first exploited to uniformly distribute tungstosilicic acid(TSA)inside the porous structure of cucurbit[1...Herein,a simple and effective outer-surface interactions assisted supramolecular hierarchical assembly has been first exploited to uniformly distribute tungstosilicic acid(TSA)inside the porous structure of cucurbit[10]uril-based single-layer 2D supramolecular-organic-frameworks(Q[10]-SOFs)in water.Importantly,the 2D Q[10]-SOFs can further serve as light harvesting antenna,achieving fast energy transfer to the embedded redox-active TSA upon photoexcitation,resulting in efficient visible light-driven selective oxidation of benzyl alcohols into the corresponding aldehydes in high yield at room temperature.Further studies revealed that the integrated of 2D Q[10]-SOFs and TSA played a key role in the catalytic process,due to the presence of a novel stepwise electron transfer route in the single-layer hybrid 2D structures.展开更多
基金This study was supported by the National Natural Science Foundation of China(Grant:41573022).
文摘The mafic dykes(dolerites)during the Early Paleozoic are widely spread in Langao-Ziyang,southern Qiling Block,and the investigation on these dykes are very important.Previous studies have mainly focused on the Silurian mafic dykes;however,research on the Earlier Paleozoic mafic dykes is relatively weak at present.Therefore,the overall understanding of the mantle source and genetic dynamic setting during the Early Paleozoic in this area is lacking.To study the accurate age and origin of the Early Paleozoic mafic dykes in Ziyang,southern Shaanxi Province,the mafic dykes from dabacunand Qinmingzhai were selected and the petrology,zircon U-Pb chronology,geochemistry,and Sr-Nd-Hf isotopes were studied.Analysis indicates that the mafic dykes studied are mainly composed of dolerite,and they are the products of the Early Ordovician(475.8-480.7 Ma).Furthermore,the dolerites belong to alkaline rock series,and they are characterized by enrichment in LREE,Rb,Ba,Sr,Nb,(87Sr/86Sr)i=0.7020-0.7050,εNd(t)=3.0-4.0),εHf(t)=4.5-12.1,176Hf/177Hf=0.282681-0.282844.This suggests that the mafic dyke were derived from the partial melting of a depleted lithospheric mantle,and the genetic process is mainly controlled by the mantle plume based on the discussion of the genetic model.Furthermore,the genetic process experienced the separation and crystallization of olivine and clinopyroxene at the same time,with little crustal contamination.
基金supported by the National Natural Science Foundation of China(32301054,82404582,32360138,32060212)First-Class Discipline Team of Skin&Mucosal Regenerative Medicine of Kunming Medical University(2024XKTDTS10)+2 种基金Key Program of Yunnan Fundamental Research Project(202301AS070036)Open Research Fund of Yunnan Characteristic Plant Extraction Laboratory(YKKF2024003)Project of Yunnan Applied Basic Research Project-Kunming Medical University Union Foundation(202301AY070001-301,202401AY070001-028,202301AY070001-012,202401AY070001-068,202301AY070001-169)。
文摘Oral ulcers(OUs)are among the most common lesions of the oral mucosa,typically associated with pain and burning sensations,and remain clinically challenging due to the scarcity of effective treatment options.Cy_(RL-QN15),a novel ultra-short cyclic heptapeptide recently shown to promote skin repair,diabetic wound healing,and follicle neogenesis,was evaluated for its therapeutic potential in mucosal repair.Using a rat OU model and a primary oral epithelial cell inflammation model,Cy_(RL-QN15)significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk,including suppression of inflammatory cytokine release from macrophages and neutrophils,reduction of pro-inflammatory factor secretion by oral epithelial cells,and enhancement of their proliferation and migration.Mechanistic studies employing alanine scanning mutagenesis and microscale thermophoresis revealed that Cy_(RL-QN15)directly interacted with Toll-like receptor 4(TLR4)via a methionine-dependent binding interface(K_(d)=2.64μmol/L),thereby inhibiting downstream MyD88/NF-κB signaling.As the first ultra-short cyclic heptapeptide identified to antagonize TLR4,Cy_(RL-QN15)represents a mechanistically distinct immunomodulatory scaffold that restores mucosal homeostasis and offers a promising therapeutic candidate for TLR4-based OU intervention.
基金supported by the National Natural Science Foundation of China(No.22271090)。
文摘Herein,a simple and effective outer-surface interactions assisted supramolecular hierarchical assembly has been first exploited to uniformly distribute tungstosilicic acid(TSA)inside the porous structure of cucurbit[10]uril-based single-layer 2D supramolecular-organic-frameworks(Q[10]-SOFs)in water.Importantly,the 2D Q[10]-SOFs can further serve as light harvesting antenna,achieving fast energy transfer to the embedded redox-active TSA upon photoexcitation,resulting in efficient visible light-driven selective oxidation of benzyl alcohols into the corresponding aldehydes in high yield at room temperature.Further studies revealed that the integrated of 2D Q[10]-SOFs and TSA played a key role in the catalytic process,due to the presence of a novel stepwise electron transfer route in the single-layer hybrid 2D structures.
