Blueberry anthocyanins(VA)and blackberry anthocyanins(RA)showed benefits on metabolic syndrome(MS)induced by high-fat diet(HFD)in mice.In this study,we investigated whether the therapeutic effects of VA and RA were ac...Blueberry anthocyanins(VA)and blackberry anthocyanins(RA)showed benefits on metabolic syndrome(MS)induced by high-fat diet(HFD)in mice.In this study,we investigated whether the therapeutic effects of VA and RA were achieved by the gut microbiota regulation and whether these effects could be replicated through fecal microbiota transplantation(FMT)using the HFD caused MS model in pseudo-germ-free mice.The results demonstrated that the beneficial effects of VA and RA on MS,including reducing body weight gain and fat accumulation,improving glucose and lipid metabolism,and mitigating intestinal barrier damage,were attributed to the gut microbiota and could be replicated by FMT.16S r RNA sequencing analysis suggested that FMT from donor mice supplemented with VA and RA could regulate the gut microbiota composition.Particularly,FMT from RA supplemented mice displayed the potential to restore the diversity of gut microbiota and the ratio of Firmicutes to Bacteroidetes.Meanwhile,FMT from VA supplemented mice appeared to exert its effects by selectively influencing specific gut microbiota,such as the genus Akkermansia.Furthermore,our analysis identified 10 common differential amplicon sequence variants(ASVs)among groups compared to HFD-HFD group.Notably,ASV_36450 was negatively associated with metabolic parameters,suggesting that Lactobacillus might be the potential bacteria in regulating MS.Overall,our study demonstrated that FMT from VA and RA supplemented mice could ameliorate MS induced by HFD in mice through regulating specific gut microbiota.展开更多
In this paper, the effect of the mediation effect is mainly used to test and analyze the regression model, and most scholars have studied the impact of the modernization of the industrial structure on the income gap. ...In this paper, the effect of the mediation effect is mainly used to test and analyze the regression model, and most scholars have studied the impact of the modernization of the industrial structure on the income gap. However, this paper is from another perspective, based on the social background of high-quality development, the main study is the impact mechanism of urban and rural income gap on the industrial structure, taking the Yangtze River Delta as the main research object, and specifically selecting 22 central cities in the Yangtze River Delta region, which is also one of the highlights of this study. The regression model is constructed by using the intermediary effect, and the four intermediary variables of fiscal expenditure (M<sub>1</sub>), fixed asset investment (M<sub>2</sub>), number of patent applications (M<sub>3</sub>), and total import and export (M<sub>4</sub>) are selected, which represent the role of the government, fixed asset investment, scientific and technological level and opening-up level, and study and analyze the inherent influence mechanism between each variable. Before doing specific research, I consulted the papers and literature of many other outstanding scholars, among which Cheng Yuhong and Cheng Chi’s “The Influence Mechanism of industrial structure of urban and rural income gap” [1] has great reference value for this paper. According to the research results, under the background of high-quality development in the Yangtze River Delta region, the expansion of the income gap between urban and rural areas will inhibit the upgrading of the industrial structure, so it is necessary to focus on building a new type of urbanization, accelerating the construction of an urban innovation system, optimizing the rural employment structure to narrow the income gap between urban and rural areas, and providing impetus for the continuous upgrading of the industrial structure.展开更多
Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic a...Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic acid rapeseed oil)were analyzed and compared using ultraperformance supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPSFC-Q-TOF-MS).Distinct TAG profiles were identified by lipidomics,principal component analysis(PCA),and heatmap visualization.Human milk was characterized by a high abundance of medium-and long-chain triacylglycerols(MLCTs),saturated-unsaturated-unsaturated(SUU)-type TAGs(sn-2 palmitic acid).In contrast,plant oils lacked MLCTs and SUU-type TAGs,containing mainly TAGs esterified long-chain polyunsaturated fatty acid.Breast milk contains about 27%MLCT,about 50%SUU-type triacylglycerols(which contain about 34%UPU-type triacylglycerols),which is significantly different from plant oils,structured fats and infant formulas.These findings provide a clear basis for optimizing the fat blend in infant formula to better mimic the unique TAG profile of human milk,thereby improving energy delivery and nutrient absorption for infants.展开更多
