INTRODUCTION Langerhans cell histiocytosis(LCH)is a rare hematologic disorder that affects patients of all ages.While most of our current understanding of LCH comes from studies of pediatric patients,data on adult cas...INTRODUCTION Langerhans cell histiocytosis(LCH)is a rare hematologic disorder that affects patients of all ages.While most of our current understanding of LCH comes from studies of pediatric patients,data on adult cases remain limited.The discovery of the BRAFV600E mutation in approximately 50%of LCH samples established LCH as a neoplastic disease,and subsequent research has identified additional activating mutations in the mitogen-activated protein kinase(MAPK)pathway.Recent advances in our understanding of the disease’s pathogenesis and treatment,combined with its rarity,have highlighted the need for comprehensive guidelines for diagnosing and treating LCH in adults(Figure 1).展开更多
To the Editor:Enteral fistula(EF)is a rare complication mostly caused by inflammatory bowel disease and in some cases by duodenal ulcer,intestinal tuberculosis,intestinal lymphoma,abdominal surgery,or necrotizing ente...To the Editor:Enteral fistula(EF)is a rare complication mostly caused by inflammatory bowel disease and in some cases by duodenal ulcer,intestinal tuberculosis,intestinal lymphoma,abdominal surgery,or necrotizing enterocolitis.[1,2]Perforative complications including perforation and EF are major complications of primary intestinal lymphoma(PIL).Vaidya et al[2]reported that in a cohort of 1062 patients with gastrointestinal lymphoma,bowel perforation occurred in 9%of the patients,and among them,the small intestine was the most common site(81%).Furthermore,perforation events occurred as the initial presentation in 51%of these patients.展开更多
基金supported by the National Natural Science Foundation of China(grant no.82370179)the Beijing Natural Science Haidian Frontier Foundation(L222081)+1 种基金National High Level Hospital Clinical Research Funding(2025-PUMCHD-003,2022-PUMCH-B-070)the Peking Union Medical College Hospital Talent Cultivation Program(category C,UBJ10707).
文摘INTRODUCTION Langerhans cell histiocytosis(LCH)is a rare hematologic disorder that affects patients of all ages.While most of our current understanding of LCH comes from studies of pediatric patients,data on adult cases remain limited.The discovery of the BRAFV600E mutation in approximately 50%of LCH samples established LCH as a neoplastic disease,and subsequent research has identified additional activating mutations in the mitogen-activated protein kinase(MAPK)pathway.Recent advances in our understanding of the disease’s pathogenesis and treatment,combined with its rarity,have highlighted the need for comprehensive guidelines for diagnosing and treating LCH in adults(Figure 1).
文摘To the Editor:Enteral fistula(EF)is a rare complication mostly caused by inflammatory bowel disease and in some cases by duodenal ulcer,intestinal tuberculosis,intestinal lymphoma,abdominal surgery,or necrotizing enterocolitis.[1,2]Perforative complications including perforation and EF are major complications of primary intestinal lymphoma(PIL).Vaidya et al[2]reported that in a cohort of 1062 patients with gastrointestinal lymphoma,bowel perforation occurred in 9%of the patients,and among them,the small intestine was the most common site(81%).Furthermore,perforation events occurred as the initial presentation in 51%of these patients.
