Cervical cancer remains a leading cause of cancer-related mortality in women,underscoring the urgent need for advanced diagnostic and therapeutic strategies.Current imaging techniques face significant limitations,incl...Cervical cancer remains a leading cause of cancer-related mortality in women,underscoring the urgent need for advanced diagnostic and therapeutic strategies.Current imaging techniques face significant limitations,including radiation exposure,high costs,and inadequate sensitivity for detecting early metastases,particularly in imaging and diagnosing tumor metastatic lesions.To overcome these challenges,we developed a multimodal imaging strategy that combined near-infrared fluorescence(NIRF,750-1700 nm)imaging with X-ray imaging,with assistance of innovative nanomaterial to achieve precise tumor targeting and comprehensive diagnostic.Specifically,we synthesized a folate acid-functionalized polydopamine-modified ICG-Bi_(2)Se_(3) nanocomposite(FA-PDA@ICG-Bi_(2)Se_(3),FPBI),which integrated the complementary advantages of NIRF,X-ray,and computerized tomography imaging.The FPBI nanocomposite leveraged the targeting capability of folate acid for specific identification of cervical cancer lesions and metastatic lymph node.Furthermore,it demonstrated robust photothermal therapeutic efficacy under near-infrared(808 nm)excitation,achieving significant tumor ablation effects.This work provides an innovative nanoplatform based strategy for multimodal imaging,precise diagnosis,and targeted therapy of cervical cancer,paving the way for improved detection and management of metastatic lesions.展开更多
基金supported by Xinjiang Uygur Autonomous Region Natural Science Foundation Youth Top Talent Project(No.2022TSYCCX0032)The Tianchi Talent Project(No.03010511)+5 种基金Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Special Science and Technology Assistance Program(No.2022E02130)Xinjiang Uygur Autonomous Region Natural Science Foundation Key Project(No.2022D01D40)Outstanding Youth Project(No.2023D01E06)Youth Science Fund(No.2022D01C715)National Science Foundation of China(Nos.82073475,52250007,62035011,82202220 and 82060326)State Key Laboratory of Pathogenesis,Prevention and treatment of High Incident Diseases in central Asia(No.SKL-HIDCA-2024-GJ9)。
文摘Cervical cancer remains a leading cause of cancer-related mortality in women,underscoring the urgent need for advanced diagnostic and therapeutic strategies.Current imaging techniques face significant limitations,including radiation exposure,high costs,and inadequate sensitivity for detecting early metastases,particularly in imaging and diagnosing tumor metastatic lesions.To overcome these challenges,we developed a multimodal imaging strategy that combined near-infrared fluorescence(NIRF,750-1700 nm)imaging with X-ray imaging,with assistance of innovative nanomaterial to achieve precise tumor targeting and comprehensive diagnostic.Specifically,we synthesized a folate acid-functionalized polydopamine-modified ICG-Bi_(2)Se_(3) nanocomposite(FA-PDA@ICG-Bi_(2)Se_(3),FPBI),which integrated the complementary advantages of NIRF,X-ray,and computerized tomography imaging.The FPBI nanocomposite leveraged the targeting capability of folate acid for specific identification of cervical cancer lesions and metastatic lymph node.Furthermore,it demonstrated robust photothermal therapeutic efficacy under near-infrared(808 nm)excitation,achieving significant tumor ablation effects.This work provides an innovative nanoplatform based strategy for multimodal imaging,precise diagnosis,and targeted therapy of cervical cancer,paving the way for improved detection and management of metastatic lesions.