The catalytic transferred of small molecules into high-value chemical products in green methods are highly perused,and has obtained huge attention.In this field,great progress has been achieved during the past five ye...The catalytic transferred of small molecules into high-value chemical products in green methods are highly perused,and has obtained huge attention.In this field,great progress has been achieved during the past five years.Followed by the roadmap(Chinese Chemical Letters,2019,30,2089-2109)written by us before five years,we think that it should be updated to give more insights in this field.Thus,we write the present roadmap based on the fast changed background.In this roadmap,oxygen and carbon dioxide reduction reactions(including at high temperature),photocatalytic hydrogen generation and carbon dioxide reduction reactions,(photo)electrocatalytic reduction of O_(2)to H_(2)O_(2)and NH_(3)generated from N_(2) are discussed.The progress and challenges in above catalytic processes are given.We believe this manuscript will give the researchers more suggestions and help them to obtain useful information in this field.展开更多
Vestibular hair cells(HCs)in the inner ear,crucial for balance and spatial orientation,are classified into type I and type II subtypes,but the mechanisms regulating their differentiation remain unclear.In this study,w...Vestibular hair cells(HCs)in the inner ear,crucial for balance and spatial orientation,are classified into type I and type II subtypes,but the mechanisms regulating their differentiation remain unclear.In this study,we examined the role of Pou4f3,an important transcription factor,in vestibular HC differentiation using Pou4f3^(DTR/DTR)(deficient)and Pou4f3CreER/CreER(knockout)mouse models.In Pou4f3-deficient mice,the HC number decreased,and immature HCs failed to develop type I characteristics,indicating a developmental arrest.While type II HCs differentiated normally,Pou4f3 deficiency disrupted HC bundle formation and cell polarity.Findings from knockout models further confirmed the essential role of Pou4f3 in vestibular HC subtype specification.This study underscores the critical role of Pou4f3 in determining vestibular HC subtypes and offers insights into potential strategies for restoring vestibular function through HC regeneration.展开更多
Cochlear hair cell(HC)damage is a primary cause of sensorineural hearing loss.In this study,we performed metabolomic profiling of cochlear sensory epithelium following neomycin-induced HC injury and identified elevate...Cochlear hair cell(HC)damage is a primary cause of sensorineural hearing loss.In this study,we performed metabolomic profiling of cochlear sensory epithelium following neomycin-induced HC injury and identified elevated arginine metabolism as a key metabolic characteristic of damaged HCs.Using a highly sensitive and specific biosensor,we confirmed that injury induced an increase in arginine levels within cochlear HCs.By manipulating the levels of arginine and its downstream metabolites,we discovered that unmetabolized arginine exerts a strong protective effect on cochlear HCs,independent of its downstream metabolites,such as nitric oxide.Furthermore,integrated metabolomic and transcriptomic analyses revealed that arginine plays a critical role in reprogramming phospholipid metabolism.Arginine supplementation enhanced membrane phospholipid saturation through the Lands cycle and de novo lipogenesis,and protected HCs from phospholipid peroxidation-induced membrane damage and subsequent cell death.Notably,arginine supplementation protected hearing from both noise-and aminoglycoside-induced injury in mice.These findings underscore the role of unmetabolized arginine in modulating phospholipid metabolism and preventing membrane damage in cochlear HCs,highlighting that targeting phospholipid metabolism is an effective hearing protection strategy.展开更多
Hypervelocity rocket sled systems are critical for testing advanced military technologies,yet track damage at speeds exceeding Mach 5 remains a significant challenge for system reliability and performance.In this stud...Hypervelocity rocket sled systems are critical for testing advanced military technologies,yet track damage at speeds exceeding Mach 5 remains a significant challenge for system reliability and performance.In this study,we investigated the hypervelocity impact response and protection for highstrength U71 Mn or bainitic steel used in rocket sled tracks.Flyer plate impact experiments using a two-stage light-gas gun were conducted to study the hypervelocity collision response,followed by the microstructural characterization via optical microscope,scanning electron microscopy equipped with electron backscatter diffraction to reveal underlying damage mechanisms.Then,the calibrated thermalmechanical coupled finite element simulations using the Johnson-Cook constitutive model and MieGrüneisen equation of state were carried out.Results indicated that bainitic steel exhibits superior impact resistance with predominantly smooth scratch-dominated damage due to its higher ductility.In contrast,U71 Mn suffered significant material spallation and crack propagation arising from brittle fracture mechanisms.Zinc-rich epoxy primer coatings effectively mitigated stress concentration and temperature rise in the substrate at impacting velocities below 2.4 km/s,so as to suppress the microstructural damage such as adiabatic shear bands and dynamic recrystallization.However,coating protection diminished at ultra-high-speed impacts due to the coating failure.Dimensional analysis established quantitative relationships of the gouge damage size to projectile mass,impact velocity,and material yield strength.This study provides in-depth insights into damage mechanisms in hypervelocity rail systems,demonstrating that bainitic steel combined with protective coatings can significantly enhance impact resistance and system reliability,offering valuable guidance for the design and optimization of hypervelocity testing platforms.展开更多
Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy...Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy on serum inflammatory factors. Methods: In this study, 90 patients with acute cerebral infarction hospitalized in Zhuji People’s Hospital from December 2023 to December 2024 were selected and divided into two groups of 45 patients in each group. The control group used standard medical treatment, and the treatment group compared the changes of serum inflammatory factors IL-CRP, TNF-α, and Hcy with Huoxue Tongmai capsule for 7 days, 14 days and 30 days, and discussed the changes of the modified Rankin scale score (mRS) and National Institutes of Health Stroke Scale (NIHSS) score. Results: At 7 days, 14 days, and 30 days of treatment, the NIHSS score, mRS score, hs-CRP, IL-6, TNF-α, and Hcy levels were statistically significant (P α, and Hcy levels in the treatment group were significantly lower than those in the control group (P Conclusion: Patients with acute cerebral infarction received Huoxue Tongmai capsule combined with edaravone right camphor, which can reduce the inflammatory reaction, improve the nerve function and improve the prognosis.展开更多
Objective: To understand the health status of transitional resettlement sites and the needs of residents on health education, and to pro-vide basis for conducting health education after ear- thquakes and other public ...Objective: To understand the health status of transitional resettlement sites and the needs of residents on health education, and to pro-vide basis for conducting health education after ear- thquakes and other public emergen-cies. Method: From May 31 to June 2, 2008 (19 to 21 days after the earthquake), field obser-vation, questionnaire survey, and structured interviews were conducted in five transitional resettlement sites. Information on health status, health service, health education, and residents’ needs on health education was col-lected. Results: 430 questionnaires were dis-tributed and 424 valid completed ones were returned. Food and water were adequately supplied. Clinics for health assistance were established and environment disinfecting was conducted regularly by public health profes-sionals. Health education was available to residents. The large proportion (98.6%, 97.9%, 88.7%, and 93.2% respectively) of the residents acknowledged that water supply, food supply, lavatories, and health service were adequate to fulfill basic needs. The overall disease in-cidence of surveyed residents was 44.8%, and diarrhea and fever with respiratory symptoms were the most common diseases. Among residents’ needs on disease prevention knowl-edge and skills, basic knowledge of infectious diseases was most desirable (49.8%), and safety knowledge of water uses was secon-darily most desirable (36.8%). The most fa-vored approach of obtaining knowledge was watching television. Conclusions: In the pe-riod of 20 days after the earthquake, Living security, health facilities, and health care ser-vice could satisfy residents’ basic needs. Post-disaster health education should con-centrate on basic knowledge and skills of communicable diseases and health- risky be-havior. Timely distributing disease prevention materials could be effective.展开更多
基金financially supported by grants from the National Natural Science Foundation of China(32170377,81973463)the Primary Research&Development Plan of Jiangsu Province(BE2020344,BE2022371)。
文摘Blueberry anthocyanins(VA)and blackberry anthocyanins(RA)showed benefits on metabolic syndrome(MS)induced by high-fat diet(HFD)in mice.In this study,we investigated whether the therapeutic effects of VA and RA were achieved by the gut microbiota regulation and whether these effects could be replicated through fecal microbiota transplantation(FMT)using the HFD caused MS model in pseudo-germ-free mice.The results demonstrated that the beneficial effects of VA and RA on MS,including reducing body weight gain and fat accumulation,improving glucose and lipid metabolism,and mitigating intestinal barrier damage,were attributed to the gut microbiota and could be replicated by FMT.16S r RNA sequencing analysis suggested that FMT from donor mice supplemented with VA and RA could regulate the gut microbiota composition.Particularly,FMT from RA supplemented mice displayed the potential to restore the diversity of gut microbiota and the ratio of Firmicutes to Bacteroidetes.Meanwhile,FMT from VA supplemented mice appeared to exert its effects by selectively influencing specific gut microbiota,such as the genus Akkermansia.Furthermore,our analysis identified 10 common differential amplicon sequence variants(ASVs)among groups compared to HFD-HFD group.Notably,ASV_36450 was negatively associated with metabolic parameters,suggesting that Lactobacillus might be the potential bacteria in regulating MS.Overall,our study demonstrated that FMT from VA and RA supplemented mice could ameliorate MS induced by HFD in mice through regulating specific gut microbiota.
文摘In this paper, the effect of the mediation effect is mainly used to test and analyze the regression model, and most scholars have studied the impact of the modernization of the industrial structure on the income gap. However, this paper is from another perspective, based on the social background of high-quality development, the main study is the impact mechanism of urban and rural income gap on the industrial structure, taking the Yangtze River Delta as the main research object, and specifically selecting 22 central cities in the Yangtze River Delta region, which is also one of the highlights of this study. The regression model is constructed by using the intermediary effect, and the four intermediary variables of fiscal expenditure (M<sub>1</sub>), fixed asset investment (M<sub>2</sub>), number of patent applications (M<sub>3</sub>), and total import and export (M<sub>4</sub>) are selected, which represent the role of the government, fixed asset investment, scientific and technological level and opening-up level, and study and analyze the inherent influence mechanism between each variable. Before doing specific research, I consulted the papers and literature of many other outstanding scholars, among which Cheng Yuhong and Cheng Chi’s “The Influence Mechanism of industrial structure of urban and rural income gap” [1] has great reference value for this paper. According to the research results, under the background of high-quality development in the Yangtze River Delta region, the expansion of the income gap between urban and rural areas will inhibit the upgrading of the industrial structure, so it is necessary to focus on building a new type of urbanization, accelerating the construction of an urban innovation system, optimizing the rural employment structure to narrow the income gap between urban and rural areas, and providing impetus for the continuous upgrading of the industrial structure.
基金supported by the National Key Research and Development Program of China(2021YFD2100700).
文摘Triacylglycerol(TAG)components in human milk,infant formulas with different fat sources,and plant oils(palm oil,flaxseed oil,sunflower oil,corn oil,soybean oil,coconut oil,low erucic acid rapeseed oil,and high oleic acid rapeseed oil)were analyzed and compared using ultraperformance supercritical fluid chromatography coupled with quadrupole time-of-flight mass spectrometry(UPSFC-Q-TOF-MS).Distinct TAG profiles were identified by lipidomics,principal component analysis(PCA),and heatmap visualization.Human milk was characterized by a high abundance of medium-and long-chain triacylglycerols(MLCTs),saturated-unsaturated-unsaturated(SUU)-type TAGs(sn-2 palmitic acid).In contrast,plant oils lacked MLCTs and SUU-type TAGs,containing mainly TAGs esterified long-chain polyunsaturated fatty acid.Breast milk contains about 27%MLCT,about 50%SUU-type triacylglycerols(which contain about 34%UPU-type triacylglycerols),which is significantly different from plant oils,structured fats and infant formulas.These findings provide a clear basis for optimizing the fat blend in infant formula to better mimic the unique TAG profile of human milk,thereby improving energy delivery and nutrient absorption for infants.
基金supported by the National Natural Science Foundation of China(Nos.22268003,22102095,52204320,U20A20246 and 12275199,U22A20418,22075196,21972110,52202208)National Key Research and Development Program of China(Nos.2023YFA1507903,2022YFB3803600,2022YFB4002501)+9 种基金SINOPEC(Beijing)Research Institute of Chemical Industry Co.,Ltd.(No.223239)the Fundamental Research Funds for the Central Universities(No.CCNU22JC017)the Postdoctoral Science Foundation of China(No.2021M692535)the Natural Science Foundation of Shaanxi Province(No.2022JQ-095)the Basic Research Project Foundation of Xi’an Jiaotong University(No.xzy012024012)the Youth Foundation of State Key Laboratory of Electrical Insulation and Power Equipment(No.EIPE2131)the Russian Science Foundation(No.22-13-00035)the Ministry of Science and Higher Education within the framework of a State Assignment of the Ioffe Institute,Russian Academy of Sciences(No.FFUG-2024-0036)Yunnan Fundamental Research Projects(No.202305AF150116)the Research Project Supported by Shanxi Scholarship Council of China(No.2022-050)。
文摘The catalytic transferred of small molecules into high-value chemical products in green methods are highly perused,and has obtained huge attention.In this field,great progress has been achieved during the past five years.Followed by the roadmap(Chinese Chemical Letters,2019,30,2089-2109)written by us before five years,we think that it should be updated to give more insights in this field.Thus,we write the present roadmap based on the fast changed background.In this roadmap,oxygen and carbon dioxide reduction reactions(including at high temperature),photocatalytic hydrogen generation and carbon dioxide reduction reactions,(photo)electrocatalytic reduction of O_(2)to H_(2)O_(2)and NH_(3)generated from N_(2) are discussed.The progress and challenges in above catalytic processes are given.We believe this manuscript will give the researchers more suggestions and help them to obtain useful information in this field.
基金supported by the National Natural Science Foundation of China(82271159,82071049,82425018,and 82101219)the STI2030-Major Projects(2022ZD0205400).
文摘Vestibular hair cells(HCs)in the inner ear,crucial for balance and spatial orientation,are classified into type I and type II subtypes,but the mechanisms regulating their differentiation remain unclear.In this study,we examined the role of Pou4f3,an important transcription factor,in vestibular HC differentiation using Pou4f3^(DTR/DTR)(deficient)and Pou4f3CreER/CreER(knockout)mouse models.In Pou4f3-deficient mice,the HC number decreased,and immature HCs failed to develop type I characteristics,indicating a developmental arrest.While type II HCs differentiated normally,Pou4f3 deficiency disrupted HC bundle formation and cell polarity.Findings from knockout models further confirmed the essential role of Pou4f3 in vestibular HC subtype specification.This study underscores the critical role of Pou4f3 in determining vestibular HC subtypes and offers insights into potential strategies for restoring vestibular function through HC regeneration.
基金supported by the National Natural Science Foundation of China(82271159,82425018,82071049,81830029,82192860,81922018,82201283,82101219,and 82192861)Shanghai Clinical Medical Research Center for Otolaryngology Diseases(20MC1920200)the STI2030-Major Projects(2022ZD0205400).
文摘Cochlear hair cell(HC)damage is a primary cause of sensorineural hearing loss.In this study,we performed metabolomic profiling of cochlear sensory epithelium following neomycin-induced HC injury and identified elevated arginine metabolism as a key metabolic characteristic of damaged HCs.Using a highly sensitive and specific biosensor,we confirmed that injury induced an increase in arginine levels within cochlear HCs.By manipulating the levels of arginine and its downstream metabolites,we discovered that unmetabolized arginine exerts a strong protective effect on cochlear HCs,independent of its downstream metabolites,such as nitric oxide.Furthermore,integrated metabolomic and transcriptomic analyses revealed that arginine plays a critical role in reprogramming phospholipid metabolism.Arginine supplementation enhanced membrane phospholipid saturation through the Lands cycle and de novo lipogenesis,and protected HCs from phospholipid peroxidation-induced membrane damage and subsequent cell death.Notably,arginine supplementation protected hearing from both noise-and aminoglycoside-induced injury in mice.These findings underscore the role of unmetabolized arginine in modulating phospholipid metabolism and preventing membrane damage in cochlear HCs,highlighting that targeting phospholipid metabolism is an effective hearing protection strategy.
基金financial support from the National Key Research and Development Program(Grant No.2024YFA1209801)the National Natural Science Foundation of China(Grant Nos.12302140,12325204)+4 种基金the China Postdoctoral Science Foundation(Grant No.2023M732794)the Fundamental Research Funds for the Central Universities of China(Grant No.sxzy012023213)the Scientific Research Program of Shaanxi Province(Grant No.2023JC-XJ-02)the Young Talent Support Program of Xi'an Science and Technology Association(Grant No.959202413069)Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(Grant No.GZB20230575)。
文摘Hypervelocity rocket sled systems are critical for testing advanced military technologies,yet track damage at speeds exceeding Mach 5 remains a significant challenge for system reliability and performance.In this study,we investigated the hypervelocity impact response and protection for highstrength U71 Mn or bainitic steel used in rocket sled tracks.Flyer plate impact experiments using a two-stage light-gas gun were conducted to study the hypervelocity collision response,followed by the microstructural characterization via optical microscope,scanning electron microscopy equipped with electron backscatter diffraction to reveal underlying damage mechanisms.Then,the calibrated thermalmechanical coupled finite element simulations using the Johnson-Cook constitutive model and MieGrüneisen equation of state were carried out.Results indicated that bainitic steel exhibits superior impact resistance with predominantly smooth scratch-dominated damage due to its higher ductility.In contrast,U71 Mn suffered significant material spallation and crack propagation arising from brittle fracture mechanisms.Zinc-rich epoxy primer coatings effectively mitigated stress concentration and temperature rise in the substrate at impacting velocities below 2.4 km/s,so as to suppress the microstructural damage such as adiabatic shear bands and dynamic recrystallization.However,coating protection diminished at ultra-high-speed impacts due to the coating failure.Dimensional analysis established quantitative relationships of the gouge damage size to projectile mass,impact velocity,and material yield strength.This study provides in-depth insights into damage mechanisms in hypervelocity rail systems,demonstrating that bainitic steel combined with protective coatings can significantly enhance impact resistance and system reliability,offering valuable guidance for the design and optimization of hypervelocity testing platforms.
文摘Objective: To explore the therapeutic effect of Huoxue Tongmai capsule combined with edaravone right camphor on patients with acute cerebral infarction (Acute Cerebral Infarction) and the effect of combination therapy on serum inflammatory factors. Methods: In this study, 90 patients with acute cerebral infarction hospitalized in Zhuji People’s Hospital from December 2023 to December 2024 were selected and divided into two groups of 45 patients in each group. The control group used standard medical treatment, and the treatment group compared the changes of serum inflammatory factors IL-CRP, TNF-α, and Hcy with Huoxue Tongmai capsule for 7 days, 14 days and 30 days, and discussed the changes of the modified Rankin scale score (mRS) and National Institutes of Health Stroke Scale (NIHSS) score. Results: At 7 days, 14 days, and 30 days of treatment, the NIHSS score, mRS score, hs-CRP, IL-6, TNF-α, and Hcy levels were statistically significant (P α, and Hcy levels in the treatment group were significantly lower than those in the control group (P Conclusion: Patients with acute cerebral infarction received Huoxue Tongmai capsule combined with edaravone right camphor, which can reduce the inflammatory reaction, improve the nerve function and improve the prognosis.
文摘Objective: To understand the health status of transitional resettlement sites and the needs of residents on health education, and to pro-vide basis for conducting health education after ear- thquakes and other public emergen-cies. Method: From May 31 to June 2, 2008 (19 to 21 days after the earthquake), field obser-vation, questionnaire survey, and structured interviews were conducted in five transitional resettlement sites. Information on health status, health service, health education, and residents’ needs on health education was col-lected. Results: 430 questionnaires were dis-tributed and 424 valid completed ones were returned. Food and water were adequately supplied. Clinics for health assistance were established and environment disinfecting was conducted regularly by public health profes-sionals. Health education was available to residents. The large proportion (98.6%, 97.9%, 88.7%, and 93.2% respectively) of the residents acknowledged that water supply, food supply, lavatories, and health service were adequate to fulfill basic needs. The overall disease in-cidence of surveyed residents was 44.8%, and diarrhea and fever with respiratory symptoms were the most common diseases. Among residents’ needs on disease prevention knowl-edge and skills, basic knowledge of infectious diseases was most desirable (49.8%), and safety knowledge of water uses was secon-darily most desirable (36.8%). The most fa-vored approach of obtaining knowledge was watching television. Conclusions: In the pe-riod of 20 days after the earthquake, Living security, health facilities, and health care ser-vice could satisfy residents’ basic needs. Post-disaster health education should con-centrate on basic knowledge and skills of communicable diseases and health- risky be-havior. Timely distributing disease prevention materials could be effective.
